Research Topics
| Howard L CorwinSummaryAffiliation: Dartmouth-Hitchcock Medical Center Country: USA Publications
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Detail Information
Publications
Roundtable debate: Controversies in the management of the septic patient--desperately seeking consensusAaron B Waxman
Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Crit Care 9:E1. 2005..This presentation is intended to show how experienced intensivists apply clinical science to their practice of critical care medicine...- Erythropoietin in the critically ill - is it more than just blood?Howard L Corwin
Dartmouth Medical School, Lebanon, New Hampshire, USA
Crit Care 8:325-6. 2004..Recently it has been demonstrated that EPO has actions other than stimulating the bone marrow. It has been suggested that due to its tissue protecting effect, EPO may be effective in improving outcome in the critically ill... - Anemia and blood transfusion in the critically ill patient: role of erythropoietinHoward L Corwin
Dartmouth Medical School, Critical Care Medicine, Intensive Care Unit, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
Crit Care 8:S42-4. 2004..Strategies to increase the production of RBCs are complementary to other approaches to reduce blood loss in the intensive care unit, and they decrease the transfusion threshold in the management of all critically ill patients... 
Blood conservation in the critically ill patientHoward L Corwin
Dartmouth Medical School, HB 7999, Hanover, NH 03755, and Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
Anesthesiol Clin North America 23:363-72, viii. 2005..This review focuses on transfusion practice in the critically ill...- Transfusion practice in the critically illHoward L Corwin
Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Crit Care Med 31:S668-71. 2003..This anemia of critical illness is a distinct clinical entity characterized by blunted erythropoietin production and abnormalities in iron metabolism identical to what is commonly referred to as the anemia of chronic disease... - The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United StatesHoward L Corwin
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Crit Care Med 32:39-52. 2004..To quantify the incidence of anemia and red blood cell (RBC) transfusion practice in critically ill patients and to examine the relationship of anemia and RBC transfusion to clinical outcomes... - Anemia and red blood cell transfusion in the critically illHoward L Corwin
Section of Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Semin Dial 19:513-6. 2006..Strategies to minimize loss of blood and increase the production of RBCs are also important in the management of all critically ill patients... - Efficacy and safety of epoetin alfa in critically ill patientsHoward L Corwin
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
N Engl J Med 357:965-76. 2007..We hypothesized that therapy with recombinant human erythropoietin (epoetin alfa) might reduce the need for red-cell transfusions... - Erythropoietin use in critically ill patients: forest and treesHoward L Corwin
Department of Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
CMAJ 177:747-9. 2007 - Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trialHoward L Corwin
Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
JAMA 288:2827-35. 2002..Anemia is common in critically ill patients and results in a large number of red blood cell (RBC) transfusions. Recent data have raised the concern that RBC transfusions may be associated with worse clinical outcomes in some patients... 
Multiple reservoirs contribute to intraoperative bacterial transmissionRandy W Loftus
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Anesth Analg 114:1236-48. 2012..Pulsed-field gel electrophoresis was used to assess the contribution of reservoir bacterial pathogens to 30-day postoperative infections...- The role of erythropoietin therapy in the critically illHoward L Corwin
Dartmouth Medical School, Lebanon, NH 03756, USA
Transfus Med Rev 20:27-33. 2006..Strategies to increase the production of RBCs are complementary to other approaches to reduce blood loss in the ICU and decrease the transfusion threshold in the management of all critically ill patients... - Reduction in ventilator associated pneumonia in a mixed intensive care unit after initiation of a novel hand hygiene programMatthew D Koff
Department of Anesthesiology, Section of Critical Care Medicine, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH 03756
J Crit Care 26:489-95. 2011..Infect Control Hosp Epidemiol 19:858-860, 1998). Contamination of provider hands may be a modifiable risk factor. We instituted a novel multimodal system designed to improve hand hygiene by ICU providers... - New developments in massive transfusion in traumaSarah E Greer
Dartmouth Hitchcock Medical Center, Departments of Surgery, USA
Curr Opin Anaesthesiol 23:246-50. 2010..This review describes recent advances in the early recognition and treatment of the coagulopathy of trauma, as well as ongoing work to define optimal resuscitation strategies... - Hand contamination of anesthesia providers is an important risk factor for intraoperative bacterial transmissionRandy W Loftus
Department of Anesthesiology and Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Anesth Analg 112:98-105. 2011..In this study, we hypothesized that bacterial contamination of anesthesia provider hands before patient contact is a risk factor for direct intraoperative bacterial transmission... - Improved survival of critically ill trauma patients treated with recombinant human erythropoietinLena M Napolitano
Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0033, USA
J Trauma 65:285-97; discussion 297-9. 2008..7% vs. 3.5%). This analysis presents trauma cohort data from both trials for evaluation of the impact of baseline factors including trauma-specific variables on outcomes... - Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literaturePaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 36:2667-74. 2008..However, the hematocrit that should be maintained in any particular patient because the risks of further transfusion of RBC outweigh the benefits remains unclear... - Transfusion practice in the critically ill: can we do better?Howard L Corwin
Crit Care Med 33:232-3. 2005 - Controversies in RBC transfusion in the critically illPaul C Hebert
Centre for Transfusion Research, University of Ottawa, and Clinical Epidemiology Program of the Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada
Chest 131:1583-90. 2007..This review will examine some of the important controversies still surrounding the use of RBC transfusion in the critically ill patient... - Blood transfusion--when is more really less?Howard L Corwin
N Engl J Med 356:1667-9. 2007 - Avoiding a blood transfusion: How much is it worth?Howard L Corwin
Crit Care Med 33:672-4. 2005 - Anemia and blood transfusion in trauma patients admitted to the intensive care unitMarc J Shapiro
Department of Surgery, Saint Louis University, Missouri 63110 0250, USA
J Trauma 55:269-73; discussion 273-4. 2003..The issue of blood use in critically injured patients requires evaluation... - Erythropoietin in the critically ill: what is the evidence?Howard L Corwin
Nephrol Dial Transplant 20:2605-8. 2005 - Efficacy of recombinant human erythropoietin in critically ill patients admitted to a long-term acute care facility: a randomized, double-blind, placebo-controlled trialMichael Silver
Kindred Health Care, Chicago, IL, USA
Crit Care Med 34:2310-6. 2006..Despite receiving fewer red blood cell transfusions, patients treated with rHuEPO achieve a higher hemoglobin level... - Efficacy of red blood cell transfusion in the critically illLena M Napolitano
Department of Surgery, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
Crit Care Clin 20:255-68. 2004.... - Acute lung injury following blood transfusion: expanding the definitionPaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 36:3080-4. 2008..The objectives of this review are to summarize current knowledge of TRALI with an emphasis on issues pertinent to the intensivist and to define the newly recognized "Delayed TRALI syndrome.".. - Efficacy of blood transfusion in the critically ill: does age of blood make a difference?Lena M Napolitano
Crit Care Med 32:594-5. 2004 - Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trialNeil Singla
Department of Anesthesia, Huntington Memorial Hospital, Pasadena, California 91105, USA
Anesth Analg 107:59-67. 2008..In this double-blind, placebo-controlled trial, we examined the efficacy and safety of clevidipine in treating postoperative hypertension in cardiac surgery patients... - Transfusion in critical care: where do we go from here?Andrew F Shorr
Chest 132:1105-6. 2007 - Is leukoreduction of blood components for everyone?Howard L Corwin
JAMA 289:1993-5. 2003 - Teamwork and collaboration in critical care: lessons from the cockpitStephen D Surgenor
Crit Care Med 31:992-3. 2003