Ann Christine Duhaime

Summary

Affiliation: Dartmouth-Hitchcock Medical Center
Country: USA

Publications

  1. ncbi Traumatic brain injury in infants: the phenomenon of subdural hemorrhage with hemispheric hypodensity ("Big Black Brain")
    Ann Christine Duhaime
    Pediatric Neurosurgery, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Prog Brain Res 161:293-302. 2007
  2. ncbi Why are clinical trials in pediatric head injury so difficult?
    Ann Christine Duhaime
    Pediatr Crit Care Med 8:71. 2007
  3. ncbi Large animal models of traumatic injury to the immature brain
    Ann Christine Duhaime
    Pediatric Neurosurgery, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Dev Neurosci 28:380-7. 2006
  4. ncbi Functional magnetic resonance imaging of the primary somatosensory cortex in piglets
    Ann Christine Duhaime
    Department of Pediatric Neurosurgery, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurosurg 104:259-64. 2006
  5. doi Interictal PET and ictal subtraction SPECT: sensitivity in the detection of seizure foci in patients with medically intractable epilepsy
    Atman Desai
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Epilepsia 54:341-50. 2013
  6. pmc Scaled cortical impact in immature swine: effect of age and gender on lesion volume
    Symeon Missios
    Division of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurotrauma 26:1943-51. 2009
  7. ncbi Chiari malformation Type I and a dolichoodontoid process responsible for sudden cardiorespiratory arrest. Case report
    Patricia B Quebada
    Section of Neurosurgery, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 103:567-70. 2005
  8. ncbi Magnetic resonance imaging studies of age-dependent responses to scaled focal brain injury in the piglet
    Ann Christine Duhaime
    Department of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 99:542-8. 2003
  9. ncbi Basic science; maturation-dependent response of the immature brain to experimental subdural hematoma
    Susan R Durham
    Pediatric Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA
    J Neurotrauma 24:5-14. 2007
  10. doi Placement of occipital condyle screws for occipitocervical fixation in a pediatric patient with occipitocervical instability after decompression for Chiari malformation
    Kimon Bekelis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg Pediatr 6:171-6. 2010

Research Grants

  1. TRAUMA TO THE DEVELOPING BRAIN--RESPONSE AND TREATMENT
    Ann Christine Duhaime; Fiscal Year: 2002
  2. Trauma to Immature Brain: Response Repair & Treatment
    Ann Christine Duhaime; Fiscal Year: 2007

Detail Information

Publications27

  1. ncbi Traumatic brain injury in infants: the phenomenon of subdural hemorrhage with hemispheric hypodensity ("Big Black Brain")
    Ann Christine Duhaime
    Pediatric Neurosurgery, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Prog Brain Res 161:293-302. 2007
    ..Insights from both clinical observation and experimental studies have helped to clarify the probable causes of this injury pattern, which appears to require a combination of stressors during a particular period of maturation...
  2. ncbi Why are clinical trials in pediatric head injury so difficult?
    Ann Christine Duhaime
    Pediatr Crit Care Med 8:71. 2007
  3. ncbi Large animal models of traumatic injury to the immature brain
    Ann Christine Duhaime
    Pediatric Neurosurgery, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Dev Neurosci 28:380-7. 2006
    ..Progress to date and future directions are outlined...
  4. ncbi Functional magnetic resonance imaging of the primary somatosensory cortex in piglets
    Ann Christine Duhaime
    Department of Pediatric Neurosurgery, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurosurg 104:259-64. 2006
    ....
  5. doi Interictal PET and ictal subtraction SPECT: sensitivity in the detection of seizure foci in patients with medically intractable epilepsy
    Atman Desai
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Epilepsia 54:341-50. 2013
    ..To determine the relative utility of these methods in the localization of seizure foci, we compared interictal PET and ictal subtraction SPECT to subdural and depth electrode recordings in patients with medically intractable epilepsy...
  6. pmc Scaled cortical impact in immature swine: effect of age and gender on lesion volume
    Symeon Missios
    Division of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurotrauma 26:1943-51. 2009
    ..There was an interaction among gender, hormone levels, and lesion size in younger subjects. Characterization of these variables allows use of this model for treatment trials for subjects at different stages of maturation...
  7. ncbi Chiari malformation Type I and a dolichoodontoid process responsible for sudden cardiorespiratory arrest. Case report
    Patricia B Quebada
    Section of Neurosurgery, Children s Hospital at Dartmouth, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 103:567-70. 2005
    ..The patient was left with permanent vocal cord paresis and spastic quadriparesis. Awareness of this rare occurrence is important in managing these congenital abnormalities and in assessing the risk of deterioration...
  8. ncbi Magnetic resonance imaging studies of age-dependent responses to scaled focal brain injury in the piglet
    Ann Christine Duhaime
    Department of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 99:542-8. 2003
    ....
  9. ncbi Basic science; maturation-dependent response of the immature brain to experimental subdural hematoma
    Susan R Durham
    Pediatric Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA
    J Neurotrauma 24:5-14. 2007
    ....
  10. doi Placement of occipital condyle screws for occipitocervical fixation in a pediatric patient with occipitocervical instability after decompression for Chiari malformation
    Kimon Bekelis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg Pediatr 6:171-6. 2010
    ..Postoperatively, she was neurologically intact. Computed tomography demonstrated a stable construct, and her cervical pain had resolved on follow-up...
  11. doi How long should cerebrospinal fluid cultures be held to detect shunt infections? Clinical article
    Atman Desai
    Division of Pediatric Neurosurgery, Children s Hospital, Dartmouth, New Hampshire, USA
    J Neurosurg Pediatr 4:184-9. 2009
    ..quot;..
  12. doi Cellular genesis in the postnatal piglet
    Andrew O Koob
    Department of Pediatric Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, United States
    Int J Dev Neurosci 26:641-6. 2008
    ..Here we describe for the first time the use of immunohistochemistry for BrdU and DCX to study cellular genesis in the piglet brain...
  13. doi Akathisia after mild traumatic head injury
    Atman Desai
    Section of Pediatric Surgery Neurosurgery, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, New Hampshire 03756, USA
    J Neurosurg Pediatr 5:460-4. 2010
    ..The literature on akathisia in pediatric patients, and especially in patients following acute head injury, is reviewed, with suggestions for an approach to these symptoms in this clinical setting...
  14. ncbi Traumatic brain injury in piglets of different ages: techniques for lesion analysis using histology and magnetic resonance imaging
    Loretta L Grate
    Department of Surgery, Hinman Box 7850, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    J Neurosci Methods 123:201-6. 2003
    ..Accurate co-registration of histologic, immunohistochemical and radiologic images at different ages was possible, which may enhance understanding of developmental aspects of brain injury pathophysiology...
  15. doi Intractable occipital lobe epilepsy: clinical characteristics and surgical treatment
    Barbara C Jobst
    Department of Neurology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Epilepsia 51:2334-7. 2010
    ..Occipital seizure onset can be easily missed in nonlesional epilepsy. Comprehensive intracranial EEG coverage of all three occipital surfaces leads to better outcomes...
  16. pmc Common data elements for neuroimaging of traumatic brain injury: pediatric considerations
    Ann Christine Duhaime
    Pediatric Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurotrauma 29:629-33. 2012
    ..The long-range goal of this project is to facilitate data sharing as well as to provide critical infrastructure for potential clinical trials in this major public health area...
  17. pmc Gender differences in head impacts sustained by collegiate ice hockey players
    Lindley L Brainard
    Simbex, Lebanon, NH 03766, USA
    Med Sci Sports Exerc 44:297-304. 2012
    ..This study aimed to quantify the frequency, magnitude, and location of head impacts sustained by male and female collegiate ice hockey players during two seasons of play...
  18. ncbi Acquired Chiari malformation type I following fractionated radiation therapy to the anterior skull base in a 20-month-old boy. Case report
    S Scott Lollis
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg 104:133-7. 2006
    ..For the time being, his family has elected for him to undergo clinical and neuroimaging follow up. The authors believe this is the first report of a progressive acquired CM-I after cranial irradiation in the pediatric population...
  19. doi Quick-brain magnetic resonance imaging for nonhydrocephalus indications
    Symeon Missios
    Division of Neurosurgery and, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg Pediatr 2:438-44. 2008
    ..The goal in this study was to characterize, quantitate, and assess the use of QB MR imaging for these additional indications...
  20. ncbi Split cord malformation as a cause of tethered cord syndrome in a 78-Year-old female
    Henry F Pallatroni
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Pediatr Neurosurg 40:80-3. 2004
    ..Because of the patient's age and poor medical condition, her symptoms were managed conservatively. This case demonstrates symptomatic deterioration in an elderly patient with a tethered spinal cord after many years of clinical stability...
  21. doi Internal structure in pineal cysts on high-resolution magnetic resonance imaging: not a sign of malignancy
    David A Pastel
    Department of Radiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosurg Pediatr 4:81-4. 2009
    ..In this paper, the authors' goal was to determine whether benign pineal cysts have smooth walls or internal structure on high-resolution MR imaging and to evaluate their imaging characteristics on FLAIR images...
  22. ncbi Recovery of language after left hemispherectomy in a sixteen-year-old girl with late-onset seizures
    Albert E Telfeian
    Division of Neurology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    Pediatr Neurosurg 37:19-21. 2002
    ..Our results indicate that dominant hemispherectomy in adolescence in the setting of late-onset seizures and Rasmussen's syndrome in the profoundly aphasic patient does not commit the patient to the prognosis of a fixed language deficit...
  23. ncbi Anthropomorphic simulations of falls, shakes, and inflicted impacts in infants
    Michael T Prange
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6392, USA
    J Neurosurg 99:143-50. 2003
    ..The authors sought to compare rotational deceleration sustained by the head among free falls, from different heights onto different surfaces, with those sustained during shaking and inflicted impact...
  24. doi Cranial vault expansion in the management of postshunt craniosynostosis and slit ventricle syndrome
    Jeffrey Weinzweig
    Division of Plastic Surgery, The Children s Hospital of Philadelphia, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Plast Reconstr Surg 122:1171-80. 2008
    ..Excessive intracranial decompression may result in ventricular collapse with the formation of slit-like ventricles and cranial vault collapse with secondary craniosynostosis...
  25. ncbi Complications of invasive monitoring used in intractable pediatric epilepsy
    Scott L Simon
    Department of Neurosurgery, University Hospital, The University of Pennsylvania, 5th Floor Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Pediatr Neurosurg 38:47-52. 2003
    ..We conclude that invasive monitoring for intractable epilepsy is generally safe...
  26. ncbi Do we and should we monitor intracranial pressure in infants with closed head injury?
    Ann Christine Duhaime
    Pediatr Crit Care Med 6:611-2. 2005
  27. pmc Classification of traumatic brain injury for targeted therapies
    Kathryn E Saatman
    University of Kentucky, Lexington, KY, USA
    J Neurotrauma 25:719-38. 2008
    ..Recommendations were made for enhancing the utility of available or emerging tools in order to facilitate implementation of a pathoanatomic classification approach for clinical trials...

Research Grants3

  1. TRAUMA TO THE DEVELOPING BRAIN--RESPONSE AND TREATMENT
    Ann Christine Duhaime; Fiscal Year: 2002
    ..This important information will be useful in the development and testing of head injury therapies appropriate for infants and children. ..
  2. Trauma to Immature Brain: Response Repair & Treatment
    Ann Christine Duhaime; Fiscal Year: 2007
    ..We believe this approach will help "bridge the gap" between rodent models and effective treatment for the many thousands of children who suffer traumatic brain injury each year. ..