D A Mahler

Summary

Affiliation: Dartmouth-Hitchcock Medical Center
Country: USA

Publications

  1. ncbi The MCID of the transition dyspnea index is a total score of one unit
    Donald A Mahler
    Dartmouth Medical School, Lebanon, New Hampshire 03656 0001, USA
    COPD 2:99-103. 2005
  2. ncbi Concurrent use of indacaterol plus tiotropium in patients with COPD provides superior bronchodilation compared with tiotropium alone: a randomised, double-blind comparison
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    Thorax 67:781-8. 2012
  3. doi Prevalence and COPD phenotype for a suboptimal peak inspiratory flow rate against the simulated resistance of the Diskus® dry powder inhaler
    Donald A Mahler
    Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
    J Aerosol Med Pulm Drug Deliv 26:174-9. 2013
  4. doi Effect of increased blood levels of β-endorphin on perception of breathlessness
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    Chest 143:1378-85. 2013
  5. doi Efficacy and safety of indacaterol and tiotropium in COPD patients according to dyspnoea severity
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Pulm Pharmacol Ther 26:348-55. 2013
  6. doi Opioids for refractory dyspnea
    Donald A Mahler
    Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA and Dartmouth Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, 5C, One Medical Center Drive, Lebanon, NH 03756, USA
    Expert Rev Respir Med 7:123-35. 2013
  7. doi Longitudinal changes in patient-reported dyspnea in patients with COPD
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH 03756 0001, USA
    COPD 9:522-7. 2012
  8. ncbi Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease
    Donald A Mahler
    Dartmouth Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
    Am J Respir Crit Care Med 166:1084-91. 2002
  9. ncbi Responsiveness of patient-reported breathlessness during exercise in persistent asthma
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756 0001, USA
    Chest 131:195-200. 2007
  10. ncbi Continuous ratings of breathlessness during exercise by children and young adults with asthma and healthy controls
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756 000, USA
    Pediatr Pulmonol 41:812-8. 2006

Detail Information

Publications43

  1. ncbi The MCID of the transition dyspnea index is a total score of one unit
    Donald A Mahler
    Dartmouth Medical School, Lebanon, New Hampshire 03656 0001, USA
    COPD 2:99-103. 2005
    ..To further establish the MCID of the interview-administered and/or the SAC TDI, we recommend that a patient's report of global ratings of change by used as an independent standard or anchor...
  2. ncbi Concurrent use of indacaterol plus tiotropium in patients with COPD provides superior bronchodilation compared with tiotropium alone: a randomised, double-blind comparison
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    Thorax 67:781-8. 2012
    ..The authors investigated the approach of dual bronchodilation using indacaterol, a once-daily long-acting β(2) agonist, and the long-acting muscarinic antagonist tiotropium, compared with tiotropium alone...
  3. doi Prevalence and COPD phenotype for a suboptimal peak inspiratory flow rate against the simulated resistance of the Diskus® dry powder inhaler
    Donald A Mahler
    Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
    J Aerosol Med Pulm Drug Deliv 26:174-9. 2013
    ....
  4. doi Effect of increased blood levels of β-endorphin on perception of breathlessness
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    Chest 143:1378-85. 2013
    ..The purpose of this investigation was to examine whether increased blood levels of β-endorphin modify breathlessness by a putative effect of binding to peripheral opioid receptors in the respiratory tract...
  5. doi Efficacy and safety of indacaterol and tiotropium in COPD patients according to dyspnoea severity
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Pulm Pharmacol Ther 26:348-55. 2013
    ..Guidelines for chronic obstructive pulmonary disease (COPD) recommend that treatment choices be based partly on symptoms...
  6. doi Opioids for refractory dyspnea
    Donald A Mahler
    Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA and Dartmouth Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, 5C, One Medical Center Drive, Lebanon, NH 03756, USA
    Expert Rev Respir Med 7:123-35. 2013
    ..Research is needed to address clinical uncertainties and to identify genetic factors to improve the use of opioids to relieve refractory dyspnea...
  7. doi Longitudinal changes in patient-reported dyspnea in patients with COPD
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH 03756 0001, USA
    COPD 9:522-7. 2012
    ....
  8. ncbi Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease
    Donald A Mahler
    Dartmouth Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
    Am J Respir Crit Care Med 166:1084-91. 2002
    ..We conclude that FSC improved lung function and reduced the severity of dyspnea compared with individual components and placebo...
  9. ncbi Responsiveness of patient-reported breathlessness during exercise in persistent asthma
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756 0001, USA
    Chest 131:195-200. 2007
    ..The hypotheses were that hypercapnia would increase and hyperoxia would decrease the slope of power production-breathlessness ratings compared with a control condition during cycle ergometry...
  10. ncbi Continuous ratings of breathlessness during exercise by children and young adults with asthma and healthy controls
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756 000, USA
    Pediatr Pulmonol 41:812-8. 2006
    ..Both groups reported more ratings of breathlessness with this technique as exercise progressed...
  11. doi Endogenous opioids modify dyspnoea during treadmill exercise in patients with COPD
    D A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Hanover, NH, USA
    Eur Respir J 33:771-7. 2009
    ..In conclusion, endogenous opioids modify dyspnoea during treadmill exercise in patients with chronic obstructive pulmonary disease by apparent alteration of central perception...
  12. pmc Patient-reported dyspnea in COPD reliability and association with stage of disease
    Donald A Mahler
    Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
    Chest 136:1473-9. 2009
    ..The two purposes of this study were to examine the test-retest reliability of three widely used dyspnea instruments and to compare dyspnea scores at different stages of disease...
  13. doi American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease
    Donald A Mahler
    Dartmouth Hitchcock Medical Center, Pulmonary and Critical Care Medicine, Lebanon, NH 03756 0001, USA
    Chest 137:674-91. 2010
    ..This consensus statement was developed based on the understanding that patients with advanced lung or heart disease are not being treated consistently and effectively for relief of dyspnea...
  14. ncbi Management of dyspnea in patients with advanced lung or heart disease: practical guidance from the American college of chest physicians consensus statement
    Donald A Mahler
    Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    Pol Arch Med Wewn 120:160-6. 2010
    ..Patients with advanced lung or heart disease are not generally being treated consistently and effectively for relief of dyspnea...
  15. doi Mechanism of greater oxygen desaturation during walking compared with cycling in patients with COPD
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
    Chest 140:351-8. 2011
    ..The purpose of this investigation was to investigate differences in ventilatory responses and gas exchange as proposed mechanisms for this observation...
  16. doi Understanding mechanisms and documenting plausibility of palliative interventions for dyspnea
    Donald A Mahler
    Dartmouth Medical School, Hanover, NH, USA, USA
    Curr Opin Support Palliat Care 5:71-6. 2011
    ..To review the mechanisms for the perception of dyspnea and to consider the plausibility of interventions that palliate dyspnea after optimal treatment of the underlying disease...
  17. ncbi Mechanisms and measurement of dyspnea in chronic obstructive pulmonary disease
    Donald A Mahler
    Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Proc Am Thorac Soc 3:234-8. 2006
    ..Patient-reported dyspnea based on activities of daily living and exercise testing provides distinct but complimentary information...
  18. ncbi Validity and responsiveness of the self-administered computerized versions of the baseline and transition dyspnea indexes
    Donald A Mahler
    Dartmouth Hitchcock Medical Center, Pulmonary and Critical Care Medicine, 3 D, 1 Medical Center Dr, Lebanon, NH 03756 0001, USA
    Chest 132:1283-90. 2007
    ..The primary purpose of this study was to examine the validity and responsiveness of the self-administered computerized (SAC) versions of the multidimensional baseline dyspnea index (BDI) and the transition dyspnea index (TDI)...
  19. ncbi Stability of dyspnea ratings after exercise training in patients with COPD
    Donald A Mahler
    Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
    Med Sci Sports Exerc 35:1083-7. 2003
    ..The purpose of this study was to examine whether patients with chronic obstructive pulmonary disease (COPD) would report similar ratings of dyspnea at the same relative exercise intensity after participation in pulmonary rehabilitation...
  20. ncbi Evaluation of dyspnea in the elderly
    Donald A Mahler
    Dartmouth Medical School, Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03755 0001, USA
    Clin Geriatr Med 19:19-33, v. 2003
    ..The American Thoracic Society recently defined dyspnea as a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity...
  21. ncbi Dyspnea relief
    D A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756 0001, USA
    Monaldi Arch Chest Dis 59:331-4. 2003
  22. ncbi Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot study
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756 0001, USA
    Chest 126:926-34. 2004
    ..To investigate the efficacy and safety of a fully human monoclonal antibody recognizing the chemokine interleukin (IL)-8 in patients with COPD...
  23. ncbi Responsiveness of continuous ratings of dyspnea during exercise in patients with COPD
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Medical School, Lebanon, NH 03756 0001, USA
    Med Sci Sports Exerc 37:529-35. 2005
    ..To examine the responsiveness of a new computerized method for patients to provide continuous ratings of dyspnea during exercise in patients with chronic obstructive pulmonary disease (COPD)...
  24. ncbi How should health-related quality of life be assessed in patients with COPD?
    D A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756 0001, USA
    Chest 117:54S-7S. 2000
    ..quot; Selected studies using disease-specific instruments have demonstrated that beta(2)-agonist, anticholinergic, and theophylline medications can improve HRQOL, as compared with placebo therapy...
  25. ncbi Efficacy of salmeterol xinafoate in the treatment of COPD
    D A Mahler
    Dartmouth Medical School, Lebanon, NH, USA
    Chest 115:957-65. 1999
    ..To examine and compare the efficacy and safety of salmeterol xinafoate, a long-acting inhaled beta2-adrenergic agonist, with inhaled ipratropium bromide and inhaled placebo in patients with COPD...
  26. ncbi Continuous measurement of breathlessness during exercise: validity, reliability, and responsiveness
    D A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon 03756 0001, USA
    J Appl Physiol 90:2188-96. 2001
    ....
  27. ncbi Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPD
    M L Ayers
    Dept of Medicine, Dartmouth Medical School, Lebanon, NH, USA
    Eur Respir J 17:1132-7. 2001
    ..03). It is concluded that with the doses used, salmeterol and ipratropium provided similar dyspnoea ratings during exercise at 1 and 6 h after administration...
  28. doi Advantages of endurance treadmill walking compared with cycling to assess bronchodilator therapy
    Xiaolei Zhang
    Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756 0001, USA
    Chest 137:1354-61. 2010
    ..The hypothesis was that patients with COPD would exhibit greater improvements in exercise endurance and relief of breathlessness with bronchodilator therapy during treadmill walking compared with cycling...
  29. ncbi Pathophysiology of dyspnea
    H L Manning
    Pulmonary Section, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Monaldi Arch Chest Dis 56:325-30. 2001
    ..Hence, the language patients use to describe their dyspnea may provide clues to the etiology of their symptoms...
  30. ncbi The effect of inhaled beta2-agonists on clinical outcomes in chronic obstructive pulmonary disease
    Donald A Mahler
    Section of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Allergy Clin Immunol 110:S298-303. 2002
    ..These results collectively demonstrate that long-acting inhaled beta(2)-agonists not only relax bronchial smooth muscle but also provide important clinical benefits in symptomatic patients with COPD...
  31. ncbi Development of self-administered versions of modified baseline and transition dyspnea indexes in COPD
    Donald A Mahler
    Section of Pulmonary and Critical Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756 0001, USA
    COPD 1:165-72. 2004
    ..The advantages of the self-administered versions include standardized methodology and computerized scoring...
  32. ncbi Assessment tools for chronic obstructive pulmonary disease: do newer metrics allow for disease modification?
    Donald A Mahler
    Division of Pulmonary and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Proc Am Thorac Soc 4:507-11. 2007
    ..Finally, we consider the impact of disease modifying therapies on some of these metrics...
  33. ncbi Comparison of continuous and discrete measurements of dyspnea during exercise in patients with COPD and normal subjects
    Gustavo Fierro-Carrion
    Dartmouth Hitchcock Medical Center Lebanon, NH 03756 0001, USA
    Chest 125:77-84. 2004
    ....
  34. doi It's about time--directing our attention toward modifying the course of COPD
    Mario Cazzola
    University of Rome Tor Vergata, Department of Internal Medicine, Unit of Respiratory Diseases, Rome, Italy
    Respir Med 102:S37-48. 2008
    ..In this review we have considered three approaches toward modifying the course of COPD: smoking cessation, reduction in lung hyperinflation through medical and surgical approaches, and long-term pharmacotherapy...
  35. ncbi More is better once again!
    Donald A Mahler
    J Cardiopulm Rehabil 25:286-7. 2005
  36. ncbi Effect of fluticasone propionate/salmeterol on lung hyperinflation and exercise endurance in COPD
    Denis E O'Donnell
    Queen s University, Kingston, ON, Canada
    Chest 130:647-56. 2006
    ..To examine the effect of fluticasone propionate, 250 microg/salmeterol, 50 microg combination (FSC 250/50) twice daily on lung hyperinflation and associated measures of exercise performance in patients with COPD...
  37. ncbi Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
    ..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment...
  38. ncbi Are you fluent in the language of dyspnea?
    Donald A Mahler
    Chest 134:476-7. 2008
  39. ncbi Measuring the effects of COPD on the patient
    Paul Jones
    St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Respir Med 99:S11-8. 2005
    ..Future developments will include computerising these methodologies to permit faster and more individual patient-centred measurements...
  40. ncbi Hit the dyspnea target!
    Donald A Mahler
    J Cardiopulm Rehabil 23:226-7. 2003
  41. ncbi Meaningful effect size and patterns of response of the transition dyspnea index
    Theodore J Witek
    Clinical and Scientific Affairs, Boehringer Ingelheim Pharmaceuticals, Inc, 900 Ridgebury Road, Ridgefield, CT 06877, USA
    J Clin Epidemiol 56:248-55. 2003
    ..Responders also had few exacerbations and better health status. The validity of the TDI is supported in a large clinical trial setting. A one-unit change in the TDI focal score represented the minimal important difference...
  42. pmc Is physical activity anti-inflammatory on the airways?
    Donald A Mahler
    Thorax 62:376. 2007
  43. ncbi Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines
    Andrew L Ries
    University of California, San Diego, Department of Pulmonary and Critical Care Medicine, UCSD Medical Center, 200 West Arbor Dr, San Diego, CA 92103 8377, USA
    Chest 131:4S-42S. 2007
    ....