Gregory J Tsongalis

Summary

Affiliation: Dartmouth-Hitchcock Medical Center
Country: USA

Publications

  1. ncbi request reprint Detection of the C282Y and H63D polymorphisms associated with hereditary hemochromatosis using the ABI 7500 fast real time PCR platform
    Laura J Tafe
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Diagn Mol Pathol 16:112-5. 2007
  2. doi request reprint Polyomavirus infection of the urinary tract presenting as hemorrhagic cystitis in an immunocompetent five-year-old boy
    Jorge L Gonzalez
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756 0001, USA
    Diagn Cytopathol 36:375-8. 2008
  3. ncbi request reprint Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians
    T Angeline
    PG and Research Department of Zoology, Lady Doak College, Madurai, Tamil Nadu, South India
    Exp Mol Pathol 77:85-8. 2004
  4. ncbi request reprint The effect of apolipoprotein E genotype on serum lipoprotein particle response to exercise
    Richard L Seip
    Cardiology Division, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102 5037, USA
    Atherosclerosis 188:126-33. 2006
  5. doi request reprint Democratizing molecular diagnostics for the developing world
    Ahmad N Abou Tayoun
    Dept of Pathology, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756
    Am J Clin Pathol 141:17-24. 2014
  6. doi request reprint Pharmacogenetics: where are we with respect to personalized medicine?
    Joel A Lefferts
    Dartmouth Medical School, Department of Pathology, Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA 1 603 650 5498 1 603 650 4845
    Expert Opin Med Diagn 1:117-28. 2007
  7. doi request reprint Molecular diagnostics: parallels between infectious disease and emerging oncology testing
    Joel A Lefferts
    Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, Dartmouth Medical School, Department of Pathology, One Medical Center Drive, Lebanon, NH 03756, USA 1 603 650 5498 1 603 650 4845
    Expert Opin Med Diagn 4:185-8. 2010
  8. ncbi request reprint Molecular diagnostics: a historical perspective
    Gregory J Tsongalis
    Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Clin Chim Acta 369:188-92. 2006
  9. ncbi request reprint Clinical genotyping: the need for interrogation of single nucleotide polymorphisms and mutations in the clinical laboratory
    Gregory J Tsongalis
    Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center Lebanon, NH 03756, USA
    Clin Chim Acta 363:127-37. 2006
  10. pmc Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 05756, USA
    J Neurotrauma 29:1111-8. 2012

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Detection of the C282Y and H63D polymorphisms associated with hereditary hemochromatosis using the ABI 7500 fast real time PCR platform
    Laura J Tafe
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Diagn Mol Pathol 16:112-5. 2007
    ..Improved software and thermocycling capabilities have resulted in a very robust TAQman assay with the advantage of a much improved turn-around-time and throughput...
  2. doi request reprint Polyomavirus infection of the urinary tract presenting as hemorrhagic cystitis in an immunocompetent five-year-old boy
    Jorge L Gonzalez
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756 0001, USA
    Diagn Cytopathol 36:375-8. 2008
    ..Although rare cases of nonhemorrhagic cystitis have been reported, to the best of our knowledge this is the first case of hemorrhagic cystitis occurring in this setting...
  3. ncbi request reprint Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians
    T Angeline
    PG and Research Department of Zoology, Lady Doak College, Madurai, Tamil Nadu, South India
    Exp Mol Pathol 77:85-8. 2004
    ..The results of this study indicate that the MTHFR A1298C SNP is more prevalent among the Tamilians when compared to the MTHFR C677T SNP, suggesting a possible role of MTHFR A1298C in the pathogenesis of heart diseases...
  4. ncbi request reprint The effect of apolipoprotein E genotype on serum lipoprotein particle response to exercise
    Richard L Seip
    Cardiology Division, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102 5037, USA
    Atherosclerosis 188:126-33. 2006
    ..In conclusion, APOE variants influence the serum LDL subpopulation response to exercise training in normolipidemic subjects. Subjects homozygous for APOE3 experienced the most beneficial lipid effects from exercise training...
  5. doi request reprint Democratizing molecular diagnostics for the developing world
    Ahmad N Abou Tayoun
    Dept of Pathology, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756
    Am J Clin Pathol 141:17-24. 2014
    ..In fact, modified molecular diagnostics for infectious diseases were rated as the top biotechnology to improve health in developing countries...
  6. doi request reprint Pharmacogenetics: where are we with respect to personalized medicine?
    Joel A Lefferts
    Dartmouth Medical School, Department of Pathology, Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA 1 603 650 5498 1 603 650 4845
    Expert Opin Med Diagn 1:117-28. 2007
    ..Several national organizations are now working on practice guidelines for the incorporation of this testing into a clinical setting. This manuscript provides an overview of where we are with respect to pharmacogenetic testing...
  7. doi request reprint Molecular diagnostics: parallels between infectious disease and emerging oncology testing
    Joel A Lefferts
    Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, Dartmouth Medical School, Department of Pathology, One Medical Center Drive, Lebanon, NH 03756, USA 1 603 650 5498 1 603 650 4845
    Expert Opin Med Diagn 4:185-8. 2010
    ....
  8. ncbi request reprint Molecular diagnostics: a historical perspective
    Gregory J Tsongalis
    Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Clin Chim Acta 369:188-92. 2006
    ..The next decade promises even more exciting technologies and applications for the field of molecular laboratory medicine...
  9. ncbi request reprint Clinical genotyping: the need for interrogation of single nucleotide polymorphisms and mutations in the clinical laboratory
    Gregory J Tsongalis
    Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center Lebanon, NH 03756, USA
    Clin Chim Acta 363:127-37. 2006
    ..Detection of single nucleotide polymorphisms (SNPs) and gene mutations is becoming more routine to the clinical laboratory...
  10. pmc Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury
    Thomas W McAllister
    Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 05756, USA
    J Neurotrauma 29:1111-8. 2012
    ..Polymorphisms in BDNF influence cognitive performance shortly after mTBI. The results raise the possibility that a functional polymorphism other than rs6265 may contribute to memory function after mTBI...
  11. doi request reprint Automation of genomic DNA isolation from formalin-fixed, paraffin-embedded tissues
    Soya S Sam
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, United States
    Pathol Res Pract 208:705-7. 2012
    ..Comparative evaluation of three DNA isolation methods indicated that the Qiagen EZ1 method surpassed the other methods with reduced hands-on-time to produce optimum concentration of quality DNA for use in routine molecular analyses...
  12. doi request reprint A validation study of a new molecular diagnostic assay: the Dartmouth-Hitchcock Medical Center experience with the GeneSearch BLN assay in breast sentinel lymph nodes
    Laura J Tafe
    Translational Research Program, Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Exp Mol Pathol 88:1-6. 2010
    ..2 mm, with our standard lymph node processing...
  13. doi request reprint KRAS detection in colonic tumors by DNA extraction from FTA paper: the molecular touch-prep
    Melissa L Petras
    Department of Pathology, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Hanover, NH, USA
    Diagn Mol Pathol 20:189-93. 2011
    ..This novel means of DNA preservation from surgical specimens would benefit from additional study and validation as a dependable and practical technique to preserve specimens for molecular testing...
  14. pmc COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults
    Heather A Wishart
    Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    J Int Neuropsychol Soc 17:174-80. 2011
    ..This study suggests the heterogeneity in COMT effects reported in the literature may be due in part to gene-gene interactions that influence central dopaminergic systems...
  15. doi request reprint Evaluating the thermostability of commercial fast real-time PCR master mixes
    Ahmad N Abou Tayoun
    Department of Pathology, Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Mol Pathol 93:261-3. 2012
    ..Our findings have implications for clinical diagnostics in the developing world where cold-chain delivery of diagnostic assays is difficult to guarantee...
  16. doi request reprint Establishment of a CYP2C19 genotyping assay for clinical use
    Mark A Cervinski
    Department of Pathology, The Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Am J Clin Pathol 139:202-7. 2013
    ....
  17. doi request reprint Cytomorphologic features of advanced lung adenocarcinomas tested for EGFR and KRAS mutations: a retrospective review of 50 cases
    Jonathan D Marotti
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Diagn Cytopathol 41:15-21. 2013
    ..039) correlated with the presence of EGFR mutations. The presence of necrosis (P = 0.030), squamoid features (P = 0.048), and poorly differentiated tumors (P = 0.025) were more likely to be identified in the KRAS positive group...
  18. doi request reprint Evaluation of the Nanosphere Verigene System and the Verigene F5/F2/MTHFR Nucleic Acid Tests
    Joel A Lefferts
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Exp Mol Pathol 87:105-8. 2009
    ..Molecular genetic testing for gene variants associated with hypercoagulability has become a standard of practice for Factor V and Factor II polymorphisms...
  19. doi request reprint [MicroRNAs: novel biomarkers for human cancer]
    Claudine L Bartels
    Department of Pathology, Darmouth Medical Schook, Darmouth Hichcock Medical Center, Lebanon, NH, USA
    Ann Biol Clin (Paris) 68:263-72. 2010
    ..The biologic roles of miRNAs in cancer suggest a correlation with prognosis and therapeutic outcome. Further investigation of these roles may lead to new approaches for the categorization, diagnosis, and treatment of human cancers...
  20. ncbi request reprint Pancreatic cyst prevalence and the risk of mucin-producing adenocarcinoma in US adults
    Timothy B Gardner
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Am J Gastroenterol 108:1546-50. 2013
    ..We aimed to determine the prevalence rate of mucin-producing adenocarcinoma in US adults with pancreatic cysts...
  21. doi request reprint Molecular oncology: current trends in diagnostics
    Joel A Lefferts
    Dartmouth Medical School, Department of Pathology, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Future Oncol 4:61-70. 2008
    ....
  22. ncbi request reprint Validation of interleukin 28B genotyping assay for clinical use
    Mark A Cervinski
    Department of Pathology, The Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States Electronic address
    Clin Biochem 47:478-80. 2014
    ..We report on our validation of a clinical genotyping assay for rs12979860 polymorphisms in the IL28B locus...
  23. doi request reprint A comprehensive assay for CFTR mutational analysis using next-generation sequencing
    Ahmad N Abou Tayoun
    Department of Pathology, Geisel School of Medicine at Dartmouth, Hanover, NH, and Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH
    Clin Chem 59:1481-8. 2013
    ..Fast sequencing of the entire coding sequence in a scalable manner could expand the detection of CFTR mutations and facilitate management of costs and turnaround times in the clinical laboratory...
  24. doi request reprint MicroRNAs as diagnostic markers for pancreatic ductal adenocarcinoma and its precursor, pancreatic intraepithelial neoplasm
    Yue Xue
    Department of Pathology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Cancer Genet 206:217-21. 2013
    ..These markers can potentially be used as diagnostic markers to distinguish PDAC and its precursor from benign lesions. ..
  25. doi request reprint Detection of the FCGR3a polymorphism using a real-time polymerase chain reaction assay
    Paul R Burchard
    Department of Pathology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Cancer Genet 206:130-4. 2013
    ..The new TaqMan assay offers several advantages over previously published assays, such as faster turnaround time and ease of interpretation. These performance characteristics make it highly suitable for use in a clinical laboratory...
  26. doi request reprint Validation of a solid-phase electrochemical array for genotyping hepatitis C virus
    Soya S Sam
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Mol Pathol 95:18-22. 2013
    ..The high performance characteristics (LOD, specificity, intra- and inter-assay precision, and accuracy), make this assay particularly well suited for clinical HCV genotyping in order to guide antiviral therapy...
  27. doi request reprint The human epidermal growth factor receptor 2 (HER2)
    Laura J Tafe
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Clin Chem Lab Med 50:23-30. 2012
    ..In this manuscript, we review the biology and clinical applications of HER2 as a biomarker of disease and as a therapeutic target...
  28. doi request reprint Use of a linear array for the detection of human papillomavirus genotypes in head and neck cancer
    Candice C Black
    Department of Pathology and Medicine, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Arch Pathol Lab Med 134:1813-7. 2010
    ..The rate of oropharyngeal cancers diagnosed among Americans younger than 50 years is increasing. Infection of the oropharynx and tonsils by the human papillomavirus (HPV) has been linked to preneoplasia and cancer...
  29. doi request reprint Correlation of polypoid colorectal adenocarcinoma with pre-existing adenomatous polyps and KRAS mutation
    Hui Chen
    Department of Pathology, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH, USA
    Cancer Genet 204:245-51. 2011
    ..In summary, grossly polypoid colorectal adenocarcinomas with a persistent pre-existing adenomatous polyp with villous architecture are strongly associated with KRAS mutations...
  30. pmc Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes
    Chantel D Sloan
    Department of Genetics and Community and Family Medicine, Computational Genetics Laboratory, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1060-9. 2010
    ..The results are consistent with polygenic influences on early neurodegenerative changes and demonstrate the effectiveness of hierarchical clustering in identifying genetic associations among multiple related phenotypic endpoints...
  31. doi request reprint MicroRNAs: novel biomarkers for human cancer
    Claudine L Bartels
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Clin Chem 55:623-31. 2009
    ..These molecules have become recognized as one of the major regulatory gatekeepers of coding genes in the human genome...
  32. doi request reprint The emerging role of the molecular diagnostics laboratory in breast cancer personalized medicine
    Francine B de Abreu
    Department of Pathology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire Dartmouth Hitchcock Medical Center and the Norris Cotton Cancer Center, Lebanon, New Hampshire
    Am J Pathol 183:1075-83. 2013
    ..These advances in both imaging and genomics contribute to more personalized and predictive patient management. We review the progress made in breast cancer diagnosis and management using these new tools. ..
  33. ncbi request reprint Quantitative assessment of the BCR-ABL transcript using the Cepheid Xpert BCR-ABL Monitor assay
    Scott D Dufresne
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03759, USA
    Arch Pathol Lab Med 131:947-50. 2007
    ....
  34. doi request reprint Recent advances in microRNA-mediated gene regulation in chronic lymphocytic leukemia
    Swati Srivastava
    Department of Pathology, Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center, Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Clin Biochem 46:901-8. 2013
    ..In this manuscript, we review miRNA biology and the association of specific miRNAs with CLL...
  35. doi request reprint Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non-small cell lung cancer: focus on epidermal growth factor receptor mutation testing and mutation-positive patients
    Monic Roengvoraphoj
    Comprehensive Thoracic Oncology Program, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756 0001, USA The Geisel School of Medicine at Dartmouth, One Rope Ferry Road, Hanover, NH 03755 1404, USA Electronic address
    Cancer Treat Rev 39:839-50. 2013
    ....
  36. doi request reprint A clinical PCR fragment analysis assay for TA repeat sizing in the UGT1A1 promoter region
    Ahmad N Abou Tayoun
    Department of Pathology, Geisel School of Medicine at Dartmouth, Hanover, NH, United States
    Clin Chim Acta 422:1-4. 2013
    ..This polymorphism is very common and, therefore, necessitates the development of reliable means of detecting it in the clinical laboratory to deliver better personalized therapy regimens...
  37. pmc Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study
    Thomas W McAllister
    Department of Psychiatry, Section of Neuropsychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Brain Inj 22:705-14. 2008
    ....
  38. doi request reprint Evaluation of a BK virus real-time PCR assay designed using novel bioinformatics technology
    Joel A Lefferts
    Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Mol Pathol 89:99-102. 2010
    ..55 log(10) copies/mL difference between the two assays. These findings suggest that despite small differences, the IntelligentMDx assay could be adopted for clinical BKV monitoring of renal transplant patients...
  39. pmc Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth College, Lebanon, NH, USA
    Mod Pathol 27:145-55. 2014
    ..1, P=0.004) exhibited a methylation profile similar to right-colon adenomas. In summary, our results indicate distinct patterns of DNA methylation, independent of CIMP genes, in adenomas of the right and left colon. ..
  40. doi request reprint The practical application of chimerism analyses in allogeneic stem cell transplant recipients: blood chimerism is equivalent to marrow chimerism
    Cocav A Rauwerdink
    Blood and Marrow Transplant Program, Section of Hematology and Oncology, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    Exp Mol Pathol 93:339-44. 2012
    ..We performed a retrospective analysis of 42 consecutive adult allogeneic SCT recipients at our institution to determine if both sample types are needed...
  41. ncbi request reprint Validation of a CYP2D6 genotyping panel on the NanoChip Molecular Biology Workstation
    Hong Kee Lee
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Clin Chem 53:823-8. 2007
    ..CYP2D6 is a highly polymorphic phase I enzyme that metabolizes 20%-25% of clinically used drugs. The objective of this study was to validate a CYP2D6 genotyping assay with the NanoChip Molecular Biology Workstation...
  42. doi request reprint MicroRNAs in chronic lymphocytic leukemia
    Brian P Ward
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Exp Mol Pathol 90:173-8. 2011
    ..Because miRNA expression levels in CLL patients differ from that of normal patients, there may be a role for these novel small molecules as biomarkers in this disease...
  43. ncbi request reprint Real-time polymerase chain reaction and laser capture microdissection for the diagnosis of BK virus infection in renal allografts
    Oyedele A Adeyi
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Am J Clin Pathol 124:537-42. 2005
    ..This technique detected BKV in tubular epithelial cells of renal allografts. To our knowledge, this is the first report of detecting BKV in laser capture microdissected renal biopsy specimens using real-time PCR...
  44. ncbi request reprint Negative urine opioid screening caused by rifampin-mediated induction of oxycodone hepatic metabolism
    Hong Kee Lee
    Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, United States
    Clin Chim Acta 367:196-200. 2006
    ..Oxycodone has become widely used in the clinic for the treatment of chronic pain. This reflects its favorable pharmacokinetics and side effect profiles...
  45. ncbi request reprint BRCA1 and BRCA2 mutation screening using SmartCycler II high-resolution melt curve analysis
    Scott D Dufresne
    Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
    Arch Pathol Lab Med 130:185-7. 2006
    ..Real-time polymerase chain reaction technologies have replaced many of the more labor-intense methods in the molecular diagnostics laboratory. Similarly, melt curve analysis can provide a rapid means of mutation screening...
  46. ncbi request reprint Genetic testing: current and future trends
    Gregory J Tsongalis
    Department of Pathology, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, New Hampshire, USA
    MLO Med Lab Obs 38:42, 44. 2006
  47. ncbi request reprint A reality check for molecular diagnostics in clinical practice
    Gregory J Tsongalis
    Department of Pathology and Laboratory Medicine, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
    Pharmacogenomics 4:667-8. 2003
  48. ncbi request reprint Prevalence of the Factor V G1691A and the Factor II/prothrombin G20210A gene polymorphisms among Tamilians
    T Angeline
    PG and Research Department of Zoology, Lady Doak College, Madurai, Tamil Nadu, India
    Exp Mol Pathol 79:9-13. 2005
    ..In addition, the results of this study do not support a role for these SNPs in acute myocardial infarction in the Tamilian population...
  49. ncbi request reprint Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Atherosclerosis 185:65-9. 2006
    ..3+/-6.6 mg/dL versus 4.7+/-1.2 mg/dL, p<0.005). These results show that genetic variation at the APOA1 gene promoter is associated with HDL subfraction redistribution resulting from exercise training...
  50. ncbi request reprint The alpha-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure
    Linda S Pescatello
    Department of Kinesiology, University of Connecticut, Storrs, CT, USA
    Clin Sci (Lond) 113:251-8. 2007
    ..Our findings indicate that the alpha-adducin Gly460Trp genotype may be useful in identifying men who have a reduced BP after lower intensity aerobic exercise...
  51. ncbi request reprint DNA STAT: the ability to perform clinical analysis in real time
    Gregory J Tsongalis
    Expert Rev Mol Diagn 5:627-8. 2005
  52. ncbi request reprint Angiotensin-converting enzyme genotype and adherence to aerobic exercise training
    Paul D Thompson
    Hartford Hospital, Hartford, CT 06102, USA
    Prev Cardiol 9:21-4. 2006
    ..These preliminary results suggest that ACE genotype affects exercise adherence and raises the possibility that superior endurance capacity in subjects with the I allele is related to a genetic propensity to adhere to an exercise regimen...
  53. ncbi request reprint MTHFR Gene polymorphisms, B-vitamins and hyperhomocystinemia in young and middle-aged acute myocardial infarction patients
    T Angeline
    PG and Research Department of Zoology, Lady Doak College, Madurai 625 002, Tamil Nadu, South India
    Exp Mol Pathol 82:227-33. 2007
    ....
  54. ncbi request reprint RAAS polymorphisms alter the acute blood pressure response to aerobic exercise among men with hypertension
    Bruce E Blanchard
    University of CT, Storrs, CT 06102, USA
    Eur J Appl Physiol 97:26-33. 2006
    ..In order to optimally prescribe exercise for its BP lowering benefits in those with hypertension, additional knowledge of how genetic variation affects the BP response to exercise is needed...