ROBERT DARNALL

Summary

Affiliation: Dartmouth-Hitchcock Medical Center
Country: USA

Publications

  1. ncbi The late preterm infant and the control of breathing, sleep, and brainstem development: a review
    Robert A Darnall
    Department of Physiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Perinatol 33:883-914; abstract x. 2006
  2. ncbi Arousal from sleep in response to intermittent hypoxia in rat pups is modulated by medullary raphe GABAergic mechanisms
    Robert A Darnall
    Department of Pediatrics, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Physiol Regul Integr Comp Physiol 302:R551-60. 2012
  3. ncbi Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases rapid eye movement sleep in the piglet: implications for sudden infant death syndrome
    Robert A Darnall
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurosci 25:8322-32. 2005
  4. ncbi The role of CO(2) and central chemoreception in the control of breathing in the fetus and the neonate
    Robert A Darnall
    Departments of Physiology and Neurobiology and Pediatrics, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 173:201-12. 2010
  5. ncbi Reversible blunting of arousal from sleep in response to intermittent hypoxia in the developing rat
    R A Darnall
    Department of Pediatrics, Dartmouth School of Medicine, Lebanon, New Hampshire, USA
    J Appl Physiol 109:1686-96. 2010
  6. ncbi Prolongation of the laryngeal chemoreflex after inhibition of the rostral ventral medulla in piglets: a role in SIDS?
    Liesbeth Van Der Velde
    Departments of Physiology, Medicine, and Pediatrics, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Appl Physiol 94:1883-95. 2003
  7. ncbi Characterization of hypoxia-induced ventilatory depression in newborn piglets
    Rene St-Jacques
    Department of Physiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 88:509-15. 2003

Research Grants

  1. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006

Collaborators

Detail Information

Publications7

  1. ncbi The late preterm infant and the control of breathing, sleep, and brainstem development: a review
    Robert A Darnall
    Department of Physiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Perinatol 33:883-914; abstract x. 2006
    ..Research focused on this group of infants will not only further our understanding of brainstem maturation during this high risk period, but will help develop focused plans for their management...
  2. ncbi Arousal from sleep in response to intermittent hypoxia in rat pups is modulated by medullary raphe GABAergic mechanisms
    Robert A Darnall
    Department of Pediatrics, Dartmouth Medical School, Lebanon, NH 03756, USA
    Am J Physiol Regul Integr Comp Physiol 302:R551-60. 2012
    ..Arousal habituation may contribute to sudden infant death syndrome, which is associated with MR serotonergic and GABAergic receptor dysfunction...
  3. ncbi Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases rapid eye movement sleep in the piglet: implications for sudden infant death syndrome
    Robert A Darnall
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurosci 25:8322-32. 2005
    ..Abnormalities in the function of these neurons may alter sleep homeostasis and contribute to the etiology of SIDS...
  4. ncbi The role of CO(2) and central chemoreception in the control of breathing in the fetus and the neonate
    Robert A Darnall
    Departments of Physiology and Neurobiology and Pediatrics, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 173:201-12. 2010
    ....
  5. ncbi Reversible blunting of arousal from sleep in response to intermittent hypoxia in the developing rat
    R A Darnall
    Department of Pediatrics, Dartmouth School of Medicine, Lebanon, New Hampshire, USA
    J Appl Physiol 109:1686-96. 2010
    ..We conclude that exposure to repeated episodes of hypoxia can cause progressive blunting of arousal, which is reversible by altering the exposure times to hypoxia and the period of recovery between hypoxia exposures...
  6. ncbi Prolongation of the laryngeal chemoreflex after inhibition of the rostral ventral medulla in piglets: a role in SIDS?
    Liesbeth Van Der Velde
    Departments of Physiology, Medicine, and Pediatrics, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Appl Physiol 94:1883-95. 2003
    ..We conclude that the RVM provides a tonic facilitatory drive to ventilation that limits the duration of the LCR, and loss of this drive may contribute to the SIDS when combined with stimuli that inhibit respiration...
  7. ncbi Characterization of hypoxia-induced ventilatory depression in newborn piglets
    Rene St-Jacques
    Department of Physiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 88:509-15. 2003
    ..We conclude that a region of the caudal mesencephalon or pons is necessary for the manifestation of depressions of ventilatory activity in the newborn pig...

Research Grants3

  1. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006
    ..Finally, we will examine the relationships among the level of arousal, post-conceptional age, sleep state, and other infant behaviors such as feeding that are also associated with changes in autonomic activity. ..