J V Fahey

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Effect of menstrual status on antibacterial activity and secretory leukocyte protease inhibitor production by human uterine epithelial cells in culture
    John V Fahey
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire 03756, USA
    J Infect Dis 185:1606-13. 2002
  2. ncbi request reprint Secretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract
    J V Fahey
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Reprod 20:1439-46. 2005
  3. doi request reprint New approaches to making the microenvironment of the female reproductive tract hostile to HIV
    John V Fahey
    Department of Physiology and Neurobiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 65:334-43. 2011
  4. ncbi request reprint Sex hormone regulation of anti-bacterial activity in rat uterine secretions and apical release of anti-bacterial factor(s) by uterine epithelial cells in culture
    John V Fahey
    Department of Physiology, Borwell Building, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Steroid Biochem Mol Biol 93:59-66. 2005
  5. doi request reprint Estradiol selectively regulates innate immune function by polarized human uterine epithelial cells in culture
    J V Fahey
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire, USA
    Mucosal Immunol 1:317-25. 2008
  6. pmc Epithelial cell secretions from the human female reproductive tract inhibit sexually transmitted pathogens and Candida albicans but not Lactobacillus
    C R Wira
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Mucosal Immunol 4:335-42. 2011
  7. pmc Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands
    Daniel O Ochiel
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Leukoc Biol 88:435-44. 2010
  8. doi request reprint CCL20/MIP3alpha is a novel anti-HIV-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Am J Reprod Immunol 62:60-71. 2009
  9. doi request reprint Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract
    Kimberly D Coleman
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Fertil Steril 92:1107-9. 2009
  10. pmc Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunology 129:207-19. 2010

Detail Information

Publications26

  1. ncbi request reprint Effect of menstrual status on antibacterial activity and secretory leukocyte protease inhibitor production by human uterine epithelial cells in culture
    John V Fahey
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire 03756, USA
    J Infect Dis 185:1606-13. 2002
    ..These results indicate that menstrual status (pre- vs. postmenopausal) influences the production of SLPI and bactericidal activity by uterine epithelial cells...
  2. ncbi request reprint Secretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract
    J V Fahey
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Reprod 20:1439-46. 2005
    ..Mucosal epithelial cells are capable of producing these factors that communicate with cells of the innate and adaptive immune systems...
  3. doi request reprint New approaches to making the microenvironment of the female reproductive tract hostile to HIV
    John V Fahey
    Department of Physiology and Neurobiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 65:334-43. 2011
    ..all of which are under hormonal control, will open new avenues to therapeutic manipulation of the FRT mucosal microenvironment. By seeking new alternatives to preventing HIV infection in women, we may finally disrupt the HIV pandemic...
  4. ncbi request reprint Sex hormone regulation of anti-bacterial activity in rat uterine secretions and apical release of anti-bacterial factor(s) by uterine epithelial cells in culture
    John V Fahey
    Department of Physiology, Borwell Building, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Steroid Biochem Mol Biol 93:59-66. 2005
    ..Further these studies suggest that epithelial cells which line the uterine lumen are a primary source of anti-bacterial activity...
  5. doi request reprint Estradiol selectively regulates innate immune function by polarized human uterine epithelial cells in culture
    J V Fahey
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire, USA
    Mucosal Immunol 1:317-25. 2008
    ..Further, it suggests that with E(2) regulation, epithelial cells that line the uterine cavity have evolved immunologically to be sensitive to viral and bacterial infections as well as the constraints of procreation...
  6. pmc Epithelial cell secretions from the human female reproductive tract inhibit sexually transmitted pathogens and Candida albicans but not Lactobacillus
    C R Wira
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Mucosal Immunol 4:335-42. 2011
    ..crispatus, which is part of the normal vaginal microflora of humans...
  7. pmc Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands
    Daniel O Ochiel
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Leukoc Biol 88:435-44. 2010
    ..These findings indicate collectively that epithelial cells confer a tolerogenic phenotype to DC in the endometrium. Our results suggest novel cellular and molecular mechanisms for the regulation of adaptive immunity within the FRT...
  8. doi request reprint CCL20/MIP3alpha is a novel anti-HIV-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH, USA
    Am J Reprod Immunol 62:60-71. 2009
    ..The role of CCL20/MIP3alpha as an antiviral is unknown. In this study, we have examined the production of CCL20/MIP3alpha by epithelial cells from the upper female reproductive tract as well as its activity as an antiviral molecule...
  9. doi request reprint Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract
    Kimberly D Coleman
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Fertil Steril 92:1107-9. 2009
    ..Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis...
  10. pmc Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunology 129:207-19. 2010
    ..Our data suggest that Trappin-2/Elafin might be an important endogenous microbicide of the female reproductive tract that is protective against HIV-1...
  11. doi request reprint Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 63:544-65. 2010
    ..In doing so, a window of STI vulnerability is created during which potential pathogens including HIV enter the reproductive tract to infect host targets...
  12. doi request reprint Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections
    Charles R Wira
    Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 65:196-211. 2011
    ..The goal of this review is to examine the spectrum of antimicrobials in the FRT and the ways in which they are regulated to provide protection against pathogens that compromise reproductive health and threaten the lives of women...
  13. pmc Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells
    Daniel O Ochiel
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 5:e14306. 2010
    ..We hypothesized in this study that specific immune modulators secreted by uterine epithelial cells modulate susceptibility of dendritic cells (DC) to infection with HIV-1...
  14. pmc Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C)
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Fertil Steril 89:1497-506. 2008
    ..To examine the expression of toll-like receptors (TLR) by primary human Fallopian tube epithelial cells (FTEC) and to determine whether exposure to the TLR3 agonist poly(I:C) induces an antiviral response...
  15. ncbi request reprint Antigen presentation by human uterine epithelial cells to autologous T cells
    John V Fahey
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Reprod Immunol 55:1-11. 2006
    ..Our goal in this study was to assess the ability of human uterine epithelial cells to present antigen to cells of the adaptive immune system...
  16. ncbi request reprint Migration inhibitory factor secretion by polarized uterine epithelial cells is enhanced in response to the TLR3 agonist poly (I:C)
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, 710W Borwell, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Am J Reprod Immunol 54:193-202. 2005
    ..The goals of this study were to determine if uterine epithelial cells produce the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF), and to see if toll-like receptor (TLR) agonists stimulate MIF secretion...
  17. ncbi request reprint Innate and adaptive immunity in female genital tract: cellular responses and interactions
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunol Rev 206:306-35. 2005
    ..By understanding the nature of this protection and the ways in which innate and adaptive immunity interact, these studies provide the opportunity to contribute to the foundation of information essential for ensuring reproductive health...
  18. ncbi request reprint Influence of stage of the reproductive cycle and estradiol on thymus cell antigen presentation
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Steroid Biochem Mol Biol 84:79-87. 2003
    ..1 and B7.2. These studies demonstrate that sex hormones play a central role in regulating antigen presentation in the thymus...
  19. ncbi request reprint Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C)
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 174:992-1002. 2005
    ....
  20. pmc The innate immune system: gatekeeper to the female reproductive tract
    Charles R Wira
    Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire 03756, USA
    Immunology 111:13-5. 2004
  21. ncbi request reprint Synergy between IL-8 and GM-CSF in reproductive tract epithelial cell secretions promotes enhanced neutrophil chemotaxis
    Li Shen
    Department of Immunology and Microbiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Cell Immunol 230:23-32. 2004
    ..These findings demonstrate that the majority of neutrophil chemoattractant activity produced by FRT EC results from the synergistic effects of IL-8 and GM-CSF...
  22. pmc Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells
    Todd M Schaefer
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Immunology 112:428-36. 2004
    ....
  23. pmc Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections
    D K Hickey
    Department of Physiology and Neurobiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Reprod Immunol 88:185-94. 2011
    ..The goal of this review is to focus on the diverse aspects of the innate and adaptive immune systems that contribute to a unique network of protection throughout the female reproductive tract...
  24. pmc Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies
    Mimi Ghosh
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 5:e11366. 2010
    ..Since female reproductive tract (FRT) secretions contain a spectrum of antimicrobials, we hypothesized that CVL from healthy HIV(+) and (-) women inhibit HIV infection...
  25. ncbi request reprint Secretion of monocyte chemotactic protein-1 by human uterine epithelium directs monocyte migration in culture
    Richard A Meter
    Department of Obstetrics and Gynecology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Fertil Steril 84:191-201. 2005
    ..To determine whether primary human uterine epithelial cells in culture are able to influence monocyte chemotaxis and to establish whether the causal agent of chemotaxis is monocyte chemotactic protein (MCP)-1...
  26. ncbi request reprint Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C)
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Hum Reprod 21:2432-9. 2006
    ..Recent insight into the immunological capabilities of the trophoblast suggests that the placenta may function as an active barrier by recognizing and responding to pathogens through Toll-like receptors (TLRs)...