AMY SUSANNE GLADFELTER

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Cytoskeleton: cirque du septins
    Amy S Gladfelter
    Dartmouth College, Department of Biological Sciences, 78 College St, Hanover, NH 03755, USA Electronic address
    Curr Biol 24:R526-8. 2014
  2. pmc Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals
    Bradley S DeMay
    Department of Biological Sciences and 2 EM Facility, Dartmouth College, Hanover, NH 03755, USA
    J Cell Biol 193:1065-81. 2011
  3. pmc Heterogeneity in mitochondrial morphology and membrane potential is independent of the nuclear division cycle in multinucleate fungal cells
    John P Gerstenberger
    Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
    Eukaryot Cell 11:353-67. 2012
  4. pmc Axl2 integrates polarity establishment, maintenance, and environmental stress response in the filamentous fungus Ashbya gossypii
    Jonathan F Anker
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Eukaryot Cell 10:1679-93. 2011
  5. doi request reprint Guides to the final frontier of the cytoskeleton: septins in filamentous fungi
    Amy S Gladfelter
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, United States
    Curr Opin Microbiol 13:720-6. 2010
  6. pmc Seeking truth on Monte Verita. Workshop on the molecular biology and biochemistry of septins and septin function
    Amy S Gladfelter
    Department of Biological Sciences, Gilman Hall, Dartmouth College, Hanover, New Hampshire 03755, USA
    EMBO Rep 8:1120-6. 2007
  7. pmc The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells
    Amy S Gladfelter
    University of Basel Biozentrum, Molecular Microbiology, Klingelbergstrasse 0 70, 4056 Basel, Switzerland
    Eukaryot Cell 6:182-97. 2007
  8. ncbi request reprint Control of filamentous fungal cell shape by septins and formins
    Amy S Gladfelter
    Dartmouth College, Department of Biology, Gilman Hall, Hanover, New Hampshire 03755, USA
    Nat Rev Microbiol 4:223-9. 2006
  9. pmc Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells
    A Katrin Hungerbuehler
    Department of Molecular Microbiology, Biozentrum University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Eukaryot Cell 6:473-86. 2007
  10. pmc AgSwe1p regulates mitosis in response to morphogenesis and nutrients in multinucleated Ashbya gossypii cells
    Hanspeter Helfer
    University of Basel Biozentrum, Molecular Microbiology, 4056 Basel, Switzerland
    Mol Biol Cell 17:4494-512. 2006

Research Grants

  1. Asynchronous mitosis in multinucleate cells
    AMY SUSANNE GLADFELTER; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Cytoskeleton: cirque du septins
    Amy S Gladfelter
    Dartmouth College, Department of Biological Sciences, 78 College St, Hanover, NH 03755, USA Electronic address
    Curr Biol 24:R526-8. 2014
    ..New work shows that septins can promote the assembly of curved bundles of F-actin, providing an unexpected molecular function for septins in cytokinesis. ..
  2. pmc Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals
    Bradley S DeMay
    Department of Biological Sciences and 2 EM Facility, Dartmouth College, Hanover, NH 03755, USA
    J Cell Biol 193:1065-81. 2011
    ..We conclude that septins assemble into dynamic, paired filaments in vivo and that this organization is conserved from yeast to mammals...
  3. pmc Heterogeneity in mitochondrial morphology and membrane potential is independent of the nuclear division cycle in multinucleate fungal cells
    John P Gerstenberger
    Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
    Eukaryot Cell 11:353-67. 2012
    ..Our results demonstrate that mitochondrial dynamics are essential in these large syncytial cells, yet morphology and membrane potential are independent of nuclear cycle state...
  4. pmc Axl2 integrates polarity establishment, maintenance, and environmental stress response in the filamentous fungus Ashbya gossypii
    Jonathan F Anker
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Eukaryot Cell 10:1679-93. 2011
    ..Axl2 serves to integrate polarity establishment, polarity maintenance, and environmental stress response for optimal polarized growth in A. gossypii...
  5. doi request reprint Guides to the final frontier of the cytoskeleton: septins in filamentous fungi
    Amy S Gladfelter
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, United States
    Curr Opin Microbiol 13:720-6. 2010
    ..Here I review the novel aspects of septin biology found in filamentous fungi and raise many open questions about these enigmatic polymers that should guide future study...
  6. pmc Seeking truth on Monte Verita. Workshop on the molecular biology and biochemistry of septins and septin function
    Amy S Gladfelter
    Department of Biological Sciences, Gilman Hall, Dartmouth College, Hanover, New Hampshire 03755, USA
    EMBO Rep 8:1120-6. 2007
  7. pmc The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells
    Amy S Gladfelter
    University of Basel Biozentrum, Molecular Microbiology, Klingelbergstrasse 0 70, 4056 Basel, Switzerland
    Eukaryot Cell 6:182-97. 2007
    ..These data suggest that the AgAPC/C may be constitutively active across the cell cycle and that proteolysis in these multinucleated cells may be regulated at the level of substrates rather than by the APC/C itself...
  8. ncbi request reprint Control of filamentous fungal cell shape by septins and formins
    Amy S Gladfelter
    Dartmouth College, Department of Biology, Gilman Hall, Hanover, New Hampshire 03755, USA
    Nat Rev Microbiol 4:223-9. 2006
    ....
  9. pmc Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells
    A Katrin Hungerbuehler
    Department of Molecular Microbiology, Biozentrum University of Basel, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Eukaryot Cell 6:473-86. 2007
    ..We propose that the cohabitation of different cyclins in nuclei has led to enhanced substrate specificity and limited functional redundancy within classes of cyclins in multinucleated cells...
  10. pmc AgSwe1p regulates mitosis in response to morphogenesis and nutrients in multinucleated Ashbya gossypii cells
    Hanspeter Helfer
    University of Basel Biozentrum, Molecular Microbiology, 4056 Basel, Switzerland
    Mol Biol Cell 17:4494-512. 2006
    ..We have generated a model in which AgSwe1p may regulate mitosis in response to cell intrinsic morphogenesis cues and external nutrient availability in multinucleated cells...
  11. pmc Asynchronous nuclear division cycles in multinucleated cells
    Amy S Gladfelter
    Department of Molecular Microbiology, Biozentrum University of Basel, 4056 Basel, Switzerland
    J Cell Biol 172:347-62. 2006
    ..We hypothesize that the continuous cytoplasm in these cells promoted the evolution of a nuclear division cycle in which CDK inhibitors primarily control CDK activity rather than oscillating mitotic cyclin proteins...
  12. ncbi request reprint Nuclear anarchy: asynchronous mitosis in multinucleated fungal hyphae
    Amy S Gladfelter
    Department of Biology, Gilman Hall, Dartmouth College, Hanover, NH 03755, USA
    Curr Opin Microbiol 9:547-52. 2006
    ..Recent work in the fungus Ashbya gossypii illustrates how unique spatial and temporal regulation of conserved cell cycle regulators directs mitosis in multinucleated cells...
  13. pmc Physical interaction between VIVID and white collar complex regulates photoadaptation in Neurospora
    Chen Hui Chen
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 107:16715-20. 2010
    ..Thus, our results demonstrate a direct molecular connection between two of the most essential light signaling components in Neurospora, VVD and WCC, illuminating a previously uncharacterized process for light-sensitive eukaryotic cells...
  14. pmc Regulation of distinct septin rings in a single cell by Elm1p and Gin4p kinases
    Bradley S DeMay
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Mol Biol Cell 20:2311-26. 2009
    ..Instead, morphological and behavioral differences in the rings require the Elm1p and Gin4p kinases. This work demonstrates that distinct higher order septin structures form within one cell because of the action of specific kinases...
  15. ncbi request reprint Interplay between septin organization, cell cycle and cell shape in yeast
    Amy S Gladfelter
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 118:1617-28. 2005
    ....
  16. ncbi request reprint Pathocycles
    Peter E Sudbery
    Department of Molecular Biology and Biotechnology, Sheffield University, Western Bank, Sheffield, S10 2TN, UK
    Fungal Genet Biol 45:1-5. 2008
  17. pmc Genetic interactions among regulators of septin organization
    Amy S Gladfelter
    Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 3:847-54. 2004
    ....
  18. ncbi request reprint Scaffold-mediated symmetry breaking by Cdc42p
    Javier E Irazoqui
    Department of Pharmacology and Cancer Biology Duke University Medical Center, Durham, NC 27710, USA
    Nat Cell Biol 5:1062-70. 2003
    ..Moreover, polarization was dependent on GTP hydrolysis by Cdc42p, suggesting that assembly of a polarization site involves cycling of Cdc42p between GTP- and GDP-bound forms, rather than functioning as a simple on/off switch...
  19. pmc Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p
    Amy S Gladfelter
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 156:315-26. 2002
    ....

Research Grants1

  1. Asynchronous mitosis in multinucleate cells
    AMY SUSANNE GLADFELTER; Fiscal Year: 2010
    ..In this work we will identify molecular sources of timing variability that will have relevance to the diverse diseases influenced by a misregulated cell division cycle. ..