Angeline S Andrew

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Arsenic activates EGFR pathway signaling in the lung
    Angeline S Andrew
    Department of Community and Family Medicine, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
    Toxicol Sci 109:350-7. 2009
  2. pmc Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population
    Angeline S Andrew
    Dartmouth Medical School Section of Biostatistics and Epidemiology, 7927 Rubin 860, One Medical Center Dr, Lebanon, NH 03756, USA
    Environ Health Perspect 116:524-31. 2008
  3. pmc DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Hered 65:105-18. 2008
  4. pmc Bladder cancer SNP panel predicts susceptibility and survival
    Angeline S Andrew
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 125:527-39. 2009
  5. ncbi request reprint Exposure to arsenic at levels found inU.S. drinking water modifies expression in the mouse lung
    Angeline S Andrew
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Toxicol Sci 100:75-87. 2007
  6. pmc DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Toxicol Lett 187:10-4. 2009
  7. pmc Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Environ Health Perspect 114:1193-8. 2006
  8. ncbi request reprint Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Carcinogenesis 27:1030-7. 2006
  9. ncbi request reprint Bladder cancer risk and personal hair dye use
    Angeline S Andrew
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 109:581-6. 2004
  10. ncbi request reprint Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water
    Angeline S Andrew
    Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 104:263-8. 2003

Collaborators

Detail Information

Publications35

  1. pmc Arsenic activates EGFR pathway signaling in the lung
    Angeline S Andrew
    Department of Community and Family Medicine, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
    Toxicol Sci 109:350-7. 2009
    ..Further work is needed to assess the clinical utility of targeting the EGFR pathway in subgroups of lung cancer patients who have been exposed to elevated levels of arsenic...
  2. pmc Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population
    Angeline S Andrew
    Dartmouth Medical School Section of Biostatistics and Epidemiology, 7927 Rubin 860, One Medical Center Dr, Lebanon, NH 03756, USA
    Environ Health Perspect 116:524-31. 2008
    ....
  3. pmc DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Hered 65:105-18. 2008
    ..These include: APE1-Asn148Gln, XRCC1-Arg399Gln and XRCC1-Arg194Trp in the BER pathway, XPD-Gln751Lys in the NER pathway and XRCC3-Thr241Met in the DSB repair pathway...
  4. pmc Bladder cancer SNP panel predicts susceptibility and survival
    Angeline S Andrew
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 125:527-39. 2009
    ..8 95% CI 1.1-3.0). Variants in the detoxification gene EPHX1 experienced longer survival (HR 0.4 (95% CI 0.2-0.8). These genes can now be assessed in multiple study populations to identify and validate SNPs appropriate for clinical use...
  5. ncbi request reprint Exposure to arsenic at levels found inU.S. drinking water modifies expression in the mouse lung
    Angeline S Andrew
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Toxicol Sci 100:75-87. 2007
    ..These data identify arsenic-modified signaling pathways that will help guide investigations into mechanisms of arsenic's health effects and clarify the threshold for biologic effects and potential disease risk...
  6. pmc DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Toxicol Lett 187:10-4. 2009
    ..01). Haplotype analysis confirmed the association of the XRCC3 241. Thus, double-strand break repair genotype may enhance arsenic associated bladder cancer susceptibility in the U.S. population...
  7. pmc Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Environ Health Perspect 114:1193-8. 2006
    ....
  8. ncbi request reprint Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Carcinogenesis 27:1030-7. 2006
    ..These results support the hypothesis that common polymorphisms in DNA repair genes modify bladder cancer risk and emphasize the need for a multifaceted statistical approach to identify gene-gene and gene-environment interactions...
  9. ncbi request reprint Bladder cancer risk and personal hair dye use
    Angeline S Andrew
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 109:581-6. 2004
    ..In light of the prevalence of hair dye use, further studies are needed that address the effects of specific colors and types of hair dyes along with the possible role of individual susceptibility...
  10. ncbi request reprint Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water
    Angeline S Andrew
    Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 104:263-8. 2003
    ..Although our findings need verification in a larger study group, they are consistent with the hypothesis that inhibition of DNA repair capacity is a potential mechanism for the co-carcinogenic activity of arsenic...
  11. pmc Arsenic exposure predicts bladder cancer survival in a US population
    Ryan C Kwong
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, 7927 Rubin 860 One Medical Center Drive, Lebanon, NH 03756, USA
    World J Urol 28:487-92. 2010
    ..While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality...
  12. pmc EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis
    Rebecca A Mason
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Carcinogenesis 30:1155-60. 2009
    ..Understanding these genetic influences on increased bladder cancer susceptibility and survival may help in cancer prevention, drug development and choice of therapeutic regimen...
  13. pmc A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire
    Corina Lesseur
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Toxicol Lett 210:100-6. 2012
    ....
  14. pmc SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 131:453-61. 2012
    ..03). Our findings suggest novel variants that may influence risk of arsenic-associated bladder cancer and those who may be at greatest risk from this widespread exposure...
  15. pmc A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasis
    Jiang Gui
    Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Hered 70:219-25. 2010
    ..The results suggest that our proposed method performs similarly, but is more computationally efficient. We then apply this new method to an analysis of a population-based bladder cancer study in New Hampshire...
  16. pmc Genomic and proteomic profiling of responses to toxic metals in human lung cells
    Angeline S Andrew
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Dartmouth College, 7927 Rubin Building, 452M 3, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Environ Health Perspect 111:825-35. 2003
    ....
  17. pmc A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis
    Jiang Gui
    Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Hum Genet 129:101-10. 2011
    ....
  18. ncbi request reprint Survival following the diagnosis of noninvasive bladder cancer: WHO/International Society of Urological Pathology versus WHO classification systems
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Urol 178:1196-200; discussion 1200. 2007
    ..In a large, nonselected population of patients with bladder cancer we rated all incident tumors using each system and compared long-term patient survival...
  19. doi request reprint Body mass and smoking are modifiable risk factors for recurrent bladder cancer
    Asaf Wyszynski
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire Program in Experimental and Molecular Medicine, Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
    Cancer 120:408-14. 2014
    ..Recurrences frequently occur, and continued surveillance is necessary to identify and treat recurrent tumors. Efforts to identify risk factors that are potentially modifiable to reduce the rate of recurrence are needed...
  20. pmc Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations
    Fabrizio Galimberti
    Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
    Int J Oncol 41:1751-61. 2012
    ..This includes tumors that express genes indicating basal HH pathway activation...
  21. pmc Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Scand J Urol Nephrol 42:237-42. 2008
    ..This study evaluated the classification and stage of bladder cancers as part of a population-based epidemiological study of bladder cancer in the Northeastern United States...
  22. ncbi request reprint Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study
    Margaret R Karagas
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
    Int J Hyg Environ Health 208:321-7. 2005
    ..12 for MTHFR 1298A>C). Thus, our findings do not support the presence of a main gene effect. The possibility that MTHFR polymorphism affects susceptibility to environmental exposures warrants further consideration...
  23. pmc A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reduction
    Kristine A Pattin
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Genet Epidemiol 33:87-94. 2009
    ..We then demonstrate this new method by applying it to a genetic epidemiology study of bladder cancer susceptibility that was previously analyzed using MDR and assessed using a 1,000-fold permutation test...
  24. pmc Selenium and risk of bladder cancer: a population-based case-control study
    Kristin Wallace
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, 7927 Rubin Building, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Cancer Prev Res (Phila) 2:70-3. 2009
    ..g., p53 positive) or within certain subsets of a population (e.g., women or moderate smokers)...
  25. pmc A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility
    Jiang Gui
    Dartmouth Medical School, Lebanon, NH 03756, USA
    Ann Hum Genet 75:20-8. 2011
    ..We show that there is no loss of success rate when this is not the case. We then apply the RMDR method to the detection of gene-gene interactions in genotype data from a population-based study of bladder cancer in New Hampshire...
  26. pmc MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors
    Xi Liu
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Clin Invest 120:1298-309. 2010
    ..Together, these findings revealed that miR-31 acts as an oncogenic miRNA (oncomir) in lung cancer by targeting specific tumor suppressors for repression...
  27. pmc Role of genetic heterogeneity and epistasis in bladder cancer susceptibility and outcome: a learning classifier system approach
    Ryan John Urbanowicz
    Department of Genetics, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire 03756, USA
    J Am Med Inform Assoc 20:603-12. 2013
    ..In particular, strategies that provide multifactor interactions or heterogeneous patterns of association can offer new insights into association studies for which traditional analytic tools have had limited success...
  28. ncbi request reprint Measures of cumulative exposure from a standardized sun exposure history questionnaire: a comparison with histologic assessment of solar skin damage
    Margaret R Karagas
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Epidemiol 165:719-26. 2007
    ..Findings suggest that cumulative, but not intermittent, measures of sun exposure derived from a personal interview appear to reflect a person's exposure history based on histologic evidence...
  29. doi request reprint A system-level pathway-phenotype association analysis using synthetic feature random forest
    Qinxin Pan
    Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States of America
    Genet Epidemiol 38:209-19. 2014
    ..The bladder cancer associated pathways we found are both consistent with existing biological knowledge and reveal novel and plausible hypotheses for future biological validations. ..
  30. pmc Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth College, Lebanon, NH, USA
    Mod Pathol 27:145-55. 2014
    ..1, P=0.004) exhibited a methylation profile similar to right-colon adenomas. In summary, our results indicate distinct patterns of DNA methylation, independent of CIMP genes, in adenomas of the right and left colon. ..
  31. pmc Characterizing genetic interactions in human disease association studies using statistical epistasis networks
    Ting Hu
    Department of Genetics, Dartmouth Medical School, Dartmouth College, Lebanon, NH, USA
    BMC Bioinformatics 12:364. 2011
    ....
  32. pmc Ecogeographic genetic epidemiology
    Chantel D Sloan
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Genet Epidemiol 33:281-9. 2009
    ....
  33. ncbi request reprint A novel pathway for nickel-induced interleukin-8 expression
    Aaron Barchowsky
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 277:24225-31. 2002
    ..These studies indicate that nickel induced IL-8 transcription through a novel pathway that requires both AP-1 and non-traditional transcription factors...
  34. pmc Evidence for the ubiquitin protease UBP43 as an antineoplastic target
    Yongli Guo
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Mol Cancer Ther 11:1968-77. 2012
    ..Differential UBP43 expression was independently detected in a normal-malignant tissue array with diverse human cancers. Taken together, these findings uncovered UBP43 as a previously unrecognized antineoplastic target...
  35. pmc Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study
    Joan Fortuny
    Respiratory and Environmental Health Research Unit, Municipal Institute of Medical Research IMIM, 08003 Barcelona, Catalonia, Spain
    BMC Urol 7:13. 2007
    ..Use of phenacetin and other analgesic and non-steroidal anti-inflammatory drugs (NSAIDs) potentially influences bladder cancer incidence, but epidemiologic evidence is limited...