Research Topics
Genomes and Genes | Jennifer M BombergerSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesiclesJennifer M Bomberger
Department of Physiology, Dartmouth Medical School, Hanover, NH, USA
PLoS Pathog 5:e1000382. 2009....- The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cellsJennifer M Bomberger
Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Biol Chem 284:18778-89. 2009..These studies demonstrate a novel function for USP10 in facilitating the deubiquitination of CFTR in early endosomes and thereby enhancing the endocytic recycling of CFTR... 
Methods to monitor cell surface expression and endocytic trafficking of CFTR in polarized epithelial cellsJennifer M Bomberger
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
Methods Mol Biol 741:271-83. 2011..This chapter examines current methods employed to measure the cell surface expression of CFTR, as well as methods to monitor CFTR movement through the endocytic pathway...
The deubiquitinating enzyme USP10 regulates the endocytic recycling of CFTR in airway epithelial cellsJennifer M Bomberger
Department of Physiology, Dartmouth Medical School, Hanover, NH, USA
Channels (Austin) 4:150-4. 2010..These studies demonstrate a novel function for USP10 in facilitating the deubiquitination of CFTR in early endosomes, thereby enhancing the endocytic recycling and cell surface expression of CFTR...- A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic systemJennifer M Bomberger
Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, United States of America
PLoS Pathog 7:e1001325. 2011.... - Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1Jennifer M Bomberger
Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 280:23926-35. 2005..These results, using both endogenous and overexpressed cellular models, indicate a novel function for NHERF-1 and RAMP3 in the internalization of the AM receptor and suggest additional regulatory mechanisms for receptor trafficking... - The DeltaF508-CFTR mutation results in increased biofilm formation by Pseudomonas aeruginosa by increasing iron availabilitySophie Moreau-Marquis
Department of Physiology, Dartmouth Medical School, Hanover, NH 03755, USA
Am J Physiol Lung Cell Mol Physiol 295:L25-37. 2008..aeruginosa biofilms with a dramatically increased antibiotic resistance. The DeltaF508-CFTR mutation enhances biofilm formation, in part, by increasing Fe release into the apical medium... - Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells?Thomas H Hampton
Dept of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
Am J Physiol Lung Cell Mol Physiol 303:L509-18. 2012..Thus studies on human airway epithelial cell lines and primary cells in vitro that propose to examine the effect of mutations in CFTR on the inflammatory response to P. aeruginosa have uncertain clinical significance with regard to CF... - The Pseudomonas aeruginosa secreted protein PA2934 decreases apical membrane expression of the cystic fibrosis transmembrane conductance regulatorDaniel P Maceachran
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
Infect Immun 75:3902-12. 2007..We propose a model in which the Cif-mediated decrease in apical membrane expression of CFTR by environmental isolates of P. aeruginosa facilitates the colonization of the CF lung by this microbe... - Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factorChristopher D Bahl
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
J Bacteriol 192:1785-95. 2010..A reassessment of the structural and functional consequences of the H269A mutation suggests that Cif's effect on host-cell CFTR expression requires the hydrolysis of an extended endogenous epoxide substrate... - Regulation of GPCR trafficking by RAMPsJennifer M Bomberger
Department of Physiology, Michigan State University, East Lansing, MI, USA
Adv Exp Med Biol 744:25-37. 2012..In this chapter, we will review the current literature on mechanisms of regulating receptor trafficking and roles that have been demonstrated for RAMPs in this regulation... - Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARĪ± and inhibits the growth of acute promyelocytic leukemiaYongli Guo
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
Cancer Res 70:9875-85. 2010..In contrast, elevation of UBP43 expression stabilized PML/RARĪ± protein and inhibited apoptosis. Taken together, our findings define the ubiquitin protease UBP43 as a novel candidate drug target for APL treatment... - Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor traffickingJennifer M Bomberger
Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 280:9297-307. 2005..These results indicate a novel function for RAMP3 in the post-endocytic sorting of the AM-R and suggest a broader regulatory role for RAMPs in receptor trafficking...