Research Topics
| B E LacySummaryAffiliation: Dartmouth-Hitchcock Medical Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Tegaserod: a new 5-HT4 agonistBrian E Lacy
Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Clin Gastroenterol 34:27-33. 2002..This article discusses the role of serotonin in gastrointestinal tract physiology, the structure and pharmacokinetic profile of tegaserod, and clinical applications of this new drug...
Partnering with gastroenterologists to evaluate patients with chronic constipationBrian E Lacy
GI Motility Laboratory, Division of Gastroenterology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
MedGenMed 7:19. 2005....- Physicians' attitudes and practices in the evaluation and treatment of irritable bowel syndromeBrian E Lacy
Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Scand J Gastroenterol 41:892-902. 2006.... - Gastrointestinal motility disorders: an updateBrian E Lacy
Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Dig Dis 24:228-42. 2006.... 
Review article: current treatment options and management of functional dyspepsiaB E Lacy
Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Aliment Pharmacol Ther 36:3-15. 2012..Symptoms of FD are non-specific and the pathophysiology is diverse, which explains in part why a universally effective treatment for FD remains elusive...- Linaclotide in the management of gastrointestinal tract disordersB E Lacy
Dartmouth Hitchcock Medical Center Gastroenterology, Lebanon, New Hampshire 03756, USA
Drugs Today (Barc) 48:197-206. 2012..Preclinical data, clinical studies and safety data will also be reviewed... - Esophageal motility disorders: medical therapyBrian E Lacy
Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
J Clin Gastroenterol 42:652-8. 2008..This review will briefly discuss the impact, etiology, and diagnosis of esophageal motility disorders, and then focus on the medical management of these disorders using evidence from well-designed, prospective studies, where available... - Irritable bowel syndrome: a syndrome in evolutionBrian E Lacy
Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
J Clin Gastroenterol 39:S230-42. 2005..We will discuss how the definition of IBS has changed, consider our evolving strategies to evaluate and diagnose IBS, and finally, provide a brief overview of treatment options for this common disorder... - Age, specialty, and practice setting predict gastroesophageal reflux disease prescribing behaviorBrian E Lacy
Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Clin Gastroenterol 39:489-94. 2005..This study was undertaken to determine physician prescribing practices in the treatment of GERD... - Gastric motility, gastroparesis, and gastric stimulationBrian E Lacy
Section of Gastroenterology and Hepatology, Area 4C, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
Surg Clin North Am 85:967-87, vi-vii. 2005..This article reviews normal and abnormal gastric motility, discusses the etiology and pathogenesis of gastroparesis, and provides an overview on new treatment options for gastroparesis, including gastric stimulation... - Irritable bowel syndrome: patients' attitudes, concerns and level of knowledgeB E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
Aliment Pharmacol Ther 25:1329-41. 2007..Irritable bowel syndrome (IBS) is a common, chronic disorder that reduces patients' quality-of-life. Although highly prevalent, little is known about patients' understanding of this disorder... - The effects of nebulized albuterol on esophageal function in asthmatic patientsBrian E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Area 4C, 1 Medical Center Drive, Lebanon, NH 03756, USA
Dig Dis Sci 53:2627-33. 2008..Changes in esophageal function in response to nebulized albuterol or placebo were evaluated over two sessions spaced 1 week apart... - Lubiprostone: a chloride channel activatorBrian E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
J Clin Gastroenterol 41:345-51. 2007..This article reviews the role of chloride channels in the GI tract, describes the structure, function, and pharmacokinetics of lubiprostone, and discusses clinically important data on this new medication... - The treatment of diabetic gastroparesis with botulinum toxin injection of the pylorusBrian E Lacy
Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
Diabetes Care 27:2341-7. 2004.... - Lubiprostone: a novel treatment for chronic constipationBrian E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Clin Interv Aging 3:357-64. 2008..This article will provide a brief overview on chloride channel function in the gastrointestinal tract, describe the structure, function, and pharmacokinetics of lubiprostone, and discuss the safety and efficacy of this new medication... - Functional dyspepsia is associated with sleep disordersBrian E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Clin Gastroenterol Hepatol 9:410-4. 2011..Functional dyspepsia (FD) is highly prevalent. We evaluated sleep quality in FD patients, and quantified the relationship between disordered sleep, FD severity, and mental and physical well-being... - The diagnosis of gastroesophageal reflux diseaseBrian E Lacy
Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Am J Med 123:583-92. 2010..The utility of commonly used tests for the diagnosis of gastroesophageal reflux disease has not been adequately reviewed... - Clinical utility of the wireless pH capsuleBrian E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
J Clin Gastroenterol 45:429-35. 2011..The aim of this prospective study was to determine whether this test changes patient diagnosis, provides new information, or alters patient care... - Prucalopride for chronic constipationBrian E Lacy
Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Drugs Today (Barc) 45:843-53. 2009..In this monograph, we review the pharmacology, mechanism of action, efficacy and safety of the selective 5-HT4 agonist prucalopride in patients with chronic constipation... - Tolerability and clinical utility of the Bravo pH capsule in childrenBrian E Lacy
Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
J Clin Gastroenterol 43:514-9. 2009..To prospectively evaluate the tolerability and clinical utility of the Bravo pH capsule in children... - Lubiprostone: chronic constipation and irritable bowel syndrome with constipationBrian E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Area 4C, 1 Medical Center Drive, Lebanon, NH 03756, USA
Expert Opin Pharmacother 10:143-52. 2009.... - The effects of an inhaled beta(2)-adrenergic agonist on lower esophageal function: a dose-response studyM D Crowell
Marvin M. Schuster Center for Digestive and Motility Disorders, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Chest 120:1184-9. 2001..Inhaled beta(2)-agonists may increase the likelihood of acid reflux in a subset of patients who receive cumulative dosing... - The effects of intraduodenal nutrient infusion on serum CCK, LES pressure, and gastroesophageal refluxB E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Neurogastroenterol Motil 23:631-e256. 2011..This study was designed to evaluate the effects of intraduodenal nutrient infusion on serum CCK levels, lower esophageal sphincter (LES) pressure, and gastroesophageal reflux (GER)... - The effects of tegaserod, a 5-HT receptor agonist, on gastric emptying in a murine model of diabetes mellitusM D Crowell
The Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurogastroenterol Motil 17:738-43. 2005..We assessed gastric emptying rates in C57BLKS/J mice, and determined the effects of tegaserod, a new selective 5-HT(4) receptor partial agonist, on gastric emptying... - Helicobacter pylori: ulcers and more: the beginning of an eraB E Lacy
Marvin M Schuster Motility Center, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
J Nutr 131:2789S-2793S. 2001..pylori, reviews the different methods of diagnosing and treating this common infection, and then focuses on the effects that H. pylori has on different organ systems within the body, including the nutritional status of those affected... - Generalized intestinal dysmotility in a patient with syringomyeliaB E Lacy
The Marvin M. Schuster Center for Digestive and Motility Disorders, The Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA
Am J Gastroenterol 96:1282-5. 2001..This report highlights the need for more objective studies of gastrointestinal motility in patients with syringomyelia... - Inflammatory causes of gastroparesis: report of five casesH Pande
Marvin M. Schuster Center for Digestive and Motility Disorders, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Dig Dis Sci 47:2664-8. 2002 - Esophageal manometry and pH monitoring: gastroenterologists' adherence to published guidelinesM Aamir Ali
Division of Gastroenterology, George Washington University Medical Center, Washington, DC, USA
J Clin Gastroenterol 39:584-90. 2005..In addition, the use of pHR to evaluate persistent GERD symptoms after anti-reflux surgery was less than anticipated... - Botulinum toxin for the treatment of gastroparesis: a preliminary reportBrian E Lacy
The Division of Digestive Disease and the Marvin M. Schuster Center for Digestive and Motility Disorders, John Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA
Am J Gastroenterol 97:1548-52. 2002..Possible mechanisms of action of botulinum toxin on the pylorus and its effects in patients with gastroparesis are discussed... - A 32-year-old woman with chronic abdominal painBrian E Lacy
Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
JAMA 299:555-65. 2008..Using the case of Ms C, we apply an evidence-based approach to highlight current knowledge in the diagnosis, evaluation, and treatment of functional dyspepsia... - Patient knowledge and perspective on irritable bowel syndrome: development of a survey instrumentKirsten Teaney Weiser
Division of Gastroenterology and Hepatology, Area 4C, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Dig Dis Sci 53:284-95. 2008..The aims of this study were to operationalize the constructs used by patients to understand their symptoms and to develop a reliable, validated questionnaire... - Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrheaNicholas J Talley
Mayo Foundation, Mayo Medical School, Rochester, Minnesota 55905, USA
Am J Gastroenterol 98:2454-9. 2003..Although there was considerable overlap of upper and lower GI symptoms in patients with IBS-C and IBS-D, the former had more frequent lower abdominal pain and bloating... - Irritable bowel syndrome: basis of clinical management strategiesJ G Rosemore
Marvin M. Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Clin Gastroenterol 35:S37-44. 2002..This review article will discuss the myriad of treatments available for patients with IBS, and provide both a clinical and practical discussion of their use, providing evidence where available and clinical experience where it is not... - Case report: botulinum toxin in hypertensive lower esophageal sphincter: a manometric case studyBrian E Lacy
The Marvin M. Schuster Center for Gastrointestinal Motility and Digestive Disorders, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA
Dysphagia 17:75-80. 2002..Current pathophysiologic hypotheses for HLES-associated dysphagia and its treatment are briefly reviewed in this report... - Irritable bowel syndrome: a primer on managementBrian E Lacy
Marvin M Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Rev Gastroenterol Disord 3:S32-42. 2003..In addition, new agents that affect the serotonin system and treat the global symptoms of IBS are described... - Therapy for irritable bowel syndromeBrian E Lacy
N Engl J Med 350:1261-3; author reply 1261-3. 2004 - Esophageal reflux and motility update: GERD, NERD and spasm. IntroductionMartin H Floch
Yale University School of Medicine, New Haven, CT 06520, USA
J Clin Gastroenterol 42:557. 2008 - Irritable bowel syndrome and functional dyspepsia: different diseases or a single disorder with different manifestations?Laura Noddin
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA
MedGenMed 7:17. 2005 - Defining and treating constipation in older adultsBrian E Lacy
Am Fam Physician 74:715-6; author reply 716. 2006 - Impact of anal incontinence on psychosocial function and health-related quality of lifeMichael D Crowell
The Marvin M Schuster Center for Digestive and Motility Disorders, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Dig Dis Sci 52:1627-31. 2007..AI was associated with impaired psychosocial function and decreased HRQOL. The frequency of AI was associated with increased HRQOL-Interference, but minimally with the degree of psychosocial impairment... - Safety and tolerability of transoral Bravo capsule placement after transnasal manometry using a validated conversion factorBrian E Lacy
Section of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Am J Gastroenterol 102:24-32. 2007.... - IBS and autonomic nervous system responses to painBrian E Lacy
J Clin Gastroenterol 40:767-8. 2006