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Genomes and Genes | Victor AmbrosSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
A uniform system for microRNA annotationVictor Ambros
Dartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA
RNA 9:277-9. 2003..Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families...
MicroRNAs and other tiny endogenous RNAs in C. elegansVictor Ambros
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Curr Biol 13:807-18. 2003..We employed cDNA sequencing and comparative genomics to identify additional C. elegans small RNAs with properties similar to miRNAs and siRNAs...- MicroRNA pathways in flies and worms: growth, death, fat, stress, and timingVictor Ambros
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Cell 113:673-6. 2003..In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing... - The regulation of genes and genomes by small RNAsVictor Ambros
Dartmouth Medical School, Hanover, NH 03755, USA
Development 134:1635-41. 2007.... - Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activityLorenzo F Sempere
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Dev Biol 259:9-18. 2003.... - Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosisNicholas S Sokol
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Genes Dev 22:1591-6. 2008..This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior... - Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growthNicholas S Sokol
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Genes Dev 19:2343-54. 2005..Thus, DmiR-1 is not required for the formation or physiological function of the larval musculature, but is required for the dramatic post-mitotic growth of larval muscle... - Identification of microRNAs and other tiny noncoding RNAs by cDNA cloningVictor Ambros
Department of Genetics, Dartmouth Medical School, Hanover, NH, USA
Methods Mol Biol 265:131-58. 2004..Northern blot hybridization is used to confirm the expression of small RNAs in vivo... - Developmental biology. Encountering microRNAs in cell fate signalingXantha Karp
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Science 310:1288-9. 2005 - Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiationLorenzo F Sempere
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Genome Biol 5:R13. 2004..lin-4, let-7 and other miRNA genes are conserved in mammals, and their potential functions in mammalian development are under active study... - The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegansAllison L Abbott
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Dev Cell 9:403-14. 2005..These results indicate that let-7 family microRNAs function in combination to affect both early and late developmental timing decisions... - Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegansRosalind C Lee
Dartmouth Medical School, Department of Genetics, Hanover, New Hamphsire 03755, USA
RNA 12:589-97. 2006..elegans. Microarray expression profiling of RNAi-defective mutant worms further suggests diverse endogenous RNAi pathways for silencing different sets of genes... - The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA bindingMarta Hristova
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Mol Cell Biol 25:11059-72. 2005..These results reinforce the conclusion that lin-14 encodes a novel class of transcription factor... - A short history of a short RNARosalind Lee
Department of Genetics Dartmouth Medical School Hanover, New Hampshire 03755, USA
Cell 116:S89-92, 1 p following S96. 2004 - The expression of the let-7 small regulatory RNA is controlled by ecdysone during metamorphosis in Drosophila melanogasterLorenzo F Sempere
Department of Genetics, Dartmouth College, Hanover, New Hampshire 03755, USA
Dev Biol 244:170-9. 2002..These results demonstrate an interaction between steroid hormone signaling and the heterochronic pathway in insects... - The functions of animal microRNAsVictor Ambros
Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
Nature 431:350-5. 2004.... - Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAiMarkus Kuhlmann
Abt Genetik, Universitat Kassel, Heinrich Plett Str 40, 34132 Kassel, Germany
Nucleic Acids Res 33:6405-17. 2005..The data show that DNA methylation plays a crucial role in epigenetic gene silencing in Dictyostelium but that different, partially overlapping mechanisms control transposon silencing... - The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegansMaria C Ow
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 22:2520-34. 2008..Therefore, the FLH-1 and FLH-2 proteins likely play a more general role in regulating gene expression in embryos... - Role of microRNAs in plant and animal developmentJames C Carrington
Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
Science 301:336-8. 2003..miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets... - The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrinAnita S R Pepper
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Development 131:2049-59. 2004..Our findings suggest that the LIN-46 protein acts as a scaffold for a multiprotein assembly that controls developmental timing, and expand the known roles of gephyrin-related proteins to development... - Potent effect of target structure on microRNA functionDang Long
Wadsworth Center, New York State Department of Health, 150 New Scotland Avenue, Albany, New York 12208, USA
Nat Struct Mol Biol 14:287-94. 2007..elegans and Drosophila melanogaster. These findings indicate a potent effect of target structure on target recognition by miRNAs and establish a structure-based framework for genome-wide identification of animal miRNA targets... - The evolution of our thinking about microRNAsVictor Ambros
University of Massachusetts Medical School Department of Molecular Medicine, 373 Plantation Street, B2-306, Worcester, Massachusetts 01605, USA
Nat Med 14:1036-40. 2008 - The 2007 George W. Beadle Medal. Robert K. HermanVictor Ambros
Genetics 175:465-6. 2007 - The 2006 Genetics Society of America Medal. Victor AmbrosGeraldine Seydoux
Genetics 172:721-2. 2006