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Genomes and Genes | Angeline S AndrewSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategyAngeline S Andrew
Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Hum Hered 65:105-18. 2008..These include: APE1-Asn148Gln, XRCC1-Arg399Gln and XRCC1-Arg194Trp in the BER pathway, XPD-Gln751Lys in the NER pathway and XRCC3-Thr241Met in the DSB repair pathway...- Arsenic activates EGFR pathway signaling in the lungAngeline S Andrew
Department of Community and Family Medicine, Dartmouth Medical School, Dartmouth College, Hanover, New Hampshire 03756, USA
Toxicol Sci 109:350-7. 2009..Further work is needed to assess the clinical utility of targeting the EGFR pathway in subgroups of lung cancer patients who have been exposed to elevated levels of arsenic... 
Exposure to arsenic at levels found inU.S. drinking water modifies expression in the mouse lungAngeline S Andrew
Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Toxicol Sci 100:75-87. 2007..These data identify arsenic-modified signaling pathways that will help guide investigations into mechanisms of arsenic's health effects and clarify the threshold for biologic effects and potential disease risk...- Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. populationAngeline S Andrew
Dartmouth Medical School Section of Biostatistics and Epidemiology, 7927 Rubin 860, One Medical Center Dr, Lebanon, NH 03756, USA
Environ Health Perspect 116:524-31. 2008.... 
Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenicAngeline S Andrew
Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Environ Health Perspect 114:1193-8. 2006....- Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibilityAngeline S Andrew
Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Carcinogenesis 27:1030-7. 2006..These results support the hypothesis that common polymorphisms in DNA repair genes modify bladder cancer risk and emphasize the need for a multifaceted statistical approach to identify gene-gene and gene-environment interactions... - DNA repair genotype interacts with arsenic exposure to increase bladder cancer riskAngeline S Andrew
Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, United States
Toxicol Lett 187:10-4. 2009..01). Haplotype analysis confirmed the association of the XRCC3 241. Thus, double-strand break repair genotype may enhance arsenic associated bladder cancer susceptibility in the U.S. population... - Bladder cancer risk and personal hair dye useAngeline S Andrew
Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
Int J Cancer 109:581-6. 2004..In light of the prevalence of hair dye use, further studies are needed that address the effects of specific colors and types of hair dyes along with the possible role of individual susceptibility... - Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking waterAngeline S Andrew
Department of Community and Family Medicine and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
Int J Cancer 104:263-8. 2003..Although our findings need verification in a larger study group, they are consistent with the hypothesis that inhibition of DNA repair capacity is a potential mechanism for the co-carcinogenic activity of arsenic... - Bladder cancer SNP panel predicts susceptibility and survivalAngeline S Andrew
Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
Hum Genet 125:527-39. 2009..8 95% CI 1.1-3.0). Variants in the detoxification gene EPHX1 experienced longer survival (HR 0.4 (95% CI 0.2-0.8). These genes can now be assessed in multiple study populations to identify and validate SNPs appropriate for clinical use... - Arsenic exposure predicts bladder cancer survival in a US populationRyan C Kwong
Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, 7927 Rubin 860 One Medical Center Drive, Lebanon, NH 03756, USA
World J Urol 28:487-92. 2010..While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality... - EGFR pathway polymorphisms and bladder cancer susceptibility and prognosisRebecca A Mason
Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Carcinogenesis 30:1155-60. 2009..Understanding these genetic influences on increased bladder cancer susceptibility and survival may help in cancer prevention, drug development and choice of therapeutic regimen... - A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New HampshireCorina Lesseur
Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
Toxicol Lett 210:100-6. 2012.... - SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancerMargaret R Karagas
Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
Hum Genet 131:453-61. 2012..03). Our findings suggest novel variants that may influence risk of arsenic-associated bladder cancer and those who may be at greatest risk from this widespread exposure... - A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasisJiang Gui
Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
Hum Hered 70:219-25. 2010..The results suggest that our proposed method performs similarly, but is more computationally efficient. We then apply this new method to an analysis of a population-based bladder cancer study in New Hampshire... - A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosisJiang Gui
Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Hum Genet 129:101-10. 2011.... - Survival following the diagnosis of noninvasive bladder cancer: WHO/International Society of Urological Pathology versus WHO classification systemsAlan R Schned
Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Urol 178:1196-200; discussion 1200. 2007..In a large, nonselected population of patients with bladder cancer we rated all incident tumors using each system and compared long-term patient survival... - A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reductionKristine A Pattin
Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Genet Epidemiol 33:87-94. 2009..We then demonstrate this new method by applying it to a genetic epidemiology study of bladder cancer susceptibility that was previously analyzed using MDR and assessed using a 1,000-fold permutation test... - Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control studyMargaret R Karagas
Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
Int J Hyg Environ Health 208:321-7. 2005..12 for MTHFR 1298A>C). Thus, our findings do not support the presence of a main gene effect. The possibility that MTHFR polymorphism affects susceptibility to environmental exposures warrants further consideration... - Genomic and proteomic profiling of responses to toxic metals in human lung cellsAngeline S Andrew
Department of Pharmacology and Toxicology, Dartmouth Medical School, Dartmouth College, 7927 Rubin Building, 452M 3, One Medical Center Drive, Lebanon, NH 03756 0001, USA
Environ Health Perspect 111:825-35. 2003.... - Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United StatesAlan R Schned
Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA
Scand J Urol Nephrol 42:237-42. 2008..This study evaluated the classification and stage of bladder cancers as part of a population-based epidemiological study of bladder cancer in the Northeastern United States... - Selenium and risk of bladder cancer: a population-based case-control studyKristin Wallace
Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, 7927 Rubin Building, 1 Medical Center Drive, Lebanon, NH 03756, USA
Cancer Prev Res (Phila) 2:70-3. 2009..g., p53 positive) or within certain subsets of a population (e.g., women or moderate smokers)... - A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibilityJiang Gui
Dartmouth Medical School, Lebanon, NH 03756, USA
Ann Hum Genet 75:20-8. 2011..We show that there is no loss of success rate when this is not the case. We then apply the RMDR method to the detection of gene-gene interactions in genotype data from a population-based study of bladder cancer in New Hampshire... 
Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutationsFabrizio Galimberti
Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
Int J Oncol 41:1751-61. 2012..This includes tumors that express genes indicating basal HH pathway activation...- MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressorsXi Liu
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Clin Invest 120:1298-309. 2010..Together, these findings revealed that miR-31 acts as an oncogenic miRNA (oncomir) in lung cancer by targeting specific tumor suppressors for repression... - Measures of cumulative exposure from a standardized sun exposure history questionnaire: a comparison with histologic assessment of solar skin damageMargaret R Karagas
Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Am J Epidemiol 165:719-26. 2007..Findings suggest that cumulative, but not intermittent, measures of sun exposure derived from a personal interview appear to reflect a person's exposure history based on histologic evidence... - Characterizing genetic interactions in human disease association studies using statistical epistasis networksTing Hu
Department of Genetics, Dartmouth Medical School, Dartmouth College, Lebanon, NH, USA
BMC Bioinformatics 12:364. 2011.... - Ecogeographic genetic epidemiologyChantel D Sloan
Computational Genetics Laboratory, Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire, USA
Genet Epidemiol 33:281-9. 2009.... - A novel pathway for nickel-induced interleukin-8 expressionAaron Barchowsky
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Biol Chem 277:24225-31. 2002..These studies indicate that nickel induced IL-8 transcription through a novel pathway that requires both AP-1 and non-traditional transcription factors... - Evidence for the ubiquitin protease UBP43 as an antineoplastic targetYongli Guo
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Mol Cancer Ther 11:1968-77. 2012..Differential UBP43 expression was independently detected in a normal-malignant tissue array with diverse human cancers. Taken together, these findings uncovered UBP43 as a previously unrecognized antineoplastic target... - Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control studyJoan Fortuny
Respiratory and Environmental Health Research Unit, Municipal Institute of Medical Research IMIM, 08003 Barcelona, Catalonia, Spain
BMC Urol 7:13. 2007..Use of phenacetin and other analgesic and non-steroidal anti-inflammatory drugs (NSAIDs) potentially influences bladder cancer incidence, but epidemiologic evidence is limited...