Paul J Beisswenger

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes
    Paul J Beisswenger
    Department of Medicine, Endocrine Metabolism Division, Dartmouth Medical School, Hanover, NH 03755, USA
    Biochim Biophys Acta 1637:98-106. 2003
  2. ncbi request reprint Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress
    Paul J Beisswenger
    Department of Medicine, Diabetes, Endocrinology and Metabolism, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Diabetes 54:3274-81. 2005
  3. doi request reprint Detection of diabetic nephropathy from advanced glycation endproducts (AGEs) differs in plasma and urine, and is dependent on the method of preparation
    Paul J Beisswenger
    Section of Diabetes, Endocrinology, and Metabolism, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03756, USA
    Amino Acids 46:311-9. 2014
  4. pmc Early progression of diabetic nephropathy correlates with methylglyoxal-derived advanced glycation end products
    Paul J Beisswenger
    Corresponding author Paul J Beisswenger
    Diabetes Care 36:3234-9. 2013
  5. doi request reprint Two fluorescent wavelengths, 440(ex)/520(em) nm and 370(ex)/440(em) nm, reflect advanced glycation and oxidation end products in human skin without diabetes
    Paul J Beisswenger
    Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Diabetes Technol Ther 14:285-92. 2012
  6. doi request reprint Glycation and biomarkers of vascular complications of diabetes
    Paul J Beisswenger
    Dartmouth Medical School, 311 Remsen Building, Hanover, NH 03755, USA
    Amino Acids 42:1171-83. 2012
  7. ncbi request reprint Ketosis leads to increased methylglyoxal production on the Atkins diet
    Benjamin G K Beisswenger
    Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Ann N Y Acad Sci 1043:201-10. 2005
  8. ncbi request reprint Transglycation--a potential new mechanism for deglycation of Schiff's bases
    Benjamin S Szwergold
    Dartmouth Medical School, Remsen 311 314, HB 7515, Hanover, NH 03755, USA
    Ann N Y Acad Sci 1043:845-64. 2005
  9. ncbi request reprint Methylglyoxal can modify GAPDH activity and structure
    Hyon Jae Lee
    Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Ann N Y Acad Sci 1043:135-45. 2005
  10. ncbi request reprint Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein
    James R Conner
    Dartmouth Medical School, Remsen 311 314, HB 7515, Hanover, NH 03755, USA
    Ann N Y Acad Sci 1043:824-36. 2005

Research Grants

  1. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2002
  2. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2003
  3. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2004
  4. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2005
  5. Glycation and mu dicarbonyls in diabetic complications
    Paul Beisswenger; Fiscal Year: 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes
    Paul J Beisswenger
    Department of Medicine, Endocrine Metabolism Division, Dartmouth Medical School, Hanover, NH 03755, USA
    Biochim Biophys Acta 1637:98-106. 2003
    ..We postulate that modification of GAPDH by environmental factors or genetic dysregulation and the resultant differences in MG production could at least partially account for this observation...
  2. ncbi request reprint Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress
    Paul J Beisswenger
    Department of Medicine, Diabetes, Endocrinology and Metabolism, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Diabetes 54:3274-81. 2005
    ....
  3. doi request reprint Detection of diabetic nephropathy from advanced glycation endproducts (AGEs) differs in plasma and urine, and is dependent on the method of preparation
    Paul J Beisswenger
    Section of Diabetes, Endocrinology, and Metabolism, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH, 03756, USA
    Amino Acids 46:311-9. 2014
    ..In plasma filtrates, HbA1c at year 5 accounted for 4.7 % of the variation in GBM width. The proportion of variation in GBM width was increased to 11.6 % when MGHI, CEL, and CML were added to the model (6.9 % increase)...
  4. pmc Early progression of diabetic nephropathy correlates with methylglyoxal-derived advanced glycation end products
    Paul J Beisswenger
    Corresponding author Paul J Beisswenger
    Diabetes Care 36:3234-9. 2013
    ..We investigated the relationship between AGEs, OPs, and progression of DN in 103 subjects with type 1 diabetes participating in the Natural History of Diabetic Nephropathy Study...
  5. doi request reprint Two fluorescent wavelengths, 440(ex)/520(em) nm and 370(ex)/440(em) nm, reflect advanced glycation and oxidation end products in human skin without diabetes
    Paul J Beisswenger
    Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Diabetes Technol Ther 14:285-92. 2012
    ..We have compared specific SAF measurements with analytically determined AGEs and oxidative biomarkers in skin collagen and determined if these measurements can be correlated with chronological aging and actinic exposure...
  6. doi request reprint Glycation and biomarkers of vascular complications of diabetes
    Paul J Beisswenger
    Dartmouth Medical School, 311 Remsen Building, Hanover, NH 03755, USA
    Amino Acids 42:1171-83. 2012
    ..The ultimate goal is to predict those requiring aggressive therapies during the earliest stages, when prevention or reversal of complications is still possible...
  7. ncbi request reprint Ketosis leads to increased methylglyoxal production on the Atkins diet
    Benjamin G K Beisswenger
    Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Ann N Y Acad Sci 1043:201-10. 2005
    ..The increase in methylglyoxal implies that potential tissue and vascular damage can occur on the Atkins diet and should be considered when choosing a weight-loss program...
  8. ncbi request reprint Transglycation--a potential new mechanism for deglycation of Schiff's bases
    Benjamin S Szwergold
    Dartmouth Medical School, Remsen 311 314, HB 7515, Hanover, NH 03755, USA
    Ann N Y Acad Sci 1043:845-64. 2005
    ..In support of this latter contention, we show that at least one transglycation product, glucose-cysteine, is found in human urine and that its concentrations are increased in diabetes...
  9. ncbi request reprint Methylglyoxal can modify GAPDH activity and structure
    Hyon Jae Lee
    Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Ann N Y Acad Sci 1043:135-45. 2005
    ..These modifications can lead to decreased enzyme activity, suggesting that conditions associated with elevated intracellular MG could modify GAPDH activity in vivo...
  10. ncbi request reprint Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein
    James R Conner
    Dartmouth Medical School, Remsen 311 314, HB 7515, Hanover, NH 03755, USA
    Ann N Y Acad Sci 1043:824-36. 2005
    ..These data suggest that FN3K and FN3KRP are constitutive "housekeeping" genes and that they play an important role in cell metabolism, possibly as deglycating enzymes...
  11. ncbi request reprint The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals
    James R Conner
    Department of Medicine, Dartmouth Medical School, Hanover, NH, USA
    Biochem Biophys Res Commun 323:932-6. 2004
    ..These data suggest that FN3K and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state...
  12. ncbi request reprint Glycated and oxidized protein degradation products are indicators of fasting and postprandial hyperglycemia in diabetes
    Naila Ahmed
    Department of Biological Sciences, University of Essex, Colchester, UK
    Diabetes Care 28:2465-71. 2005
    ....
  13. ncbi request reprint Mealtime 50/50 basal + prandial insulin analogue mixture with a basal insulin analogue, both plus metformin, in the achievement of target HbA1c and pre- and postprandial blood glucose levels in patients with type 2 diabetes: a multinational, 24-week, rand
    David C Robbins
    Diabetes and Endocrine Platform Team, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Clin Ther 29:2349-64. 2007
    ..Using lispro mix (LM) 50/50 before meals may be a logical approach to achieving glycemic targets (glycosylated hemoglobin [HbA(lc)] and pre- and postprandial blood glucose [BG] concentrations) in these patients...

Research Grants5

  1. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2002
    ..Increased understanding of the role played by enzymatic mechanisms that determine levels of dicarbonyls and Amadori products and their resulting AGEs is essential if we are to find effective strategies to prevent diabetic nephropathy. ..
  2. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2003
    ..Increased understanding of the role played by enzymatic mechanisms that determine levels of dicarbonyls and Amadori products and their resulting AGEs is essential if we are to find effective strategies to prevent diabetic nephropathy. ..
  3. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2004
    ..Increased understanding of the role played by enzymatic mechanisms that determine levels of dicarbonyls and Amadori products and their resulting AGEs is essential if we are to find effective strategies to prevent diabetic nephropathy. ..
  4. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2005
    ..Increased understanding of the role played by enzymatic mechanisms that determine levels of dicarbonyls and Amadori products and their resulting AGEs is essential if we are to find effective strategies to prevent diabetic nephropathy. ..
  5. Glycation and mu dicarbonyls in diabetic complications
    Paul Beisswenger; Fiscal Year: 2006
    ..These exciting research projects, and new ones on the horizon, combined with the proposed mentoring/training program offers real opportunities of attracting and rewarding a new generation of clinical investigators. ..