JAMES GORHAM

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury
    Jack T Lin
    Department of Microbiology and Immunology, The Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Lab Invest 85:550-61. 2005
  2. pmc 1 + 1 = 3: Development and validation of a SNP-based algorithm to identify genetic contributions from three distinct inbred mouse strains
    James D Gorham
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, USA
    J Biomol Tech 23:136-46. 2012
  3. ncbi request reprint Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis
    J D Gorham
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 166:6413-22. 2001
  4. ncbi request reprint Transforming growth factor-beta1, Th1 responses, and autoimmune liver disease
    James D Gorham
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Transfusion 45:51S-59S. 2005
  5. ncbi request reprint TGF-beta 1 regulates antigen-specific CD4+ T cell responses in the periphery
    Richard T Robinson
    Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Immunol 179:71-9. 2007
  6. pmc Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver
    James G Cripps
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hepatology 52:1350-9. 2010
  7. ncbi request reprint Necroinflammatory liver disease in BALB/c background, TGF-beta 1-deficient mice requires CD4+ T cells
    Lynnie A Rudner
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 170:4785-92. 2003
  8. ncbi request reprint TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet
    Jack T Lin
    Department of Microbiology and Immunology and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 174:5950-8. 2005
  9. ncbi request reprint TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1
    Il Kyoo Park
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 175:5666-74. 2005
  10. pmc The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitis
    Michael W Milks
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Liver Int 29:1307-15. 2009

Research Grants

  1. Mechanisms of liver disease in a mouse model of AIH
    JAMES GORHAM; Fiscal Year: 2006
  2. A novel inbred mouse model of autoimmune hepatitis
    JAMES GORHAM; Fiscal Year: 2002
  3. Chemokines in Autoimmune Hepatitis
    JAMES GORHAM; Fiscal Year: 2009
  4. Chemokines in Autoimmune Hepatitis
    James D Gorham; Fiscal Year: 2010
  5. Chemokines in Autoimmune Hepatitis
    JAMES GORHAM; Fiscal Year: 2009
  6. Genetic Linkage Analysis of Liver Disease in Mice
    JAMES GORHAM; Fiscal Year: 2006
  7. Mechanisms of liver disease in a mouse model of AIH
    JAMES GORHAM; Fiscal Year: 2003
  8. INFLAMMATION:CYTOKINE/GLUCOCORTICOID INTERACTIONS
    JAMES GORHAM; Fiscal Year: 2001
  9. Chemokines in Autoimmune Hepatitis
    James D Gorham; Fiscal Year: 2011

Collaborators

  • J J Letterio
  • Leonard D Shultz
  • James P AuBuchon
  • Edward Usherwood
  • Richard T Robinson
  • Jack T Lin
  • James G Cripps
  • Il Kyoo Park
  • Jing Wang
  • Michael W Milks
  • Tatsuro Yoshida
  • Cory L Ahonen
  • Tamar J Kitzmiller
  • Margaret A French
  • Justin M M Cates
  • James L Sung
  • Lynnie A Rudner
  • Ian Blumenthal
  • Ann Maria
  • Todd A Pearson
  • Jennifer L Sargent
  • Michael L Whitfield
  • Kathryn A English
  • Heping Lin
  • Anna Wasiuk
  • Sean C Gifford
  • Shinichiro Fuse
  • Larry J Dumont
  • Mark W Bitensky
  • Arief A Suriawinata
  • Kevin Y Foster
  • Randolph J Noelle
  • Mary Jo Turk
  • Marc S Ernstoff
  • Ross M Kedl
  • Luxi Xia
  • Stacey L Martin
  • Darci A Dyer
  • Hillary D White
  • Elizabeth M Duncan
  • Douglas M Franz

Detail Information

Publications16

  1. ncbi request reprint MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury
    Jack T Lin
    Department of Microbiology and Immunology, The Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Lab Invest 85:550-61. 2005
    ..This constitutes the first direct evidence that susceptibility to autoimmune hepatocellular damage, at least in mice, can be determined by genetic loci distinct from the MHC...
  2. pmc 1 + 1 = 3: Development and validation of a SNP-based algorithm to identify genetic contributions from three distinct inbred mouse strains
    James D Gorham
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, USA
    J Biomol Tech 23:136-46. 2012
    ..We have established and validated an analysis algorithm based on binary SNP data that can successfully identify the donor strain origins of chromosomal regions in mice that are bred from three distinct inbred mouse strains...
  3. ncbi request reprint Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis
    J D Gorham
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 166:6413-22. 2001
    ..This represents the first murine model of hepatitis that develops spontaneously, is restricted by genetic background, and is dependent upon the Th1 cytokine IFN-gamma, and that thus recapitulates these important aspects of AIH...
  4. ncbi request reprint Transforming growth factor-beta1, Th1 responses, and autoimmune liver disease
    James D Gorham
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Transfusion 45:51S-59S. 2005
    ..In this review, I summarize findings published or in press from our laboratory on disease pathogenesis in TGF-beta1-/- mice and then discuss some of the exciting (as-yet-unpublished) directions our laboratory is currently taking...
  5. ncbi request reprint TGF-beta 1 regulates antigen-specific CD4+ T cell responses in the periphery
    Richard T Robinson
    Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Immunol 179:71-9. 2007
    ..These results indicate that CD4+ T cells in TGF-beta1(-/-) mice are activated by and respond to self-Ags present in the periphery, and define a key role for TGF-beta1 in the peripheral regulation of Ag-specific CD4+ T cell responses...
  6. pmc Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver
    James G Cripps
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hepatology 52:1350-9. 2010
    ..The rapid accumulation of CD11b(+)Gr1(+) cells in Tgfb1(-/-) liver was abrogated when mice were either depleted of CD4(+) T cells or rendered unable to produce IFN-γ, showing that Th1 activity induces MDSC accumulation...
  7. ncbi request reprint Necroinflammatory liver disease in BALB/c background, TGF-beta 1-deficient mice requires CD4+ T cells
    Lynnie A Rudner
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 170:4785-92. 2003
    ..Furthermore, TGF-beta1 has a critical role in homeostatic regulation of the hepatic immune system, inhibiting the development or expansion of hepatic cytolytic CD4(+) T cells...
  8. ncbi request reprint TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet
    Jack T Lin
    Department of Microbiology and Immunology and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 174:5950-8. 2005
    ..These data show that TGF-beta1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4(+) T cells at priming and at recall...
  9. ncbi request reprint TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1
    Il Kyoo Park
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 175:5666-74. 2005
    ..Together, these data show that TGF-beta1 suppresses IFN-gamma signaling and transcriptional responses in CD4+ T cells through the PTP Shp-1...
  10. pmc The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitis
    Michael W Milks
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Liver Int 29:1307-15. 2009
    ..These results provide a clearer understanding of the role of Ifng in the molecular basis of necroinflammatory liver disease...
  11. pmc End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of Fas
    Richard T Robinson
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 182:3278-84. 2009
    ....
  12. pmc TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent
    Il Kyoo Park
    Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Mol Immunol 44:3283-90. 2007
    ..Thus, TGF-beta1's inhibition of IFN-gamma signaling in T cells is mediated through a highly specific Smad3 independent, MEK/ERK-dependent signaling pathway...
  13. pmc Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines
    Cory L Ahonen
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Blood 111:3116-25. 2008
    ..These findings provide intelligent strategies for the formulation of multifactorial vaccines to achieve maximal efficacy in cancer vaccine trials in humans...
  14. ncbi request reprint CD28 co-stimulation regulates the effect of transforming growth factor-beta1 on the proliferation of naïve CD4+ T cells
    James L Sung
    Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Int Immunopharmacol 3:233-45. 2003
    ....
  15. ncbi request reprint Restriction of the CD4+ T-cell receptor repertoire prevents immune pathology in TGF-beta1 knockout mice
    Richard T Robinson
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Lab Invest 86:815-28. 2006
    ..Rather, T-cell activation and pathology in TGF-beta1-/- mice appear to be functions of typical TCR activation pathways. This supports the hypothesis that immune pathology in TGF-beta1-/- mice is self-antigen triggered...
  16. doi request reprint The effects of additive solution pH and metabolic rejuvenation on anaerobic storage of red cells
    Tatsuro Yoshida
    Biomedical Engineering Department, Boston University College of Engineering, Boston, Massachusetts 02215, USA
    Transfusion 48:2096-105. 2008
    ..Our objective was to determine whether anaerobic storage with acidified additive solution (AS) coupled with metabolic rejuvenation might further improve the benefits of anaerobic storage...

Research Grants11

  1. Mechanisms of liver disease in a mouse model of AIH
    JAMES GORHAM; Fiscal Year: 2006
    ..The final aim is to analyze the genetics, mechanisms, and specificity of hepatic BALB/c-TGF-b1(-/-) effector cytotoxic T lymphocytes. ..
  2. A novel inbred mouse model of autoimmune hepatitis
    JAMES GORHAM; Fiscal Year: 2002
    ..The proposal seeks to understand mechanisms that regulate the development of inflammation in the liver, so as to gain insights into the pathogenic mechanisms of AIH and other hepatic inflammatory diseases. ..
  3. Chemokines in Autoimmune Hepatitis
    JAMES GORHAM; Fiscal Year: 2009
    ..In this project, we test the role of specific chemokine pathways, neutrophils, and regulatory T cells in the development of autoimmune hepatitis in mice lacking the protein TGF-21. ..
  4. Chemokines in Autoimmune Hepatitis
    James D Gorham; Fiscal Year: 2010
    ..In this project, we test the role of specific chemokine pathways, neutrophils, and regulatory T cells in the development of autoimmune hepatitis in mice lacking the protein TGF-21. ..
  5. Chemokines in Autoimmune Hepatitis
    JAMES GORHAM; Fiscal Year: 2009
    ..In this project, we test the role of specific chemokine pathways, neutrophils, and regulatory T cells in the development of autoimmune hepatitis in mice lacking the protein TGF-21. ..
  6. Genetic Linkage Analysis of Liver Disease in Mice
    JAMES GORHAM; Fiscal Year: 2006
    ..This will have important implications for understanding the genetic basis of autoimmune hepatitis, and of hepatocellular damage in the settings of HCV infection. ..
  7. Mechanisms of liver disease in a mouse model of AIH
    JAMES GORHAM; Fiscal Year: 2003
    ..The final aim is to analyze the genetics, mechanisms, and specificity of hepatic BALB/c-TGF-b1(-/-) effector cytotoxic T lymphocytes. ..
  8. INFLAMMATION:CYTOKINE/GLUCOCORTICOID INTERACTIONS
    JAMES GORHAM; Fiscal Year: 2001
    ..abstract_text> ..
  9. Chemokines in Autoimmune Hepatitis
    James D Gorham; Fiscal Year: 2011
    ..In this project, we test the role of specific chemokine pathways, neutrophils, and regulatory T cells in the development of autoimmune hepatitis in mice lacking the protein TGF-21. ..