Research Topics
| D A MahlerSummaryAffiliation: Dartmouth-Hitchcock Medical Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Longitudinal changes in patient-reported dyspnea in patients with COPDDonald A Mahler
Section of Pulmonary and Critical Care Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH 03756 0001, USA
COPD 9:522-7. 2012....
Concurrent use of indacaterol plus tiotropium in patients with COPD provides superior bronchodilation compared with tiotropium alone: a randomised, double-blind comparisonDonald A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
Thorax 67:781-8. 2012..The authors investigated the approach of dual bronchodilation using indacaterol, a once-daily long-acting β(2) agonist, and the long-acting muscarinic antagonist tiotropium, compared with tiotropium alone...- Continuous ratings of breathlessness during exercise by children and young adults with asthma and healthy controlsDonald A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756 000, USA
Pediatr Pulmonol 41:812-8. 2006..Both groups reported more ratings of breathlessness with this technique as exercise progressed... - Efficacy of salmeterol xinafoate in the treatment of COPDD A Mahler
Dartmouth Medical School, Lebanon, NH, USA
Chest 115:957-65. 1999..To examine and compare the efficacy and safety of salmeterol xinafoate, a long-acting inhaled beta2-adrenergic agonist, with inhaled ipratropium bromide and inhaled placebo in patients with COPD... - The MCID of the transition dyspnea index is a total score of one unitDonald A Mahler
Dartmouth Medical School, Lebanon, New Hampshire 03656 0001, USA
COPD 2:99-103. 2005..To further establish the MCID of the interview-administered and/or the SAC TDI, we recommend that a patient's report of global ratings of change by used as an independent standard or anchor... - Responsiveness of patient-reported breathlessness during exercise in persistent asthmaDonald A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756 0001, USA
Chest 131:195-200. 2007..The hypotheses were that hypercapnia would increase and hyperoxia would decrease the slope of power production-breathlessness ratings compared with a control condition during cycle ergometry... - Validity and responsiveness of the self-administered computerized versions of the baseline and transition dyspnea indexesDonald A Mahler
Dartmouth Hitchcock Medical Center, Pulmonary and Critical Care Medicine, 3 D, 1 Medical Center Dr, Lebanon, NH 03756 0001, USA
Chest 132:1283-90. 2007..The primary purpose of this study was to examine the validity and responsiveness of the self-administered computerized (SAC) versions of the multidimensional baseline dyspnea index (BDI) and the transition dyspnea index (TDI)... - Endogenous opioids modify dyspnoea during treadmill exercise in patients with COPDD A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Hanover, NH, USA
Eur Respir J 33:771-7. 2009..In conclusion, endogenous opioids modify dyspnoea during treadmill exercise in patients with chronic obstructive pulmonary disease by apparent alteration of central perception... 
Patient-reported dyspnea in COPD reliability and association with stage of diseaseDonald A Mahler
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
Chest 136:1473-9. 2009..The two purposes of this study were to examine the test-retest reliability of three widely used dyspnea instruments and to compare dyspnea scores at different stages of disease...- American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart diseaseDonald A Mahler
Dartmouth Hitchcock Medical Center, Pulmonary and Critical Care Medicine, Lebanon, NH 03756 0001, USA
Chest 137:674-91. 2010..This consensus statement was developed based on the understanding that patients with advanced lung or heart disease are not being treated consistently and effectively for relief of dyspnea... - Management of dyspnea in patients with advanced lung or heart disease: practical guidance from the American college of chest physicians consensus statementDonald A Mahler
Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
Pol Arch Med Wewn 120:160-6. 2010..Patients with advanced lung or heart disease are not generally being treated consistently and effectively for relief of dyspnea... - Mechanism of greater oxygen desaturation during walking compared with cycling in patients with COPDDonald A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
Chest 140:351-8. 2011..The purpose of this investigation was to investigate differences in ventilatory responses and gas exchange as proposed mechanisms for this observation... - Understanding mechanisms and documenting plausibility of palliative interventions for dyspneaDonald A Mahler
Dartmouth Medical School, Hanover, NH, USA, USA
Curr Opin Support Palliat Care 5:71-6. 2011..To review the mechanisms for the perception of dyspnea and to consider the plausibility of interventions that palliate dyspnea after optimal treatment of the underlying disease... - Mechanisms and measurement of dyspnea in chronic obstructive pulmonary diseaseDonald A Mahler
Dartmouth Medical School, Lebanon, NH 03756 0001, USA
Proc Am Thorac Soc 3:234-8. 2006..Patient-reported dyspnea based on activities of daily living and exercise testing provides distinct but complimentary information... - Responsiveness of continuous ratings of dyspnea during exercise in patients with COPDDonald A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
Med Sci Sports Exerc 37:529-35. 2005..To examine the responsiveness of a new computerized method for patients to provide continuous ratings of dyspnea during exercise in patients with chronic obstructive pulmonary disease (COPD)... - Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary diseaseDonald A Mahler
Dartmouth Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
Am J Respir Crit Care Med 166:1084-91. 2002..We conclude that FSC improved lung function and reduced the severity of dyspnea compared with individual components and placebo... - Evaluation of dyspnea in the elderlyDonald A Mahler
Dartmouth Medical School, Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03755 0001, USA
Clin Geriatr Med 19:19-33, v. 2003..The American Thoracic Society recently defined dyspnea as a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity... - Stability of dyspnea ratings after exercise training in patients with COPDDonald A Mahler
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
Med Sci Sports Exerc 35:1083-7. 2003..The purpose of this study was to examine whether patients with chronic obstructive pulmonary disease (COPD) would report similar ratings of dyspnea at the same relative exercise intensity after participation in pulmonary rehabilitation... - Dyspnea reliefD A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756-0001, USA
Monaldi Arch Chest Dis 59:331-4. 2003 - Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot studyDonald A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756 0001, USA
Chest 126:926-34. 2004..To investigate the efficacy and safety of a fully human monoclonal antibody recognizing the chemokine interleukin (IL)-8 in patients with COPD... - How should health-related quality of life be assessed in patients with COPD?D A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
Chest 117:54S-7S. 2000..quot; Selected studies using disease-specific instruments have demonstrated that beta(2)-agonist, anticholinergic, and theophylline medications can improve HRQOL, as compared with placebo therapy... - Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPDM L Ayers
Dept of Medicine, Dartmouth Medical School, Lebanon, NH, USA
Eur Respir J 17:1132-7. 2001..03). It is concluded that with the doses used, salmeterol and ipratropium provided similar dyspnoea ratings during exercise at 1 and 6 h after administration... - Continuous measurement of breathlessness during exercise: validity, reliability, and responsivenessD A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon 03756 0001, USA
J Appl Physiol 90:2188-96. 2001.... - Advantages of endurance treadmill walking compared with cycling to assess bronchodilator therapyXiaolei Zhang
Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756 0001, USA
Chest 137:1354-61. 2010..The hypothesis was that patients with COPD would exhibit greater improvements in exercise endurance and relief of breathlessness with bronchodilator therapy during treadmill walking compared with cycling... - Pathophysiology of dyspneaH L Manning
Pulmonary Section, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
Monaldi Arch Chest Dis 56:325-30. 2001..Hence, the language patients use to describe their dyspnea may provide clues to the etiology of their symptoms... - The effect of inhaled beta2-agonists on clinical outcomes in chronic obstructive pulmonary diseaseDonald A Mahler
Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
J Allergy Clin Immunol 110:S298-303. 2002..These results collectively demonstrate that long-acting inhaled beta(2)-agonists not only relax bronchial smooth muscle but also provide important clinical benefits in symptomatic patients with COPD... - Assessment tools for chronic obstructive pulmonary disease: do newer metrics allow for disease modification?Donald A Mahler
Division of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
Proc Am Thorac Soc 4:507-11. 2007..Finally, we consider the impact of disease modifying therapies on some of these metrics... - Development of self-administered versions of modified baseline and transition dyspnea indexes in COPDDonald A Mahler
Section of Pulmonary and Critical Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756 0001, USA
COPD 1:165-72. 2004..The advantages of the self-administered versions include standardized methodology and computerized scoring... - Comparison of continuous and discrete measurements of dyspnea during exercise in patients with COPD and normal subjectsGustavo Fierro-Carrion
NH 03756-0001, USA
Chest 125:77-84. 2004..Regression parameters and absolute thresholds discriminate between patients with COPD and healthy subjects... - Meaningful effect size and patterns of response of the transition dyspnea indexTheodore J Witek
Clinical and Scientific Affairs, Boehringer Ingelheim Pharmaceuticals, Inc, 900 Ridgebury Road, Ridgefield, CT 06877, USA
J Clin Epidemiol 56:248-55. 2003..Responders also had few exacerbations and better health status. The validity of the TDI is supported in a large clinical trial setting. A one-unit change in the TDI focal score represented the minimal important difference... - Are you fluent in the language of dyspnea?Donald A Mahler
Chest 134:476-7. 2008 - It's about time--directing our attention toward modifying the course of COPDMario Cazzola
University of Rome Tor Vergata, Department of Internal Medicine, Unit of Respiratory Diseases, Rome, Italy
Respir Med 102:S37-48. 2008..In this review we have considered three approaches toward modifying the course of COPD: smoking cessation, reduction in lung hyperinflation through medical and surgical approaches, and long-term pharmacotherapy... - More is better once again!Donald A Mahler
J Cardiopulm Rehabil 25:286-7. 2005 - Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtableDenis E O'Donnell
Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
Proc Am Thorac Soc 4:145-68. 2007..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment... - Hit the dyspnea target!Donald A Mahler
J Cardiopulm Rehabil 23:226-7. 2003 - Measuring the effects of COPD on the patientPaul Jones
St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
Respir Med 99:S11-8. 2005..Future developments will include computerising these methodologies to permit faster and more individual patient-centred measurements... - Effect of fluticasone propionate/salmeterol on lung hyperinflation and exercise endurance in COPDDenis E O'Donnell
Queen s University, Kingston, ON, Canada
Chest 130:647-56. 2006..To examine the effect of fluticasone propionate, 250 microg/salmeterol, 50 microg combination (FSC 250/50) twice daily on lung hyperinflation and associated measures of exercise performance in patients with COPD... - Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice GuidelinesAndrew L Ries
University of California, San Diego, Department of Pulmonary and Critical Care Medicine, UCSD Medical Center, 200 West Arbor Dr, San Diego, CA 92103 8377, USA
Chest 131:4S-42S. 2007.... - Is physical activity anti-inflammatory on the airways?Donald A Mahler
Thorax 62:376. 2007