Barbara Conradt

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion
    Stephane G Rolland
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    J Cell Biol 186:525-40. 2009
  2. pmc Genetic control of programmed cell death during animal development
    Barbara Conradt
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Annu Rev Genet 43:493-523. 2009
  3. pmc Gem-1 encodes an SLC16 monocarboxylate transporter-related protein that functions in parallel to the gon-2 TRPM channel during gonad development in Caenorhabditis elegans
    Benedict J Kemp
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genetics 181:581-91. 2009
  4. pmc A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans
    Yun Lu
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 108:E813-22. 2011
  5. ncbi request reprint C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions
    Claus Schertel
    Dartmouth Medical School, Department of Genetics, Norris Cotton Cancer Center, 7400 Remsen, Hanover, NH 03755, USA
    Development 134:3691-701. 2007
  6. pmc Control of apoptosis by asymmetric cell division
    Julia Hatzold
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS Biol 6:e84. 2008
  7. pmc New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics
    Stephane G Rolland
    Dartmouth Medical School, Department of Genetics, Norris Cotton Cancer Center, 7400 Remsen, Hanover, NH 03755, USA
    Curr Opin Cell Biol 22:852-8. 2010
  8. ncbi request reprint The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans
    Phillip Grote
    Department of Genetics, Dartmouth Medical School, Norris Cotton Cancer Center, 7400 Remsen, Hanover, New Hampshire 03755, USA
    Dev Cell 11:561-73. 2006
  9. pmc Recombinant expression, biophysical characterization, and cardiolipin-induced changes of two Caenorhabditis elegans cytochrome c proteins
    Amber J Vincelli
    Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    Biochemistry 52:653-66. 2013

Research Grants

Collaborators

  • Stephane G Rolland
  • Yun Lu
  • Eric Lambie
  • Julia Hatzold
  • Amber J Vincelli
  • Benedict J Kemp
  • Claus Schertel
  • Phillip Grote
  • Ekaterina V Pletneva
  • Jonas Hanske
  • Fangfang Zhong
  • Danielle S Pottinger
  • Diane L Church

Detail Information

Publications9

  1. pmc The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion
    Stephane G Rolland
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    J Cell Biol 186:525-40. 2009
    ..Therefore, we propose that the BCL-2-like CED-9 acts through FZO-1/Mfn1,2 and EAT-3/Opa1 to promote mitochondrial fusion in response to specific cellular signals...
  2. pmc Genetic control of programmed cell death during animal development
    Barbara Conradt
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Annu Rev Genet 43:493-523. 2009
    ..Recent studies have revealed that many of the regulatory pathways involved play additional important roles in development, which confirms that the programmed cell death fate is an integral aspect of animal development...
  3. pmc Gem-1 encodes an SLC16 monocarboxylate transporter-related protein that functions in parallel to the gon-2 TRPM channel during gonad development in Caenorhabditis elegans
    Benedict J Kemp
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genetics 181:581-91. 2009
    ..GEM-1GFP is expressed within the gonadal precursor cells and localizes to the plasma membrane. Therefore, we propose that GEM-1 acts in parallel to the GON-2 channel to promote cation uptake within the developing gonad...
  4. pmc A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans
    Yun Lu
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 108:E813-22. 2011
    ..We speculate that this function of BCL2-like proteins may be as couplers of mitochondrial fusion and fission...
  5. ncbi request reprint C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions
    Claus Schertel
    Dartmouth Medical School, Department of Genetics, Norris Cotton Cancer Center, 7400 Remsen, Hanover, NH 03755, USA
    Development 134:3691-701. 2007
    ..Our results have implications for the general mechanisms through which RB-like proteins control gene expression, the role of RB-, DP- and E2F-like proteins in apoptosis, and the regulation of apoptosis...
  6. pmc Control of apoptosis by asymmetric cell division
    Julia Hatzold
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS Biol 6:e84. 2008
    ..Furthermore, based on our results, we propose that this pathway directly controls the apoptotic fate in C. elegans, and possibly other animals as well...
  7. pmc New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics
    Stephane G Rolland
    Dartmouth Medical School, Department of Genetics, Norris Cotton Cancer Center, 7400 Remsen, Hanover, NH 03755, USA
    Curr Opin Cell Biol 22:852-8. 2010
    ..Here, we review the functions of mitochondrial fusion and fission in apoptotic and nonapoptotic cells and how members of the BCL2 family of proteins regulate these functions...
  8. ncbi request reprint The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans
    Phillip Grote
    Department of Genetics, Dartmouth Medical School, Norris Cotton Cancer Center, 7400 Remsen, Hanover, New Hampshire 03755, USA
    Dev Cell 11:561-73. 2006
    ..Similar interactions may function in sex determination and developmental regulation in other species...
  9. pmc Recombinant expression, biophysical characterization, and cardiolipin-induced changes of two Caenorhabditis elegans cytochrome c proteins
    Amber J Vincelli
    Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    Biochemistry 52:653-66. 2013
    ..1 and CYC-2.2 to those of mammalian cyt c suggest that C. elegans proteins, particularly the former, could serve as useful models for examining the mechanism of cyt c-CL interactions in live organisms...

Research Grants11

  1. Analysis of Cell Death Regulation in C.elegans
    Barbara Conradt; Fiscal Year: 2005
    ..elegans but in higher organisms, including humans, as well. ..
  2. Analysis of Cell Death Regulation in C.elegans
    Barbara Conradt; Fiscal Year: 2006
    ..elegans but in higher organisms, including humans, as well. ..
  3. Analysis of Cell Death Regulation in Caenorhabditis elegans
    Barbara Conradt; Fiscal Year: 2007
    ..elegans but in higher organisms, including humans, as well. ..
  4. Analysis of Cell Death Regulation in C. elegans
    Barbara Conradt; Fiscal Year: 2009
    ..Therefore, the proposed studies will contribute to our basic understanding of developmental health disorders and are specifically relevant to understanding the behavior of cancer stem cells and, hence, tumorigenesis. ..
  5. Regulation and role of dynamin-related GTPases in C. elegans apoptosis
    Barbara Conradt; Fiscal Year: 2010
    ..Therefore, results from the proposed studies will improve our knowledge of apoptosis and hence our ability to understand and treat various human disorders. ..
  6. Analysis of Cell Death Regulation in C. elegans
    Barbara Conradt; Fiscal Year: 2010
    ..Therefore, the proposed studies will contribute to our basic understanding of developmental health disorders and are specifically relevant to understanding the behavior of cancer stem cells and, hence, tumorigenesis. ..
  7. Analysis of Cell Death Regulation in C. elegans
    Barbara Conradt; Fiscal Year: 2010
    ..Therefore, the proposed studies will contribute to our basic understanding of developmental health disorders and are specifically relevant to understanding the behavior of cancer stem cells and, hence, tumorigenesis. ..
  8. Regulation and role of dynamin-related GTPases in C. elegans apoptosis
    Barbara Conradt; Fiscal Year: 2009
    ..Therefore, results from the proposed studies will improve our knowledge of apoptosis and hence our ability to understand and treat various human disorders. ..
  9. Analysis of Cell Death Regulation in C.elegans
    Barbara Conradt; Fiscal Year: 2004
    ..elegans but in higher organisms, including humans, as well. ..