L A Flashman

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Apathy and the processing of novelty in schizophrenia
    Robert M Roth
    Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, New Hampshire, 03756 0001, USA
    Schizophr Res 98:232-8. 2008
  2. ncbi request reprint Specific frontal lobe subregions correlated with unawareness of illness in schizophrenia: a preliminary study
    L A Flashman
    Department of Psychiatry Dartmouth Medical School, Lebanon, NH 03756, USA
    J Neuropsychiatry Clin Neurosci 13:255-7. 2001
  3. ncbi request reprint Smaller brain size associated with unawareness of illness in patients with schizophrenia
    L A Flashman
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Psychiatry 157:1167-9. 2000
  4. ncbi request reprint Review of cognition and brain structure in schizophrenia: profiles, longitudinal course, and effects of treatment
    Laura A Flashman
    Department of Psychiatry, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
    Psychiatr Clin North Am 27:1-18, vii. 2004
  5. ncbi request reprint Brain activation on fMRI and verbal memory ability: functional neuroanatomic correlates of CVLT performance
    S C Johnson
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Int Neuropsychol Soc 7:55-62. 2001
  6. ncbi request reprint Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study
    T W McAllister
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Neurology 53:1300-8. 1999
  7. ncbi request reprint Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele
    H A Wishart
    Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH 03756 0001, USA
    Neurology 67:1221-4. 2006
  8. ncbi request reprint Neuroanatomic substrates of semantic memory impairment in Alzheimer's disease: patterns of functional MRI activation
    A J Saykin
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Int Neuropsychol Soc 5:377-92. 1999
  9. ncbi request reprint Differential working memory load effects after mild traumatic brain injury
    T W McAllister
    Section of Neuropsychiatry and Brain Imaging Laboratory, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Neuroimage 14:1004-12. 2001
  10. pmc Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes
    T W McAllister
    Department of Psychiatry, Dartmouth Medical School, Lebanon
    Neurology 78:1777-84. 2012

Detail Information

Publications47

  1. pmc Apathy and the processing of novelty in schizophrenia
    Robert M Roth
    Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, New Hampshire, 03756 0001, USA
    Schizophr Res 98:232-8. 2008
    ..The present findings indicate that schizophrenia is associated with slowed information processing, but do not support the hypothesis that apathy in schizophrenia is associated with abnormal processing of novelty...
  2. ncbi request reprint Specific frontal lobe subregions correlated with unawareness of illness in schizophrenia: a preliminary study
    L A Flashman
    Department of Psychiatry Dartmouth Medical School, Lebanon, NH 03756, USA
    J Neuropsychiatry Clin Neurosci 13:255-7. 2001
    ..Significant inverse correlations were seen between unawareness and bilateral middle frontal gyrus volume and between symptom misattribution and superior frontal gyrus volume...
  3. ncbi request reprint Smaller brain size associated with unawareness of illness in patients with schizophrenia
    L A Flashman
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Psychiatry 157:1167-9. 2000
    ..Although several neuropsychological studies have supported the notion of frontal and parietal lobe involvement in unawareness of illness in schizophrenia, neuroanatomic differences have not been examined...
  4. ncbi request reprint Review of cognition and brain structure in schizophrenia: profiles, longitudinal course, and effects of treatment
    Laura A Flashman
    Department of Psychiatry, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
    Psychiatr Clin North Am 27:1-18, vii. 2004
    ....
  5. ncbi request reprint Brain activation on fMRI and verbal memory ability: functional neuroanatomic correlates of CVLT performance
    S C Johnson
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Int Neuropsychol Soc 7:55-62. 2001
    ....
  6. ncbi request reprint Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study
    T W McAllister
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Neurology 53:1300-8. 1999
    ..To assess patterns of regional brain activation in response to varying working memory loads shortly after mild traumatic brain injury (MTBI)...
  7. ncbi request reprint Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele
    H A Wishart
    Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH 03756 0001, USA
    Neurology 67:1221-4. 2006
    ..To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon3 allele...
  8. ncbi request reprint Neuroanatomic substrates of semantic memory impairment in Alzheimer's disease: patterns of functional MRI activation
    A J Saykin
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Int Neuropsychol Soc 5:377-92. 1999
    ....
  9. ncbi request reprint Differential working memory load effects after mild traumatic brain injury
    T W McAllister
    Section of Neuropsychiatry and Brain Imaging Laboratory, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Neuroimage 14:1004-12. 2001
    ..This suggests that injury-related changes in ability to activate or modulate WM processing resources might underlie some of the memory complaints after MTBI...
  10. pmc Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes
    T W McAllister
    Department of Psychiatry, Dartmouth Medical School, Lebanon
    Neurology 78:1777-84. 2012
    ..To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes...
  11. ncbi request reprint Effects of retroactive and proactive interference on word list recall in schizophrenia
    I J Torres
    Department of Psychiatry, University of Chicago Medical School, IL 60637 1470, USA
    J Int Neuropsychol Soc 7:481-90. 2001
    ..Furthermore, this difference appeared to be related to the frontally-mediated central executive functions that were preferentially associated with RI but not PI susceptibility...
  12. pmc Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI
    A J Saykin
    Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA
    Neurology 67:834-42. 2006
    ....
  13. ncbi request reprint Deep brain stimulation in neuropsychiatric disorders
    R M Roth
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Curr Psychiatry Rep 3:366-72. 2001
    ..Finally, emerging and potential novel areas of application of DBS for the treatment of neuropsychiatric disorders and symptoms are discussed...
  14. ncbi request reprint Brain activation patterns associated with working memory in relapsing-remitting MS
    H A Wishart
    Department of Psychiatry, Dartmouth Medical School Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
    Neurology 62:234-8. 2004
    ..Patients with multiple sclerosis (MS) show changes in brain activation patterns during visual and motor tasks that include decreases in the typical local network for a function and increases in other brain regions...
  15. pmc Subjective rating of working memory is associated with frontal lobe volume in schizophrenia
    Matthew A Garlinghouse
    Neuropsychology Service and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Schizophr Res 120:71-5. 2010
    ..It remains unclear to what extent such patients are able to accurately gauge the integrity of their working memory in their daily lives...
  16. pmc Judgment in older adults: development and psychometric evaluation of the Test of Practical Judgment (TOP-J)
    L A Rabin
    Dartmouth Medical School, Lebanon, NH, USA
    J Clin Exp Neuropsychol 29:752-67. 2007
    ..Longitudinal assessments are being performed to examine predictive validity of the TOP-J for cognitive progression in our clinical groups...
  17. ncbi request reprint Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele
    Heather A Wishart
    Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Dr, Lebanon, NH 03756 0001, USA
    Am J Psychiatry 163:1603-10. 2006
    ..The purpose of this study was to determine whether brain activation patterns associated with working memory differ as a function of apolipoprotein E (APOE) genotype in cognitively intact adults...
  18. ncbi request reprint Functional magnetic resonance imaging of executive control in bipolar disorder
    Robert M Roth
    Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Neuroreport 17:1085-9. 2006
    ..These findings add to the growing body of evidence implicating neural circuitry subserving executive control in bipolar disorder...
  19. ncbi request reprint Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics
    Thomas W McAllister
    Section of Neuropsychiatry, Neuropsychology Program, Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurotrauma 23:1450-67. 2006
    ..We review the evidence from fMRI and neurogenetic studies that support the role of catecholaminergic dysregulation in the etiology of WM complaints and deficits after mild and moderate TBI...
  20. pmc Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlates
    Laura A Flashman
    Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, and New Hampshire Hospital, Lebanon, NH, USA
    Psychiatry Res 154:147-55. 2007
    ..CSP, while prevalent, was not more frequent in our sample of patients with schizophrenia, and had few associations with symptom severity or neuropsychological deficits...
  21. ncbi request reprint Apathy and its treatment
    Robert M Roth
    Laura A Flashman, PhD Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Curr Treat Options Neurol 9:363-70. 2007
    ..In the interim, careful evaluation of possible psychosocial and biological contributors to apathy in any given patient is suggested, with treatment planning based accordingly...
  22. pmc Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study
    Thomas W McAllister
    Department of Psychiatry, Section of Neuropsychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Brain Inj 22:705-14. 2008
    ....
  23. ncbi request reprint Event-related functional magnetic resonance imaging of response inhibition in obsessive-compulsive disorder
    Robert M Roth
    Brain Imaging Laboratory, Departments of Psychiatry and Radiology, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    Biol Psychiatry 62:901-9. 2007
    ..Obsessive-compulsive disorder (OCD) has been hypothesized to involve inhibitory control dysfunction related to abnormal frontal-striatal-thalamic-cortical (FSTC) circuitry...
  24. ncbi request reprint Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756
    Am J Psychiatry 162:1749-51. 2005
    ..The authors tested the hypothesis that the dopamine D2 receptor T allele (formerly described as the A1 allele) would be associated with poorer performance on memory and attention tasks following mild traumatic brain injury...
  25. ncbi request reprint Lack of awareness and its impact in traumatic brain injury
    Laura A Flashman
    Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    NeuroRehabilitation 17:285-96. 2002
    ..Finally, a review of the literature studying lack of awareness in TBI, its relationship to injury severity, the impact of lack of awareness on outcome, and intervention approaches is presented...
  26. ncbi request reprint Disorders of awareness in neuropsychiatric syndromes: an update
    Laura A Flashman
    Neuropsychology Program, Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Curr Psychiatry Rep 4:346-53. 2002
    ..Although most research has used neuropsychologic measures to assess brain functioning, more recent, limited literature in AD and schizophrenia has begun to examine neural correlates of unawareness using structural and functional imaging...
  27. ncbi request reprint Apathy in schizophrenia: reduced frontal lobe volume and neuropsychological deficits
    Robert M Roth
    Department of Psychiatry, Dartmouth Medical School and New Hampshire Hospital, Lebanon 03756 0001, USA
    Am J Psychiatry 161:157-9. 2004
    ..Apathy is a common negative symptom in schizophrenia. The authors investigated neuropsychological performance and regional brain volumes in schizophrenia patients with high versus low levels of apathy...
  28. ncbi request reprint Working memory deficits after traumatic brain injury: catecholaminergic mechanisms and prospects for treatment -- a review
    Thomas W McAllister
    Department of Psychiatry, Section of Neuropsychiatry and the Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
    Brain Inj 18:331-50. 2004
    ..Current knowledge gaps and research needs are identified...
  29. ncbi request reprint Contribution of organizational strategy to verbal learning and memory in adults with attention-deficit/hyperactivity disorder
    Robert M Roth
    Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH, USA
    Neuropsychology 18:78-84. 2004
    ..The pattern of findings suggests that decreased verbal learning and memory in adult ADHD is due in part to situational anxiety and not to poor use of organizational strategies during encoding...
  30. ncbi request reprint Cholinergic enhancement of frontal lobe activity in mild cognitive impairment
    Andrew J Saykin
    Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
    Brain 127:1574-83. 2004
    ....
  31. ncbi request reprint Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments
    Thomas W McAllister
    Department of Psychiatry, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Curr Psychiatry Rep 6:364-71. 2004
    ..Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described...
  32. ncbi request reprint Neuropsychiatric syndromes in adults with intellectual disability: issues in assessment and treatment
    Richard B Ferrell
    Neuropsychiatry Service, Dartmouth Medical School at New Hampshire Hospital, 36 Clinton Street, Concord, NH 03301, USA
    Curr Psychiatry Rep 6:380-90. 2004
    ..Community-based models of support with neuropsychiatric intervention can be a potent therapeutic combination in the management of challenging behaviors in individuals with ID...
  33. ncbi request reprint Neuroimaging findings in mild traumatic brain injury
    T W McAllister
    Section of Neuropsychiatry and Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Clin Exp Neuropsychol 23:775-91. 2001
    ..It is, therefore, important to be aware of the advantages and limitations of the various available imaging modalities. This paper selectively reviews the pertinent literature on the structural and functional imaging in mild TBI...
  34. pmc Verbal fluency performance in amnestic MCI and older adults with cognitive complaints
    Katherine E Nutter-Upham
    Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH, USA
    Arch Clin Neuropsychol 23:229-41. 2008
    ..Overall, our findings highlight the importance of including multiple verbal fluency tests in assessment batteries targeting preclinical dementia populations and suggest that individual fluency tasks may tap specific cognitive processes...
  35. pmc Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes
    Chantel D Sloan
    Department of Genetics and Community and Family Medicine, Computational Genetics Laboratory, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1060-9. 2010
    ..The results are consistent with polygenic influences on early neurodegenerative changes and demonstrate the effectiveness of hierarchical clustering in identifying genetic associations among multiple related phenotypic endpoints...
  36. pmc Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints
    Paul J Wang
    Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Neurobiol Aging 27:1613-7. 2006
    ....
  37. pmc Chronic deep brain stimulation for the treatment of tremor in multiple sclerosis: review and case reports
    H A Wishart
    Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    J Neurol Neurosurg Psychiatry 74:1392-7. 2003
    ..Deep brain stimulation (DBS) offers a non-ablative alternative to thalamotomy for the surgical treatment of medically refractory tremor in multiple sclerosis. However, relatively few outcomes have been reported...
  38. doi request reprint Nonclinical obsessive-compulsive symptoms and executive functions in schizophrenia
    Sheba R Kumbhani
    Dartmouth Medical School, Department of Psychiatry, One Medical Center Dr, Lebanon, NH 03756 0001, USA
    J Neuropsychiatry Clin Neurosci 22:304-12. 2010
    ..Performance-based scores showed few correlations with OCS. Findings indicate that severity of nonclinical OCS subtypes contributes to the heterogeneity of executive functions in schizophrenia...
  39. pmc Lack of relationship between psychological denial and unawareness of illness in schizophrenia-spectrum disorders
    Carrie L Kruck
    Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Psychiatry Res 169:33-8. 2009
    ..The patient group and the healthy comparison group did not differ in their use of self-deception. The current results do not support the psychological denial theory of unawareness of illness in schizophrenia-spectrum disorders...
  40. ncbi request reprint Executive dysfunction following traumatic brain injury: neural substrates and treatment strategies
    Brenna C McDonald
    Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA
    NeuroRehabilitation 17:333-44. 2002
    ..This review summarizes the nature of executive deficits following TBI, their neuroanatomical substrates, selected assessment and treatment strategies, and recent research findings and trends...
  41. ncbi request reprint Self- and informant reports of executive function on the BRIEF-A in MCI and older adults with cognitive complaints
    Laura A Rabin
    Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH, USA
    Arch Clin Neuropsychol 21:721-32. 2006
    ..Overall findings indicate that the BRIEF-A is sensitive to subtle executive changes in MCI and CC and suggest the need for research to determine if executive complaints are predictive of clinical course...
  42. ncbi request reprint Sex differences in semantic language processing: a functional MRI study
    L C Baxter
    Brain Imaging Laboratory, Department of Psychiatry DHMC, Dartmouth Medical School, Lebanon, NH 03756, USA
    Brain Lang 84:264-72. 2003
    ..Results support both an interhemispheric and an intrahemispheric model of sex differences in language, suggesting that the models may not be mutually exclusive...
  43. pmc Hippocampal volume and shape analysis in an older adult population
    Tara L McHugh
    Department of Psychiatry, Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH, USA
    Clin Neuropsychol 21:130-45. 2007
    ..These and other novel directions in research on hippocampal function and dysfunction will be facilitated by the use of reliable, comprehensive, and consistent segmentation and measurement methods...
  44. ncbi request reprint The differential diagnosis of pseudobulbar affect (PBA). Distinguishing PBA among disorders of mood and affect. Proceedings of a roundtable meeting
    David B Arciniegas
    Neuropsychiatry Service, Department of Psychiatry, University of Colorado School of Medicine, Denver, Colorado 80211, USA
    CNS Spectr 10:1-14; quiz 15-6. 2005
    ..The material presented in this monograph will help clinicians better recognize, diagnose, and treat PBA, and will form a foundation for understanding and interpreting future studies of this condition...
  45. ncbi request reprint Neuropsychological impairment in borderline personality disorder
    Elena S Monarch
    The Virtual Reality Treatment Center, 154 Waterman Street, Providence, RI 02906, USA
    Psychiatr Clin North Am 27:67-82, viii-ix. 2004
    ..The authors recommend that clinicians routinely screen BPD patients for cognitive dysfunction and highlight the roles that this important knowledge can have in treatment...
  46. ncbi request reprint The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: a volumetric MRI study
    Brittany R Copenhaver
    Department of Psychology, Dartmouth College, Hanover, NH 03755, USA
    Psychiatry Res 147:93-103. 2006
    ..Results suggest that atrophy of the fornix and mammillary bodies becomes apparent at the point of conversion from MCI to AD. Longitudinal assessments are needed to delineate the time course and extent of the observed volumetric changes...
  47. ncbi request reprint Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderly
    Jennifer Duncan Davis
    Brown Medical School, Rhode Island Hospital Physicians Office Building, Suite 430, 110 Lockwood Street, Providence, RI 02903, USA
    Curr Psychiatry Rep 5:384-90. 2003
    ..The purpose of this review is to summarize existing data on the cognitive and neuropsychiatric consequences of subclinical hypothyroidism, benefits of treatment, and recommendations for screening and monitoring in older adults...