Research Topics
Species | L A FlashmanSummaryAffiliation: Dartmouth Medical School Country: USA Publications
| Collaborators
|
Detail Information
Publications
Apathy and the processing of novelty in schizophreniaRobert M Roth
Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, New Hampshire, 03756 0001, USA
Schizophr Res 98:232-8. 2008..The present findings indicate that schizophrenia is associated with slowed information processing, but do not support the hypothesis that apathy in schizophrenia is associated with abnormal processing of novelty...
Specific frontal lobe subregions correlated with unawareness of illness in schizophrenia: a preliminary studyL A Flashman
Department of Psychiatry Dartmouth Medical School, Lebanon, NH 03756, USA
J Neuropsychiatry Clin Neurosci 13:255-7. 2001..Significant inverse correlations were seen between unawareness and bilateral middle frontal gyrus volume and between symptom misattribution and superior frontal gyrus volume...- Smaller brain size associated with unawareness of illness in patients with schizophreniaL A Flashman
Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Psychiatry 157:1167-9. 2000..Although several neuropsychological studies have supported the notion of frontal and parietal lobe involvement in unawareness of illness in schizophrenia, neuroanatomic differences have not been examined... - Review of cognition and brain structure in schizophrenia: profiles, longitudinal course, and effects of treatmentLaura A Flashman
Department of Psychiatry, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
Psychiatr Clin North Am 27:1-18, vii. 2004.... - Brain activation on fMRI and verbal memory ability: functional neuroanatomic correlates of CVLT performanceS C Johnson
Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
J Int Neuropsychol Soc 7:55-62. 2001.... - Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI studyT W McAllister
Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Neurology 53:1300-8. 1999..To assess patterns of regional brain activation in response to varying working memory loads shortly after mild traumatic brain injury (MTBI)... - Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 alleleH A Wishart
Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH 03756 0001, USA
Neurology 67:1221-4. 2006..To determine whether cognitively intact adults with the APOE epsilon3/epsilon4 genotype show reduced gray matter density on voxel-based morphometry (VBM) vs those homozygous for the epsilon3 allele... - Neuroanatomic substrates of semantic memory impairment in Alzheimer's disease: patterns of functional MRI activationA J Saykin
Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
J Int Neuropsychol Soc 5:377-92. 1999.... - Differential working memory load effects after mild traumatic brain injuryT W McAllister
Section of Neuropsychiatry and Brain Imaging Laboratory, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Neuroimage 14:1004-12. 2001..This suggests that injury-related changes in ability to activate or modulate WM processing resources might underlie some of the memory complaints after MTBI... - Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletesT W McAllister
Department of Psychiatry, Dartmouth Medical School, Lebanon
Neurology 78:1777-84. 2012..To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes... - Effects of retroactive and proactive interference on word list recall in schizophreniaI J Torres
Department of Psychiatry, University of Chicago Medical School, IL 60637 1470, USA
J Int Neuropsychol Soc 7:481-90. 2001..Furthermore, this difference appeared to be related to the frontally-mediated central executive functions that were preferentially associated with RI but not PI susceptibility... - Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCIA J Saykin
Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA
Neurology 67:834-42. 2006.... - Deep brain stimulation in neuropsychiatric disordersR M Roth
Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756 0001, USA
Curr Psychiatry Rep 3:366-72. 2001..Finally, emerging and potential novel areas of application of DBS for the treatment of neuropsychiatric disorders and symptoms are discussed... - Brain activation patterns associated with working memory in relapsing-remitting MSH A Wishart
Department of Psychiatry, Dartmouth Medical School/Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756-0001, USA
Neurology 62:234-8. 2004..CONCLUSIONS: Relative to controls, patients with mild RRMS showed shifts in brain activation patterns within and beyond typical components of working memory circuitry... - Subjective rating of working memory is associated with frontal lobe volume in schizophreniaMatthew A Garlinghouse
Neuropsychology Service and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, NH 03756 0001, USA
Schizophr Res 120:71-5. 2010..It remains unclear to what extent such patients are able to accurately gauge the integrity of their working memory in their daily lives... - Judgment in older adults: development and psychometric evaluation of the Test of Practical Judgment (TOP-J)L A Rabin
Dartmouth Medical School, Lebanon, NH, USA
J Clin Exp Neuropsychol 29:752-67. 2007..Longitudinal assessments are being performed to examine predictive validity of the TOP-J for cognitive progression in our clinical groups... - Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 alleleHeather A Wishart
Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Dr, Lebanon, NH 03756 0001, USA
Am J Psychiatry 163:1603-10. 2006..The purpose of this study was to determine whether brain activation patterns associated with working memory differ as a function of apolipoprotein E (APOE) genotype in cognitively intact adults... - Functional magnetic resonance imaging of executive control in bipolar disorderRobert M Roth
Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire, USA
Neuroreport 17:1085-9. 2006..These findings add to the growing body of evidence implicating neural circuitry subserving executive control in bipolar disorder... - Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogeneticsThomas W McAllister
Section of Neuropsychiatry, Neuropsychology Program, Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Neurotrauma 23:1450-67. 2006..We review the evidence from fMRI and neurogenetic studies that support the role of catecholaminergic dysregulation in the etiology of WM complaints and deficits after mild and moderate TBI... - Cavum septum pellucidum in schizophrenia: clinical and neuropsychological correlatesLaura A Flashman
Neuropsychology Program and Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, and New Hampshire Hospital, Lebanon, NH, USA
Psychiatry Res 154:147-55. 2007..CSP, while prevalent, was not more frequent in our sample of patients with schizophrenia, and had few associations with symptom severity or neuropsychological deficits... - Apathy and its treatmentRobert M Roth
Laura A Flashman, PhD Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
Curr Treat Options Neurol 9:363-70. 2007..In the interim, careful evaluation of possible psychosocial and biological contributors to apathy in any given patient is suggested, with treatment planning based accordingly... - Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension studyThomas W McAllister
Department of Psychiatry, Section of Neuropsychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Brain Inj 22:705-14. 2008.... - Event-related functional magnetic resonance imaging of response inhibition in obsessive-compulsive disorderRobert M Roth
Brain Imaging Laboratory, Departments of Psychiatry and Radiology, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
Biol Psychiatry 62:901-9. 2007..Obsessive-compulsive disorder (OCD) has been hypothesized to involve inhibitory control dysfunction related to abnormal frontal-striatal-thalamic-cortical (FSTC) circuitry... - Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injuryThomas W McAllister
Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756
Am J Psychiatry 162:1749-51. 2005..The authors tested the hypothesis that the dopamine D2 receptor T allele (formerly described as the A1 allele) would be associated with poorer performance on memory and attention tasks following mild traumatic brain injury... - Lack of awareness and its impact in traumatic brain injuryLaura A Flashman
Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
NeuroRehabilitation 17:285-96. 2002..Finally, a review of the literature studying lack of awareness in TBI, its relationship to injury severity, the impact of lack of awareness on outcome, and intervention approaches is presented... - Disorders of awareness in neuropsychiatric syndromes: an updateLaura A Flashman
Neuropsychology Program, Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Curr Psychiatry Rep 4:346-53. 2002..Although most research has used neuropsychologic measures to assess brain functioning, more recent, limited literature in AD and schizophrenia has begun to examine neural correlates of unawareness using structural and functional imaging... - Apathy in schizophrenia: reduced frontal lobe volume and neuropsychological deficitsRobert M Roth
Department of Psychiatry, Dartmouth Medical School and New Hampshire Hospital, Lebanon 03756 0001, USA
Am J Psychiatry 161:157-9. 2004..Apathy is a common negative symptom in schizophrenia. The authors investigated neuropsychological performance and regional brain volumes in schizophrenia patients with high versus low levels of apathy... - Working memory deficits after traumatic brain injury: catecholaminergic mechanisms and prospects for treatment -- a reviewThomas W McAllister
Department of Psychiatry, Section of Neuropsychiatry and the Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
Brain Inj 18:331-50. 2004..Current knowledge gaps and research needs are identified... - Contribution of organizational strategy to verbal learning and memory in adults with attention-deficit/hyperactivity disorderRobert M Roth
Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH, USA
Neuropsychology 18:78-84. 2004..The pattern of findings suggests that decreased verbal learning and memory in adult ADHD is due in part to situational anxiety and not to poor use of organizational strategies during encoding... - Cholinergic enhancement of frontal lobe activity in mild cognitive impairmentAndrew J Saykin
Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03756, USA
Brain 127:1574-83. 2004.... - Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatmentsThomas W McAllister
Department of Psychiatry, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Curr Psychiatry Rep 6:364-71. 2004..Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described... - Neuropsychiatric syndromes in adults with intellectual disability: issues in assessment and treatmentRichard B Ferrell
Neuropsychiatry Service, Dartmouth Medical School at New Hampshire Hospital, 36 Clinton Street, Concord, NH 03301, USA
Curr Psychiatry Rep 6:380-90. 2004..Community-based models of support with neuropsychiatric intervention can be a potent therapeutic combination in the management of challenging behaviors in individuals with ID... - Neuroimaging findings in mild traumatic brain injuryT W McAllister
Section of Neuropsychiatry and Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
J Clin Exp Neuropsychol 23:775-91. 2001..It is, therefore, important to be aware of the advantages and limitations of the various available imaging modalities. This paper selectively reviews the pertinent literature on the structural and functional imaging in mild TBI... - Verbal fluency performance in amnestic MCI and older adults with cognitive complaintsKatherine E Nutter-Upham
Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH, USA
Arch Clin Neuropsychol 23:229-41. 2008..Overall, our findings highlight the importance of including multiple verbal fluency tests in assessment batteries targeting preclinical dementia populations and suggest that individual fluency tasks may tap specific cognitive processes... - Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypesChantel D Sloan
Department of Genetics and Community and Family Medicine, Computational Genetics Laboratory, Dartmouth Medical School, Lebanon, New Hampshire, USA
Am J Med Genet B Neuropsychiatr Genet 153:1060-9. 2010..The results are consistent with polygenic influences on early neurodegenerative changes and demonstrate the effectiveness of hierarchical clustering in identifying genetic associations among multiple related phenotypic endpoints... - Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaintsPaul J Wang
Brain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Neurobiol Aging 27:1613-7. 2006.... - Chronic deep brain stimulation for the treatment of tremor in multiple sclerosis: review and case reportsH A Wishart
Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
J Neurol Neurosurg Psychiatry 74:1392-7. 2003..Deep brain stimulation (DBS) offers a non-ablative alternative to thalamotomy for the surgical treatment of medically refractory tremor in multiple sclerosis. However, relatively few outcomes have been reported... 
Nonclinical obsessive-compulsive symptoms and executive functions in schizophreniaSheba R Kumbhani
Dartmouth Medical School, Department of Psychiatry, One Medical Center Dr, Lebanon, NH 03756 0001, USA
J Neuropsychiatry Clin Neurosci 22:304-12. 2010..Performance-based scores showed few correlations with OCS. Findings indicate that severity of nonclinical OCS subtypes contributes to the heterogeneity of executive functions in schizophrenia...- Lack of relationship between psychological denial and unawareness of illness in schizophrenia-spectrum disordersCarrie L Kruck
Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, NH 03756 0001, USA
Psychiatry Res 169:33-8. 2009..The patient group and the healthy comparison group did not differ in their use of self-deception. The current results do not support the psychological denial theory of unawareness of illness in schizophrenia-spectrum disorders... - Executive dysfunction following traumatic brain injury: neural substrates and treatment strategiesBrenna C McDonald
Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA
NeuroRehabilitation 17:333-44. 2002..This review summarizes the nature of executive deficits following TBI, their neuroanatomical substrates, selected assessment and treatment strategies, and recent research findings and trends... - Self- and informant reports of executive function on the BRIEF-A in MCI and older adults with cognitive complaintsLaura A Rabin
Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, Lebanon, NH, USA
Arch Clin Neuropsychol 21:721-32. 2006..Overall findings indicate that the BRIEF-A is sensitive to subtle executive changes in MCI and CC and suggest the need for research to determine if executive complaints are predictive of clinical course... - Sex differences in semantic language processing: a functional MRI studyL C Baxter
Brain Imaging Laboratory, Department of Psychiatry DHMC, Dartmouth Medical School, Lebanon, NH 03756, USA
Brain Lang 84:264-72. 2003..Results support both an interhemispheric and an intrahemispheric model of sex differences in language, suggesting that the models may not be mutually exclusive... - Hippocampal volume and shape analysis in an older adult populationTara L McHugh
Department of Psychiatry, Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH, USA
Clin Neuropsychol 21:130-45. 2007..These and other novel directions in research on hippocampal function and dysfunction will be facilitated by the use of reliable, comprehensive, and consistent segmentation and measurement methods... - The differential diagnosis of pseudobulbar affect (PBA). Distinguishing PBA among disorders of mood and affect. Proceedings of a roundtable meetingDavid B Arciniegas
Neuropsychiatry Service, Department of Psychiatry, University of Colorado School of Medicine, Denver, Colorado 80211, USA
CNS Spectr 10:1-14; quiz 15-6. 2005..The material presented in this monograph will help clinicians better recognize, diagnose, and treat PBA, and will form a foundation for understanding and interpreting future studies of this condition... - Neuropsychological impairment in borderline personality disorderElena S Monarch
The Virtual Reality Treatment Center, 154 Waterman Street, Providence, RI 02906, USA
Psychiatr Clin North Am 27:67-82, viii-ix. 2004..The authors recommend that clinicians routinely screen BPD patients for cognitive dysfunction and highlight the roles that this important knowledge can have in treatment... - The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: a volumetric MRI studyBrittany R Copenhaver
Department of Psychology, Dartmouth College, Hanover, NH 03755, USA
Psychiatry Res 147:93-103. 2006..Results suggest that atrophy of the fornix and mammillary bodies becomes apparent at the point of conversion from MCI to AD. Longitudinal assessments are needed to delineate the time course and extent of the observed volumetric changes... - Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderlyJennifer Duncan Davis
Brown Medical School, Rhode Island Hospital Physicians Office Building, Suite 430, 110 Lockwood Street, Providence, RI 02903, USA
Curr Psychiatry Rep 5:384-90. 2003..The purpose of this review is to summarize existing data on the cognitive and neuropsychiatric consequences of subclinical hypothyroidism, benefits of treatment, and recommendations for screening and monitoring in older adults...