Alexander Hartov

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Adaptive spatial calibration of a 3D ultrasound system
    Alex Hartov
    Dartmouth College, Hanover, New Hampshire 03766, USA
    Med Phys 37:2121-30. 2010
  2. doi request reprint A comparative analysis of coregistered ultrasound and magnetic resonance imaging in neurosurgery
    Alex Hartov
    Thayer School of Engineering, Dartmouth College, HB 8000, Hanover, NH 03755, USA
    Neurosurgery 62:91-9; discussion 99-101. 2008
  3. ncbi request reprint Assimilating intraoperative data with brain shift modeling using the adjoint equations
    Karen E Lunn
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755 800, USA
    Med Image Anal 9:281-93. 2005
  4. ncbi request reprint Excitation patterns in three-dimensional electrical impedance tomography
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Physiol Meas 26:S185-97. 2005
  5. pmc Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid)
    David W Roberts
    Dartmouth Medical School, Hanover, NH, USA
    Neurosurg Clin N Am 23:371-7. 2012
  6. pmc Model-based estimation of ventricular deformation in the cat brain
    Fenghong Liu
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Med Image Comput Comput Assist Interv 12:308-15. 2009
  7. ncbi request reprint Imaging the breast with EIS: an initial study of exam consistency
    Todd E Kerne
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Physiol Meas 23:221-36. 2002
  8. ncbi request reprint In vivo quantification of retraction deformation modeling for updated image-guidance during neurosurgery
    Leah A Platenik
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Biomed Eng 49:823-35. 2002
  9. ncbi request reprint A noncontacting 3-D digitizer for use in image-guided neurosurgery
    Hai Sun
    Thayer School of Engineering, Hanover, NH, USA
    Stereotact Funct Neurosurg 80:120-4. 2003
  10. pmc Video rate electrical impedance tomography of vascular changes: preclinical development
    Ryan Halter
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    Physiol Meas 29:349-64. 2008

Research Grants

Collaborators

Detail Information

Publications39

  1. pmc Adaptive spatial calibration of a 3D ultrasound system
    Alex Hartov
    Dartmouth College, Hanover, New Hampshire 03766, USA
    Med Phys 37:2121-30. 2010
    ..The user interaction is limited to collecting ultrasound data on which the calibration is based...
  2. doi request reprint A comparative analysis of coregistered ultrasound and magnetic resonance imaging in neurosurgery
    Alex Hartov
    Thayer School of Engineering, Dartmouth College, HB 8000, Hanover, NH 03755, USA
    Neurosurgery 62:91-9; discussion 99-101. 2008
    ..This work presents qualitative and quantitative side-by-side comparisons of oblique coregistered magnetic resonance imaging (MRI) scans and ultrasound images obtained during 35 neurosurgical procedures...
  3. ncbi request reprint Assimilating intraoperative data with brain shift modeling using the adjoint equations
    Karen E Lunn
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755 800, USA
    Med Image Anal 9:281-93. 2005
    ..The scheme is illustrated in a 2D simulation and in a 2D approximation based on a patient case using actual OR data...
  4. ncbi request reprint Excitation patterns in three-dimensional electrical impedance tomography
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Physiol Meas 26:S185-97. 2005
    ..However, in terms of quantitative imaging an excitation pattern where all electrode layers are in phase produces better results...
  5. pmc Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid)
    David W Roberts
    Dartmouth Medical School, Hanover, NH, USA
    Neurosurg Clin N Am 23:371-7. 2012
    ..These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development...
  6. pmc Model-based estimation of ventricular deformation in the cat brain
    Fenghong Liu
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Med Image Comput Comput Assist Interv 12:308-15. 2009
    ....
  7. ncbi request reprint Imaging the breast with EIS: an initial study of exam consistency
    Todd E Kerne
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Physiol Meas 23:221-36. 2002
    ..Overall, these results suggest that EIS breast exams are consistent provided the electrode placement is well controlled, typically with better than 1 cm accuracy...
  8. ncbi request reprint In vivo quantification of retraction deformation modeling for updated image-guidance during neurosurgery
    Leah A Platenik
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Biomed Eng 49:823-35. 2002
    ....
  9. ncbi request reprint A noncontacting 3-D digitizer for use in image-guided neurosurgery
    Hai Sun
    Thayer School of Engineering, Hanover, NH, USA
    Stereotact Funct Neurosurg 80:120-4. 2003
    ..We show that this approach improves the accuracy of registration in a phantom study, and demonstrate the ability to capture cortical motion in six clinical cases...
  10. pmc Video rate electrical impedance tomography of vascular changes: preclinical development
    Ryan Halter
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    Physiol Meas 29:349-64. 2008
    ..The distinguishability analysis suggests that a system such as the one developed here may provide a means to characterize the hemodynamics associated with blood flow through the peripheral vasculature...
  11. doi request reprint Genetic and least squares algorithms for estimating spectral EIS parameters of prostatic tissues
    Ryan J Halter
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Physiol Meas 29:S111-23. 2008
    ..01) were observed between CaP and BPH for the spectral parameters Deltarho and f(c); this is especially important since current prostate cancer screening methods do not reliably differentiate between these two tissue types...
  12. pmc Mutual-information-based image to patient re-registration using intraoperative ultrasound in image-guided neurosurgery
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 35:4612-24. 2008
    ..2 deg, respectively). The proposed scheme is automatic, sufficiently robust, and computationally efficient (<2 min), and holds promise for routine clinical use in the operating room during image-guided neurosurgical procedures...
  13. doi request reprint Arbitrary geometry patient interfaces for breast cancer detection and monitoring with electrical impedance tomography
    Preston Manwaring
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:1178-80. 2008
    ..Preliminary experimental results are presented...
  14. pmc The correlation of in vivo and ex vivo tissue dielectric properties to validate electromagnetic breast imaging: initial clinical experience
    Ryan J Halter
    Thayer School of Engineering, Darmouth College, Hanover, NH 03755, USA
    Physiol Meas 30:S121-36. 2009
    ..We present these results in addition to a case study demonstrating how discrete point spectroscopy measurements of the tissue can be correlated and used to validate EM imaging studies...
  15. pmc Brain-skull contact boundary conditions in an inverse computational deformation model
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Med Image Anal 13:659-72. 2009
    ..9 min on average, but may be further reduced by applying an iterative solver to the linear systems of equations involved and/or by local refinement of the mesh in regions of interest...
  16. pmc Data assimilation using a gradient descent method for estimation of intraoperative brain deformation
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Med Image Anal 13:744-56. 2009
    ....
  17. pmc Electrical properties of prostatic tissues: II. Spectral admittivity properties
    Ryan J Halter
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Urol 182:1608-13. 2009
    ..The frequency dependence of these properties is also a function of tissue morphology. We evaluated the potential of this spectral dependence to provide additional diagnostic information for prostate cancer detection...
  18. pmc Electrical properties of prostatic tissues: I. Single frequency admittivity properties
    Ryan J Halter
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Urol 182:1600-7. 2009
    ..We evaluated how well these electrical properties discriminate cancer from noncancer tissues in the prostate...
  19. pmc Combining multiple true 3D ultrasound image volumes through re-registration and rasterization
    Songbai Ji
    Dartmouth College, Thayer School of Engineering, HB8000, Hanover, NH 03755, USA
    Med Image Comput Comput Assist Interv 12:795-802. 2009
    ..2 mm) and rotational (38.5 degrees) capture ranges for the MI re-registration of two volumetric 3DUS images. The technique is applicable in any clinical application in which volumetric true 3DUS is acquired...
  20. ncbi request reprint Electrical impedance spectroscopy of the breast: clinical imaging results in 26 subjects
    Todd E Kerner
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Med Imaging 21:638-45. 2002
    ..Overall, multifrequency electrical impedance imaging appears promising for detecting breast malignancies, but improvements must be made before the method reaches its full potential...
  21. pmc Real-time interpolation for true 3-dimensional ultrasound image volumes
    Songbai Ji
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    J Ultrasound Med 30:243-52. 2011
    ....
  22. doi request reprint Electrical impedance spectroscopy of benign and malignant prostatic tissues
    Ryan J Halter
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Urol 179:1580-6. 2008
    ..We used electrical impedance spectroscopy to evaluate how significantly the electrical properties of benign and malignant prostatic tissues differ with the goal of providing clinicians with a new biomarker to aid in diagnosis...
  23. doi request reprint A broadband high-frequency electrical impedance tomography system for breast imaging
    Ryan J Halter
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Biomed Eng 55:650-9. 2008
    ..0237 S/m at 10 kHz to 0.2174 S/m at 10 MHz. These findings are consistent with impedance values reported in the literature...
  24. ncbi request reprint Multi-frequency electrical impedance tomography of the breast: new clinical results
    Nirmal K Soni
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755 8000, USA
    Physiol Meas 25:301-14. 2004
    ..Tissues with high radiodensity also had increased conductivity and permittivity...
  25. ncbi request reprint Design and implementation of a high frequency electrical impedance tomography system
    Ryan Halter
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Physiol Meas 25:379-90. 2004
    ..Signal generation and detection, software design and preliminary system specifications are discussed...
  26. ncbi request reprint Statistical estimation of resistance/conductance by electrical impedance tomography measurements
    Eugene Demidenko
    Department of Mathematics, Dartmouth College, 7927 Rubin, DHMC, Lebanon, NH 03756, USA
    IEEE Trans Med Imaging 23:829-38. 2004
    ..Our theory may be applied to various tests including EIT hardware calibration and whether the medium is homogeneous. These tests are illustrated on phantom agar data...
  27. ncbi request reprint On optimal current patterns for electrical impedance tomography
    Eugene Demidenko
    Section of Biostatistics and Epidemiology and the Department of Mathematics, Dartmouth College, Lebanon, NH 03756, USA
    IEEE Trans Biomed Eng 52:238-48. 2005
    ..Our statistical model is able to discriminate between a homogenous agar phantom and one with a 2 mm air hole with error probability (p-value) 1/1000...
  28. ncbi request reprint Displacement estimation with co-registered ultrasound for image guided neurosurgery: a quantitative in vivo porcine study
    Karen E Lunn
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 USA
    IEEE Trans Med Imaging 22:1358-68. 2003
    ....
  29. ncbi request reprint Cortical surface tracking using a stereoscopic operating microscope
    Hai Sun
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    Neurosurgery 56:86-97; discussion 86-97. 2005
    ..To measure and compensate for soft tissue deformation during image-guided neurosurgery, we have developed a novel approach to estimate the three-dimensional (3-D) topology of the cortical surface and track its motion over time...
  30. ncbi request reprint Electrical impedance spectroscopy of the human prostate
    Ryan J Halter
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Biomed Eng 54:1321-7. 2007
    ..This is in agreement with trends observed in other tissues reported in much of the literature. Expanded studies are needed to further validate this finding and to explore the biological mechanism responsible for generating the results...
  31. ncbi request reprint Experimental justification for using 3D conductivity reconstructions in electrical impedance tomography
    Ryan J Halter
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Physiol Meas 28:S115-27. 2007
    ..2 in the particular case presented here. These findings should ultimately be incorporated to clinical imaging with EIT when circular electrode arrays are employed...
  32. ncbi request reprint A novel data calibration scheme for electrical impedance tomography
    Nirmal K Soni
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755 8000, USA
    Physiol Meas 24:421-35. 2003
    ....
  33. ncbi request reprint Data-guided brain deformation modeling: evaluation of a 3-D adjoint inversion method in porcine studies
    Karen E Lunn
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Biomed Eng 53:1893-900. 2006
    ..The guidelines established for selection of model parameters are starting points for further optimization of the method under clinical conditions...
  34. ncbi request reprint Stereopsis-guided brain shift compensation
    Hai Sun
    Dartmouth Medical School, 172 Kellogg Building, Hanover, NH 03755 USA
    IEEE Trans Med Imaging 24:1039-52. 2005
    ..Based on data from two representative clinical cases, we show that stereopsis guidance improves the accuracy of brain shift compensation both at and below the cortical surface...
  35. doi request reprint 3D electric impedance tomography reconstruction on multi-core computing platforms
    Andrea Borsic
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:1175-7. 2008
    ....
  36. ncbi request reprint Variation in breast EIT measurements due to menstrual cycle
    Alexander Hartov
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03766, USA
    Physiol Meas 25:295-9. 2004
    ..It seems that a larger study may be in order to establish this fact definitively...
  37. ncbi request reprint Comparisons of three alternative breast modalities in a common phantom imaging experiment
    Dun Li
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 30:2194-205. 2003
    ..Future work includes the minimization of bias (artifacts) on the periphery of electrical impedance spectroscopy images to improve cross modality correlation and implementation of the multimodality diagnosis for breast cancer detection...
  38. ncbi request reprint Using multiple-electrode impedance measurements to monitor cryosurgery
    Alex Hartov
    Thayer School of Engineering, Dartmouth College, Hanover and HMIP LLC, Lebanon, New Hampshire 03766, USA
    Med Phys 29:2806-14. 2002
    ..These findings suggest that using multielectrode impedance sensing may constitute a means for monitoring cryosurgery...
  39. ncbi request reprint Coregistered intraoperative ultrasonography in resection of malignant glioma
    Dimitrios C Nikas
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Neurosurg Focus 14:e6. 2003
    ..The authors present their experience with coregistration of preoperative imaging data to intraoperative ultrasonography in the resection of high-grade gliomas, focusing on methodology and clinical observation...

Research Grants5

  1. Cryosurgery with Electrical Impedance Tomography
    Alexander Hartov; Fiscal Year: 2001
    ..The integration of EIT capabilities with their existing equipment would constitutive a unique and possible very significant improvement in the current state of the art in cryosurgery. ..
  2. Prostate Cancer Screening With Electrical Impedance Measurements
    Alexander Hartov; Fiscal Year: 2007
    ..We also will develop new electronics and reconstruction techniques applicable to this configuration. This project capitalizes on our group's extensive experience in impedance imaging. ..
  3. Prostate Cancer Screening With Electrical Impedance Measurements
    Alexander Hartov; Fiscal Year: 2010
    ..We also will develop new electronics and reconstruction techniques applicable to this configuration. This project capitalizes on our group's extensive experience in impedance imaging. ..