B E Lacy

Summary

Affiliation: Dartmouth-Hitchcock Medical Center
Country: USA

Publications

  1. ncbi request reprint Tegaserod: a new 5-HT4 agonist
    Brian E Lacy
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Gastroenterol 34:27-33. 2002
  2. pmc Partnering with gastroenterologists to evaluate patients with chronic constipation
    Brian E Lacy
    GI Motility Laboratory, Division of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    MedGenMed 7:19. 2005
  3. ncbi request reprint Physicians' attitudes and practices in the evaluation and treatment of irritable bowel syndrome
    Brian E Lacy
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Scand J Gastroenterol 41:892-902. 2006
  4. ncbi request reprint Gastrointestinal motility disorders: an update
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Dig Dis 24:228-42. 2006
  5. doi request reprint Review article: current treatment options and management of functional dyspepsia
    B E Lacy
    Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Aliment Pharmacol Ther 36:3-15. 2012
  6. doi request reprint Linaclotide in the management of gastrointestinal tract disorders
    B E Lacy
    Dartmouth Hitchcock Medical Center Gastroenterology, Lebanon, New Hampshire 03756, USA
    Drugs Today (Barc) 48:197-206. 2012
  7. ncbi request reprint Lubiprostone: a chloride channel activator
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Clin Gastroenterol 41:345-51. 2007
  8. ncbi request reprint Age, specialty, and practice setting predict gastroesophageal reflux disease prescribing behavior
    Brian E Lacy
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Gastroenterol 39:489-94. 2005
  9. pmc Lubiprostone: a novel treatment for chronic constipation
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Interv Aging 3:357-64. 2008
  10. ncbi request reprint Gastric motility, gastroparesis, and gastric stimulation
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Area 4C, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Surg Clin North Am 85:967-87, vi-vii. 2005

Detail Information

Publications43

  1. ncbi request reprint Tegaserod: a new 5-HT4 agonist
    Brian E Lacy
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Gastroenterol 34:27-33. 2002
    ..This article discusses the role of serotonin in gastrointestinal tract physiology, the structure and pharmacokinetic profile of tegaserod, and clinical applications of this new drug...
  2. pmc Partnering with gastroenterologists to evaluate patients with chronic constipation
    Brian E Lacy
    GI Motility Laboratory, Division of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    MedGenMed 7:19. 2005
    ....
  3. ncbi request reprint Physicians' attitudes and practices in the evaluation and treatment of irritable bowel syndrome
    Brian E Lacy
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Scand J Gastroenterol 41:892-902. 2006
    ....
  4. ncbi request reprint Gastrointestinal motility disorders: an update
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Dig Dis 24:228-42. 2006
    ....
  5. doi request reprint Review article: current treatment options and management of functional dyspepsia
    B E Lacy
    Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Aliment Pharmacol Ther 36:3-15. 2012
    ..Symptoms of FD are non-specific and the pathophysiology is diverse, which explains in part why a universally effective treatment for FD remains elusive...
  6. doi request reprint Linaclotide in the management of gastrointestinal tract disorders
    B E Lacy
    Dartmouth Hitchcock Medical Center Gastroenterology, Lebanon, New Hampshire 03756, USA
    Drugs Today (Barc) 48:197-206. 2012
    ..Preclinical data, clinical studies and safety data will also be reviewed...
  7. ncbi request reprint Lubiprostone: a chloride channel activator
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Clin Gastroenterol 41:345-51. 2007
    ..This article reviews the role of chloride channels in the GI tract, describes the structure, function, and pharmacokinetics of lubiprostone, and discusses clinically important data on this new medication...
  8. ncbi request reprint Age, specialty, and practice setting predict gastroesophageal reflux disease prescribing behavior
    Brian E Lacy
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Gastroenterol 39:489-94. 2005
    ..This study was undertaken to determine physician prescribing practices in the treatment of GERD...
  9. pmc Lubiprostone: a novel treatment for chronic constipation
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Interv Aging 3:357-64. 2008
    ..This article will provide a brief overview on chloride channel function in the gastrointestinal tract, describe the structure, function, and pharmacokinetics of lubiprostone, and discuss the safety and efficacy of this new medication...
  10. ncbi request reprint Gastric motility, gastroparesis, and gastric stimulation
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Area 4C, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Surg Clin North Am 85:967-87, vi-vii. 2005
    ..This article reviews normal and abnormal gastric motility, discusses the etiology and pathogenesis of gastroparesis, and provides an overview on new treatment options for gastroparesis, including gastric stimulation...
  11. ncbi request reprint Irritable bowel syndrome: patients' attitudes, concerns and level of knowledge
    B E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Aliment Pharmacol Ther 25:1329-41. 2007
    ..Irritable bowel syndrome (IBS) is a common, chronic disorder that reduces patients' quality-of-life. Although highly prevalent, little is known about patients' understanding of this disorder...
  12. doi request reprint Esophageal motility disorders: medical therapy
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Clin Gastroenterol 42:652-8. 2008
    ..This review will briefly discuss the impact, etiology, and diagnosis of esophageal motility disorders, and then focus on the medical management of these disorders using evidence from well-designed, prospective studies, where available...
  13. doi request reprint The effects of nebulized albuterol on esophageal function in asthmatic patients
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Area 4C, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Dig Dis Sci 53:2627-33. 2008
    ..Changes in esophageal function in response to nebulized albuterol or placebo were evaluated over two sessions spaced 1 week apart...
  14. ncbi request reprint Irritable bowel syndrome: a syndrome in evolution
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Clin Gastroenterol 39:S230-42. 2005
    ..We will discuss how the definition of IBS has changed, consider our evolving strategies to evaluate and diagnose IBS, and finally, provide a brief overview of treatment options for this common disorder...
  15. ncbi request reprint The treatment of diabetic gastroparesis with botulinum toxin injection of the pylorus
    Brian E Lacy
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Diabetes Care 27:2341-7. 2004
    ....
  16. doi request reprint Clinical utility of the wireless pH capsule
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Clin Gastroenterol 45:429-35. 2011
    ..The aim of this prospective study was to determine whether this test changes patient diagnosis, provides new information, or alters patient care...
  17. doi request reprint Functional dyspepsia is associated with sleep disorders
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Clin Gastroenterol Hepatol 9:410-4. 2011
    ..Functional dyspepsia (FD) is highly prevalent. We evaluated sleep quality in FD patients, and quantified the relationship between disordered sleep, FD severity, and mental and physical well-being...
  18. doi request reprint The diagnosis of gastroesophageal reflux disease
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Am J Med 123:583-92. 2010
    ..The utility of commonly used tests for the diagnosis of gastroesophageal reflux disease has not been adequately reviewed...
  19. doi request reprint Prucalopride for chronic constipation
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Drugs Today (Barc) 45:843-53. 2009
    ..In this monograph, we review the pharmacology, mechanism of action, efficacy and safety of the selective 5-HT4 agonist prucalopride in patients with chronic constipation...
  20. doi request reprint Tolerability and clinical utility of the Bravo pH capsule in children
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Clin Gastroenterol 43:514-9. 2009
    ..To prospectively evaluate the tolerability and clinical utility of the Bravo pH capsule in children...
  21. ncbi request reprint Lubiprostone: chronic constipation and irritable bowel syndrome with constipation
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Area 4C, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Expert Opin Pharmacother 10:143-52. 2009
    ....
  22. doi request reprint Functional dyspepsia: the economic impact to patients
    B E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Aliment Pharmacol Ther 38:170-7. 2013
    ..Although highly prevalent, little is known about the economic impact of functional dyspepsia (FD)...
  23. ncbi request reprint The effects of an inhaled beta(2)-adrenergic agonist on lower esophageal function: a dose-response study
    M D Crowell
    Marvin M. Schuster Center for Digestive and Motility Disorders, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 120:1184-9. 2001
    ..Inhaled beta(2)-agonists may increase the likelihood of acid reflux in a subset of patients who receive cumulative dosing...
  24. doi request reprint The effects of intraduodenal nutrient infusion on serum CCK, LES pressure, and gastroesophageal reflux
    B E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Neurogastroenterol Motil 23:631-e256. 2011
    ..This study was designed to evaluate the effects of intraduodenal nutrient infusion on serum CCK levels, lower esophageal sphincter (LES) pressure, and gastroesophageal reflux (GER)...
  25. ncbi request reprint The effects of tegaserod, a 5-HT receptor agonist, on gastric emptying in a murine model of diabetes mellitus
    M D Crowell
    The Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurogastroenterol Motil 17:738-43. 2005
    ..We assessed gastric emptying rates in C57BLKS/J mice, and determined the effects of tegaserod, a new selective 5-HT(4) receptor partial agonist, on gastric emptying...
  26. ncbi request reprint Helicobacter pylori: ulcers and more: the beginning of an era
    B E Lacy
    Marvin M Schuster Motility Center, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    J Nutr 131:2789S-2793S. 2001
    ..pylori, reviews the different methods of diagnosing and treating this common infection, and then focuses on the effects that H. pylori has on different organ systems within the body, including the nutritional status of those affected...
  27. ncbi request reprint Generalized intestinal dysmotility in a patient with syringomyelia
    B E Lacy
    The Marvin M. Schuster Center for Digestive and Motility Disorders, The Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA
    Am J Gastroenterol 96:1282-5. 2001
    ..This report highlights the need for more objective studies of gastrointestinal motility in patients with syringomyelia...
  28. ncbi request reprint Inflammatory causes of gastroparesis: report of five cases
    H Pande
    Marvin M Schuster Center for Digestive and Motility Disorders, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Dig Dis Sci 47:2664-8. 2002
  29. ncbi request reprint Botulinum toxin for the treatment of gastroparesis: a preliminary report
    Brian E Lacy
    The Division of Digestive Disease and the Marvin M Schuster Center for Digestive and Motility Disorders, John Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA
    Am J Gastroenterol 97:1548-52. 2002
    ..Possible mechanisms of action of botulinum toxin on the pylorus and its effects in patients with gastroparesis are discussed...
  30. ncbi request reprint Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrhea
    Nicholas J Talley
    Mayo Foundation, Mayo Medical School, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 98:2454-9. 2003
    ..We aimed to determine and to compare the distribution of GI symptoms, both, upper and lower, among IBS-C and IBS-D patients...
  31. ncbi request reprint Esophageal manometry and pH monitoring: gastroenterologists' adherence to published guidelines
    M Aamir Ali
    Division of Gastroenterology, George Washington University Medical Center, Washington, DC, USA
    J Clin Gastroenterol 39:584-90. 2005
    ..To determine whether gastroenterologists use esophageal manometry (EM) and esophageal pH recording (pHR) in accordance with published guidelines...
  32. ncbi request reprint Patient knowledge and perspective on irritable bowel syndrome: development of a survey instrument
    Kirsten Teaney Weiser
    Division of Gastroenterology and Hepatology, Area 4C, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Dig Dis Sci 53:284-95. 2008
    ..The aims of this study were to operationalize the constructs used by patients to understand their symptoms and to develop a reliable, validated questionnaire...
  33. doi request reprint A 32-year-old woman with chronic abdominal pain
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    JAMA 299:555-65. 2008
    ..Using the case of Ms C, we apply an evidence-based approach to highlight current knowledge in the diagnosis, evaluation, and treatment of functional dyspepsia...
  34. ncbi request reprint Safety and tolerability of transoral Bravo capsule placement after transnasal manometry using a validated conversion factor
    Brian E Lacy
    Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Am J Gastroenterol 102:24-32. 2007
    ....
  35. ncbi request reprint Impact of anal incontinence on psychosocial function and health-related quality of life
    Michael D Crowell
    The Marvin M Schuster Center for Digestive and Motility Disorders, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Dig Dis Sci 52:1627-31. 2007
    ..AI was associated with impaired psychosocial function and decreased HRQOL. The frequency of AI was associated with increased HRQOL-Interference, but minimally with the degree of psychosocial impairment...
  36. ncbi request reprint Case report: botulinum toxin in hypertensive lower esophageal sphincter: a manometric case study
    Brian E Lacy
    The Marvin M Schuster Center for Gastrointestinal Motility and Digestive Disorders, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA
    Dysphagia 17:75-80. 2002
    ..Current pathophysiologic hypotheses for HLES-associated dysphagia and its treatment are briefly reviewed in this report...
  37. ncbi request reprint Irritable bowel syndrome: basis of clinical management strategies
    J G Rosemore
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Gastroenterol 35:S37-44. 2002
    ..This review article will discuss the myriad of treatments available for patients with IBS, and provide both a clinical and practical discussion of their use, providing evidence where available and clinical experience where it is not...
  38. ncbi request reprint Defining and treating constipation in older adults
    Brian E Lacy
    Am Fam Physician 74:715-6; author reply 716. 2006
  39. doi request reprint Esophageal reflux and motility update: GERD, NERD and spasm. Introduction
    Martin H Floch
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Gastroenterol 42:557. 2008
  40. ncbi request reprint Irritable bowel syndrome: a primer on management
    Brian E Lacy
    Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Rev Gastroenterol Disord 3:S32-42. 2003
    ..In addition, new agents that affect the serotonin system and treat the global symptoms of IBS are described...
  41. ncbi request reprint Therapy for irritable bowel syndrome
    Brian E Lacy
    N Engl J Med 350:1261-3; author reply 1261-3. 2004
  42. pmc Irritable bowel syndrome and functional dyspepsia: different diseases or a single disorder with different manifestations?
    Laura Noddin
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
    MedGenMed 7:17. 2005
  43. ncbi request reprint IBS and autonomic nervous system responses to pain
    Brian E Lacy
    J Clin Gastroenterol 40:767-8. 2006