Scott C Davis

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 110:9025-30. 2013
  2. pmc Comparing implementations of magnetic-resonance-guided fluorescence molecular tomography for diagnostic classification of brain tumors
    Scott C Davis
    Dartmouth College, Thayer School of Engineering, HB 8000, Hanover, New Hampshire 03755, USA
    J Biomed Opt 15:051602. 2010
  3. pmc MRI-coupled fluorescence tomography quantifies EGFR activity in brain tumors
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 17:271-6. 2010
  4. pmc Tissue drug concentration determines whether fluorescence or absorption measurements are more sensitive in diffuse optical tomography of exogenous contrast agents
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D262-72. 2009
  5. pmc Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Rev Sci Instrum 79:064302. 2008
  6. pmc Detecting epidermal growth factor receptor tumor activity in vivo during cetuximab therapy of murine gliomas
    Summer L Gibbs-Strauss
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    Acad Radiol 17:7-17. 2010
  7. pmc High vascular delivery of EGF, but low receptor binding rate is observed in AsPC-1 tumors as compared to normal pancreas
    Kimberley S Samkoe
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Mol Imaging Biol 14:472-9. 2012
  8. ncbi request reprint Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth
    Dax S Kepshire
    Thayer School of Engineering, Dartmouth College, New Hampshire 03755, USA
    Appl Opt 46:1669-78. 2007
  9. pmc Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation
    Rongxiao Zhang
    Dartmouth College, Department of Physics and Astronomy, Hanover, NH 03755, USA
    J Biomed Opt 18:50503. 2013
  10. pmc Pulsed-light imaging for fluorescence guided surgery under normal room lighting
    Kristian Sexton
    Thayer School of Engineering at Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 38:3249-52. 2013

Detail Information

Publications33

  1. pmc Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 110:9025-30. 2013
    ..3 ± 0.5 nM (n = 5), consistent with values estimated in comparative invasive imaging and ex vivo studies...
  2. pmc Comparing implementations of magnetic-resonance-guided fluorescence molecular tomography for diagnostic classification of brain tumors
    Scott C Davis
    Dartmouth College, Thayer School of Engineering, HB 8000, Hanover, New Hampshire 03755, USA
    J Biomed Opt 15:051602. 2010
    ..Bulk fluorescence spectroscopy techniques performed as well as most imaging techniques, suggesting that complex imaging algorithms may be unnecessary to diagnose EGFR status in these tissue volumes...
  3. pmc MRI-coupled fluorescence tomography quantifies EGFR activity in brain tumors
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 17:271-6. 2010
    ..This report demonstrates the diagnostic potential of magnetic resonance imaging (MRI)-coupled fluorescence molecular tomography (FMT) to determine epidermal growth factor receptor (EGFR) status in brain cancer...
  4. pmc Tissue drug concentration determines whether fluorescence or absorption measurements are more sensitive in diffuse optical tomography of exogenous contrast agents
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Appl Opt 48:D262-72. 2009
    ..Specifically, fluorescence measurements are favorable if background drug concentrations are below 135-200 nM for LuTex and 25-50 nM for ICG, while absorption measurements are more sensitive above these ranges...
  5. pmc Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue
    Scott C Davis
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Rev Sci Instrum 79:064302. 2008
    ..A pilot murine study using an orthotopic glioma tumor model demonstrates optical-MRI imaging of an epidermal growth factor receptor targeted fluorescent probe in vivo...
  6. pmc Detecting epidermal growth factor receptor tumor activity in vivo during cetuximab therapy of murine gliomas
    Summer L Gibbs-Strauss
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    Acad Radiol 17:7-17. 2010
    ....
  7. pmc High vascular delivery of EGF, but low receptor binding rate is observed in AsPC-1 tumors as compared to normal pancreas
    Kimberley S Samkoe
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Mol Imaging Biol 14:472-9. 2012
    ..Here, the in vivo delivery and binding kinetics of epidermal growth factor receptor (EGFR) was determined for normal pancreas and AsPC-1 orthotopic pancreatic tumors known to overexpress EGFR...
  8. ncbi request reprint Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth
    Dax S Kepshire
    Thayer School of Engineering, Dartmouth College, New Hampshire 03755, USA
    Appl Opt 46:1669-78. 2007
    ..However, increases in tissue curvature and/or the addition of prior information are expected to improve the linearity of the response. The potential for this type of imaging technique to serve as a surgical guide is highlighted...
  9. pmc Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation
    Rongxiao Zhang
    Dartmouth College, Department of Physics and Astronomy, Hanover, NH 03755, USA
    J Biomed Opt 18:50503. 2013
    ..Translating this approach to the clinic could facilitate direct sensing of pO(2) during radiotherapy...
  10. pmc Pulsed-light imaging for fluorescence guided surgery under normal room lighting
    Kristian Sexton
    Thayer School of Engineering at Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 38:3249-52. 2013
    ..Resection of orthotopic brain tumors in mice also suggests that the pulsed-light system provides superior sensitivity in vivo...
  11. pmc Dual-tracer background subtraction approach for fluorescent molecular tomography
    Kenneth M Tichauer
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:16003. 2013
    ..The approach is demonstrated in simulations, a phantom study, and in a mouse glioma imaging study, demonstrating substantial improvement over conventional and homogenous background subtraction image reconstruction approaches...
  12. pmc Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data
    Jia Wang
    Dartmouth College, Department of Physics and Astronomy, Hanover, New Hampshire 03755, USA
    J Biomed Opt 13:041305. 2008
    ..The system and algorithms developed here should provide an optimal way to quantify regions with the goal of image-guided breast tissue spectroscopy within the MRI...
  13. pmc Fluorescence tomography characterization for sub-surface imaging with protoporphyrin IX
    Dax Kepshire
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Opt Express 16:8581-93. 2008
    ....
  14. pmc Rapid magnetic resonance-guided near-infrared mapping to image pulsatile hemoglobin in the breast
    Zhiqiu Li
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 35:3964-6. 2010
    ..A 0.1 s temporal delay of the absorption pulse within adipose tissue relative to fibroglandular tissue was found, in an initial human study, showing the potential for novel contrast imaging of fast flow signals in deep tissue...
  15. pmc Fast segmentation and high-quality three-dimensional volume mesh creation from medical images for diffuse optical tomography
    Michael Jermyn
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:86007. 2013
    ..These capabilities represent a significant step toward enabling translational multimodal NIR research for both expert and nonexpert users in an open-source platform...
  16. pmc Projection imaging of photon beams by the Čerenkov effect
    Adam K Glaser
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    Med Phys 40:012101. 2013
    ..A novel technique for beam profiling of megavoltage photon beams was investigated for the first time by capturing images of the induced Čerenkov emission in water, as a potential surrogate for the imparted dose in irradiated media...
  17. pmc Three-dimensional Čerenkov tomography of energy deposition from ionizing radiation beams
    Adam K Glaser
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 38:634-6. 2013
    ..By capturing multiple projection images of the Čerenkov light induced by a medical linear accelerator x-ray photon beam, we demonstrate the successful three-dimensional tomographic reconstruction of the imparted dose distribution...
  18. pmc Projection imaging of photon beams using Čerenkov-excited fluorescence
    Adam K Glaser
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Phys Med Biol 58:601-19. 2013
    ....
  19. ncbi request reprint Image analysis methods for diffuse optical tomography
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:33001. 2006
    ..Each of these three major areas of image interpretation and analysis are reviewed in the context of medical imaging as well as how they are used to quantify the performance of diffuse optical imaging of tissue...
  20. pmc Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Philos Trans A Math Phys Eng Sci 369:4531-57. 2011
    ..Most beneficial inclusion of prior information has been in the inversion/reconstruction process, because it solves the mathematical intractability. However, it is not clear that this is always the most beneficial stage...
  21. doi request reprint Čerenkov excited fluorescence tomography using external beam radiation
    Jennifer Lynn Demers
    Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, New Hampshire 03755, USA
    Opt Lett 38:1364-6. 2013
    ..Fluorescent diffuse tomographic images showed a linear response between the concentration and the reconstructed values. The potential to apply this molecular imaging in treatment with molecular reporters appears promising...
  22. pmc White light-informed optical properties improve ultrasound-guided fluorescence tomography of photoactive protoporphyrin IX
    Brendan P Flynn
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:046008. 2013
    ..These data suggest that this implementation of USFT is capable of regional PpIX mapping in human skin tumors during photodynamic therapy, to be used in dosimetric evaluations...
  23. pmc Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms
    Adam K Glaser
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 37:1193-5. 2012
    ..This observation has the potential to significantly increase the value of Cherenkov emission spectroscopy during radiation therapy to monitor tissue molecular events...
  24. pmc Fluorescent molecular imaging and dosimetry tools in photodynamic therapy
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
    Methods Mol Biol 635:207-22. 2010
    ..Each of these methods is described below, the application to imaging photosensitizer uptake is discussed, and developing methods to image molecular responses to therapy are outlined...
  25. pmc Cerenkov emission induced by external beam radiation stimulates molecular fluorescence
    Johan Axelsson
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 38:4127-32. 2011
    ..This study quantifies the emissions and also demonstrates that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms...
  26. ncbi request reprint CT contrast predicts pancreatic cancer treatment response to verteporfin-based photodynamic therapy
    Michael Jermyn
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Phys Med Biol 59:1911-21. 2014
    ..This study is the first to show that contrast CT provides needed surrogate dosimetry information to predict treatment response in a manner which uses standard-of-care clinical images, rather than invasive dosimetry methods...
  27. pmc Video-rate optical dosimetry and dynamic visualization of IMRT and VMAT treatment plans in water using Cherenkov radiation
    Adam K Glaser
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755
    Med Phys 41:062102. 2014
    ....
  28. pmc System development for high frequency ultrasound-guided fluorescence quantification of skin layers
    Josiah D Gruber
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 15:026028. 2010
    ..Pilot in-vivo data are also presented, showing recovery of subcutaneous tumor tissue values of protoporphyrin IX in a subcutaneous U251 tumor, which has less fluorescence than the skin...
  29. pmc Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    J Photochem Photobiol B 98:77-94. 2010
    ....
  30. pmc Video-rate near infrared tomography to image pulsatile absorption properties in thick tissue
    Zhiqiu Li
    Thayer School of Engineering, Dartmouth College, Hanover NH 0375, USA
    Opt Express 17:12043-56. 2009
    ..The ability to image thick tissue and the capacity to image periodic changes in absorption makes this design well suited for tracking thick tissue hemodynamics in vivo during MR or CT imaging...
  31. ncbi request reprint Spectrally resolved bioluminescence optical tomography
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 31:365-7. 2006
    ..The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity...
  32. pmc Čerenkov radiation emission and excited luminescence (CREL) sensitivity during external beam radiation therapy: Monte Carlo and tissue oxygenation phantom studies
    Rongxiao Zhang
    Department of Physics and Astronomy, Dartmouth College, Hanover NH 03755, USA
    Biomed Opt Express 3:2381-94. 2012
    ....
  33. pmc Multichannel diffuse optical Raman tomography for bone characterization in vivo: a phantom study
    Jennifer Lynn H Demers
    Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, USA
    Biomed Opt Express 3:2299-305. 2012
    ..Images with high contrast to background ratios of Raman yield and accurate spatial resolution were recovered using a model-based diffuse tomography approach...