Mimi Ghosh

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunology 129:207-19. 2010
  2. pmc Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C)
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Fertil Steril 89:1497-506. 2008
  3. pmc Modulation of hepatocyte growth factor secretion in human female reproductive tract stromal fibroblasts by poly (I:C) and estradiol
    Kimberly D Coleman
    Physiology Department, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 67:44-53. 2012
  4. pmc Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands
    Daniel O Ochiel
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Leukoc Biol 88:435-44. 2010
  5. pmc Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 5:e11366. 2010
  6. pmc CCL20/MIP3alpha is a novel anti-HIV-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Am J Reprod Immunol 62:60-71. 2009
  7. pmc Genital tract viral load in HIV Type 1-positive women correlates with specific cytokine levels in cervical-vaginal secretions but is not a determinant of infectious virus or anti-HIV activity
    Lucy R Mukura
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    AIDS Res Hum Retroviruses 28:1533-9. 2012
  8. pmc Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol
    Mickey V Patel
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 7:e35654. 2012
  9. pmc Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells
    Daniel O Ochiel
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 5:e14306. 2010
  10. pmc Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 63:544-65. 2010

Collaborators

Detail Information

Publications16

  1. pmc Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunology 129:207-19. 2010
    ..Our data suggest that Trappin-2/Elafin might be an important endogenous microbicide of the female reproductive tract that is protective against HIV-1...
  2. pmc Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C)
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Fertil Steril 89:1497-506. 2008
    ..To examine the expression of toll-like receptors (TLR) by primary human Fallopian tube epithelial cells (FTEC) and to determine whether exposure to the TLR3 agonist poly(I:C) induces an antiviral response...
  3. pmc Modulation of hepatocyte growth factor secretion in human female reproductive tract stromal fibroblasts by poly (I:C) and estradiol
    Kimberly D Coleman
    Physiology Department, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 67:44-53. 2012
    ..We hypothesized that estradiol and poly (I:C), a synthetic RNA mimic, may have a regulatory effect on HGF secretion by stromal fibroblasts from FRT tissues...
  4. pmc Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands
    Daniel O Ochiel
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Leukoc Biol 88:435-44. 2010
    ..These findings indicate collectively that epithelial cells confer a tolerogenic phenotype to DC in the endometrium. Our results suggest novel cellular and molecular mechanisms for the regulation of adaptive immunity within the FRT...
  5. pmc Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 5:e11366. 2010
    ..Since female reproductive tract (FRT) secretions contain a spectrum of antimicrobials, we hypothesized that CVL from healthy HIV(+) and (-) women inhibit HIV infection...
  6. pmc CCL20/MIP3alpha is a novel anti-HIV-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Am J Reprod Immunol 62:60-71. 2009
    ..The role of CCL20/MIP3alpha as an antiviral is unknown. In this study, we have examined the production of CCL20/MIP3alpha by epithelial cells from the upper female reproductive tract as well as its activity as an antiviral molecule...
  7. pmc Genital tract viral load in HIV Type 1-positive women correlates with specific cytokine levels in cervical-vaginal secretions but is not a determinant of infectious virus or anti-HIV activity
    Lucy R Mukura
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    AIDS Res Hum Retroviruses 28:1533-9. 2012
    ..BV status did not have a significant effect on anti-HIV activity. These findings further our understanding of the role of GTVL in determining the cytokine and chemokine milieu in the female reproductive tract...
  8. pmc Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol
    Mickey V Patel
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 7:e35654. 2012
    ....
  9. pmc Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells
    Daniel O Ochiel
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 5:e14306. 2010
    ..We hypothesized in this study that specific immune modulators secreted by uterine epithelial cells modulate susceptibility of dendritic cells (DC) to infection with HIV-1...
  10. pmc Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 63:544-65. 2010
    ..In doing so, a window of STI vulnerability is created during which potential pathogens including HIV enter the reproductive tract to infect host targets...
  11. pmc Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections
    Charles R Wira
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 65:196-211. 2011
    ..The goal of this review is to examine the spectrum of antimicrobials in the FRT and the ways in which they are regulated to provide protection against pathogens that compromise reproductive health and threaten the lives of women...
  12. ncbi Innate Immunity in the Vagina (Part II): Anti-HIV Activity and Antiviral Content of Human Vaginal Secretions
    Mickey V Patel
    Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
    Am J Reprod Immunol 72:22-33. 2014
    ..Whether the concentrations of antiviral proteins, and anti-HIV activity, within human vaginal secretions change across the menstrual cycle is unknown...
  13. pmc New approaches to making the microenvironment of the female reproductive tract hostile to HIV
    John V Fahey
    Department of Physiology and Neurobiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 65:334-43. 2011
    ..all of which are under hormonal control, will open new avenues to therapeutic manipulation of the FRT mucosal microenvironment. By seeking new alternatives to preventing HIV infection in women, we may finally disrupt the HIV pandemic...
  14. pmc Human uterine natural killer cells but not blood natural killer cells inhibit human immunodeficiency virus type 1 infection by secretion of CXCL12
    Teddy F Mselle
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Virol 83:11188-95. 2009
    ....
  15. doi Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract
    Kimberly D Coleman
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Fertil Steril 92:1107-9. 2009
    ..Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis...
  16. pmc Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis
    Stephanie J Bissel
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 160:927-41. 2002
    ..These data suggest that presynaptic damage occurs independent of pathological changes associated with SIVE, whereas postsynaptic damage is more tightly linked to regional presence of both activated and infected macrophages...