Research Topics
| D J MalenkaSummaryAffiliation: Dartmouth-Hitchcock Medical Center Country: USA Publications
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Detail Information
Publications
The relationship between operator volume and outcomes after percutaneous coronary interventions in high volume hospitals in 1994-1996: the northern New England experience. Northern New England Cardiovascular Disease Study GroupD J Malenka
Section of Cardiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Am Coll Cardiol 34:1471-80. 1999..The purpose of this study was to examine the relationship between annual operator volume and outcomes of percutaneous coronary interventions (PCIs) using contemporaneous data...- Comparing long-term survival of patients with multivessel coronary disease after CABG or PCI: analysis of BARI-like patients in northern New EnglandDavid J Malenka
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Circulation 112:I371-6. 2005..Our goal in this study was to compare long-term survival of MVD patients treated with CABG vs PCI in contemporary practice... - Confusion in coronary revascularization in women: a structured approach to reviewing the dataDavid J Malenka
Department of Medicine, Dartmouth Medical School Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Cardiol Rev 14:303-7. 2006..It is suggested that a structured approach to data reporting can better track the emerging data on coronary revascularization in women... - Postmarketing surveillance of medical devices using Medicare claimsDavid J Malenka
Dartmouth Hitchcock Medical Center, in Lebanon, New Hampshire, USA
Health Aff (Millwood) 24:928-37. 2005.... 
Outcomes following coronary stenting in the era of bare-metal vs the era of drug-eluting stentsDavid J Malenka
Section of Cardiology, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
JAMA 299:2868-76. 2008..Our study focused on the effect of stent type on population-based interventional outcomes...- Gender-related changes in the practice and outcomes of percutaneous coronary interventions in Northern New England from 1994 to 1999David J Malenka
Section of Cardiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Am Coll Cardiol 40:2092-101. 2002..We sought to determine whether the changing practice of interventional cardiology has been associated with improved outcomes for women, and how these outcomes compare with those for men... - Differences in outcomes between women and men associated with percutaneous transluminal coronary angioplasty. A regional prospective study of 13,061 procedures. Northern New England Cardiovascular Disease Study GroupD J Malenka
Section of Cardiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Circulation 94:II99-104. 1996..Differences in patient characteristics, comorbidities, severity of illness, and treatments were examined and crude and adjusted odds ratios (ORs) for women versus men reported... - The Northern New England Cardiovascular Disease Study Group: a regional collaborative effort for continuous quality improvement in cardiovascular diseaseD J Malenka
Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Jt Comm J Qual Improv 24:594-600. 1998..Demonstrating the variability in practice patterns can be a potent stimulus to try to answer the important questions... - Cause of in-hospital death in 12,232 consecutive patients undergoing percutaneous transluminal coronary angioplasty. The Northern New England Cardiovascular Disease Study GroupD J Malenka
Sections of Cardiology and Clinical Research, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Am Heart J 137:632-8. 1999..To better describe the epidemiologic causes of death after PTCA, we undertook a systematic review of all in-hospital PTCA deaths in Northern New England from 1990 to 1993... - Changing outcomes in percutaneous coronary interventions: a study of 34,752 procedures in northern New England, 1990 to 1997. Northern New England Cardiovascular Disease Study GroupP D McGrath
Center for Outcomes Research and Evaluation, Department of Medicine, Maine Medical Center, Portland 04102, USA
J Am Coll Cardiol 34:674-80. 1999..We sought to evaluate the changing outcomes of percutaneous coronary interventions (PCIs) in recent years... 
Long-term survival of the very elderly undergoing coronary artery bypass graftingDonald S Likosky
Department of Surgery, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
Ann Thorac Surg 85:1233-7. 2008..Increasing numbers of the very elderly are undergoing coronary artery bypass graft surgery (CABG). Short-term results have been studied, but few data are available concerning long-term outcomes...- Intra- and postoperative predictors of stroke after coronary artery bypass graftingDonald S Likosky
Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Ann Thorac Surg 76:428-34; discussion 435. 2003..We developed a risk prediction model for stroke based on factors in intra- and postoperative care, after adjusting for a patient's preoperative risk... - Transient and persistent renal dysfunction are predictors of survival after percutaneous coronary intervention: insights from the Dartmouth Dynamic RegistryJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH 03756, USA
Catheter Cardiovasc Interv 72:347-54. 2008..We sought to determine if transient and persistent elevations in creatinine following percutaneous coronary intervention (PCI) resulted in poor survival... - Serious renal dysfunction after percutaneous coronary interventions can be predictedJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH, USA
Am Heart J 155:260-6. 2008..0 mg/dL absolute increase in creatinine, or a > or = 50% increase in creatinine). We hypothesized that preprocedural patient characteristics could be used to predict the risk of post-PCI SRD... - Improved in-hospital mortality in women undergoing coronary artery bypass grafting. Northern New England Cardiovascular Disease Study GroupD J O'Rourke
Section of Cardiology, Veterans Affairs Hospital, White River Junction, Vermont, USA
Ann Thorac Surg 71:507-11. 2001..Few studies have examined the changes in in-hospital mortality for women over time. We describe the changing case mix and mortality for women undergoing coronary artery bypass grafting (CABG) from 1987 to 1997 in northern New England... - Outcome of mild periprosthetic regurgitation detected by intraoperative transesophageal echocardiographyD J O'Rourke
Section of Cardiology, Veterans Affairs Hospital, White River Junction, Vermont, USA
J Am Coll Cardiol 38:163-6. 2001..The goal of this study was to determine the outcome of trivial or mild periprosthetic regurgitation (PPR) identified by intraoperative transesophageal echocardiography (TEE)... - Changes in the use of carotid revascularization among the medicare populationPhilip P Goodney
Section of Vascular Surgery, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03766, USA
Arch Surg 143:170-3. 2008..It remains unknown if the increasing use of carotid artery stenting (CAS) has caused a change in the population-based use of carotid endarterectomy (CEA). We sought to examine national trends in carotid revascularization... - Real world, long-term outcomes comparison between paclitaxel-eluting and sirolimus-eluting stent platformsMandeep S Sidhu
Section of Cardiology, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Interv Cardiol 23:167-75. 2010..2% for SES (95% CI 94.7-97.3) and 95.3% for PES (95% CI 93.7-96.5). SES and PES drug-eluting stent platforms have good and similar extended outcomes in this real world registry of unselected patients having PCI... - Long-term survival after surgery versus percutaneous intervention in octogenarians with multivessel coronary diseaseLawrence J Dacey
Department of Cardiothoracic Surgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Ann Thorac Surg 84:1904-11; discussion 1904-11. 2007..We studied the long-term survival of octogenarians with multivessel coronary artery disease undergoing PCI or CABG who might have been candidates for either procedure... - Prediction of survival after coronary revascularization: modeling short-term, mid-term, and long-term survivalTodd A MacKenzie
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
Ann Thorac Surg 87:463-72. 2009..We report on the development and validation of models for predicting long-term survival after coronary artery bypass graft surgery and percutaneous coronary intervention on the basis of recent experience... - Survival in patients with peripheral vascular disease after percutaneous coronary intervention and coronary artery bypass graft surgeryDaniel J O'Rourke
Section of Cardiology, Veterans Affairs Hospital, Hartland Road, White River Junction, Vermont 05006, USA
Ann Thorac Surg 78:466-70; discussion 470. 2004..The objective of this study was to compare survival in patients with PVD who underwent percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) surgery for multivessel coronary artery disease... - N-acetylcysteine prophylaxis significantly reduces the risk of radiocontrast-induced nephropathy: comprehensive meta-analysisMichael H Duong
Section of Cardiology, Dartmouth Hitchcock Medical Center, Lebanon, NW 03756, USA
Catheter Cardiovasc Interv 64:471-9. 2005..08). Prophylaxis with NAC significantly reduces the risk for RCIN. The reasons for improvement in serum creatinine in patients treated with NAC are unclear, but may include improved renal blood flow due to NAC and/or vigorous hydration... - Predicting vascular complications in percutaneous coronary interventionsWinthrop D Piper
Clinical Research Section, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Am Heart J 145:1022-9. 2003..Using a large, current, regional registry of percutaneous coronary interventions (PCI), we identified risk factors for postprocedure vascular complications and developed a scoring system to estimate individual patient risk... - Intraoperative and postoperative variables associated with strokes following cardiac surgeryDonald S Likosky
Department of Medicine, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire 03756, USA
Heart Surg Forum 7:E271-6. 2004..In the present study, we quantified the association between intraoperative and postoperative variables and stroke mechanisms while adjusting for patient and disease characteristics... - Sodium bicarbonate plus N-acetylcysteine prophylaxis: a meta-analysisJeremiah R Brown
The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire, USA
JACC Cardiovasc Interv 2:1116-24. 2009..We sought to conduct a meta-analysis to compare N-acetylcysteine (NAC) in combination with sodium bicarbonate (NaHCO(3)) for the prevention of contrast-induced acute kidney injury (AKI)... - Appropriateness of coronary artery bypass graft surgery performed in northern New EnglandGerald T O'Connor
Department of Medicine and of Community and Family Medicine, and Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire 03756, USA
J Am Coll Cardiol 51:2323-8. 2008..The goal of this study was to assess the concordance between the American College of Cardiology (ACC) and the American Heart Association (AHA) 2004 Guideline Update for Coronary Artery Bypass Graft Surgery and actual clinical practice... - Adjusting for patient differences in predicting hospital mortality for percutaneous coronary interventions in the Clinical Outcomes Assessment ProgramCharles Maynard
Department of Medicine, University of Washington, Department of Veterans Affairs Puget Sound Healthcare System, Seattle, Wash, USA
Am Heart J 145:658-64. 2003..This study describes the development and testing of models for predicting hospital mortality in patients undergoing PCI... - Determination of etiologic mechanisms of strokes secondary to coronary artery bypass graft surgeryDonald S Likosky
Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Stroke 34:2830-4. 2003..We developed and implemented a classification system to identify the distribution and timing of stroke subtypes... - The impact of hematocrit drop on long-term survival after cardiac catheterization: insights from the Dartmouth Dynamic RegistryCalvin C Leung
Department of Medicine, Section of Internal Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Catheter Cardiovasc Interv 75:378-86. 2010..The long-term prognostic implication of post-procedural hematocrit drops in patients undergoing cardiac catheterization outside the clinical trial setting is not well defined... - The framing effect of relative and absolute riskD J Malenka
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire
J Gen Intern Med 8:543-8. 1993..CONCLUSIONS: The "framing" of benefit (or risk) in relative versus absolute terms may have a major influence on patient preference... - Long-term survival of the very elderly undergoing aortic valve surgeryDonald S Likosky
Department of Surgery, Dartmouth Hitchcock Medical Center, Hanover, NH, USA
Circulation 120:S127-33. 2009..Increasing numbers of the very elderly are undergoing aortic valve procedures. We describe the short- and long-term survivorship for this cohort... - Multivariable prediction of renal insufficiency developing after cardiac surgeryJeremiah R Brown
Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Lebanon, NH 03756, USA
Circulation 116:I139-43. 2007..We hypothesized that preoperative patient characteristics could be used to predict the patient-specific risk of developing postoperative renal insufficiency... - Humoral and cellular factors responsible for coronary collateral formationJonathan A Sherman
Section of Cardiology, Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA
Am J Cardiol 98:1194-7. 2006..Rather, cellular properties, such as cell adhesion, or genetic differences between patients may be the driving force for collateral development... - Classification and atherosclerosis distribution in patients with left main coronary diseaseCraig A Thompson
Cardiology Section, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Interv Cardiol 22:431-6. 2009.... - Outcomes of percutaneous coronary interventions performed at centers without and with onsite coronary artery bypass graft surgeryDavid E Wennberg
Center for Outcomes Research and Evaluation, Portland, ME 04101, USA
JAMA 292:1961-8. 2004..An ongoing debate focuses on whether institutions should perform percutaneous coronary interventions (PCIs) without an onsite coronary artery bypass graft (CABG) surgery program... - Outcomes of percutaneous coronary intervention among elderly patients in cardiogenic shock: a multicenter, decade-long experienceHarold L Dauerman
University of Vermont College of Medicine, Burlington, Vermont, USA
J Invasive Cardiol 15:380-4. 2003..The objective of this study was to determine the characteristics and hospital mortality rate for elderly patients in cardiogenic shock undergoing emergent percutaneous coronary intervention (PCI)... - Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trialLeo R Zacharski
Research Service 151, White River Junction VA Medical Center, Department of Veterans Affairs Medical Center, 215 North Hartland Road, White River Junction, VT 05009, USA
J Natl Cancer Inst 100:996-1002. 2008..Excess iron has been implicated in cancer risk through increased iron-catalyzed free radical-mediated oxidative stress... - Multicenter experience in revascularization of very elderly patientsEric D Peterson
The Outcomes Research and Assessment Group, The Duke Clinical Research Institute, Durham, NC 27715, USA
Am Heart J 148:486-92. 2004..We pooled the largest PCI and CABG clinical registries in the United States to better understand revascularization procedure use, risks and outcomes in patients aged > or =75 years... - Frequency of stress testing to document ischemia prior to elective percutaneous coronary interventionGrace A Lin
Division of General Internal Medicine, University of California, San Francisco, USA
JAMA 300:1765-73. 2008..Guidelines call for documenting ischemia in patients with stable coronary artery disease prior to elective percutaneous coronary intervention (PCI)... - The relation between patients' outcomes and the volume of cardioverter-defibrillator implantation procedures performed by physicians treating Medicare beneficiariesSana M Al-Khatib
Duke Clinical Research Institute, Durham, North Carolina 22715, USA
J Am Coll Cardiol 46:1536-40. 2005..The purpose of this study is to determine if implantable cardioverter-defibrillator (ICD) implantation should be limited to physicians with high procedural volume... - ACC/AHA key data elements and definitions for measuring the clinical management and outcomes of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing ComRobert L McNamara
Circulation 109:3223-43. 2004 - ACC/AHA key data elements and definitions for measuring the clinical management and outcomes of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing ComRobert L McNamara
J Am Coll Cardiol 44:475-95. 2004 - Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trialLeo R Zacharski
White River Junction VA Medical Center, Research Service, Department of Veterans Affairs Medical Center, White River Junction, VT 05001, USA
JAMA 297:603-10. 2007..Accumulation of iron in excess of physiologic requirements has been implicated in risk of cardiovascular disease because of increased iron-catalyzed free radical-mediated oxidative stress...