Research Topics
Genomes and GenesSpecies | Paul J BeisswengerSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetesPaul J Beisswenger
Department of Medicine, Endocrine Metabolism Division, Dartmouth Medical School, Hanover, NH 03755, USA
Biochim Biophys Acta 1637:98-106. 2003..We postulate that modification of GAPDH by environmental factors or genetic dysregulation and the resultant differences in MG production could at least partially account for this observation...- Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stressPaul J Beisswenger
Department of Medicine, Diabetes, Endocrinology and Metabolism, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Diabetes 54:3274-81. 2005.... 
Two fluorescent wavelengths, 440(ex)/520(em) nm and 370(ex)/440(em) nm, reflect advanced glycation and oxidation end products in human skin without diabetesPaul J Beisswenger
Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Diabetes Technol Ther 14:285-92. 2012..We have compared specific SAF measurements with analytically determined AGEs and oxidative biomarkers in skin collagen and determined if these measurements can be correlated with chronological aging and actinic exposure...- Glycation and biomarkers of vascular complications of diabetesPaul J Beisswenger
Dartmouth Medical School, 311 Remsen Building, Hanover, NH 03755, USA
Amino Acids 42:1171-83. 2012..The ultimate goal is to predict those requiring aggressive therapies during the earliest stages, when prevention or reversal of complications is still possible... - Ketosis leads to increased methylglyoxal production on the Atkins dietBenjamin G K Beisswenger
Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
Ann N Y Acad Sci 1043:201-10. 2005..The increase in methylglyoxal implies that potential tissue and vascular damage can occur on the Atkins diet and should be considered when choosing a weight-loss program... - Transglycation--a potential new mechanism for deglycation of Schiff's basesBenjamin S Szwergold
Dartmouth Medical School, Remsen 311 314, HB 7515, Hanover, NH 03755, USA
Ann N Y Acad Sci 1043:845-64. 2005..In support of this latter contention, we show that at least one transglycation product, glucose-cysteine, is found in human urine and that its concentrations are increased in diabetes... - Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related proteinJames R Conner
Dartmouth Medical School, Remsen 311 314, HB 7515, Hanover, NH 03755, USA
Ann N Y Acad Sci 1043:824-36. 2005..These data suggest that FN3K and FN3KRP are constitutive "housekeeping" genes and that they play an important role in cell metabolism, possibly as deglycating enzymes... - Methylglyoxal can modify GAPDH activity and structureHyon Jae Lee
Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
Ann N Y Acad Sci 1043:135-45. 2005..These modifications can lead to decreased enzyme activity, suggesting that conditions associated with elevated intracellular MG could modify GAPDH activity in vivo... - The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signalsJames R Conner
Department of Medicine, Dartmouth Medical School, Hanover, NH, USA
Biochem Biophys Res Commun 323:932-6. 2004..These data suggest that FN3K and FN3KRP act as protein repair enzymes and are expressed constitutively in human cells independently of some of the variables altered in the diabetic state... - Glycated and oxidized protein degradation products are indicators of fasting and postprandial hyperglycemia in diabetesNaila Ahmed
Department of Biological Sciences, University of Essex, Colchester, UK
Diabetes Care 28:2465-71. 2005.... - Mealtime 50/50 basal + prandial insulin analogue mixture with a basal insulin analogue, both plus metformin, in the achievement of target HbA1c and pre- and postprandial blood glucose levels in patients with type 2 diabetes: a multinational, 24-week, randDavid C Robbins
Diabetes and Endocrine Platform Team, Eli Lilly and Company, Indianapolis, IN 46285, USA
Clin Ther 29:2349-64. 2007..Using lispro mix (LM) 50/50 before meals may be a logical approach to achieving glycemic targets (glycosylated hemoglobin [HbA(lc)] and pre- and postprandial blood glucose [BG] concentrations) in these patients...
Research Grants
- ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATIONPaul Beisswenger; Fiscal Year: 2005..Increased understanding of the role played by enzymatic mechanisms that determine levels of dicarbonyls and Amadori products and their resulting AGEs is essential if we are to find effective strategies to prevent diabetic nephropathy. ..
- Glycation and mu dicarbonyls in diabetic complicationsPaul Beisswenger; Fiscal Year: 2006..These exciting research projects, and new ones on the horizon, combined with the proposed mentoring/training program offers real opportunities of attracting and rewarding a new generation of clinical investigators. ..