JOHN ANTHONY BARON

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Risk factors for revision of primary total hip arthroplasty: a systematic review
    Julian Jz Prokopetz
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Musculoskelet Disord 13:251. 2012
  2. pmc Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs
    Boris Pasche
    Division of Hematology Oncology, The University of Alabama at Birmingham and UAB Comprehensive Cancer Center, Birmingham, AL 35203, USA
    J Exp Clin Cancer Res 29:57. 2010
  3. pmc Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study
    Deirdre P Cronin-Fenton
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, Aarhus N, Denmark
    Breast Cancer Res 12:R15. 2010
  4. pmc Oestrogen receptor alpha gene haplotype and postmenopausal breast cancer risk: a case control study
    Sara Wedren
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 6:R437-49. 2004
  5. pmc Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study
    Sara Wedren
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    BMC Cancer 8:322. 2008
  6. ncbi request reprint A randomized trial of aspirin to prevent colorectal adenomas
    John A Baron
    Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    N Engl J Med 348:891-9. 2003
  7. ncbi request reprint A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas
    John A Baron
    Department of Medicine, The Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, USA
    Gastroenterology 131:1674-82. 2006
  8. pmc Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa
    Kristin Wallace
    Department of Medicine, Dartmouth Medical School, Evergreen Center, Lebanon, NH 03756, USA
    Cancer Prev Res (Phila) 3:1552-64. 2010
  9. ncbi request reprint Aspirin and NSAIDs for the prevention of colorectal cancer
    John A Baron
    Evergreen Center, Biostatistics and Epidemiology, Lebanon, NH 03756, USA
    Recent Results Cancer Res 181:223-9. 2009
  10. doi request reprint Statins and the colorectum: hope for chemoprevention?
    John A Baron
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Prev Res (Phila) 3:573-5. 2010

Research Grants

Detail Information

Publications76

  1. pmc Risk factors for revision of primary total hip arthroplasty: a systematic review
    Julian Jz Prokopetz
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Musculoskelet Disord 13:251. 2012
    ....
  2. pmc Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs
    Boris Pasche
    Division of Hematology Oncology, The University of Alabama at Birmingham and UAB Comprehensive Cancer Center, Birmingham, AL 35203, USA
    J Exp Clin Cancer Res 29:57. 2010
    ..This phenotype was first observed in mice, then in lymphoblastoid cell lines from patients with microsatellite stable colorectal tumors...
  3. pmc Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study
    Deirdre P Cronin-Fenton
    Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Alle 43 45, Aarhus N, Denmark
    Breast Cancer Res 12:R15. 2010
    ....
  4. pmc Oestrogen receptor alpha gene haplotype and postmenopausal breast cancer risk: a case control study
    Sara Wedren
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 6:R437-49. 2004
    ..Because breast cancer development is dependent on oestrogenic influence, we have investigated whether polymorphisms in the oestrogen receptor alpha gene (ESR1) are associated with breast cancer risk...
  5. pmc Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study
    Sara Wedren
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    BMC Cancer 8:322. 2008
    ..One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen receptor alpha gene (ESR1) is associated with endometrial cancer risk...
  6. ncbi request reprint A randomized trial of aspirin to prevent colorectal adenomas
    John A Baron
    Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    N Engl J Med 348:891-9. 2003
    ..Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel...
  7. ncbi request reprint A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas
    John A Baron
    Department of Medicine, The Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, USA
    Gastroenterology 131:1674-82. 2006
    ..We conducted a randomized, placebo-controlled, double-blind trial to assess whether use of the selective COX-2 inhibitor rofecoxib would reduce the risk of colorectal adenomas...
  8. pmc Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa
    Kristin Wallace
    Department of Medicine, Dartmouth Medical School, Evergreen Center, Lebanon, NH 03756, USA
    Cancer Prev Res (Phila) 3:1552-64. 2010
    ..These data have important implications regarding the safety of supplementary folate administration in healthy adults, given the hypothesis that methylation in normal mucosa may predispose to colorectal neoplasia...
  9. ncbi request reprint Aspirin and NSAIDs for the prevention of colorectal cancer
    John A Baron
    Evergreen Center, Biostatistics and Epidemiology, Lebanon, NH 03756, USA
    Recent Results Cancer Res 181:223-9. 2009
    ..Together these data provide convincing evidence for the chemopreventive efficacy ofNSAIDs in the large bowel...
  10. doi request reprint Statins and the colorectum: hope for chemoprevention?
    John A Baron
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Prev Res (Phila) 3:573-5. 2010
    ..The perspective discusses the implications of these data and how they fit into the context of previous investigations...
  11. ncbi request reprint Epidemiology of non-steroidal anti-inflammatory drugs and cancer
    John A Baron
    Departments of Medicine, and Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, N H, USA
    Prog Exp Tumor Res 37:1-24. 2003
    ..Nonetheless, with the increased understanding of the clinical effects of NSAIDs on cancer, the development of effective chemoprevention with these drugs appears to be a real possibility...
  12. ncbi request reprint Neoplastic and antineoplastic effects of beta-carotene on colorectal adenoma recurrence: results of a randomized trial
    John A Baron
    Department of Medicine, Dartmouth Medical School, Evergreen Center, Lebanon, NH 03766, USA
    J Natl Cancer Inst 95:717-22. 2003
    ..Although beta-carotene supplementation appeared not to increase the risk of cancer generally, it is not clear if smoking and/or alcohol use alters the effect of beta-carotene on carcinogenesis at sites outside the lung...
  13. ncbi request reprint Nonsteroidal anti-inflammatory drugs and cancer prevention
    J A Baron
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Annu Rev Med 51:511-23. 2000
    ..The mechanisms underlying any chemopreventive effect of NSAIDs are not clear. Inhibition of cyclooxygenase is one possibility, but pathways independent of cyclooxygenase and prostaglandins are also possible...
  14. ncbi request reprint Prolonged effect of calcium supplementation on risk of colorectal adenomas in a randomized trial
    Maria V Grau
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
    J Natl Cancer Inst 99:129-36. 2007
    ..Calcium supplementation has been shown to decrease the risk of recurrence of colorectal adenomas in randomized trials. However, the duration of this protective effect after cessation of active supplementation is not known...
  15. pmc The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum
    Kristin Wallace
    Department of Community and Family Medicine, Dartmouth Medical School, Hanover, New Hamsphire, USA
    Cancer Epidemiol Biomarkers Prev 18:2310-7. 2009
    ..Our results suggest that several common lifestyle and dietary variables are associated with risk for serrated polyps, and some of these may differ for the right and left colorectum...
  16. ncbi request reprint A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer
    Robert S Sandler
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7555, USA
    N Engl J Med 348:883-90. 2003
    ..Experimental studies in animals and observational studies in humans suggest that regular aspirin use may decrease the risk of colorectal adenomas, the precursors to most colorectal cancers...
  17. ncbi request reprint Effect of calcium supplementation on the risk of large bowel polyps
    Kristin Wallace
    Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Natl Cancer Inst 96:921-5. 2004
    ..However, few studies have examined the effect of calcium on the risk of different types of colorectal lesions or dietary determinants of this effect...
  18. ncbi request reprint Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study
    Kristin Wallace
    Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Cancer Epidemiol Biomarkers Prev 12:464-7. 2003
    ..50 for total selenium and P for trend = 0.20 for bound selenium). Thus, our findings do not indicate a clear association between serum selenium concentrations and adenoma recurrence...
  19. ncbi request reprint Risk of prostate cancer in a randomized clinical trial of calcium supplementation
    John A Baron
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Epidemiol Biomarkers Prev 14:586-9. 2005
    ..In some studies, high calcium intake has been associated with an increased risk of prostate cancer, but no randomized studies have investigated this issue...
  20. ncbi request reprint Fat, fiber, meat and the risk of colorectal adenomas
    Douglas J Robertson
    Veterans Hospital, White River Junction, Vermont, and Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    Am J Gastroenterol 100:2789-95. 2005
    ..The aim of this study was to determine the relationship between fat, fiber, and meat intake, and risk of colorectal adenoma recurrence...
  21. ncbi request reprint Acute effects of nicotine on serum glucose insulin growth hormone and cortisol in healthy smokers
    Thomas M Morgan
    Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Hannover, NH, USA
    Metabolism 53:578-82. 2004
    ..Further research is needed to determine the clinical implications of the unexpected finding that nicotine decreased growth hormone levels in female smokers...
  22. doi request reprint Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial
    John A Baron
    Departments of Medicine, and of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
    Lancet 372:1756-64. 2008
    ..We report the cardiovascular outcomes of a long-term follow-up of participants in the trial...
  23. doi request reprint Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial
    Leo R Zacharski
    Research Service 151, White River Junction VA Medical Center, Department of Veterans Affairs Medical Center, 215 North Hartland Road, White River Junction, VT 05009, USA
    J Natl Cancer Inst 100:996-1002. 2008
    ..Excess iron has been implicated in cancer risk through increased iron-catalyzed free radical-mediated oxidative stress...
  24. ncbi request reprint K-ras mutations in incident sporadic colorectal adenomas
    Elizabeth L R Barry
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03766, USA
    Cancer 106:1036-40. 2006
    ..In the current study, the authors investigated associations with K-ras mutation in incident sporadic colorectal adenomas that occurred during a chemoprevention trial of calcium supplementation...
  25. ncbi request reprint Early life factors in relation to breast cancer risk in postmenopausal women
    Linda Titus-Ernstoff
    Norris Cotton Cancer Center and the Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer Epidemiol Biomarkers Prev 11:207-10. 2002
    ..Overall, our results are consistent with previous studies and suggest that these early life factors have a modest influence on breast cancer risk in postmenopausal women...
  26. ncbi request reprint Chemoprevention in gastrointestinal cancers: current status
    Maria V Grau
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03766, USA
    Basic Clin Pharmacol Toxicol 98:281-7. 2006
    ..TJ-9, polyprenoic acid and anti-aflatoxin compounds are also possible avenues that deserve future research...
  27. ncbi request reprint Bilateral total knee replacement: staging and pulmonary embolism
    Jane Barrett
    Department of Medicine, Dartmouth Medical School, 46 Centerra Parkway, Evergreen Building, Suite 300, Lebanon, NH 03766, USA
    J Bone Joint Surg Am 88:2146-51. 2006
    ..A greater risk of pulmonary embolism after simultaneous total knee replacement has been reported by some authors, but little national data are available...
  28. ncbi request reprint Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention
    Elizabeth L R Barry
    Department of Community and Family Medicine, Dartmouth Medical School, 46 Centerra Parkway, Ste 300, Lebanon, NH 03766, USA
    J Natl Cancer Inst 98:1494-500. 2006
    ..Previous research suggests that the G315A single-nucleotide polymorphism in the ornithine decarboxylase (ODC) gene may be a genetic marker for risk of colorectal neoplasia and may also modify the association of aspirin use with risk...
  29. ncbi request reprint Effect of NSAIDs on the recurrence of nonmelanoma skin cancer
    Maria V Grau
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03766, USA
    Int J Cancer 119:682-6. 2006
    ..There were some indications of a modest, nonsignificant reduction on the number of BCCs and SCCs with NSAID use. Our data suggest a weak and inconsistent chemopreventive effect of NSAIDs on BCC and SCC...
  30. ncbi request reprint Folic acid for the prevention of colorectal adenomas: a randomized clinical trial
    Bernard F Cole
    Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
    JAMA 297:2351-9. 2007
    ..Laboratory and epidemiological data suggest that folic acid may have an antineoplastic effect in the large intestine...
  31. ncbi request reprint Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial
    Todd MacKenzie
    Department of Medicine, Dartmouth Medical School, Hanover, NH 03755, USA
    Metabolism 56:1694-8. 2007
    ..This study provides evidence that daily caffeine intake reduces insulin sensitivity; the effect persists for at least a week and is evident up to 12 hours after administration...
  32. pmc Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial
    Elizabeth L Barry
    Department of Community and Family Medicine, Dartmouth Medical School, Suite 300, Evergreen Center, 46 Centerra Parkway, Lebanon, NH 03756, USA
    Cancer Epidemiol Biomarkers Prev 18:2726-33. 2009
    ..These results support the hypothesis that COX-2 plays a role in the etiology of colon cancer and may be a target for aspirin chemoprevention and warrant further investigation in other colorectal adenoma and cancer populations...
  33. ncbi request reprint Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial
    Leo R Zacharski
    White River Junction VA Medical Center, Research Service, Department of Veterans Affairs Medical Center, White River Junction, VT 05001, USA
    JAMA 297:603-10. 2007
    ..Accumulation of iron in excess of physiologic requirements has been implicated in risk of cardiovascular disease because of increased iron-catalyzed free radical-mediated oxidative stress...
  34. pmc Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal adenoma risk: observational follow-up of a randomized study
    Maria V Grau
    Departments of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA
    J Natl Cancer Inst 101:267-76. 2009
    ..We examined the persistence of the protective effect after the cessation of randomized aspirin treatment and whether it is affected by the duration and frequency of subsequent NSAID use...
  35. ncbi request reprint Mortality and pulmonary embolism after fracture in the elderly
    Jane A Barrett
    Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH 03755, USA
    Osteoporos Int 14:889-94. 2003
    ..6 to 1.8, and for patients with proximal humerus fractures the risk ratio was 1.4. All lower-limb fractures carried a higher risk of PE than any upper-limb fracture...
  36. ncbi request reprint Interaction of calcium supplementation and nonsteroidal anti-inflammatory drugs and the risk of colorectal adenomas
    Maria V Grau
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hamsphire, USA
    Cancer Epidemiol Biomarkers Prev 14:2353-8. 2005
    ..Calcium and aspirin have both been found to be chemopreventive against colorectal neoplasia. However, the joint effect of the two agents has not been well investigated...
  37. ncbi request reprint Survival following total hip replacement
    Jane Barrett
    Department of Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Evergreen Building, Suite 300, 46 Centerra Parkway, Lebanon, NH 03766, USA
    J Bone Joint Surg Am 87:1965-71. 2005
    ..The purpose of our investigation was to assess whether the association had the characteristics of a causal relationship or whether it might appear to be due to comorbidity or other factors...
  38. ncbi request reprint Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial
    Maria V Grau
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
    J Natl Cancer Inst 95:1765-71. 2003
    ..Although these nutrients are inter-related metabolically in bone and in the normal intestine, their potential interactions in large-bowel carcinogenesis are not well understood...
  39. ncbi request reprint TGFBR1*6A may contribute to hereditary colorectal cancer
    Yansong Bian
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 880, Chicago, IL 60611, USA
    J Clin Oncol 23:3074-8. 2005
    ..To test this hypothesis, we determined whether TGFBR16A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients...
  40. ncbi request reprint The association of physical activity and body mass index with the risk of large bowel polyps
    Kristin Wallace
    Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Cancer Epidemiol Biomarkers Prev 14:2082-6. 2005
    ..After the second study colonoscopy, we asked subjects questions about their leisure time physical activity. Seven hundred eighty-seven subjects completed at least part of the physical activity questionnaire...
  41. ncbi request reprint Quality of colonoscopy reporting: a process of care study
    Douglas J Robertson
    Dartmouth Medical School, Section of Biostatistics and Epidemiology, Lebanon, New Hampshire, USA
    Am J Gastroenterol 97:2651-6. 2002
    ..The aim of this study was to assess the quality of colonoscopy reporting and to identify possible areas of improvement...
  42. ncbi request reprint Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, NOR4411A, Los Angeles, CA 90089 9175, USA
    Cancer Res 67:11128-32. 2007
    ..These data suggest that common variants may play important roles in the risk of CRC...
  43. ncbi request reprint Skin cancers and non-hodgkin lymphoma among users of systemic glucocorticoids: a population-based cohort study
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    J Natl Cancer Inst 96:709-11. 2004
    ..68, 95% CI = 1.16 to 5.29). Our data suggest that use of glucocorticoids may be a shared risk factor for certain skin cancers and lymphomas...
  44. pmc Effect of calcium supplementation on fracture risk: a double-blind randomized controlled trial
    Heike A Bischoff-Ferrari
    Department of Rheumatology and Institute of Physical Medicine, University Hospital Zurich, Zurich, Switzerland
    Am J Clin Nutr 87:1945-51. 2008
    ..The effect of supplementation with calcium alone on risk fractures in a healthy population is not clear...
  45. pmc Prediagnostic use of hormone therapy and mortality after breast cancer
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:864-71. 2008
    ..Due to the high prevalence of past and current hormone use, it is important to investigate whether these preparations are related to breast cancer mortality...
  46. ncbi request reprint Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
    Robert S Bresalier
    Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston 77030 4009, USA
    N Engl J Med 352:1092-102. 2005
    ....
  47. ncbi request reprint Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials
    Heike A Bischoff-Ferrari
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 86:1780-90. 2007
    ..The role of total calcium intake in the prevention of hip fracture risk has not been well established...
  48. pmc MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial
    A Joan Levine
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2409-15. 2008
    ..Our findings indicate that the MTHFR genotype does not change adenoma risk in a manner similar to its effect on colorectal cancer, and does not modify the effect of folate supplementation on metachronous adenoma risk...
  49. pmc Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk
    Virginia G Kaklamani
    Cancer Genetics Program, Division of Hematology and Oncology, Department of Medicine and Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    JAMA 300:1523-31. 2008
    ..While there is evidence of an association between circulating adiponectin levels and colorectal cancer risk, no association between genes of the adiponectin pathway and colorectal cancer have been reported to date...
  50. ncbi request reprint What now for aspirin and cancer prevention?
    John A Baron
    J Natl Cancer Inst 96:4-5. 2004
  51. doi request reprint Physical activity and survival after diagnosis of invasive breast cancer
    Crystal N Holick
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 17:379-86. 2008
    ..This study provides support for reduced overall mortality and mortality from breast cancer among women who engage in physical activity after breast cancer diagnosis...
  52. ncbi request reprint Dietary calcium and vitamin D intake and risk of colorectal cancer: a prospective cohort study in women
    Paul Terry
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Nutr Cancer 43:39-46. 2002
    ..Vitamin D intake was not clearly associated with risk. In sum, our data suggest that high calcium intake may lower colorectal cancer risk...
  53. ncbi request reprint Early failures of total hip replacement: effect of surgeon volume
    Elena Losina
    Department of Biostatistics, Boston University School of Public Health and Robert B Brigham Arthritis and Musculoskeletal Clinical Research Center, Boston, Massachusetts 02118, USA
    Arthritis Rheum 50:1338-43. 2004
    ..To determine whether provider volume is associated with early failures following total hip replacement (THR) requiring revision...
  54. ncbi request reprint Postmenopausal estrogen and progestin use in relation to breast cancer risk
    Polly A Newcomb
    University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53706, USA
    Cancer Epidemiol Biomarkers Prev 11:593-600. 2002
    ..09; 95% CI, 1.07-4.07 for ever use versus nonuse). Estrogen-progestin use, both sequential and continuous, appears to be more strongly associated with risk of breast cancer than use of estrogen alone...
  55. ncbi request reprint Postmenopausal hormone therapy and risk of breast cancer by histologic type (United States)
    Laura M Newcomer
    Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 14:225-33. 2003
    ..Postmenopausal hormone use and risk of breast cancer by histopathology was examined in a large multi-centered population-based case-control study...
  56. ncbi request reprint Early life risk factors in cancer: the relation of birth weight to adult obesity
    Nicole M Leong
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 103:789-91. 2003
    ..76). These data suggest that both low and high birth weights are associated with higher adult BMI and support the hypothesis that fetal experience may influence adult obesity with potential consequences for risk of several major cancers...
  57. ncbi request reprint Fever of unknown origin and cancer: a population-based study
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Lancet Oncol 6:851-5. 2005
    ..We aimed to assess the risk of cancer and survival after hospital admission for fever of unknown origin in a nationwide Danish follow-up study...
  58. ncbi request reprint Survival after hip fracture
    Bahman Y Farahmand
    Institute of Environmental Medicine, Karolinska Institute, Box 210, 17177, Stockholm, Sweden
    Osteoporos Int 16:1583-90. 2005
    ..Hip fracture patients have a substantially increased risk of death that persists for at least 6 years post-fracture. The relative excess mortality is independent of comorbidity and known hip fracture risk factors...
  59. ncbi request reprint Rates and outcomes of primary and revision total hip replacement in the United States medicare population
    Nizar N Mahomed
    Toronto Western Hospital, ON, Canada
    J Bone Joint Surg Am 85:27-32. 2003
    ..The objective of this study was to characterize the rates and immediate postoperative outcomes of primary and revision total hip replacement in persons sixty-five years of age and older residing in the United States...
  60. ncbi request reprint Epidemiology of total knee replacement in the United States Medicare population
    Nizar N Mahomed
    Musculoskeletal Health and Arthritis Program, Toronto Western Hospital, University Health Network, 399 Bathurst Street, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Bone Joint Surg Am 87:1222-8. 2005
    ..The aim of the present study was to describe the rates of primary and revision total knee replacement and selected outcomes in persons older than sixty-five years of age in the United States...
  61. ncbi request reprint Colorectal cancer in patients under close colonoscopic surveillance
    Douglas J Robertson
    Section of Gastroenterology, VA Medical Center, White River Junction, Vermont 05009, USA
    Gastroenterology 129:34-41. 2005
    ..We determined the incidence of CRC in patients under colonoscopic surveillance and examined the circumstances and risk factors for CRC and adenoma with high-grade dysplasia...
  62. ncbi request reprint Aspirin may be more effective in preventing colorectal adenomas in patients with higher BMI (United States)
    Sangmi Kim
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Cancer Causes Control 17:1299-304. 2006
    ..The more pronounced effect of 325 mg aspirin in individuals with higher BMI suggests a possible protective role of anti-inflammatory aspirin against increased adipose-driven cytokines among obese subjects...
  63. ncbi request reprint Neighborhoods matter: use of hospitals with worse outcomes following total knee replacement by patients from vulnerable populations
    Elena Losina
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Arch Intern Med 167:182-7. 2007
    ....
  64. ncbi request reprint Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial
    Angel Lanas
    Department of Medicine, University Clinic Hospital, Instituto Aragones de Ciencias de la Salud CIBER HEPAD Zaragoza, Spain
    Gastroenterology 132:490-7. 2007
    ....
  65. ncbi request reprint (Nutritional) chemoprevention of cancer: what's up?
    John A Baron
    J Natl Cancer Inst 98:945-6. 2006
  66. ncbi request reprint Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study
    Douglas J Robertson
    VA Medical Center, White River Junction, VT 05009, USA
    Gastroenterology 133:755-60. 2007
    ....
  67. ncbi request reprint Can aspirin keep mortality at bay?
    John A Baron
    Arch Intern Med 167:535-6. 2007
  68. ncbi request reprint Reported use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors was not associated with reduced recurrence of colorectal adenomas
    Jeffrey T Wei
    Division of Gastroenterology and Hepatology, University of North Carolina, Campus Box 7080, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 14:1026-7. 2005
    ..Lack of statistical power from limited exposure to HMG-CoA reductase inhibitors might be responsible for the lack of association...
  69. ncbi request reprint Cholecystectomy and the risk of recurrent colorectal adenomas
    Lisa C Vinikoor
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7555, USA
    Cancer Epidemiol Biomarkers Prev 16:1523-5. 2007
    ..34; 95% CI, 0.97-1.85) but the 95% CIs included the null in both cases. We conclude that the increased risk for colorectal cancer following cholecystectomy seems to be due to a biological process occurring after the adenoma has developed...
  70. ncbi request reprint Folate and colo-rectal cancer risk
    Peter Sanderson
    Nutrition Division, Food Standards Agency, London WC2 6NH, UK
    Br J Nutr 98:1299-304. 2007
    ..Also, the need to study further the influence of genetically defined subgroups was highlighted for future research...
  71. ncbi request reprint Accuracy of colorectal polyp self-reports: findings from the colon cancer family registry
    Lisa Madlensky
    Moores UCSD Cancer Center, 3855 Health Sciences Drive, MC0901, La Jolla, CA 92093 0901, USA
    Cancer Epidemiol Biomarkers Prev 16:1898-901. 2007
    ..However, it is not known how accurately patients are able to self-report the presence or absence of adenomas following colonoscopy...
  72. ncbi request reprint Re: Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    John L Hopper
    J Natl Cancer Inst 95:1010-1; author reply 1012-3. 2003
  73. ncbi request reprint Postmenopausal hormone replacement therapy and risk of acute pancreatitis: a population-based case-control study
    Mette S Tetsche
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    Am J Gastroenterol 102:275-8. 2007
    ..To examine whether acute pancreatitis is associated with the use of postmenopausal hormonal replacement therapy in Danish women over 45 yr of age...
  74. ncbi request reprint Incidence rates of dislocation, pulmonary embolism, and deep infection during the first six months after elective total hip replacement
    Charlotte B Phillips
    Robert Breck Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Bone Joint Surg Am 85:20-6. 2003
    ..As a result, a greater proportion of complications occurs following discharge. Data on the incidence trends of major complications of total hip replacement would facilitate recognition and management of these adverse events...
  75. ncbi request reprint The age-at-diagnosis fallacy
    John A Baron
    Arch Intern Med 166:1670; author reply 1671. 2006
  76. ncbi request reprint Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort study
    Henrik Toft Sørensen
    Department of Clinical Epidemiology, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Lancet 370:1773-9. 2007
    ..Other studies, however, do not show this association. To help clarify these discrepant findings, we aimed to investigate the risk of arterial cardiovascular events in patients who were diagnosed with venous thromboembolism...

Research Grants33

  1. ASPIRIN/FOLATE PREVENTION OF LARGE BOWEL POLYPS
    John Baron; Fiscal Year: 2007
    ....
  2. Colorectal Chemoprevention with Calcium and Vitamin D
    John Baron; Fiscal Year: 2007
    ..abstract_text> ..
  3. Colorectal Chemoprevention with Calcium and Vitamin D
    John Baron; Fiscal Year: 2009
    ..g. osteoporosis). We now request funds to complete the planned treatment and follow-up for all 2,200 randomized subjects, prepare for the first efficacy analyses, and implement a post-treatment follow-up. ..
  4. Colorectal Chemoprevention with Calcium and Vitamin D
    John Baron; Fiscal Year: 2009
    ..In the study proposed here, we will evaluate the ability of supplemental vitamin D to reduce the risk of developing those infectious disorders. ..
  5. Colorectal Chemoprevention with Calcium and Vitamin D
    JOHN ANTHONY BARON; Fiscal Year: 2010
    ..g. osteoporosis). We now request funds to complete the planned treatment and follow-up for all 2,200 randomized subjects, prepare for the first efficacy analyses, and implement a post-treatment follow-up. ..
  6. ASPIRIN/FOLATE PREVENTION OF LARGE BOWEL POLYPS
    JOHN ANTHONY BARON; Fiscal Year: 2010
    ....
  7. ASPIRIN/FOLATE PREVENTION OF LARGE BOWEL POLYPS
    John Baron; Fiscal Year: 1999
    ..We also propose to measure urinary thromboxane B2, and red blood cell and serum folate near the time of study completion. These will be used as measures of compliance with study agents. ..
  8. ASPIRIN PREVENTION OF LARGE BOWEL POLYPS
    John Baron; Fiscal Year: 1993
    ..The study will also help elucidate the biology of large bowel carcinogenesis by defining the impact of a prostaglandin synthetase inhibitor on the occurrence of neoplastic polyps...