- A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01Alan Eastman
Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA
Mol Cancer Ther 1:1067-78. 2002..Hence, ICP-1 appears to be a more selective inhibitor of the S and G2 cell cycle checkpoint than previously studied analogues and is worthy of study in preclinical tumor models...
- Cell cycle checkpoints and their impact on anticancer therapeutic strategiesAlan Eastman
Department of Pharmacology, and the Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Cell Biochem 91:223-31. 2004..However, these defects also represent an Achilles heel that can be targeted to improve current therapeutic strategies...