Robert A Darnall
Affiliation: Dartmouth Medical School
- The effects of a GABA(A) agonist in the rostral ventral medulla on sleep and breathing in newborn pigletsR A Darnall
Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Sleep 24:514-27. 2001..We hypothesized that inhibition of neurons in the RVM would produce less wakefulness or increase the low frequency power (delta) during Quiet sleep...
- The carotid body and arousal in the fetus and neonateRobert A Darnall
Department of Pediatrics, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, United States
Respir Physiol Neurobiol 185:132-43. 2013..This review will focus on arousal in response to hypoxia and CO(2) in the fetus and newborn and will outline what we know (and do not know) about the involvement of the carotid body in this process...
- Prolongation of the laryngeal chemoreflex after inhibition of the rostral ventral medulla in piglets: a role in SIDS?Liesbeth Van Der Velde
Departments of Physiology, Medicine, and Pediatrics, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Appl Physiol 94:1883-95. 2003..We conclude that the RVM provides a tonic facilitatory drive to ventilation that limits the duration of the LCR, and loss of this drive may contribute to the SIDS when combined with stimuli that inhibit respiration...
- Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases rapid eye movement sleep in the piglet: implications for sudden infant death syndromeRobert A Darnall
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Neurosci 25:8322-32. 2005..Abnormalities in the function of these neurons may alter sleep homeostasis and contribute to the etiology of SIDS...
- Arousal from sleep in response to intermittent hypoxia in rat pups is modulated by medullary raphe GABAergic mechanismsRobert A Darnall
Department of Pediatrics, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Physiol Regul Integr Comp Physiol 302:R551-60. 2012..Arousal habituation may contribute to sudden infant death syndrome, which is associated with MR serotonergic and GABAergic receptor dysfunction...
- Characterization of hypoxia-induced ventilatory depression in newborn pigletsRene St-Jacques
Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Exp Physiol 88:509-15. 2003..We conclude that a region of the caudal mesencephalon or pons is necessary for the manifestation of depressions of ventilatory activity in the newborn pig...
- The late preterm infant and the control of breathing, sleep, and brainstem development: a reviewRobert A Darnall
Department of Physiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Clin Perinatol 33:883-914; abstract x. 2006..Research focused on this group of infants will not only further our understanding of brainstem maturation during this high risk period, but will help develop focused plans for their management...
- The role of CO(2) and central chemoreception in the control of breathing in the fetus and the neonateRobert A Darnall
Departments of Physiology and Neurobiology and Pediatrics, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA
Respir Physiol Neurobiol 173:201-12. 2010....
- Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure?Zuzanna J Kubicka
Department of Pediatrics, Division of Neonatal Perinatal Medicine, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA
Pediatrics 121:82-8. 2008..We hypothesized that clinically relevant levels of continuous positive airway pressure would not be achieved if a nasal leak is maintained...