G S Gerhard

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)
    Glenn S Gerhard
    Department of Pathology, Penn State College of Medicine, Hershey, PA, USA
    Exp Gerontol 37:1055-68. 2002
  2. ncbi Molecular cloning and sequence analysis of the Danio rerio catalase gene
    G S Gerhard
    Department of Pathology, Penn State College of Medicine, Hershey, PA 17033, USA
    Comp Biochem Physiol B Biochem Mol Biol 127:447-57. 2000
  3. ncbi Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation
    G S Gerhard
    Department of Pathology, Dartmouth Medical School, VA Research Bldg Room 2 140, 215 N Main St, White River Junction, VT 05009, USA
    Arch Pathol Lab Med 125:1107-9. 2001
  4. ncbi Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors
    Glenn S Gerhard
    Department of Pathology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Mech Ageing Dev 123:155-66. 2002
  5. ncbi Genetic differences in hepatic lipid peroxidation potential and iron levels in mice
    Glenn S Gerhard
    Department of Pathology, Penn State College of Medicine, Hershey, PA, USA
    Mech Ageing Dev 123:167-76. 2002
  6. ncbi A call to fins! Zebrafish as a gerontological model
    Glenn S Gerhard
    Department of Pathology, Dartmouth Medical School, Hanover, NH, USA
    Aging Cell 1:104-11. 2002
  7. ncbi Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda
    P R Sinclair
    VA Medical Center, White River Junction, VT 05009, USA
    Hepatology 33:406-12. 2001
  8. ncbi The effects of temperature reduction on gene expression and oxidative stress in skeletal muscle from adult zebrafish
    Renae L Malek
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:363-73. 2004
  9. ncbi Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice
    Nadia Gorman
    VA Medical Center, White River Junction, VT 05009, USA
    Hepatology 40:942-50. 2004
  10. ncbi Atherosclerosis: a manifestation of chronic iron toxicity?
    Leo R Zacharski
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Vasc Med 8:153-5. 2003

Collaborators

Detail Information

Publications24

  1. ncbi Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)
    Glenn S Gerhard
    Department of Pathology, Penn State College of Medicine, Hershey, PA, USA
    Exp Gerontol 37:1055-68. 2002
    ..These data and a growing abundance of related biological resources suggest that the zebrafish may be a compelling model organism for studies on aging...
  2. ncbi Molecular cloning and sequence analysis of the Danio rerio catalase gene
    G S Gerhard
    Department of Pathology, Penn State College of Medicine, Hershey, PA 17033, USA
    Comp Biochem Physiol B Biochem Mol Biol 127:447-57. 2000
    ..Biochem. Biophys. 317 (1995) 267-274). A stem-loop structure is also predicted adjacent to the zebrafish CA repeat, suggesting a similar role in catalase gene regulation...
  3. ncbi Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation
    G S Gerhard
    Department of Pathology, Dartmouth Medical School, VA Research Bldg Room 2 140, 215 N Main St, White River Junction, VT 05009, USA
    Arch Pathol Lab Med 125:1107-9. 2001
    ....
  4. ncbi Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors
    Glenn S Gerhard
    Department of Pathology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Mech Ageing Dev 123:155-66. 2002
    ..We infer that age-related high level mutational damage in mtDNA from human skin fibroblasts may manifest both sequence and inter-individual specificity...
  5. ncbi Genetic differences in hepatic lipid peroxidation potential and iron levels in mice
    Glenn S Gerhard
    Department of Pathology, Penn State College of Medicine, Hershey, PA, USA
    Mech Ageing Dev 123:167-76. 2002
    ..0006. At least two potentially relevant candidate genes reside close to this chromosomal position. Hepatic lipid peroxidation potential appears to be a strain related trait in mice that is amenable to QTL analysis...
  6. ncbi A call to fins! Zebrafish as a gerontological model
    Glenn S Gerhard
    Department of Pathology, Dartmouth Medical School, Hanover, NH, USA
    Aging Cell 1:104-11. 2002
    ..These features, coupled with a growing abundance of biological resources, including an ongoing genome sequencing project, make the zebrafish a compelling model organism for studies on aging...
  7. ncbi Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda
    P R Sinclair
    VA Medical Center, White River Junction, VT 05009, USA
    Hepatology 33:406-12. 2001
    ..No increases in CYP1A2 or other cytochrome P450s were detected in the Hfe-null mutant mice. We conclude that this experimental model of uroporphyria is a valid model for further investigations into the mechanism of PCT...
  8. ncbi The effects of temperature reduction on gene expression and oxidative stress in skeletal muscle from adult zebrafish
    Renae L Malek
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:363-73. 2004
    ..Additional studies will be required to further delineate the role of altered gene expression and oxidative stress on the longevity-promoting effects of temperature reduction...
  9. ncbi Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice
    Nadia Gorman
    VA Medical Center, White River Junction, VT 05009, USA
    Hepatology 40:942-50. 2004
    ..In conclusion, this study demonstrates a strong effect of genetic background on ethanol-induced uroporphyria, which is probably due to a greater effect of ethanol on iron metabolism in the susceptible strain...
  10. ncbi Atherosclerosis: a manifestation of chronic iron toxicity?
    Leo R Zacharski
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Vasc Med 8:153-5. 2003
  11. ncbi Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2
    Nadia Gorman
    VA Medical Center, White River Junction, VT 05009, USA
    Toxicol Appl Pharmacol 221:235-42. 2007
    ..In conclusion, some minimal basal expression of CYP1A2 is essential for HCB-mediated enhancement of uroporphyria, but increases in CYP1A2 above that level are not essential...
  12. ncbi Comparative aspects of zebrafish (Danio rerio) as a model for aging research
    Glenn S Gerhard
    Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17822, USA
    Exp Gerontol 38:1333-41. 2003
    ..This review compares zebrafish with the more widely used model organisms used for aging research, including yeast, worms, flies, mice, and humans...
  13. ncbi The enigmatic role of the hemochromatosis protein (HFE) in iron absorption
    Michael J Chorney
    Department of Microbiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Trends Mol Med 9:118-25. 2003
    ..Although the HFE protein appears to modulate the function of the transferrin receptor in vitro, its precise role in vivo remains obscure. With multiple cell types involved in iron metabolism, the function of HFE is likely to be complex...
  14. ncbi Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway?
    Paul N Meyer
    H107, Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Blood Cells Mol Dis 29:274-85. 2002
    ..These data suggest that HFE and TNFR2 may contribute to a common pathway of the iron stores regulator insuring the controlled efflux of gut iron...
  15. ncbi Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda
    Peter R Sinclair
    VA Medical Center, White River Junction, VT 05009, USA
    Hepatology 37:351-8. 2003
    ..Ethanol-treated Hfe(-/-) mice seem to be an excellent model for studies of alcohol-mediated PCT...
  16. ncbi Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron
    Nadia Gorman
    VA Medical Center, White River Junction, VT 05009, USA
    Hepatology 35:912-21. 2002
    ....
  17. ncbi Aging and kyphosis
    Glenn S Gerhard
    Weis Center for Research, Danville, Pennsylvania 17822-2600, USA
    J Gerontol A Biol Sci Med Sci 58:968. 2003
  18. ncbi IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells
    Wen Jie Zhang
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China
    Cytokine 42:39-47. 2008
    ....
  19. ncbi Outcomes of preoperative weight loss in high-risk patients undergoing gastric bypass surgery
    Christopher D Still
    Geisinger Health Care System, Department of Gastroenterology and Nutrition, 100 N Academy Rd, Mail Code 2111, Danville, PA 17882 2111, USA
    Arch Surg 142:994-8; discussion 999. 2007
    ..Modest, preoperative weight loss will improve perioperative outcomes among high-risk, morbidly obese patients undergoing Roux-en-Y gastric bypass...
  20. ncbi Small laboratory fish as models for aging research
    Glenn S Gerhard
    Weis Center for Research, Geisinger Clinic, Danville, PA 17822, United States
    Ageing Res Rev 6:64-72. 2007
    ..Under-explored areas for which these fish may also provide unique research opportunities include their use as platforms for disease modeling, drug discovery, and regenerative medicine...
  21. ncbi Genes for gestational iron loading?
    Glenn S Gerhard
    Gastroenterology 127:1861; author reply 1861-2. 2004
  22. ncbi Zebrafish, killifish, neither fish, both fish?
    Glenn S Gerhard
    J Gerontol A Biol Sci Med Sci 59:B873-5. 2004
  23. ncbi High-throughput non-heme iron assay for animal tissues
    Martin A Grundy
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Biochem Biophys Methods 59:195-200. 2004
    ..The microplate assay is highly sensitive and specific, and is a simple and effective method for the measurement of non-heme iron for animal tissues that will enable the application of high-throughput of genetic methodologies...
  24. ncbi Association of morbid obesity with FTO and INSIG2 allelic variants
    Xin Chu
    Weis Center for Research, Geisinger Clinic, 100 N Academy Ave, Danville, PA 17822, USA
    Arch Surg 143:235-40; discussion 241. 2008
    ....