Research Topics
| Jeremiah R BrownSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Detail Information
Publications
The prognostic value of using the duration of acute kidney injury in cardiac surgery: an example using two antifibrinolyticsJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Section of Cardiology Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Extra Corpor Technol 43:227-31. 2011..09, 95% confidence interval [CI] = 1.65-2.65). AKI duration added to the AKIN definition of AKI may provide the necessary sensitivity and specificity for evaluating renal outcomes in clinical trials...
Determinants of acute kidney injury duration after cardiac surgery: an externally validated toolJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Section of Cardiology Dartmouth Hitchcock Medical Center, and Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Ann Thorac Surg 93:570-6. 2012..We sought to identify perioperative risk factors that predict duration of AKI, a complication that effects short and long-term survival...- Sodium bicarbonate plus N-acetylcysteine prophylaxis: a meta-analysisJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire, USA
JACC Cardiovasc Interv 2:1116-24. 2009..We sought to conduct a meta-analysis to compare N-acetylcysteine (NAC) in combination with sodium bicarbonate (NaHCO(3)) for the prevention of contrast-induced acute kidney injury (AKI)... - Does safe dosing of iodinated contrast prevent contrast-induced acute kidney injury?Jeremiah R Brown
Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth College, Lebanon, NH, USA
Circ Cardiovasc Interv 3:346-50. 2010..We hypothesized that there is a relationship between contrast volume and CI-AKI and that there might be reason to track incremental contrast volumes above and below the MACD limit... - Duration of acute kidney injury impacts long-term survival after cardiac surgeryJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Section of Cardiology, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Lebanon, New Hampshire, USA
Ann Thorac Surg 90:1142-8. 2010..However, it is not known how adverse long-term consequences vary according to the duration of AKI. We sought to determine the association between duration of AKI and survival... - Anti-inflammatory effect of aprotinin: a meta-analysisJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice and Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Extra Corpor Technol 41:79-86. 2009.... - Using biomarkers to improve the preoperative prediction of death in coronary artery bypass graft patientsJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth College and Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Extra Corpor Technol 42:293-300. 2010..The added measurement of multiple biomarkers outside of preoperative risk factors may be an unnecessary use of health care resources with little added benefit for predicting in-hospital mortality... - How do centres begin the process to prevent contrast-induced acute kidney injury: a report from a new regional collaborativeJeremiah R Brown
Dartmouth Hitchcock Medical Center, HB 7505, One Medical Center Drive, Lebanon, NH 03756, USA
BMJ Qual Saf 21:54-62. 2012..Reducing the risk of CI-AKI is a patient safety objective set by the National Quality Forum... - Does tight glucose control prevent myocardial injury and inflammation?Jeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Extra Corpor Technol 43:144-52. 2011..Future studies are needed to evaluate the cardiotoxic mechanisms of hyperglycemia postulated in this study... - Cardiac troponin T levels in on- and off-pump coronary artery bypass surgeryJeremiah R Brown
Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Lebanon, New Hampshire, USA
Heart Surg Forum 10:E42-6. 2007..We tested the hypothesis that the additional myocardial injury associated with CCAB compared with OPCAB is sustained when patients are stratified by priority and 2- or 3-vessel disease... - Invited commentaryJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH 03756, USA
Ann Thorac Surg 86:1202-3. 2008 - The evaluation of creatinine clearance, estimated glomerular filtration rate and serum creatinine in predicting contrast-induced acute kidney injury among patients undergoing percutaneous coronary interventionAlina M Robert
Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Cardiology, Lebanon, NH, USA
Cardiovasc Revasc Med 13:3-10. 2012.... - Primary percutaneous coronary intervention for patients presenting with ST-elevation myocardial infarction: process improvements in rural prehospital care delivered by emergency medical servicesMichael E Rezaee
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH 03756, USA
Prog Cardiovasc Dis 53:210-8. 2010..Therefore, we evaluated EMS processes of care before and after a period of continuous quality improvement to improve E2B times in our rural tertiary care medical center... - Long-term survival after cardiac surgery is predicted by estimated glomerular filtration rateJeremiah R Brown
Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH 03756, USA
Ann Thorac Surg 86:4-11. 2008..Postoperative eGFR and its association with long-term survival have not been well studied... - Reduction in intraoperative bacterial contamination of peripheral intravenous tubing through the use of a passive catheter care systemRandy W Loftus
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756, USA
Anesth Analg 115:1315-23. 2012..The secondary aim was to evaluate the impact of this novel intervention on the combined incidence of 30-day postoperative infections and IV catheter-associated phlebitis... - Long-term survival and cardiac troponin T elevation in on- and off-pump coronary artery bypass surgeryJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire 03756, USA
Heart Surg Forum 11:E163-8. 2008..We tested the hypothesis that long-term survival rates for CCAB and OPCAB patients were similar when stratified by cTnT concentration... - Cardiac surgery-associated acute kidney injury: a comparison of two consensus criteriaAlina M Robert
Internal Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Ann Thorac Surg 90:1939-43. 2010..We sought to estimate the ability of both the RIFLE and and AKIN criteria to predict the risk of in-hospital mortality in the setting of cardiac surgery... - Outcomes of diabetics receiving bare-metal stents versus drug-eluting stentsVijay S Ramanath
Section of Cardiology, Department of Medicine, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire
Catheter Cardiovasc Interv 76:473-81. 2010.... - Real world, long-term outcomes comparison between paclitaxel-eluting and sirolimus-eluting stent platformsMandeep S Sidhu
Section of Cardiology, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Interv Cardiol 23:167-75. 2010..2% for SES (95% CI 94.7-97.3) and 95.3% for PES (95% CI 93.7-96.5). SES and PES drug-eluting stent platforms have good and similar extended outcomes in this real world registry of unselected patients having PCI... - Transient and persistent renal dysfunction are predictors of survival after percutaneous coronary intervention: insights from the Dartmouth Dynamic RegistryJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH 03756, USA
Catheter Cardiovasc Interv 72:347-54. 2008..We sought to determine if transient and persistent elevations in creatinine following percutaneous coronary intervention (PCI) resulted in poor survival... - Multivariable prediction of renal insufficiency developing after cardiac surgeryJeremiah R Brown
Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Lebanon, NH 03756, USA
Circulation 116:I139-43. 2007..We hypothesized that preoperative patient characteristics could be used to predict the patient-specific risk of developing postoperative renal insufficiency... - Interaction of gender and age on post cardiac catheterization contrast-induced acute kidney injuryR Bhullar Sidhu
Section of Internal Medicine, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Am J Cardiol 102:1482-6. 2008..5% vs 11.0%, p <0.001) and >80-year-old (18.7% vs 15.1%, p = 0.048) groups, but no differences were seen in the younger cohorts. In conclusion, geriatric women are at greatest risk for the development of CIAKI after angiography... - Effect of prior cardiac operations on survival after coronary artery bypass graftingDonald S Likosky
Department of Medicine, Dartmouth College, Hanover, NH, USA
Ann Thorac Surg 92:1260-7. 2011..We examined a recent regional experience to determine the effect of a prior cardiac operation on short-term and midterm outcomes after coronary artery bypass grafting (CABG)... - Multiple reservoirs contribute to intraoperative bacterial transmissionRandy W Loftus
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Anesth Analg 114:1236-48. 2012..Pulsed-field gel electrophoresis was used to assess the contribution of reservoir bacterial pathogens to 30-day postoperative infections... - The impact of hematocrit drop on long-term survival after cardiac catheterization: insights from the Dartmouth Dynamic RegistryCalvin C Leung
Department of Medicine, Section of Internal Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Catheter Cardiovasc Interv 75:378-86. 2010..The long-term prognostic implication of post-procedural hematocrit drops in patients undergoing cardiac catheterization outside the clinical trial setting is not well defined... - Classification and treatment of coronary artery bifurcation lesions: putting the Medina classification to the testDavid M Zlotnick
Section of Cardiology, Dartmouth Hitchcock Medical Center Dartmouth Medical School, Lebanon, NH 03756, USA
Cardiovasc Revasc Med 13:228-33. 2012..The objective of this study was to characterize the inter-observer variability of the Medina classification and examine its contribution to treatment selection strategy... - Perioperative increases in serum creatinine are predictive of increased 90-day mortality after coronary artery bypass graft surgeryJeremiah R Brown
Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Lebanon, NH, USA
Circulation 114:I409-13. 2006..However, perioperative increases in serum creatinine and the association with mortality has not been well-studied. We assessed the hypothesis that perioperative increases in creatinine are associated with increased 90-day mortality... - The diabetic disadvantage: historical outcomes measures in diabetic patients undergoing cardiac surgery -- the pre-intravenous insulin eraJeremiah R Brown
Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Lebanon, NH, USA
Semin Thorac Cardiovasc Surg 18:281-8. 2006..001). In summary, The Diabetic Disadvantage in the pre-intravenous insulin era is characterized by worse short- and long-term outcomes for diabetic patients undergoing cardiac surgery in the United States and Canada... - Prevention of intravenous bacterial injection from health care provider hands: the importance of catheter design and handlingRandy W Loftus
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr Lebanon, NH 03756
Anesth Analg 115:1109-19. 2012..The secondary aims were to identify risk factors for bacterial injection and to estimate the quantity of bacterial organisms injected during catheter handling... - Contrast-induced acute kidney injury: the at-risk patient and protective measuresJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Section of Cardiology, Dartmouth Medical School, Hanover, NH, USA
Curr Cardiol Rep 12:440-5. 2010..Contrast agents may play a role in preventing CI-AKI. Implement catheter-laboratory technology and awareness to limit the amount of contrast dye used for any patient... - Classification and atherosclerosis distribution in patients with left main coronary diseaseCraig A Thompson
Cardiology Section, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Interv Cardiol 22:431-6. 2009.... - Review of case-mix corrected survival curvesTodd A MacKenzie
Northern New England Cardiovascular Disease Study Group, Lebanon, New Hampshire 03756, USA
Ann Thorac Surg 93:1416-25. 2012..The purpose of this report is to describe, illustrate, and review several approaches to case-mix adjusted survival (or event-free) curves... - Serious renal dysfunction after percutaneous coronary interventions can be predictedJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH, USA
Am Heart J 155:260-6. 2008..0 mg/dL absolute increase in creatinine, or a > or = 50% increase in creatinine). We hypothesized that preprocedural patient characteristics could be used to predict the risk of post-PCI SRD... - Primary percutaneous coronary intervention for patients presenting with ST-segment elevation myocardial infarction: process improvement in a rural ST-segment elevation myocardial infarction receiving centerNathaniel W Niles
Section of Cardiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756
Prog Cardiovasc Dis 53:202-9. 2010..CONCLUSIONS: Important improvement in the process of acute STEMI patient care was accomplished in the rural percutaneous coronary intervention center setting by implementing evidence-based strategies... - Invited commentaryJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, One Medical Center Dr, Lebanon, NH 03756, USA
Ann Thorac Surg 84:1502-3. 2007 - Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgeryJeremiah R Brown
Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, NH, USA
Circulation 115:2801-13. 2007..Since the 1980s, antifibrinolytic therapies have assisted surgical teams in reducing the amount of blood loss. To date, however, serious questions remain regarding the safety and effectiveness of these agents... - Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgeryRandy W Loftus
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Anesthesiology 113:639-46. 2010..Little is known regarding its efficacy in opiate-dependent patients with a history of chronic pain. We hypothesized that ketamine would reduce postoperative opiate consumption in this patient population... - Hand contamination of anesthesia providers is an important risk factor for intraoperative bacterial transmissionRandy W Loftus
Department of Anesthesiology and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Anesth Analg 112:98-105. 2011..In this study, we hypothesized that bacterial contamination of anesthesia provider hands before patient contact is a risk factor for direct intraoperative bacterial transmission... - Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guidelineVictor A Ferraris
Ann Thorac Surg 83:S27-86. 2007.... - Aprotinin in cardiac surgeryJeremiah R Brown
N Engl J Med 354:1953-7; author reply 1953-7. 2006 - Neurocognitive outcomes of off-pump versus on-pump coronary artery bypass: a prospective randomized controlled trialFelix Hernandez
Cardiothoracic Surgery, Eastern Maine Medical Center, 417 State St, Suite 421, Bangor, ME 04401, USA
Ann Thorac Surg 84:1897-903. 2007..We examined short-term and intermediate-term neurocognitive and index admission morbidity and mortality after coronary artery bypass surgery performed with and without the use of extracorporeal circulation... - Estimated glomerular filtration rate and renal functionRuyun Jin
Medical Data Research Center, Providence Health and Services, Portland, OR 97225, USA
Ann Thorac Surg 86:1-3. 2008..An eGFR/creatinine conversion table for individual patients derived from the eGFR equation with clinically significant cutpoints is given, which can be used by physicians as a pragmatic reference...