Research Topics
| Tayyaba HasanSummaryAffiliation: Dartmouth Medical School Country: USA Publications
| Collaborators
|
Detail Information
Publications
Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopyVenkataramanan Krishnaswamy
Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
J Biomed Opt 14:014004. 2009....- Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft modelsKimberley S Samkoe
Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
Int J Radiat Oncol Biol Phys 76:251-9. 2010.... 
Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor modelBin Chen
Thayer School of Engineering, 80000 Cummings Hall, Dartmouth College, Hanover, NH 03755, USA
Clin Cancer Res 11:720-7. 2005....- High vascular delivery of EGF, but low receptor binding rate is observed in AsPC-1 tumors as compared to normal pancreasKimberley S Samkoe
Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
Mol Imaging Biol 14:472-9. 2012..Here, the in vivo delivery and binding kinetics of epidermal growth factor receptor (EGFR) was determined for normal pancreas and AsPC-1 orthotopic pancreatic tumors known to overexpress EGFR... - Noninvasive measurement of aminolevulinic acid-induced protoporphyrin IX fluorescence allowing detection of murine glioma in vivoSummer L Gibbs-Strauss
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 14:014007. 2009..The red light bleaching is found to increase the ability to accurately quantify PpIX fluorescence in vivo, but decreases the specificity of detection between tumor-bearing and nontumor-bearing groups... - Detecting epidermal growth factor receptor tumor activity in vivo during cetuximab therapy of murine gliomasSummer L Gibbs-Strauss
Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
Acad Radiol 17:7-17. 2010.... - Combining vascular and cellular targeting regimens enhances the efficacy of photodynamic therapyBin Chen
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Int J Radiat Oncol Biol Phys 61:1216-26. 2005..CONCLUSIONS: Our results suggest that targeting both tumor vascular and cellular compartments by combining a long-interval PDT with a short-interval PDT can be an effective and safe way to enhance PDT damage to tumor tissue... - Pretreatment photosensitizer dosimetry reduces variation in tumor responseXiaodong Zhou
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Int J Radiat Oncol Biol Phys 64:1211-20. 2006..Conclusions: This research suggests that accurate quantification of tissue photosensitizer levels and subsequent adjustment of light dose will allow for reduced subject variation and improved treatment consistency... - Blood flow dynamics after photodynamic therapy with verteporfin in the RIF-1 tumorBin Chen
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Radiat Res 160:452-9. 2003..These results support the hypothesis that temporal pharmacokinetic changes in the distribution of the photosensitizer between the tumor parenchyma and blood vessels can significantly alter the tumor target of PDT... - Peptide-induced inflammatory increase in vascular permeability improves photosensitizer delivery and intersubject photodynamic treatment efficacyXiaodong Zhou
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Radiat Res 168:299-307. 2007..There was also a significant reduction in the interindividual variability in with substance P plus PDT from 64% to 13%. The resulting treatment was therefore more effective and there was less variability in dose between subjects... - In vivo quantification of tumor receptor binding potential with dual-reporter molecular imagingKenneth M Tichauer
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Mol Imaging Biol 14:584-92. 2012..A dual-reporter methodology capable of quantifying available receptor binding potential of tumors in vivo within a clinically relevant time scale is presented... - Tumor vascular area correlates with photosensitizer uptake: analysis of verteporfin microvascular delivery in the Dunning rat prostate tumorXiaodong Zhou
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Photochem Photobiol 82:1348-57. 2006..This study presents a method to systematically analyze micro-heterogeneity as well as possible methods to increase delivery and homogeneity of photosensitizer within tumor tissue... - Diagnostic detection of diffuse glioma tumors in vive with molecular fluorescent probe-based transmission spectroscopySummer L Gibbs-Strauss
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755 8000, USA
Med Phys 36:974-83. 2009..Optical transmitted fluorescent signal may add significant benefit for clinical cases of diffuse infiltrative growth pattern glioma tumors given sufficient optimization of the signal acquisition for each patient... - Protoporphyrin IX level correlates with number of mitochondria, but increase in production correlates with tumor cell sizeSummer L Gibbs
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Photochem Photobiol 82:1334-41. 2006..The study indicates that use of L1 in tumors with a lower innate production of PpIX with ALA alone may be the most productive approach to this combined delivery... - Analysis of effective molecular diffusion rates for verteporfin in subcutaneous versus orthotopic Dunning prostate tumorsXiaodong Zhou
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Photochem Photobiol 79:323-31. 2004.... - Photobleaching-based dosimetry predicts deposited dose in ALA-PpIX PDT of rodent esophagusChao Sheng
Thayer School of Engineering, Dartmouth College, Harvard Medical School, Boston, MA, USA
Photochem Photobiol 83:738-48. 2007..This detection system and rodent model can be used for prospective dosimetry studies that focus on optimization of esophageal PDT... 
Protoporphyrin IX fluorescence photobleaching increases with the use of fractionated irradiation in the esophagusBrian W Pogue
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 13:034009. 2008....- System development for high frequency ultrasound-guided fluorescence quantification of skin layersJosiah D Gruber
Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
J Biomed Opt 15:026028. 2010..Pilot in-vivo data are also presented, showing recovery of subcutaneous tumor tissue values of protoporphyrin IX in a subcutaneous U251 tumor, which has less fluorescence than the skin... - Improved tumor contrast achieved by single time point dual-reporter fluorescence imagingKenneth M Tichauer
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
J Biomed Opt 17:066001. 2012.... - Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressureSason Torosean
Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire, USA
Nanomedicine 9:151-8. 2013.... - Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivityBrian W Pogue
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Cancer Res 63:1025-33. 2003..4 +/- 1.4 days, and when PDT was given at the same time as radiation, the delay was 8.1 +/- 1.5 days. This observation indicates that the combined effect in the latter case was greater than additive (P = 0.049)...