Patrick Dolph

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Arrestin: roles in the life and death of retinal neurons
    Patrick J Dolph
    Department of Biological Sciences, Dartmouth College, 6044 Gilman, Hanover, NH 03755, USA
    Neuroscientist 8:347-55. 2002
  2. pmc Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration
    Yashodhan Chinchore
    Department of Biology, Dartmouth College, Hanover, New Hampshire, United States of America
    PLoS Genet 5:e1000377. 2009
  3. pmc Characterization of two dominant alleles of the major rhodopsin-encoding gene ninaE in Drosophila
    Amitavo Mitra
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Mol Vis 17:3224-33. 2011
  4. pmc Roles of the Drosophila SK channel (dSK) in courtship memory
    Ahmad N Abou Tayoun
    Department of Biology, Dartmouth College, Hanover, New Hampshire, United States of America
    PLoS ONE 7:e34665. 2012
  5. doi request reprint New insights into Drosophila vision
    Patrick Dolph
    Dartmouth College, Hanover, NH 03755, USA
    Neuron 57:1-2. 2008
  6. ncbi request reprint Loss of the phospholipase C gene product induces massive endocytosis of rhodopsin and arrestin in Drosophila photoreceptors
    Nicholas R Orem
    Department of Biological Sciences, Dartmouth College, 6044 Gilman, Hanover, NH 03755, USA
    Vision Res 42:497-505. 2002
  7. ncbi request reprint Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons
    Nathan R Deleault
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Neurochem 85:1614-23. 2003
  8. ncbi request reprint An essential role for endocytosis of rhodopsin through interaction of visual arrestin with the AP-2 adaptor
    Nicholas R Orem
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Sci 119:3141-8. 2006
  9. ncbi request reprint Epitope masking of rhabdomeric rhodopsin during endocytosis-induced retinal degeneration
    Nicholas R Orem
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Mol Vis 8:455-61. 2002

Research Grants

Collaborators

  • Mel Feany
  • Nicholas R Orem
  • Amitavo Mitra
  • Yashodhan Chinchore
  • Ahmad N Abou Tayoun
  • Nathan R Deleault
  • CLAUDIO PIKIELNY
  • Ronald Kinser
  • Luxi Xia
  • Surachai Supattapone
  • Meghan E Cook
  • David A Harris
  • Koren Nishina

Detail Information

Publications9

  1. ncbi request reprint Arrestin: roles in the life and death of retinal neurons
    Patrick J Dolph
    Department of Biological Sciences, Dartmouth College, 6044 Gilman, Hanover, NH 03755, USA
    Neuroscientist 8:347-55. 2002
    ..Due to its central role in cellular signaling, misregulation or misfunction of arrestin can have dramatic affects on cell viability and have direct implications in human disease...
  2. pmc Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration
    Yashodhan Chinchore
    Department of Biology, Dartmouth College, Hanover, New Hampshire, United States of America
    PLoS Genet 5:e1000377. 2009
    ..Together these data implicate buildup of rhodopsin in the late endosomal system as a novel trigger of death of photoreceptor neurons...
  3. pmc Characterization of two dominant alleles of the major rhodopsin-encoding gene ninaE in Drosophila
    Amitavo Mitra
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Mol Vis 17:3224-33. 2011
    ....
  4. pmc Roles of the Drosophila SK channel (dSK) in courtship memory
    Ahmad N Abou Tayoun
    Department of Biology, Dartmouth College, Hanover, New Hampshire, United States of America
    PLoS ONE 7:e34665. 2012
    ..These findings highlight important functions for dSK in courtship memory and suggest that SK channels can mediate multiple forms of behavioral plasticity...
  5. doi request reprint New insights into Drosophila vision
    Patrick Dolph
    Dartmouth College, Hanover, NH 03755, USA
    Neuron 57:1-2. 2008
    ..In this issue of Neuron, Wang and colleagues and Acharya and colleagues have further exploited the Drosophila genetic system to characterize two new phototransduction players...
  6. ncbi request reprint Loss of the phospholipase C gene product induces massive endocytosis of rhodopsin and arrestin in Drosophila photoreceptors
    Nicholas R Orem
    Department of Biological Sciences, Dartmouth College, 6044 Gilman, Hanover, NH 03755, USA
    Vision Res 42:497-505. 2002
    ..Interestingly, the internalized rhodopsin is rapidly degraded, but the arrestin is fully stable. The data are discussed with respect to mechanisms of arrestin-mediated endocytosis and human retinal disease...
  7. ncbi request reprint Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons
    Nathan R Deleault
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Neurochem 85:1614-23. 2003
    ..Our work reveals the presence of mechanisms in neurons that specifically counterbalance the production of misfolded PrP conformations, and provides an opportunity to study these processes in a model organism amenable to genetic analysis...
  8. ncbi request reprint An essential role for endocytosis of rhodopsin through interaction of visual arrestin with the AP-2 adaptor
    Nicholas R Orem
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    J Cell Sci 119:3141-8. 2006
    ....
  9. ncbi request reprint Epitope masking of rhabdomeric rhodopsin during endocytosis-induced retinal degeneration
    Nicholas R Orem
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Mol Vis 8:455-61. 2002
    ..To determine the fate of rhodopsin during endocytosis-mediated retinal degeneration...

Research Grants9

  1. TRANSDUCTION AND RETINAL DEGENERATION IN DROSOPHILA
    Patrick Dolph; Fiscal Year: 1999
    ..The fourth aim is to pursue the characterization of the other mutations recovered in the screens. ..
  2. TRANSDUCTION AND RETINAL DEGENERATION IN DROSOPHILA
    Patrick Dolph; Fiscal Year: 2000
    ..The fourth aim is to pursue the characterization of the other mutations recovered in the screens. ..
  3. TRANSDUCTION AND RETINAL DEGENERATION IN DROSOPHILA
    Patrick Dolph; Fiscal Year: 2001
    ..The fourth aim is to pursue the characterization of the other mutations recovered in the screens. ..
  4. Photoreceptor cell degeneration in D. melanogaster
    Patrick Dolph; Fiscal Year: 2004
    ..Gene products involved in coupling rhodopsin/arrestin complex formation with the cell death machinery will be identified and characterized. ..
  5. Photoreceptor cell degeneration in D. melanogaster
    Patrick Dolph; Fiscal Year: 2005
    ..Gene products involved in coupling rhodopsin/arrestin complex formation with the cell death machinery will be identified and characterized. ..
  6. Photoreceptor cell degeneration in D. melanogaster
    Patrick Dolph; Fiscal Year: 2006
    ..Gene products involved in coupling rhodopsin/arrestin complex formation with the cell death machinery will be identified and characterized. ..
  7. Photoreceptor cell degeneration in D. melanogaster
    Patrick Dolph; Fiscal Year: 2007
    ..Gene products involved in coupling rhodopsin/arrestin complex formation with the cell death machinery will be identified and characterized. ..
  8. Lysosomal Proteases and Retinal Degeneration
    Patrick Dolph; Fiscal Year: 2007
    ..Moreover, since there are numerous cathepsin inhibitors available, there is the possibility that this work could provide potential therapies for retinal disease. ..