Research Topics
Genomes and Genes | Kathleen A MartinSummaryAffiliation: Dartmouth-Hitchcock Medical Center Country: USA Publications
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Publications
The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiationKathleen A Martin
Department of Surgery, Section of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Am J Physiol Cell Physiol 286:C507-17. 2004..In conclusion, we report that regulation of VSMC differentiation is a novel function of the rapamycin-sensitive mTOR signaling pathway...
Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4Min Ding
Section of Vascular Surgery, Department of Surgery, Dartmouth Medical School, Lebanon, NH, USA
Arterioscler Thromb Vasc Biol 31:1403-10. 2011..The adipocyte-secreted hormone adiponectin exerts important cardioprotective and antidiabetic effects. Little is known about its effect on vascular smooth muscle cells (VSMC), key cells in restenosis, hypertension, and atherosclerosis...- Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signalingKathleen A Martin
Division of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Biol Chem 282:36112-20. 2007.... - Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotypeMin Ding
Dartmouth Medical School, Department of Surgery, Section of Vascular Surgery, Lebanon, NH 03756, USA
J Mol Cell Cardiol 52:474-84. 2012..This article is part of a Special Issue entitled "Local Signaling in Myocytes"... - Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiationZsolt Kasza
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
J Mol Cell Cardiol 46:682-94. 2009..We conclude that prevention of de-differentiation and proliferation through a paracrine positive feedback mechanism is a major cardioprotective function of prostacyclin... - Lovastatin induces VSMC differentiation through inhibition of Rheb and mTORRobert J Wagner
Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Am J Physiol Cell Physiol 299:C119-27. 2010..In conclusion, these findings illustrate a mechanism for the cardioprotective effects of lovastatin through inhibition of Rheb and mTORC1 and promotion of a differentiated VSMC phenotype... - Regulation of vascular smooth muscle cell differentiationEva M Rzucidlo
Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH 03756, USA
J Vasc Surg 45:A25-32. 2007.... - Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiationDavid J Brown
Department of Surgery, Section of Vascular Surgery, Hitchcock Medical Center, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
J Vasc Surg 41:509-16. 2005..This pathway may suggest targets for therapeutic interventions for intimal hyperplasia and restenosis... - Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturitionKristina M Fetalvero
Department of Surgery, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Clin Invest 118:3966-79. 2008..Our observations have important implications regarding activation of the myometrium prior to the onset of labor... - Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstructionJeremiah Stitham
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Biol Chem 286:7060-9. 2011..This study demonstrates the potential utility of in vitro functional characterization in predicting clinical phenotypes and represents the most comprehensive characterization of human prostacyclin receptor genetic variants to date... - The prostacyclin receptor induces human vascular smooth muscle cell differentiation via the protein kinase A pathwayKristina M Fetalvero
Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Physiol Heart Circ Physiol 290:H1337-46. 2006..This provides important mechanistic insights into the induction of cardiovascular events with the use of selective COX-2 inhibitors... - Cardioprotective prostacyclin signaling in vascular smooth muscleKristina M Fetalvero
Department of Pharmacology and Toxicology, 7650 Remsen, Dartmouth Medical School, Hanover, NH 03755, and Department of Surgery, Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States
Prostaglandins Other Lipid Mediat 82:109-18. 2007..Understanding the role of prostacyclin and other eicosanoid mediators in the vasculature may lead to improved therapeutic and preventative options for cardiovascular disease... - Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumorsDennis Liang Fei
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
Cancer Res 70:1981-8. 2010..Thus, we provide an important insight into the etiology of arsenic-induced human carcinogenesis, which may be relevant to millions of people exposed to high levels of arsenic worldwide... - Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cellsChohreh Partovian
Angiogenesis Research Center, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Mol Cell 32:140-9. 2008..Thus, S4-dependent targeting of PKCalpha to the plasma membrane is required for recruitment of mTORC2 components to the rafts and Akt activation... 
The human prostacyclin receptor from structure function to diseaseKathleen A Martin
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Prog Mol Biol Transl Sci 89:133-66. 2009..The coming decade is likely to yield many further exciting advances...- Shp shape: FAKs about hypertrophyKathleen A Martin
Circ Res 103:776-8. 2008 - Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibitionEric Arehart
Department of Pharmacology and Toxicology, Dartmouth Hitchcock Medical Center, Hanover, NH 03755, USA
Circ Res 102:986-93. 2008..Combining both biochemical and clinical approaches, we conclude that diminished prostacyclin receptor signaling may contribute, in part, to the underlying adverse cardiovascular outcomes observed with cyclooxygenase-2 inhibition... - Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophyJulie R McMullen
Beth Israel Deaconess Medical Center, Cardiovascular Division, 330 Brookline Ave, SL 408, Boston, MA 02215, USA
Mol Cell Biol 24:6231-40. 2004..These studies suggest that S6Ks alone are not essential for the development of cardiac hypertrophy... - Coordinate regulation of translation by the PI 3-kinase and mTOR pathwaysKathleen A Martin
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Adv Cancer Res 86:1-39. 2002..The translational effectors regulated by the PI 3-kinase and mTOR pathways and their roles in regulation of cellular growth will be the primary focus of this review...