Eugene Demidenko

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Standard error of inverse prediction for dose-response relationship: approximate and exact statistical inference
    Eugene Demidenko
    Dartmouth Physically Based Biodosimetry Center for Medical Countermeasures Against Radiation Dart Dose CMCR, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
    Stat Med 32:2048-61. 2013
  2. pmc Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 78:1193-200. 2010
  3. ncbi Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Int J Radiat Oncol Biol Phys 61:1503-9. 2005
  4. ncbi In vivo EPR dosimetry to quantify exposures to clinically significant doses of ionising radiation
    Harold M Swartz
    EPR Center for Viable Systems, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Radiat Prot Dosimetry 120:163-70. 2006
  5. ncbi The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiat Res 168:218-25. 2007
  6. pmc Tissue pO2 of orthotopic 9L and C6 gliomas and tumor-specific response to radiotherapy and hyperoxygenation
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 73:878-85. 2009
  7. ncbi Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 59:834-43. 2004
  8. pmc Physically-based biodosimetry using in vivo EPR of teeth in patients undergoing total body irradiation
    Benjamin B Williams
    Department of Diagnostic Radiology, Dartmouth Physically based Biodosimetry Center for Medical Countermeasures against Radiation, Dartmouth Medical School, Hanover, New Hampshire, USA
    Int J Radiat Biol 87:766-75. 2011
  9. ncbi Pretreatment photosensitizer dosimetry reduces variation in tumor response
    Xiaodong Zhou
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 64:1211-20. 2006
  10. ncbi Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model
    Bin Chen
    Thayer School of Engineering, 80000 Cummings Hall, Dartmouth College, Hanover, NH 03755, USA
    Clin Cancer Res 11:720-7. 2005

Collaborators

Detail Information

Publications41

  1. pmc Standard error of inverse prediction for dose-response relationship: approximate and exact statistical inference
    Eugene Demidenko
    Dartmouth Physically Based Biodosimetry Center for Medical Countermeasures Against Radiation Dart Dose CMCR, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
    Stat Med 32:2048-61. 2013
    ..We illustrate our theory with electron paramagnetic resonance tooth dosimetry for a rapid estimation of the radiation dose received in the event of nuclear terrorism...
  2. pmc Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 78:1193-200. 2010
    ..We report repeated measurements of orthotopic F98 tumor pO(2) and relate this to the effect of carbogen inhalation on tumor growth when combined with hypofractionated radiotherapy...
  3. ncbi Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Int J Radiat Oncol Biol Phys 61:1503-9. 2005
    ..Efaproxiral reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumors...
  4. ncbi In vivo EPR dosimetry to quantify exposures to clinically significant doses of ionising radiation
    Harold M Swartz
    EPR Center for Viable Systems, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Radiat Prot Dosimetry 120:163-70. 2006
    ....
  5. ncbi The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiat Res 168:218-25. 2007
    ..This is the first study to demonstrate the ability of efaproxiral to increase tumor oxygenation and to increase the tumor growth inhibition of radiotherapy over 5 days of treatment...
  6. pmc Tissue pO2 of orthotopic 9L and C6 gliomas and tumor-specific response to radiotherapy and hyperoxygenation
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 73:878-85. 2009
    ..3 Gy of radiation and carbogen inhalation on orthotopic 9L and C6 gliomas and on the contralateral brain pO(2) in rats using a new and potentially widely useful method, multisite in vivo electron paramagnetic resonance oximetry...
  7. ncbi Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 59:834-43. 2004
    ....
  8. pmc Physically-based biodosimetry using in vivo EPR of teeth in patients undergoing total body irradiation
    Benjamin B Williams
    Department of Diagnostic Radiology, Dartmouth Physically based Biodosimetry Center for Medical Countermeasures against Radiation, Dartmouth Medical School, Hanover, New Hampshire, USA
    Int J Radiat Biol 87:766-75. 2011
    ..In vivo electron paramagnetic resonance (EPR) spectroscopy of tooth enamel has been developed to meet this need...
  9. ncbi Pretreatment photosensitizer dosimetry reduces variation in tumor response
    Xiaodong Zhou
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 64:1211-20. 2006
    ..Conclusions: This research suggests that accurate quantification of tissue photosensitizer levels and subsequent adjustment of light dose will allow for reduced subject variation and improved treatment consistency...
  10. ncbi Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model
    Bin Chen
    Thayer School of Engineering, 80000 Cummings Hall, Dartmouth College, Hanover, NH 03755, USA
    Clin Cancer Res 11:720-7. 2005
    ....
  11. ncbi Spin traps: in vitro toxicity and stability of radical adducts
    Nadeem Khan
    Department of Diagnostic Radiology, EPR Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Free Radic Biol Med 34:1473-81. 2003
    ..It then should be feasible to select the spin trap(s) best suited for the proposed study...
  12. pmc Radiotherapy in conjunction with 7-hydroxystaurosporine: a multimodal approach with tumor pO2 as a potential marker of therapeutic response
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Radiat Res 172:592-7. 2009
    ..This multimodal approach could be used to enhance the outcome of radiotherapy. Furthermore, tumor pO2 could be a potential marker of therapeutic response...
  13. pmc Oxygen consumption rates and oxygen concentration in molt-4 cells and their mtDNA depleted (rho0) mutants
    Jiangang Shen
    EPR Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biophys J 84:1291-8. 2003
    ..The results are consistent with our earlier findings suggesting that such oxygen gradients may be a general phenomenon found in most or all cell systems under appropriate conditions...
  14. pmc Repeated tumor pO(2) measurements by multi-site EPR oximetry as a prognostic marker for enhanced therapeutic efficacy of fractionated radiotherapy
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA
    Radiother Oncol 91:126-31. 2009
    ..To investigate the temporal effects of single or fractionated radiotherapy on subcutaneous RIF-1 tumor pO(2) and to determine the therapeutic outcomes when the timing of fractionations is guided by tumor pO(2)...
  15. ncbi Comparison of EPR oximetry and Eppendorf polarographic electrode assessments of rat brain PtO2
    JULIA A O'HARA
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Physiol Meas 25:1413-23. 2004
    ....
  16. pmc Electron paramagnetic resonance dosimetry for a large-scale radiation incident
    Harold M Swartz
    Dartmouth Medical School, Hanover, NH 03755, USA
    Health Phys 103:255-67. 2012
    ..The authors conclude that electron paramagnetic resonance dosimetry is likely to be a useful part of triage for a large-scale radiation incident...
  17. pmc Determinants of NCI Cancer Center attendance in Medicare patients with lung, breast, colorectal, or prostate cancer
    Tracy Onega
    The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Hanover, NH, USA
    J Gen Intern Med 24:205-10. 2009
    ..S. This study identified determinants of NCI-Cancer Center attendance in Medicare cancer patients...
  18. ncbi Cerebral tissue oxygenation in reversible focal ischemia in rats: multi-site EPR oximetry measurements
    Huagang Hou
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Physiol Meas 26:131-41. 2005
    ..In addition, the ability simultaneously to measure the pO2 in several sites provides important additional information that should help to differentiate between changes in the PO2 due toglobal or local mechanisms...
  19. pmc Development of in vivo tooth EPR for individual radiation dose estimation and screening
    Benjamin B Williams
    Dartmouth Medical School, 704 Vail HP7785, Hanover, NH 03755, USA
    Health Phys 98:327-38. 2010
    ..In summary, it seems plausible that the EPR dosimetry techniques will have an important role in retrospective dosimetry for exposures involving large numbers of individuals...
  20. ncbi Simultaneous measurement of rat brain cortex PtO2 using EPR oximetry and a fluorescence fiber-optic sensor during normoxia and hyperoxia
    JULIA A O'HARA
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Physiol Meas 26:203-13. 2005
    ..26 to 0.95 (carbogen) were similar by the two methods and (4) in some rats breathing carbogen, absolute values of PtO(2) were above the sensitive range of the OxyLite method...
  21. ncbi Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors
    Seiko Toraya-Brown
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Nanomedicine 10:1273-85. 2014
    ..Our results demonstrate the promising potential of local hyperthermia treatment applied to identified tumors in inducing anti-tumor immune responses that reduce the risk of recurrence and metastasis...
  22. ncbi High spatial resolution multisite EPR oximetry of transient focal cerebral ischemia in the rat
    Benjamin B Williams
    Dartmouth EPR Center, Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1691-8. 2007
    ..These measurements demonstrate the capabilities of the HSRMS oximetry technique and set the stage for more extensive physiologic studies...
  23. ncbi pO2 and regional blood flow in a rabbit model of limb ischemia
    Oleg Y Grinberg
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Physiol Meas 25:659-70. 2004
    ..Within two weeks of occlusion the pO2 is recovered to 45% of baseline. This study demonstrates, for the first time, the applicability of EPR oximetry in animals larger than rodents...
  24. ncbi Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cancer Res 63:1025-33. 2003
    ..4 +/- 1.4 days, and when PDT was given at the same time as radiation, the delay was 8.1 +/- 1.5 days. This observation indicates that the combined effect in the latter case was greater than additive (P = 0.049)...
  25. ncbi Measurements of clinically significant doses of ionizing radiation using non-invasive in vivo EPR spectroscopy of teeth in situ
    Harold M Swartz
    Dartmouth Medical School, EPR Center for Viable Systems, Hanover, NH 03755, USA
    Appl Radiat Isot 62:293-9. 2005
    ..In its current state of development, it probably is sufficient for most applications related to terrorism or nuclear warfare, for decision-making for action for individuals in regard to acute effects from exposure to ionizing radiation...
  26. pmc Advances in a framework to compare bio-dosimetry methods for triage in large-scale radiation events
    Ann Barry Flood
    Geisel School of Medicine at Dartmouth, EPR Center, Hanover, NH 03768, USA
    Radiat Prot Dosimetry 159:77-86. 2014
    ....
  27. ncbi Development and validation of an ex vivo electron paramagnetic resonance fingernail biodosimetric method
    Xiaoming He
    Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    Radiat Prot Dosimetry 159:172-81. 2014
    ....
  28. pmc Influence of NCI cancer center attendance on mortality in lung, breast, colorectal, and prostate cancer patients
    Tracy Onega
    The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Hanover, NH 03756, USA
    Med Care Res Rev 66:542-60. 2009
    ..Attendance at NCI cancer centers is associated with a significant survival benefit for the four major cancers among Medicare beneficiaries...
  29. pmc Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARĪ± and inhibits the growth of acute promyelocytic leukemia
    Yongli Guo
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Res 70:9875-85. 2010
    ..In contrast, elevation of UBP43 expression stabilized PML/RARĪ± protein and inhibited apoptosis. Taken together, our findings define the ubiquitin protease UBP43 as a novel candidate drug target for APL treatment...
  30. pmc MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors
    Xi Liu
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Clin Invest 120:1298-309. 2010
    ..Together, these findings revealed that miR-31 acts as an oncogenic miRNA (oncomir) in lung cancer by targeting specific tumor suppressors for repression...
  31. pmc Radiation dose prediction using data on time to emesis in the case of nuclear terrorism
    Eugene Demidenko
    Section of Biostatistics and Epidemiology, Hanover, New Hampshire, USA
    Radiat Res 171:310-9. 2009
    ..More reliable methods for after-the-fact assessment of radiation dose are needed to complement the use of time to emesis...
  32. pmc Mapping disease at an approximated individual level using aggregate data: a case study of mapping New Hampshire birth defects
    Xun Shi
    Department of Geography, Dartmouth College, 6017 Fairchild, Hanover, NH 03755, USA
    Int J Environ Res Public Health 10:4161-74. 2013
    ..High resolution maps based on objective spatial units are needed to more precisely detect associations between disease and environmental factors...
  33. pmc Three endpoints of in vivo tumour radiobiology and their statistical estimation
    Eugene Demidenko
    Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Int J Radiat Biol 86:164-73. 2010
    ..To mathematically define doubling time (DT), tumour-growth delay (TGD) and cancer-cell surviving fraction (SF) in vivo using exponential growth and regrowth models with tumour volume measurements obtained from animal experiments...
  34. ncbi Plasma membrane cholesterol: a possible barrier to intracellular oxygen in normal and mutant CHO cells defective in cholesterol metabolism
    Nadeem Khan
    Department of Diagnostic Radiology, EPR Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biochemistry 42:23-9. 2003
    ..The results indicate that the concentration of cholesterol in the plasma membrane can be an important factor for the magnitude of the oxygen gradient observed across the cell membrane...
  35. pmc Cutaneous alpha, beta and gamma human papillomaviruses in relation to squamous cell carcinoma of the skin: a population-based study
    Shohreh F Farzan
    Department of Community and Family Medicine and the Norris Cotton Cancer Center, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH 03756, USA
    Int J Cancer 133:1713-20. 2013
    ..Overall, the association between cutaneous HPVs and skin cancers appears to be specific to SCC and to genus beta HPVs in a general US population. ..
  36. pmc Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy
    Seiko Toraya-Brown
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
    Integr Biol (Camb) 5:159-71. 2013
    ....
  37. ncbi A polygon-based locally-weighted-average method for smoothing disease rates of small units
    Xun Shi
    Department of Geography, Dartmouth College, Hanover, New Hampshire 03755, USA
    Epidemiology 18:523-8. 2007
    ..Disease rates for geographic areas with small populations may be unstable. Therefore, accurate nonparametric methods for smoothing or stabilizing rates are needed...
  38. ncbi Lysosomes and trivalent arsenic treatment in acute promyelocytic leukemia
    Sutisak Kitareewan
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Natl Cancer Inst 99:41-52. 2007
    ..When resistance to all-trans-retinoic acid develops, an effective treatment is arsenic trioxide (arsenite), which also induces this degradation. We investigated the mechanism of arsenite-induced PML/RAR alpha degradation...
  39. ncbi Sample size and optimal design for logistic regression with binary interaction
    Eugene Demidenko
    Dartmouth Medical School, Hanover, NH 03755, U S A
    Stat Med 27:36-46. 2008
    ..Our sample size and power calculations with interaction can be carried out online at www.dartmouth.edu/ approximately eugened...
  40. pmc Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas
    Yan Ma
    Department of Pharmacology and Toxicology, and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 104:4089-94. 2007
    ..This article reports unique mouse lung cancer models that replicate many carcinogenic changes found in patients. These models provide insights into the carcinogenesis process and implicate cyclin E as a therapeutic target in the lung...
  41. ncbi Changes in oxygenation of intracranial tumors with carbogen: a BOLD MRI and EPR oximetry study
    Jeff F Dunn
    NMR and EPR Research Centers, Department of Diagnostic Radiology, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire, USA
    J Magn Reson Imaging 16:511-21. 2002
    ..To examine, using blood oxygen level dependent (BOLD) MRI and EPR oximetry, the changes in oxygenation of intracranial tumors induced by carbogen breathing...