A I Green

..We report on rates of co-occurring substance use disorders in patients within their first episode of schizophrenia-related psychosis from a multicenter, international treatment trial of olanzapine vs. haloperidol...

..The data from this study suggest some clinical benefits for olanzapine as compared to haloperidol in first episode patients, which must be weighed against those adverse effects that are more likely with olanzapine...

..Further research is required, but early evidence suggests that at least some atypical antipsychotics may prove to be therapeutically effective in the treatment of patients with schizophrenia and comorbid substance use disorder...

..The adjunctive use of naltrexone or other agents also may be helpful. Further research on the optimal pharmacologic approach to patients with dual diagnosis is needed...

..Further studies are required to establish a solid evidence base of best practices for the use of medications in these patients...

..Ultimately, any medication given to these patients will need to be prescribed within psychosocial treatment programs aimed at assisting these patients in limiting and ultimately ceasing substance use...

..These data further suggest that clozapine may serve as a prototype for developing novel treatments for alcohol abuse...

..The use of clozapine by patients with co-occurring substance disorders deserves further study in randomized clinical trials...

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..This study compared the acute and long-term effectiveness of haloperidol with that of olanzapine in patients with first-episode psychosis in a large, controlled clinical trial...

..They also highlight the need to explore the extent to which glucose modulates nonmemory cognitive functions such as attention, and to understand more generally how glucose availability and regulation influence cognition...

..This research, however, could be biased by selection factors. Studying patients who are currently in substance abuse remission could control for level of motivation to stop using substances and other methodological confounds...

..Current treatments are based on a much stronger evidence base, are more patient-centered, and are more likely to target autonomy and recovery...

..The central recommendation is to move rapidly from efficacy studies to more credible and valid effectiveness studies, in order to facilitate the adoption of evidence-based interventions in routine practice settings...

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..Summit faculty member opinion is compared with field survey results, and recommendations are made for future research...

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..The efficacy of clozapine was examined in a group of patients with treatment-refractory bipolar disorder, manic type with psychotic features...

..The efficacy of possible treatments for comorbid schizophrenia and substance abuse are weighed, including typical and atypical antipsychotics and psychosocial interventions, and a list of possible adjunctive agents is provided...

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..Studies of other agents, employed in the pharmacotherapy of alcohol and substance use disorders without schizophrenia, are currently underway in patients with schizophrenia and comorbid disorders...

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..Our data suggest that a beta-adrenergic blocking agent may be effective in reducing the incidence and severity of clozapine-induced myocarditis...

..Our data suggest that both risperidone and clozapine elevate plasma NE levels via enhanced neurotransmitter spillover, with risperidone producing a smaller effect...

..We propose that effective treatments may in part work through the modulation of brain reward circuitry dysfunction...

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..Treatment of ADHD and substance use disorders in adults; 3. Effects of substance abuse on the onset, severity, and treatment of schizophrenia. Recommendations for further research will be presented...

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..Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function...

..This improvement is particularly relevant early in the course of schizophrenia...

..Approximately 50% of patients with schizophrenia or schizoaffective disorder attempt suicide, and approximately 10% die of suicide. Study results suggest that clozapine therapy significantly reduces suicidal behavior in these patients...

..The panel focused on social anxiety disorder, depression, bipolar disorder, and schizophrenia...

..Because of the complexity of the design issues, a steering committee, suicide monitoring board, and publication committee were established to assist with their management...

..This raises the possibility that antipsychotics might alter such pathomorphologic progression in early-stage schizophrenia...

..An algorithm summarizing the consensus recommendations is provided in an appendix...

..Substantial weight gain is common with many atypical antipsychotics...

..This study examines whether longer time to all-cause medication discontinuation is also linked to better functional outcomes...

..Confirmation that CLOZ decreases alcohol use in this population would have important public health implications and could lead to a new use for CLOZ. ..

..Finding medications that may be able to limit cannabis use and thereby reduce adverse outcomes in patients with schizophrenia is of great public health importance. ..

..Finding medications that may be able to limit cannabis use and thereby reduce adverse outcomes in patients with schizophrenia is of great public health importance. ..

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..Finding new medications, safer than CLOZ, that may be able to limit cannabis use In patients with SCHIZ is thus of considerable public health relevance. ..

..The long-term goal of our research is to create better treatments for alcoholism in patients with SCH (and possibly even in those without SCH). ..

..If the results of this study confirm the preliminary data, they could suggest a new use for CLOZ, one that could have important public health implications. ..

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