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Genomes and Genes | Victor AmbrosSummaryAffiliation: Dartmouth Medical School Country: USA Publications
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Publications
The functions of animal microRNAsVictor Ambros
Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
Nature 431:350-5. 2004....- Control of developmental timing in Caenorhabditis elegansV Ambros
Department of Biological Sciences, Dartmouth College, Hanover 03755, USA
Curr Opin Genet Dev 10:428-33. 2000..These regulators interact with each other to elaborate stage-specific regulatory switches and act through downstream effectors to control the timing of cell-type-specific developmental events... - microRNAs: tiny regulators with great potentialV Ambros
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Cell 107:823-6. 2001..These microRNAs are diverse in sequence and expression patterns, and are evolutionarily widespread, suggesting that they may participate in a wide range of genetic regulatory pathways... - Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activityLorenzo F Sempere
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Dev Biol 259:9-18. 2003.... 
Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosisNicholas S Sokol
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Genes Dev 22:1591-6. 2008..This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior...- Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growthNicholas S Sokol
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Genes Dev 19:2343-54. 2005..Thus, DmiR-1 is not required for the formation or physiological function of the larval musculature, but is required for the dramatic post-mitotic growth of larval muscle... - Developmental biology. Encountering microRNAs in cell fate signalingXantha Karp
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Science 310:1288-9. 2005 - MicroRNA pathways in flies and worms: growth, death, fat, stress, and timingVictor Ambros
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Cell 113:673-6. 2003..In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing... - Identification of microRNAs and other tiny noncoding RNAs by cDNA cloningVictor Ambros
Department of Genetics, Dartmouth Medical School, Hanover, NH, USA
Methods Mol Biol 265:131-58. 2004..Northern blot hybridization is used to confirm the expression of small RNAs in vivo... - MicroRNAs and other tiny endogenous RNAs in C. elegansVictor Ambros
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Curr Biol 13:807-18. 2003..We employed cDNA sequencing and comparative genomics to identify additional C. elegans small RNAs with properties similar to miRNAs and siRNAs... - Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiationLorenzo F Sempere
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA
Genome Biol 5:R13. 2004..lin-4, let-7 and other miRNA genes are conserved in mammals, and their potential functions in mammalian development are under active study... - The regulation of genes and genomes by small RNAsVictor Ambros
Dartmouth Medical School, Hanover, NH 03755, USA
Development 134:1635-41. 2007.... - The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA bindingMarta Hristova
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Mol Cell Biol 25:11059-72. 2005..These results reinforce the conclusion that lin-14 encodes a novel class of transcription factor... - The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegansAllison L Abbott
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Dev Cell 9:403-14. 2005..These results indicate that let-7 family microRNAs function in combination to affect both early and late developmental timing decisions... - An extensive class of small RNAs in Caenorhabditis elegansR C Lee
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Science 294:862-4. 2001..elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse... - A short history of a short RNARosalind Lee
Department of Genetics Dartmouth Medical School Hanover, New Hampshire 03755, USA
Cell 116:S89-92, 1 p following S96. 2004 - Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cellsV Ambros
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
Development 126:1947-56. 1999..Coupling developmental decisions to cell cycle transitions may provide a mechanism for prioritizing or ordering choices of cell fates for multipotential cells... - The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translationP H Olsen
Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
Dev Biol 216:671-80. 1999.... - Structure and function analysis of LIN-14, a temporal regulator of postembryonic developmental events in Caenorhabditis elegansY Hong
Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
Mol Cell Biol 20:2285-95. 2000..These results support the view that LIN-14 controls developmental timing in C. elegans by regulating gene expression in the nucleus... - The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factorF J Slack
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
Mol Cell 5:659-69. 2000..We suggest that late larval activation of let-7 RNA expression downregulates LIN-41 to relieve inhibition of lin-29... - The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNAE G Moss
Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
Cell 88:637-46. 1997..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates... - Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegansRosalind C Lee
Dartmouth Medical School, Department of Genetics, Hanover, New Hamphsire 03755, USA
RNA 12:589-97. 2006..elegans. Microarray expression profiling of RNAi-defective mutant worms further suggests diverse endogenous RNAi pathways for silencing different sets of genes... - Heterochronic genes and the temporal control of C. elegans developmentV Ambros
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755
Trends Genet 10:123-7. 1994.... - Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegansY Hong
Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
Development 125:3585-97. 1998..In vulva precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 stage... - The temporal control of cell cycle and cell fate in Caenorhabditis elegansV Ambros
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
Novartis Found Symp 237:203-14; discussion 214-20. 2001..Some choices of cell fate that occur in response to inductive or lateral signals are linked to cell cycle progression, suggesting that cell cycle phase can confer a critical period for developmental potential in certain cells... - A uniform system for microRNA annotationVictor Ambros
Dartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA
RNA 9:277-9. 2003..Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families... - The expression of the let-7 small regulatory RNA is controlled by ecdysone during metamorphosis in Drosophila melanogasterLorenzo F Sempere
Department of Genetics, Dartmouth College, Hanover, New Hampshire 03755, USA
Dev Biol 244:170-9. 2002..These results demonstrate an interaction between steroid hormone signaling and the heterochronic pathway in insects... - The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrinAnita S R Pepper
Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Development 131:2049-59. 2004..Our findings suggest that the LIN-46 protein acts as a scaffold for a multiprotein assembly that controls developmental timing, and expand the known roles of gephyrin-related proteins to development... - The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegansMaria C Ow
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 22:2520-34. 2008..Therefore, the FLH-1 and FLH-2 proteins likely play a more general role in regulating gene expression in embryos... - Potent effect of target structure on microRNA functionDang Long
Wadsworth Center, New York State Department of Health, 150 New Scotland Avenue, Albany, New York 12208, USA
Nat Struct Mol Biol 14:287-94. 2007..elegans and Drosophila melanogaster. These findings indicate a potent effect of target structure on target recognition by miRNAs and establish a structure-based framework for genome-wide identification of animal miRNA targets... - The evolution of our thinking about microRNAsVictor Ambros
University of Massachusetts Medical School Department of Molecular Medicine, 373 Plantation Street, B2-306, Worcester, Massachusetts 01605, USA
Nat Med 14:1036-40. 2008 - Role of microRNAs in plant and animal developmentJames C Carrington
Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
Science 301:336-8. 2003..miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets... - Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAiMarkus Kuhlmann
Abt Genetik, Universitat Kassel, Heinrich Plett Str 40, 34132 Kassel, Germany
Nucleic Acids Res 33:6405-17. 2005..The data show that DNA methylation plays a crucial role in epigenetic gene silencing in Dictyostelium but that different, partially overlapping mechanisms control transposon silencing... - The 2007 George W. Beadle Medal. Robert K. HermanVictor Ambros
Genetics 175:465-6. 2007 - The 2006 Genetics Society of America Medal. Victor AmbrosGeraldine Seydoux
Genetics 172:721-2. 2006