Victor Ambros

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
  2. ncbi request reprint Control of developmental timing in Caenorhabditis elegans
    V Ambros
    Department of Biological Sciences, Dartmouth College, Hanover 03755, USA
    Curr Opin Genet Dev 10:428-33. 2000
  3. ncbi request reprint microRNAs: tiny regulators with great potential
    V Ambros
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Cell 107:823-6. 2001
  4. ncbi request reprint Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Dev Biol 259:9-18. 2003
  5. pmc Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Genes Dev 22:1591-6. 2008
  6. pmc Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 19:2343-54. 2005
  7. ncbi request reprint Developmental biology. Encountering microRNAs in cell fate signaling
    Xantha Karp
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Science 310:1288-9. 2005
  8. ncbi request reprint MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Cell 113:673-6. 2003
  9. ncbi request reprint Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning
    Victor Ambros
    Department of Genetics, Dartmouth Medical School, Hanover, NH, USA
    Methods Mol Biol 265:131-58. 2004
  10. ncbi request reprint MicroRNAs and other tiny endogenous RNAs in C. elegans
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Curr Biol 13:807-18. 2003

Collaborators

Detail Information

Publications35

  1. ncbi request reprint The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
    ....
  2. ncbi request reprint Control of developmental timing in Caenorhabditis elegans
    V Ambros
    Department of Biological Sciences, Dartmouth College, Hanover 03755, USA
    Curr Opin Genet Dev 10:428-33. 2000
    ..These regulators interact with each other to elaborate stage-specific regulatory switches and act through downstream effectors to control the timing of cell-type-specific developmental events...
  3. ncbi request reprint microRNAs: tiny regulators with great potential
    V Ambros
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Cell 107:823-6. 2001
    ..These microRNAs are diverse in sequence and expression patterns, and are evolutionarily widespread, suggesting that they may participate in a wide range of genetic regulatory pathways...
  4. ncbi request reprint Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Dev Biol 259:9-18. 2003
    ....
  5. pmc Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Genes Dev 22:1591-6. 2008
    ..This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior...
  6. pmc Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 19:2343-54. 2005
    ..Thus, DmiR-1 is not required for the formation or physiological function of the larval musculature, but is required for the dramatic post-mitotic growth of larval muscle...
  7. ncbi request reprint Developmental biology. Encountering microRNAs in cell fate signaling
    Xantha Karp
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Science 310:1288-9. 2005
  8. ncbi request reprint MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Cell 113:673-6. 2003
    ..In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing...
  9. ncbi request reprint Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning
    Victor Ambros
    Department of Genetics, Dartmouth Medical School, Hanover, NH, USA
    Methods Mol Biol 265:131-58. 2004
    ..Northern blot hybridization is used to confirm the expression of small RNAs in vivo...
  10. ncbi request reprint MicroRNAs and other tiny endogenous RNAs in C. elegans
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Curr Biol 13:807-18. 2003
    ..We employed cDNA sequencing and comparative genomics to identify additional C. elegans small RNAs with properties similar to miRNAs and siRNAs...
  11. pmc Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
    Lorenzo F Sempere
    Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
    Genome Biol 5:R13. 2004
    ..lin-4, let-7 and other miRNA genes are conserved in mammals, and their potential functions in mammalian development are under active study...
  12. ncbi request reprint The regulation of genes and genomes by small RNAs
    Victor Ambros
    Dartmouth Medical School, Hanover, NH 03755, USA
    Development 134:1635-41. 2007
    ....
  13. pmc The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding
    Marta Hristova
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Mol Cell Biol 25:11059-72. 2005
    ..These results reinforce the conclusion that lin-14 encodes a novel class of transcription factor...
  14. pmc The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans
    Allison L Abbott
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Dev Cell 9:403-14. 2005
    ..These results indicate that let-7 family microRNAs function in combination to affect both early and late developmental timing decisions...
  15. ncbi request reprint An extensive class of small RNAs in Caenorhabditis elegans
    R C Lee
    Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
    Science 294:862-4. 2001
    ..elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse...
  16. ncbi request reprint A short history of a short RNA
    Rosalind Lee
    Department of Genetics Dartmouth Medical School Hanover, New Hampshire 03755, USA
    Cell 116:S89-92, 1 p following S96. 2004
  17. ncbi request reprint Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells
    V Ambros
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Development 126:1947-56. 1999
    ..Coupling developmental decisions to cell cycle transitions may provide a mechanism for prioritizing or ordering choices of cell fates for multipotential cells...
  18. ncbi request reprint The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    P H Olsen
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Dev Biol 216:671-80. 1999
    ....
  19. pmc Structure and function analysis of LIN-14, a temporal regulator of postembryonic developmental events in Caenorhabditis elegans
    Y Hong
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Mol Cell Biol 20:2285-95. 2000
    ..These results support the view that LIN-14 controls developmental timing in C. elegans by regulating gene expression in the nucleus...
  20. ncbi request reprint The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor
    F J Slack
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Mol Cell 5:659-69. 2000
    ..We suggest that late larval activation of let-7 RNA expression downregulates LIN-41 to relieve inhibition of lin-29...
  21. ncbi request reprint The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
    E G Moss
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cell 88:637-46. 1997
    ..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates...
  22. pmc Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans
    Rosalind C Lee
    Dartmouth Medical School, Department of Genetics, Hanover, New Hamphsire 03755, USA
    RNA 12:589-97. 2006
    ..elegans. Microarray expression profiling of RNAi-defective mutant worms further suggests diverse endogenous RNAi pathways for silencing different sets of genes...
  23. ncbi request reprint Heterochronic genes and the temporal control of C. elegans development
    V Ambros
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755
    Trends Genet 10:123-7. 1994
    ....
  24. ncbi request reprint Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans
    Y Hong
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Development 125:3585-97. 1998
    ..In vulva precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 stage...
  25. ncbi request reprint The temporal control of cell cycle and cell fate in Caenorhabditis elegans
    V Ambros
    Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
    Novartis Found Symp 237:203-14; discussion 214-20. 2001
    ..Some choices of cell fate that occur in response to inductive or lateral signals are linked to cell cycle progression, suggesting that cell cycle phase can confer a critical period for developmental potential in certain cells...
  26. pmc A uniform system for microRNA annotation
    Victor Ambros
    Dartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA
    RNA 9:277-9. 2003
    ..Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families...
  27. ncbi request reprint The expression of the let-7 small regulatory RNA is controlled by ecdysone during metamorphosis in Drosophila melanogaster
    Lorenzo F Sempere
    Department of Genetics, Dartmouth College, Hanover, New Hampshire 03755, USA
    Dev Biol 244:170-9. 2002
    ..These results demonstrate an interaction between steroid hormone signaling and the heterochronic pathway in insects...
  28. ncbi request reprint The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin
    Anita S R Pepper
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Development 131:2049-59. 2004
    ..Our findings suggest that the LIN-46 protein acts as a scaffold for a multiprotein assembly that controls developmental timing, and expand the known roles of gephyrin-related proteins to development...
  29. pmc The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans
    Maria C Ow
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 22:2520-34. 2008
    ..Therefore, the FLH-1 and FLH-2 proteins likely play a more general role in regulating gene expression in embryos...
  30. ncbi request reprint Potent effect of target structure on microRNA function
    Dang Long
    Wadsworth Center, New York State Department of Health, 150 New Scotland Avenue, Albany, New York 12208, USA
    Nat Struct Mol Biol 14:287-94. 2007
    ..elegans and Drosophila melanogaster. These findings indicate a potent effect of target structure on target recognition by miRNAs and establish a structure-based framework for genome-wide identification of animal miRNA targets...
  31. doi request reprint The evolution of our thinking about microRNAs
    Victor Ambros
    University of Massachusetts Medical School Department of Molecular Medicine, 373 Plantation Street, B2 306, Worcester, Massachusetts 01605, USA
    Nat Med 14:1036-40. 2008
  32. ncbi request reprint Role of microRNAs in plant and animal development
    James C Carrington
    Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
    Science 301:336-8. 2003
    ..miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets...
  33. pmc Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi
    Markus Kuhlmann
    Abt Genetik, Universitat Kassel, Heinrich Plett Str 40, 34132 Kassel, Germany
    Nucleic Acids Res 33:6405-17. 2005
    ..The data show that DNA methylation plays a crucial role in epigenetic gene silencing in Dictyostelium but that different, partially overlapping mechanisms control transposon silencing...
  34. pmc The 2007 George W. Beadle Medal. Robert K. Herman
    Victor Ambros
    Genetics 175:465-6. 2007
  35. pmc The 2006 Genetics Society of America Medal. Victor Ambros
    Geraldine Seydoux
    Genetics 172:721-2. 2006