Barbara A Fox

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Infect Immun 78:3744-52. 2010
  2. pmc Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment
    Jason R Baird
    Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    Cancer Res 73:3842-51. 2013
  3. pmc Genetic identification of essential indels and domains in carbamoyl phosphate synthetase II of Toxoplasma gondii
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, 652E Borwell Building, Lebanon, NH 03756, USA
    Int J Parasitol 39:533-9. 2009
  4. pmc Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication
    Jason P Gigley
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 182:1069-78. 2009
  5. pmc Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control
    Barbara A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    PLoS Pathog 7:e1002236. 2011
  6. pmc Long-term immunity to lethal acute or chronic type II Toxoplasma gondii infection is effectively induced in genetically susceptible C57BL/6 mice by immunization with an attenuated type I vaccine strain
    Jason P Gigley
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, New Hampshire 03756, USA
    Infect Immun 77:5380-8. 2009
  7. pmc Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines
    Barbara A Fox
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Trends Parasitol 29:431-7. 2013
  8. ncbi request reprint De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Nature 415:926-9. 2002
  9. pmc Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Eukaryot Cell 10:1193-206. 2011
  10. pmc An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii
    Eric Y Denkers
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Infect Immun 80:476-82. 2012

Collaborators

Detail Information

Publications19

  1. pmc Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Infect Immun 78:3744-52. 2010
    ....
  2. pmc Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment
    Jason R Baird
    Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    Cancer Res 73:3842-51. 2013
    ..Immunochemotherapeutic applications of cps might be broadly useful to reawaken natural immunity in the highly immunosuppressive microenvironment of most solid tumors...
  3. pmc Genetic identification of essential indels and domains in carbamoyl phosphate synthetase II of Toxoplasma gondii
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, 652E Borwell Building, Lebanon, NH 03756, USA
    Int J Parasitol 39:533-9. 2009
    ..Collectively, these findings identify novel features of T. gondii CPSII as potential parasite-selective targets for drug development...
  4. pmc Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication
    Jason P Gigley
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 182:1069-78. 2009
    ..These findings offer new insight into immunological mechanisms and local host responses to a non-replicating type I parasite infection associated with development of long-lasting immunity to Toxoplasma gondii...
  5. pmc Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control
    Barbara A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    PLoS Pathog 7:e1002236. 2011
    ..We conclude that encounter between Toxoplasma ROP16 and the host cell STAT signaling cascade has pleiotropic downstream effects that act in multiple and complex ways to direct the course of infection...
  6. pmc Long-term immunity to lethal acute or chronic type II Toxoplasma gondii infection is effectively induced in genetically susceptible C57BL/6 mice by immunization with an attenuated type I vaccine strain
    Jason P Gigley
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, New Hampshire 03756, USA
    Infect Immun 77:5380-8. 2009
    ..Collectively, these results suggest that more effective immune control of chronic type II infection in the genetically susceptible B6 background is established by vaccination with the nonreplicating type I uracil auxotroph cps1-1 strain...
  7. pmc Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines
    Barbara A Fox
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Trends Parasitol 29:431-7. 2013
    ....
  8. ncbi request reprint De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Nature 415:926-9. 2002
    ..Our findings indicate the significance of the de novo pyrimidine biosynthesis pathway for the virulence of parasitic protozoa, and suggest routes for developing vaccines and chemotherapy...
  9. pmc Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Eukaryot Cell 10:1193-206. 2011
    ....
  10. pmc An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii
    Eric Y Denkers
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Infect Immun 80:476-82. 2012
    ....
  11. pmc TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite
    Woraporn Sukhumavasi
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 181:3464-73. 2008
    ..gondii strain. Our results demonstrate that MyD88 is required to control Toxoplasma infection, but that the parasite can trigger adaptive immunity without the need for this TLR adaptor molecule...
  12. pmc CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1
    Elizabeth Charles
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Infect Immun 78:3484-92. 2010
    ..These data suggest that retinal MHC class II and PD-L1 expression is a novel mechanism by which the retina protects itself from CD4 T-cell-mediated immune damage in ocular toxoplasmosis and other types of retinal immune responses...
  13. pmc Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge
    Jason R Baird
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Immunol 190:469-78. 2013
    ..The combination of efficacy, systemic antitumor immune response, and complete attenuation with no observed host toxicity demonstrates the potential value of this novel cancer therapy...
  14. pmc Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Eukaryot Cell 8:520-9. 2009
    ....
  15. ncbi request reprint Toxoplasma gondii: generation of novel truncation mutations in the linker domain of dihydrofolate reductase-thymidylate synthase
    Alexia A Belperron
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Exp Parasitol 106:179-82. 2004
  16. ncbi request reprint Organisation and sequence determination of glutamine-dependent carbamoyl phosphate synthetase II in Toxoplasma gondii
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Int J Parasitol 33:89-96. 2003
    ....
  17. ncbi request reprint Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formation
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Centre Drive, Lebanon, NH 03756, USA
    Int J Parasitol 34:323-31. 2004
    ..gondii infection. These findings are consistent with a model of host-parasite evolution that allowed host control of bradyzoite induction by trading off virulence for increased transmission...
  18. ncbi request reprint Plasmodium falciparum: fine-mapping of an epitope of the serine repeat antigen that is a target of parasite-inhibitory antibodies
    Barbara A Fox
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Exp Parasitol 101:69-72. 2002