Alan R Schned

Summary

Affiliation: Dartmouth-Hitchcock Medical Center
Country: USA

Publications

  1. pmc Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Scand J Urol Nephrol 42:237-42. 2008
  2. ncbi request reprint Survival following the diagnosis of noninvasive bladder cancer: WHO/International Society of Urological Pathology versus WHO classification systems
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Urol 178:1196-200; discussion 1200. 2007
  3. pmc Clinical and immunologic effects of intranodal autologous tumor lysate-dendritic cell vaccine with Aldesleukin (Interleukin 2) and IFN-{alpha}2a therapy in metastatic renal cell carcinoma patients
    Thomas Schwaab
    Medical Oncology Immunotherapy Group, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Clin Cancer Res 15:4986-92. 2009
  4. pmc DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Toxicol Lett 187:10-4. 2009
  5. pmc Bladder cancer SNP panel predicts susceptibility and survival
    Angeline S Andrew
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 125:527-39. 2009
  6. pmc Arsenic exposure predicts bladder cancer survival in a US population
    Ryan C Kwong
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, 7927 Rubin 860 One Medical Center Drive, Lebanon, NH 03756, USA
    World J Urol 28:487-92. 2010
  7. pmc Body mass and smoking are modifiable risk factors for recurrent bladder cancer
    Asaf Wyszynski
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire Program in Experimental and Molecular Medicine, Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
    Cancer 120:408-14. 2014
  8. pmc EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis
    Rebecca A Mason
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Carcinogenesis 30:1155-60. 2009
  9. pmc HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer
    Angeline S Andrew
    Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
    PLoS ONE 7:e51301. 2012
  10. ncbi request reprint Developing a rational tumor vaccine therapy for renal cell carcinoma: immune yin and yang
    Marc S Ernstoff
    Medical Oncology Immunotherapy Group, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Cancer Res 13:733s-740s. 2007

Collaborators

Detail Information

Publications23

  1. pmc Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Scand J Urol Nephrol 42:237-42. 2008
    ..This study evaluated the classification and stage of bladder cancers as part of a population-based epidemiological study of bladder cancer in the Northeastern United States...
  2. ncbi request reprint Survival following the diagnosis of noninvasive bladder cancer: WHO/International Society of Urological Pathology versus WHO classification systems
    Alan R Schned
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Urol 178:1196-200; discussion 1200. 2007
    ..In a large, nonselected population of patients with bladder cancer we rated all incident tumors using each system and compared long-term patient survival...
  3. pmc Clinical and immunologic effects of intranodal autologous tumor lysate-dendritic cell vaccine with Aldesleukin (Interleukin 2) and IFN-{alpha}2a therapy in metastatic renal cell carcinoma patients
    Thomas Schwaab
    Medical Oncology Immunotherapy Group, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Clin Cancer Res 15:4986-92. 2009
    ..To evaluate the clinical and immunologic outcomes of DC (dendritic cell) vaccine with interleukin (IL)-2 and IFN-alpha 2a in metastatic renal cell carcinoma patients...
  4. pmc DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, United States
    Toxicol Lett 187:10-4. 2009
    ..01). Haplotype analysis confirmed the association of the XRCC3 241. Thus, double-strand break repair genotype may enhance arsenic associated bladder cancer susceptibility in the U.S. population...
  5. pmc Bladder cancer SNP panel predicts susceptibility and survival
    Angeline S Andrew
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Hum Genet 125:527-39. 2009
    ..8 95% CI 1.1-3.0). Variants in the detoxification gene EPHX1 experienced longer survival (HR 0.4 (95% CI 0.2-0.8). These genes can now be assessed in multiple study populations to identify and validate SNPs appropriate for clinical use...
  6. pmc Arsenic exposure predicts bladder cancer survival in a US population
    Ryan C Kwong
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Norris Cotton Cancer Center, Dartmouth Medical School, 7927 Rubin 860 One Medical Center Drive, Lebanon, NH 03756, USA
    World J Urol 28:487-92. 2010
    ..While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality...
  7. pmc Body mass and smoking are modifiable risk factors for recurrent bladder cancer
    Asaf Wyszynski
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire Program in Experimental and Molecular Medicine, Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
    Cancer 120:408-14. 2014
    ..Recurrences frequently occur, and continued surveillance is necessary to identify and treat recurrent tumors. Efforts to identify risk factors that are potentially modifiable to reduce the rate of recurrence are needed...
  8. pmc EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis
    Rebecca A Mason
    Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Carcinogenesis 30:1155-60. 2009
    ..Understanding these genetic influences on increased bladder cancer susceptibility and survival may help in cancer prevention, drug development and choice of therapeutic regimen...
  9. pmc HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer
    Angeline S Andrew
    Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
    PLoS ONE 7:e51301. 2012
    ..This biologic process-based analysis suggests candidate susceptibility markers and supports the theory that disrupted hormone regulation plays a role in bladder carcinogenesis...
  10. ncbi request reprint Developing a rational tumor vaccine therapy for renal cell carcinoma: immune yin and yang
    Marc S Ernstoff
    Medical Oncology Immunotherapy Group, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Cancer Res 13:733s-740s. 2007
    ....
  11. ncbi request reprint Ureteroscopic biopsy of upper tract urothelial carcinoma using a novel ureteroscopic biopsy forceps
    Shaun E L Wason
    Department of Urology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Can J Urol 19:6560-5. 2012
    ....
  12. doi request reprint Passive bioelectrical properties for assessing high- and low-grade prostate adenocarcinoma
    Ryan J Halter
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Prostate 71:1759-67. 2011
    ..Because Gleason grading is also based on tissue architecture we explored the hypothesis that the electrical properties might also provide discriminating power between high- and low-Gleason grade cancers...
  13. ncbi request reprint Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility
    Angeline S Andrew
    Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Carcinogenesis 27:1030-7. 2006
    ..These results support the hypothesis that common polymorphisms in DNA repair genes modify bladder cancer risk and emphasize the need for a multifaceted statistical approach to identify gene-gene and gene-environment interactions...
  14. doi request reprint Intraperitoneal India ink deposits appearing as endometriosis in a patient with chronic pelvic pain
    Kristin K Algoe
    Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Departments of Obstetrics and Gynecology and Pathology, Lebanon, NH 03756, USA
    Obstet Gynecol 112:448-50. 2008
    ..Visualization and biopsy of suspicious peritoneum can confirm endometriosis. Endoscopic India ink tattooing can lead to peritoneum that visually mimics endometriosis...
  15. doi request reprint Polyomavirus infection of the urinary tract presenting as hemorrhagic cystitis in an immunocompetent five-year-old boy
    Jorge L Gonzalez
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756 0001, USA
    Diagn Cytopathol 36:375-8. 2008
    ..Although rare cases of nonhemorrhagic cystitis have been reported, to the best of our knowledge this is the first case of hemorrhagic cystitis occurring in this setting...
  16. ncbi request reprint Bladder cancer risk and personal hair dye use
    Angeline S Andrew
    Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    Int J Cancer 109:581-6. 2004
    ..In light of the prevalence of hair dye use, further studies are needed that address the effects of specific colors and types of hair dyes along with the possible role of individual susceptibility...
  17. ncbi request reprint Immunological effects of granulocyte-macrophage colony-stimulating factor and autologous tumor vaccine in patients with renal cell carcinoma
    Thomas Schwaab
    Uro oncology Group, Norris Cotton Cancer Center at Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756 0001, USA
    J Urol 171:1036-42. 2004
    ..We evaluated the effects of weekly then monthly autologous tumor vaccine combined with daily granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with RCC as a method of stimulating antigen presenting cells...
  18. ncbi request reprint Impaired cytolytic activity in peripheral blood T cells from renal cell carcinoma patients
    Todd S Crocenzi
    Uro Oncology Program, Norris Cotton Cancer Center and the Section of Hematology Oncology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
    Clin Immunol 117:6-11. 2005
    ..8 LU vs. 194.6 LU, P = 0.025). Exposure to rhIL-2 increased T cell-mediated lysis in both groups. Disruption of T cell cytotoxicity in RCC patients can be overcome by exposure to rhIL-2...
  19. ncbi request reprint Electrical impedance spectroscopy of the human prostate
    Ryan J Halter
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    IEEE Trans Biomed Eng 54:1321-7. 2007
    ..This is in agreement with trends observed in other tissues reported in much of the literature. Expanded studies are needed to further validate this finding and to explore the biological mechanism responsible for generating the results...
  20. ncbi request reprint Real-time polymerase chain reaction and laser capture microdissection for the diagnosis of BK virus infection in renal allografts
    Oyedele A Adeyi
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Am J Clin Pathol 124:537-42. 2005
    ..This technique detected BKV in tubular epithelial cells of renal allografts. To our knowledge, this is the first report of detecting BKV in laser capture microdissected renal biopsy specimens using real-time PCR...
  21. ncbi request reprint Distinct mechanisms of action of anti-CD154 in early versus late treatment of murine lupus nephritis
    Sergio A Quezada
    Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Arthritis Rheum 48:2541-54. 2003
    ..The aims of this study were to identify the mechanism of this early effect, to determine whether late anti-CD154 treatment could halt established nephritis, and, if so, to examine potential mechanisms of late efficacy...
  22. ncbi request reprint Occupation and bladder cancer risk in a population-based case-control study in New Hampshire
    Joanne S Colt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Occupational and Environmental Epidemiology Branch, Bethesda, MD 20892 7240, USA
    Cancer Causes Control 15:759-69. 2004
    ..To identify occupations with excess bladder cancer risk in New Hampshire, where bladder cancer mortality rates have been elevated for decades...
  23. ncbi request reprint Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 65:7081-5. 2005
    ..02) controlled for TP53 staining intensity and other survival-associated factors. Classifying tumors based on SFRP methylation status and TP53 protein staining intensity may be a clinically powerful predictor of invasive, deadly disease...