Kathleen A Martin

Summary

Affiliation: Dartmouth-Hitchcock Medical Center
Country: USA

Publications

  1. ncbi request reprint The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation
    Kathleen A Martin
    Department of Surgery, Section of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Am J Physiol Cell Physiol 286:C507-17. 2004
  2. pmc Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4
    Min Ding
    Section of Vascular Surgery, Department of Surgery, Dartmouth Medical School, Lebanon, NH, USA
    Arterioscler Thromb Vasc Biol 31:1403-10. 2011
  3. ncbi request reprint Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
    Kathleen A Martin
    Division of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 282:36112-20. 2007
  4. pmc Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype
    Min Ding
    Dartmouth Medical School, Department of Surgery, Section of Vascular Surgery, Lebanon, NH 03756, USA
    J Mol Cell Cardiol 52:474-84. 2012
  5. pmc Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation
    Zsolt Kasza
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Mol Cell Cardiol 46:682-94. 2009
  6. ncbi request reprint Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiation
    David J Brown
    Department of Surgery, Section of Vascular Surgery, Hitchcock Medical Center, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Vasc Surg 41:509-16. 2005
  7. pmc Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR
    Robert J Wagner
    Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Am J Physiol Cell Physiol 299:C119-27. 2010
  8. ncbi request reprint Regulation of vascular smooth muscle cell differentiation
    Eva M Rzucidlo
    Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Vasc Surg 45:A25-32. 2007
  9. pmc Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition
    Kristina M Fetalvero
    Department of Surgery, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Clin Invest 118:3966-79. 2008
  10. pmc Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 286:7060-9. 2011

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation
    Kathleen A Martin
    Department of Surgery, Section of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Am J Physiol Cell Physiol 286:C507-17. 2004
    ..In conclusion, we report that regulation of VSMC differentiation is a novel function of the rapamycin-sensitive mTOR signaling pathway...
  2. pmc Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4
    Min Ding
    Section of Vascular Surgery, Department of Surgery, Dartmouth Medical School, Lebanon, NH, USA
    Arterioscler Thromb Vasc Biol 31:1403-10. 2011
    ..The adipocyte-secreted hormone adiponectin exerts important cardioprotective and antidiabetic effects. Little is known about its effect on vascular smooth muscle cells (VSMC), key cells in restenosis, hypertension, and atherosclerosis...
  3. ncbi request reprint Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
    Kathleen A Martin
    Division of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 282:36112-20. 2007
    ....
  4. pmc Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype
    Min Ding
    Dartmouth Medical School, Department of Surgery, Section of Vascular Surgery, Lebanon, NH 03756, USA
    J Mol Cell Cardiol 52:474-84. 2012
    ..This article is part of a Special Issue entitled "Local Signaling in Myocytes"...
  5. pmc Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation
    Zsolt Kasza
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Mol Cell Cardiol 46:682-94. 2009
    ..We conclude that prevention of de-differentiation and proliferation through a paracrine positive feedback mechanism is a major cardioprotective function of prostacyclin...
  6. ncbi request reprint Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiation
    David J Brown
    Department of Surgery, Section of Vascular Surgery, Hitchcock Medical Center, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    J Vasc Surg 41:509-16. 2005
    ..We aimed to determine the intracellular signaling mechanisms by which ECs promote a differentiated SMC phenotype...
  7. pmc Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR
    Robert J Wagner
    Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Am J Physiol Cell Physiol 299:C119-27. 2010
    ..In conclusion, these findings illustrate a mechanism for the cardioprotective effects of lovastatin through inhibition of Rheb and mTORC1 and promotion of a differentiated VSMC phenotype...
  8. ncbi request reprint Regulation of vascular smooth muscle cell differentiation
    Eva M Rzucidlo
    Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Vasc Surg 45:A25-32. 2007
    ....
  9. pmc Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturition
    Kristina M Fetalvero
    Department of Surgery, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Clin Invest 118:3966-79. 2008
    ..Our observations have important implications regarding activation of the myometrium prior to the onset of labor...
  10. pmc Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction
    Jeremiah Stitham
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 286:7060-9. 2011
    ..This study demonstrates the potential utility of in vitro functional characterization in predicting clinical phenotypes and represents the most comprehensive characterization of human prostacyclin receptor genetic variants to date...
  11. ncbi request reprint The prostacyclin receptor induces human vascular smooth muscle cell differentiation via the protein kinase A pathway
    Kristina M Fetalvero
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Physiol Heart Circ Physiol 290:H1337-46. 2006
    ..This provides important mechanistic insights into the induction of cardiovascular events with the use of selective COX-2 inhibitors...
  12. ncbi request reprint Cardioprotective prostacyclin signaling in vascular smooth muscle
    Kristina M Fetalvero
    Department of Pharmacology and Toxicology, 7650 Remsen, Dartmouth Medical School, Hanover, NH 03755, and Department of Surgery, Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States
    Prostaglandins Other Lipid Mediat 82:109-18. 2007
    ..Understanding the role of prostacyclin and other eicosanoid mediators in the vasculature may lead to improved therapeutic and preventative options for cardiovascular disease...
  13. pmc Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors
    Dennis Liang Fei
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Res 70:1981-8. 2010
    ..Thus, we provide an important insight into the etiology of arsenic-induced human carcinogenesis, which may be relevant to millions of people exposed to high levels of arsenic worldwide...
  14. pmc Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells
    Chohreh Partovian
    Angiogenesis Research Center, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Mol Cell 32:140-9. 2008
    ..Thus, S4-dependent targeting of PKCalpha to the plasma membrane is required for recruitment of mTORC2 components to the rafts and Akt activation...
  15. doi request reprint The human prostacyclin receptor from structure function to disease
    Kathleen A Martin
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Prog Mol Biol Transl Sci 89:133-66. 2009
    ..The coming decade is likely to yield many further exciting advances...
  16. pmc Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK
    Anne Marie Thompson
    Section of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
    PLoS ONE 9:e85495. 2014
    ..We have demonstrated a supplemental avenue where-by resveratrol may promote health by maintaining and enhancing plasticity of the vasculature. ..
  17. pmc Shp shape: FAKs about hypertrophy
    Kathleen A Martin
    Circ Res 103:776-8. 2008
  18. pmc Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition
    Eric Arehart
    Department of Pharmacology and Toxicology, Dartmouth Hitchcock Medical Center, Hanover, NH 03755, USA
    Circ Res 102:986-93. 2008
    ..Combining both biochemical and clinical approaches, we conclude that diminished prostacyclin receptor signaling may contribute, in part, to the underlying adverse cardiovascular outcomes observed with cyclooxygenase-2 inhibition...
  19. pmc Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy
    Julie R McMullen
    Beth Israel Deaconess Medical Center, Cardiovascular Division, 330 Brookline Ave, SL 408, Boston, MA 02215, USA
    Mol Cell Biol 24:6231-40. 2004
    ..These studies suggest that S6Ks alone are not essential for the development of cardiac hypertrophy...
  20. ncbi request reprint Coordinate regulation of translation by the PI 3-kinase and mTOR pathways
    Kathleen A Martin
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Adv Cancer Res 86:1-39. 2002
    ..The translational effectors regulated by the PI 3-kinase and mTOR pathways and their roles in regulation of cellular growth will be the primary focus of this review...