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Genomes and Genes | Eugene DemidenkoSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
Radiation dose prediction using data on time to emesis in the case of nuclear terrorismEugene Demidenko
Section of Biostatistics and Epidemiology, Hanover, New Hampshire, USA
Radiat Res 171:310-9. 2009..More reliable methods for after-the-fact assessment of radiation dose are needed to complement the use of time to emesis...
On optimal current patterns for electrical impedance tomographyEugene Demidenko
Section of Biostatistics and Epidemiology and the Department of Mathematics, Dartmouth College, Lebanon, NH 03756, USA
IEEE Trans Biomed Eng 52:238-48. 2005..Our statistical model is able to discriminate between a homogenous agar phantom and one with a 2 mm air hole with error probability (p-value) 1/1000...- An analytic solution to the homogeneous EIT problem on the 2D disk and its application to estimation of electrode contact impedancesEugene Demidenko
Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, NH 03755, USA
Physiol Meas 32:1453-71. 2011..Statistical hypothesis testing is used to test whether the contact impedances are the same across electrodes or all equal zero. Our solution can be especially useful for a rapid real-time test for bad surface contact in clinical setting... - Three endpoints of in vivo tumour radiobiology and their statistical estimationEugene Demidenko
Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Int J Radiat Biol 86:164-73. 2010..To mathematically define doubling time (DT), tumour-growth delay (TGD) and cancer-cell surviving fraction (SF) in vivo using exponential growth and regrowth models with tumour volume measurements obtained from animal experiments... - Sample size and optimal design for logistic regression with binary interactionEugene Demidenko
Dartmouth Medical School, Hanover, NH 03755, U S A
Stat Med 27:36-46. 2008..Our sample size and power calculations with interaction can be carried out online at www.dartmouth.edu/ approximately eugened... - Sample size determination for logistic regression revisitedEugene Demidenko
Dartmouth Medical School, Hanover, NH 03755, USA
Stat Med 26:3385-97. 2007..Approximately, the optimal number of controls to cases is equal to the square root of the alternative odds ratio. Our sample size and power calculations can be carried out online at www.dartmouth.edu/ approximately eugened... - Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomasNadeem Khan
EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
Int J Radiat Oncol Biol Phys 78:1193-200. 2010..We report repeated measurements of orthotopic F98 tumor pO(2) and relate this to the effect of carbogen inhalation on tumor growth when combined with hypofractionated radiotherapy... - In vivo EPR dosimetry to quantify exposures to clinically significant doses of ionising radiationHarold M Swartz
EPR Center for Viable Systems, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
Radiat Prot Dosimetry 120:163-70. 2006.... - Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry studyHuagang Hou
Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
Int J Radiat Oncol Biol Phys 61:1503-9. 2005..The information on the dynamics of tumor pO(2) after efaproxiral administration illustrates the ability of efaproxiral to increase intracranial tumor oxygenation... - The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in miceHuagang Hou
Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
Radiat Res 168:218-25. 2007..This is the first study to demonstrate the ability of efaproxiral to increase tumor oxygenation and to increase the tumor growth inhibition of radiotherapy over 5 days of treatment... 
Influence of place of residence in access to specialized cancer care for African AmericansTracy Onega
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH 03756, USA
J Rural Health 26:12-9. 2010..Disparities in cancer care for rural residents and for African Americans have been documented, but the interaction of these factors is not well understood...- Physically-based biodosimetry using in vivo EPR of teeth in patients undergoing total body irradiationBenjamin B Williams
Department of Diagnostic Radiology, Dartmouth Physically based Biodosimetry Center for Medical Countermeasures against Radiation, Dartmouth Medical School, Hanover, New Hampshire, USA
Int J Radiat Biol 87:766-75. 2011..In vivo electron paramagnetic resonance (EPR) spectroscopy of tooth enamel has been developed to meet this need... - Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor modelBin Chen
Thayer School of Engineering, 80000 Cummings Hall, Dartmouth College, Hanover, NH 03755, USA
Clin Cancer Res 11:720-7. 2005.... - Tissue pO2 of orthotopic 9L and C6 gliomas and tumor-specific response to radiotherapy and hyperoxygenationNadeem Khan
EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
Int J Radiat Oncol Biol Phys 73:878-85. 2009..3 Gy of radiation and carbogen inhalation on orthotopic 9L and C6 gliomas and on the contralateral brain pO(2) in rats using a new and potentially widely useful method, multisite in vivo electron paramagnetic resonance oximetry... - Radiotherapy in conjunction with 7-hydroxystaurosporine: a multimodal approach with tumor pO2 as a potential marker of therapeutic responseNadeem Khan
EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Radiat Res 172:592-7. 2009..This multimodal approach could be used to enhance the outcome of radiotherapy. Furthermore, tumor pO2 could be a potential marker of therapeutic response... - Pretreatment photosensitizer dosimetry reduces variation in tumor responseXiaodong Zhou
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
Int J Radiat Oncol Biol Phys 64:1211-20. 2006..Conclusions: This research suggests that accurate quantification of tissue photosensitizer levels and subsequent adjustment of light dose will allow for reduced subject variation and improved treatment consistency... - Determinants of NCI Cancer Center attendance in Medicare patients with lung, breast, colorectal, or prostate cancerTracy Onega
The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Hanover, NH, USA
J Gen Intern Med 24:205-10. 2009..S. This study identified determinants of NCI-Cancer Center attendance in Medicare cancer patients... - Race versus place of service in mortality among medicare beneficiaries with cancerTracy Onega
The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Lebanon, New Hampshire, USA
Cancer 116:2698-706. 2010.... - Comparison of EPR oximetry and Eppendorf polarographic electrode assessments of rat brain PtO2JULIA A O'HARA
EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
Physiol Meas 25:1413-23. 2004.... - Electron paramagnetic resonance dosimetry for a large-scale radiation incidentHarold M Swartz
Dartmouth Medical School, Hanover, NH 03755, USA
Health Phys 103:255-67. 2012..The authors conclude that electron paramagnetic resonance dosimetry is likely to be a useful part of triage for a large-scale radiation incident... - Repeated tumor pO(2) measurements by multi-site EPR oximetry as a prognostic marker for enhanced therapeutic efficacy of fractionated radiotherapyHuagang Hou
Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA
Radiother Oncol 91:126-31. 2009..To investigate the temporal effects of single or fractionated radiotherapy on subcutaneous RIF-1 tumor pO(2) and to determine the therapeutic outcomes when the timing of fractionations is guided by tumor pO(2)... - Development of in vivo tooth EPR for individual radiation dose estimation and screeningBenjamin B Williams
Dartmouth Medical School, 704 Vail HP7785, Hanover, NH 03755, USA
Health Phys 98:327-38. 2010..In summary, it seems plausible that the EPR dosimetry techniques will have an important role in retrospective dosimetry for exposures involving large numbers of individuals... - Simultaneous measurement of rat brain cortex PtO2 using EPR oximetry and a fluorescence fiber-optic sensor during normoxia and hyperoxiaJULIA A O'HARA
EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
Physiol Meas 26:203-13. 2005..26 to 0.95 (carbogen) were similar by the two methods and (4) in some rats breathing carbogen, absolute values of PtO(2) were above the sensitive range of the OxyLite method... - Cerebral tissue oxygenation in reversible focal ischemia in rats: multi-site EPR oximetry measurementsHuagang Hou
EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
Physiol Meas 26:131-41. 2005..In addition, the ability simultaneously to measure the pO2 in several sites provides important additional information that should help to differentiate between changes in the PO2 due toglobal or local mechanisms... - Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI studyHuagang Hou
Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
Int J Radiat Oncol Biol Phys 59:834-43. 2004..The dynamics of tumor pO(2) after RSR13 administration may be useful for the design of clinical protocols using allosteric hemoglobin effectors... - High spatial resolution multisite EPR oximetry of transient focal cerebral ischemia in the ratBenjamin B Williams
Dartmouth EPR Center, Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Antioxid Redox Signal 9:1691-8. 2007..These measurements demonstrate the capabilities of the HSRMS oximetry technique and set the stage for more extensive physiologic studies... - pO2 and regional blood flow in a rabbit model of limb ischemiaOleg Y Grinberg
EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
Physiol Meas 25:659-70. 2004..Within two weeks of occlusion the pO2 is recovered to 45% of baseline. This study demonstrates, for the first time, the applicability of EPR oximetry in animals larger than rodents... - Influence of NCI cancer center attendance on mortality in lung, breast, colorectal, and prostate cancer patientsTracy Onega
The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Hanover, NH 03756, USA
Med Care Res Rev 66:542-60. 2009..Attendance at NCI cancer centers is associated with a significant survival benefit for the four major cancers among Medicare beneficiaries... - Alcohol retail density and demographic predictors of health disparities: a geographic analysisEthan M Berke
Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH 03766, USA
Am J Public Health 100:1967-71. 2010..We examined whether the geographic density of alcohol retailers was greater in geographic areas with higher levels of demographic characteristics that predict health disparities... - Measurement error and confidence intervals for ROC curvesTor D Tosteson
Dartmouth Medical School, Lebanon, NH 03756, USA
Biom J 47:409-16. 2005..An application from a study of emerging imaging modalities in breast cancer is used to demonstrate the new techniques... - Statistical estimation of resistance/conductance by electrical impedance tomography measurementsEugene Demidenko
Department of Mathematics, Dartmouth College, 7927 Rubin, DHMC, Lebanon, NH 03756, USA
IEEE Trans Med Imaging 23:829-38. 2004..Our theory may be applied to various tests including EIT hardware calibration and whether the medium is homogeneous. These tests are illustrated on phantom agar data... - DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategyAngeline S Andrew
Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Hum Hered 65:105-18. 2008..These include: APE1-Asn148Gln, XRCC1-Arg399Gln and XRCC1-Arg194Trp in the BER pathway, XPD-Gln751Lys in the NER pathway and XRCC3-Thr241Met in the DSB repair pathway... - Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenicAngeline S Andrew
Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Environ Health Perspect 114:1193-8. 2006.... - MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressorsXi Liu
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Clin Invest 120:1298-309. 2010..Together, these findings revealed that miR-31 acts as an oncogenic miRNA (oncomir) in lung cancer by targeting specific tumor suppressors for repression... - A polygon-based locally-weighted-average method for smoothing disease rates of small unitsXun Shi
Department of Geography, Dartmouth College, Hanover, New Hampshire 03755, USA
Epidemiology 18:523-8. 2007..Disease rates for geographic areas with small populations may be unstable. Therefore, accurate nonparametric methods for smoothing or stabilizing rates are needed... - Log transformation benefits parameter estimation in microwave tomographic imagingPaul M Meaney
Thayer School of Engineering, Dartmouth College, Hanover New Hampshire 03755, USA
Med Phys 34:2014-23. 2007..In addition, several high contrast imaging experiments are performed, which demonstrate that different subsets of data are emphasized in each method and may contribute to the overall image quality differences... - Power and sample size calculations for generalized regression models with covariate measurement errorTor D Tosteson
Dartmouth Medical School, Lebanon NH 03756, USA
Stat Med 22:1069-82. 2003..An example is given from an ongoing study of cancer and exposure to arsenic as measured by toenail concentrations and tap water samples... - Measurements of clinically significant doses of ionizing radiation using non-invasive in vivo EPR spectroscopy of teeth in situHarold M Swartz
Dartmouth Medical School, EPR Center for Viable Systems, Hanover, NH 03755, USA
Appl Radiat Isot 62:293-9. 2005..In its current state of development, it probably is sufficient for most applications related to terrorism or nuclear warfare, for decision-making for action for individuals in regard to acute effects from exposure to ionizing radiation... - Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemiaYongli Guo
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
Cancer Res 70:9875-85. 2010..In contrast, elevation of UBP43 expression stabilized PML/RARα protein and inhibited apoptosis. Taken together, our findings define the ubiquitin protease UBP43 as a novel candidate drug target for APL treatment... - Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New HampshireMargaret R Karagas
Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
Cancer Causes Control 15:465-72. 2004..To examine the effects of lower levels of arsenic exposure on bladder cancer incidence, we conducted a case-control study in New Hampshire, USA where levels above 10 micro/l are commonly found in private wells... - Spin traps: in vitro toxicity and stability of radical adductsNadeem Khan
Department of Diagnostic Radiology, EPR Center, Dartmouth Medical School, Hanover, NH 03755, USA
Free Radic Biol Med 34:1473-81. 2003..It then should be feasible to select the spin trap(s) best suited for the proposed study... - Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)Glenn S Gerhard
Department of Pathology, Penn State College of Medicine, Hershey, PA, USA
Exp Gerontol 37:1055-68. 2002..These data and a growing abundance of related biological resources suggest that the zebrafish may be a compelling model organism for studies on aging... - Changes in oxygenation of intracranial tumors with carbogen: a BOLD MRI and EPR oximetry studyJeff F Dunn
NMR and EPR Research Centers, Department of Diagnostic Radiology, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire, USA
J Magn Reson Imaging 16:511-21. 2002..To examine, using blood oxygen level dependent (BOLD) MRI and EPR oximetry, the changes in oxygenation of intracranial tumors induced by carbogen breathing... - Oxygen consumption rates and oxygen concentration in molt-4 cells and their mtDNA depleted (rho0) mutantsJiangang Shen
EPR Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Biophys J 84:1291-8. 2003..The results are consistent with our earlier findings suggesting that such oxygen gradients may be a general phenomenon found in most or all cell systems under appropriate conditions... - Standard error of inverse prediction for dose-response relationship: approximate and exact statistical inferenceEugene Demidenko
Dartmouth Physically Based Biodosimetry Center for Medical Countermeasures Against Radiation Dart Dose CMCR, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, U S A
Stat Med 32:2048-61. 2013..We illustrate our theory with electron paramagnetic resonance tooth dosimetry for a rapid estimation of the radiation dose received in the event of nuclear terrorism. Copyright © 2012 John Wiley & Sons, Ltd... - Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivityBrian W Pogue
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
Cancer Res 63:1025-33. 2003..4 +/- 1.4 days, and when PDT was given at the same time as radiation, the delay was 8.1 +/- 1.5 days. This observation indicates that the combined effect in the latter case was greater than additive (P = 0.049)... - Geographic access to cancer care in the U.STracy Onega
The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Cancer 112:909-18. 2008..This study estimated travel time to specialized cancer care settings for the continental U.S. population and calculated per capita oncologist supply... - Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapySeiko Toraya-Brown
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
Integr Biol (Camb) 5:159-71. 2013.... - Smoking restrictions and hospitalization for acute coronary events in GermanyJames D Sargent
Department of Pediatrics, Dartmouth Medical School, Lebanon, NH, USA
Clin Res Cardiol 101:227-35. 2012..To study the effects of smoking restrictions in Germany on coronary syndromes and their associated costs... - The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude miceSujatha Sundaram
Departments of Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Clin Cancer Res 9:2350-6. 2003..The purpose of this research was to evaluate theinfluence of the combination of the vitamin D(3) analogue EB 1089 with fractionated radiation on growth and apoptosis of MCF-7 tumor xenografts in athymic mice... - Statistical comparison of color cancer cell imagesEugene Demidenko
Dartmouth Medical School, Lebanon, NH 03756, USA
Oncol Rep 15:1077-9. 2006..We applied a well-established multivariate analysis of variances (MANOVA) on the logit scale so that image comparison was reduced to the classic chi-square test... - Lysosomes and trivalent arsenic treatment in acute promyelocytic leukemiaSutisak Kitareewan
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
J Natl Cancer Inst 99:41-52. 2007..When resistance to all-trans-retinoic acid develops, an effective treatment is arsenic trioxide (arsenite), which also induces this degradation. We investigated the mechanism of arsenite-induced PML/RAR alpha degradation... - Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomasYan Ma
Department of Pharmacology and Toxicology, and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
Proc Natl Acad Sci U S A 104:4089-94. 2007..This article reports unique mouse lung cancer models that replicate many carcinogenic changes found in patients. These models provide insights into the carcinogenesis process and implicate cyclin E as a therapeutic target in the lung... - Plasma membrane cholesterol: a possible barrier to intracellular oxygen in normal and mutant CHO cells defective in cholesterol metabolismNadeem Khan
Department of Diagnostic Radiology, EPR Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Biochemistry 42:23-9. 2003..The results indicate that the concentration of cholesterol in the plasma membrane can be an important factor for the magnitude of the oxygen gradient observed across the cell membrane... - Influence analysis for linear mixed-effects modelsEugene Demidenko
Dartmouth Medical School, Hanover, NH 03755, USA
Stat Med 24:893-909. 2005..These influence measures are applied to an analysis of 5-year Medicare reimbursements to colon cancer patients to identify the most influential observations and their effects on the fixed-effects coefficients... - Magnetic resonance imaging studies of age-dependent responses to scaled focal brain injury in the pigletAnn Christine Duhaime
Department of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Neurosurg 99:542-8. 2003....