Rabih O Darouiche

Summary

Country: USA

Publications

  1. ncbi request reprint A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group
    R O Darouiche
    Department of Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030, USA
    N Engl J Med 340:1-8. 1999
  2. ncbi request reprint Activity of antimicrobial-impregnated silicone tissue expanders
    Rabih O Darouiche
    Center for Prostheses Infection, Infectious Disease Section, Baylor College of Medicine, 1333 Moursund Avenue, Suite A221, Houston, TX 77030, USA
    Ann Plast Surg 49:567-71. 2002
  3. doi request reprint Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices
    Maria D Hernandez
    Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    Infect Control Hosp Epidemiol 30:190-2. 2009
  4. doi request reprint Antimicrobial and antibiofilm efficacy of triclosan and DispersinB combination
    Rabih O Darouiche
    Center for Prostheses Infections and Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
    J Antimicrob Chemother 64:88-93. 2009
  5. pmc Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters
    Saima Aslam
    Infectious Disease Section, Department of Medicine, Baylor College of Medicine, and Room 4B 370, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Antimicrob Agents Chemother 51:1556-8. 2007
  6. doi request reprint Pilot trial of N-acetylcysteine and tigecycline as a catheter-lock solution for treatment of hemodialysis catheter-associated bacteremia
    Saima Aslam
    Sections of Infectious Disease, Department of Medicine, Baylor College of Medicine, the Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 29:894-7. 2008
  7. pmc Catheter-associated infections: pathogenesis affects prevention
    Barbara W Trautner
    Department of Medicine, Infectious Diseases Section, Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Arch Intern Med 164:842-50. 2004
  8. doi request reprint Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis
    Rabih O Darouiche
    Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 362:18-26. 2010
  9. ncbi request reprint Prolonged bacterial exposure to minocycline/rifampicin-impregnated vascular catheters does not affect antimicrobial activity of catheters
    Saima Aslam
    Section of Infectious Diseases, Department of Medicine and Center for Prosthesis Infection, Baylor College of Medicine and Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    J Antimicrob Chemother 60:148-51. 2007
  10. doi request reprint Comparative assessment of antimicrobial activities of antibiotic-treated penile prostheses
    Mohammad D Mansouri
    Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    Eur Urol 56:1039-45. 2009

Research Grants

Detail Information

Publications71

  1. ncbi request reprint A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group
    R O Darouiche
    Department of Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030, USA
    N Engl J Med 340:1-8. 1999
    ..We compared the rates of catheter colonization and catheter-related bloodstream infection associated with these two kinds of antiinfective catheters...
  2. ncbi request reprint Activity of antimicrobial-impregnated silicone tissue expanders
    Rabih O Darouiche
    Center for Prostheses Infection, Infectious Disease Section, Baylor College of Medicine, 1333 Moursund Avenue, Suite A221, Houston, TX 77030, USA
    Ann Plast Surg 49:567-71. 2002
    ..These findings prompt future exploration of the anti-infective efficacy of these antimicrobial-impregnated devices...
  3. doi request reprint Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices
    Maria D Hernandez
    Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    Infect Control Hosp Epidemiol 30:190-2. 2009
    ..Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model...
  4. doi request reprint Antimicrobial and antibiofilm efficacy of triclosan and DispersinB combination
    Rabih O Darouiche
    Center for Prostheses Infections and Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA
    J Antimicrob Chemother 64:88-93. 2009
    ....
  5. pmc Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters
    Saima Aslam
    Infectious Disease Section, Department of Medicine, Baylor College of Medicine, and Room 4B 370, Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Antimicrob Agents Chemother 51:1556-8. 2007
    ..N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis...
  6. doi request reprint Pilot trial of N-acetylcysteine and tigecycline as a catheter-lock solution for treatment of hemodialysis catheter-associated bacteremia
    Saima Aslam
    Sections of Infectious Disease, Department of Medicine, Baylor College of Medicine, the Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 29:894-7. 2008
    ..Treatment was successful for 15 (83%) of the 18 case patients within 90 days of follow-up, with a median catheter retention interval of 64.5 days...
  7. pmc Catheter-associated infections: pathogenesis affects prevention
    Barbara W Trautner
    Department of Medicine, Infectious Diseases Section, Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Arch Intern Med 164:842-50. 2004
    ..Preventive strategies that avoid the use of antimicrobial agents may be necessary in this population...
  8. doi request reprint Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis
    Rabih O Darouiche
    Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 362:18-26. 2010
    ..We hypothesized that preoperative skin cleansing with chlorhexidine-alcohol is more protective against infection than is povidone-iodine...
  9. ncbi request reprint Prolonged bacterial exposure to minocycline/rifampicin-impregnated vascular catheters does not affect antimicrobial activity of catheters
    Saima Aslam
    Section of Infectious Diseases, Department of Medicine and Center for Prosthesis Infection, Baylor College of Medicine and Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    J Antimicrob Chemother 60:148-51. 2007
    ..We assessed the in vitro effect of exposing various bacteria to minocycline/rifampicin-impregnated vascular catheters on the antimicrobial activity of the catheters and the antimicrobial susceptibility of tested organisms...
  10. doi request reprint Comparative assessment of antimicrobial activities of antibiotic-treated penile prostheses
    Mohammad D Mansouri
    Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    Eur Urol 56:1039-45. 2009
    ..Since bacterial colonization of the implant is a prelude to clinical infection, antimicrobial modification of the devices may inhibit device colonization and subsequent infection...
  11. ncbi request reprint In-vitro and in-vivo activity of antimicrobial-coated prosthetic heart valve sewing cuffs
    Rabih O Darouiche
    Center for Prostheses Infection, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Heart Valve Dis 11:99-104. 2002
    ..The study aims were to examine the antimicrobial activity in vitro and anti-infective efficacy in vivo of prosthetic heart valve sewing cuffs coated with minocycline and rifampin...
  12. pmc Role of biofilm in catheter-associated urinary tract infection
    Barbara W Trautner
    Department of Medicine, Infectious Diseases Section, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Infect Control 32:177-83. 2004
    ..Currently, no proven effective strategies exist for prevention of catheter-associated urinary tract infection in persons who are chronically catheterized...
  13. doi request reprint Nonstaphylococcal infections of cardiac implantable electronic devices
    George M Viola
    Baylor College of Medicine, Department of Medicine, Section of Infectious Diseases, One Baylor Plaza, BCM 286, Room N1319, Houston, TX 77030, USA
    Circulation 121:2085-91. 2010
    ..Little is known about nonstaphylococcal CIED-related infections, which make up approximately 10% to 30% of all CIED infections...
  14. ncbi request reprint In vivo efficacy of antimicrobe-impregnated saline-filled silicone implants
    Rabih O Darouiche
    Center for Prostheses Infection, Infectious Disease Section, and Division of Plastic Surgery, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Plast Reconstr Surg 109:1352-7. 2002
    ..Antimicrobe-impregnated implants also have the potential of reducing the likelihood of capsular contracture...
  15. pmc In vitro activity and durability of a combination of an antibiofilm and an antibiotic against vascular catheter colonization
    Mohammad D Mansouri
    Baylor College of Medicine, Houston, Texas, USA
    Antimicrob Agents Chemother 57:621-5. 2013
    ..0001) by all tested pathogens compared to control catheters. These in vitro results suggest that this antimicrobial combination can potentially be used to combat catheter colonization and catheter-associated infection...
  16. doi request reprint Evaluating effectiveness of antibiotic polymethylmethacrylate beads in achieving wound sterilization and graft preservation in patients with early and late vascular graft infections
    Mun Jye Poi
    Department of Vascular Surgery, Baylor College of Medicine, Houston, TX, USA
    Surgery 153:673-82. 2013
    ..The objective of the study was to evaluate the effectiveness of antibiotic-based polymethylmethacrylate (ab-PMMA) beads in achieving wound sterilization and graft preservation in patients with vascular graft infections...
  17. pmc Risk factors and outcomes of fungal ventricular-assist device infections
    Saima Aslam
    Baylor College of Medicine, Houston, Texas, USA
    Clin Infect Dis 50:664-71. 2010
    ..The objectives of this study were to investigate the frequency of fungal VAD infections and assess various risk factors and their effects on mortality as compared with bacterial VAD infections...
  18. doi request reprint Efficacy of combination of chlorhexidine and protamine sulphate against device-associated pathogens
    Rabih O Darouiche
    Center for Prostheses Infection and Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    J Antimicrob Chemother 61:651-7. 2008
    ....
  19. ncbi request reprint In vivo efficacy of antimicrobial-coated devices
    Rabih O Darouiche
    Center for Prostheses Infection, Baylor College of Medicine, 1333 Moursund Avenue, Suite A221, Houston, TX 77030, USA
    J Bone Joint Surg Am 89:792-7. 2007
    ..The objective of this animal study was to assess the efficacy of a coating with minocycline and rifampin to prevent colonization of a grit-blasted titanium implant and subsequent osteomyelitis...
  20. pmc Coating urinary catheters with an avirulent strain of Escherichia coli as a means to establish asymptomatic colonization
    Barbara W Trautner
    Department of Medicine, Infectious Diseases Section, Center for Prostheses Infection, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 28:92-4. 2007
    ..Ten of 12 subjects were successfully colonized for 14 days or more. The rate of symptomatic UTI during colonization was 0.15 per 100 patient-days...
  21. pmc Increased expression of type-1 fimbriae by nonpathogenic Escherichia coli 83972 results in an increased capacity for catheter adherence and bacterial interference
    Barbara W Trautner
    Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 198:899-906. 2008
    ..We hypothesized that improving the catheter adherence of E. coli 83972 would improve its bacterial interference properties...
  22. ncbi request reprint Healthcare costs associated with hemodialysis catheter-related infections: a single-center experience
    Venkataraman Ramanathan
    Renal Section, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 28:606-9. 2007
    ..Hypoalbuminemia and bacteremia due to methicillin-resistant Staphylococcus aureus (MRSA) are associated with higher healthcare costs; bacteremia due to MRSA is also associated with poor survival rates...
  23. ncbi request reprint Bacterial interference for prevention of urinary tract infection: a prospective, randomized, placebo-controlled, double-blind pilot trial
    Rabih O Darouiche
    Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    Clin Infect Dis 41:1531-4. 2005
    ..Patients whose bladders became colonized with Escherichia coli 83972 were half as likely (P=.01) than noncolonized patients to develop UTI during the subsequent year...
  24. pmc Bacterial translocation across ePTFE vascular graft surfaces
    Supriya Narasimhan
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Infect 60:486-90. 2010
    ..We assessed whether methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli could translocate through pores of ePTFE grafts...
  25. pmc Comparison of antimicrobial impregnation with tunneling of long-term central venous catheters: a randomized controlled trial
    Rabih O Darouiche
    Center for Prostheses Infection, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann Surg 242:193-200. 2005
    ..We sought to compare the impact of antimicrobial impregnation to that of tunneling of long-term central venous catheters on the rates of catheter colonization and catheter-related bloodstream infection...
  26. pmc Escherichia coli 83972 inhibits catheter adherence by a broad spectrum of uropathogens
    Barbara W Trautner
    Department of Medicine, Infectious Diseases Section, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Urology 61:1059-62. 2003
    ..To explore this phenomenon further, we investigated in vitro whether E. coli 83972 could likewise inhibit catheter colonization by gram-negative and fungal uropathogens (Providencia stuartii, uropathogenic E. coli, and Candida albicans)...
  27. ncbi request reprint Treatment of infections associated with surgical implants
    Rabih O Darouiche
    Center for Prostheses Infection and the Infectious Disease Section, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 350:1422-9. 2004
  28. pmc Prevention of catheter-associated urinary tract infection
    Barbara W Trautner
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas, USA
    Curr Opin Infect Dis 18:37-41. 2005
    ..Considerable work is being done in this area, but little clinical progress has been made. The purpose of this review is to analyze recent publications concerning prevention of catheter-associated urinary tract infection...
  29. ncbi request reprint In vitro activity and in vivo efficacy of antimicrobial-coated vascular grafts
    Rabih O Darouiche
    Center for Prostheses Infection, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Ann Vasc Surg 18:497-501. 2004
    ..8/30 = 27%, p = 0.033) and device-related infection (0/24 = 0% vs. 6/30 = 20%, p = 0.028) than uncoated grafts. These promising results encourage the clinical evaluation of vascular grafts coated with minocycline and rifampin...
  30. ncbi request reprint Device-related infective endocarditis, with special consideration of implanted intravascular and cardiac devices in a predominantly male population
    Ingrid L Roig
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA
    Scand J Infect Dis 44:753-60. 2012
    ..We describe our experience of patients with IE, with particular attention to the role of pre-existing intravascular catheters and implanted cardiac devices in the pathogenesis...
  31. doi request reprint Characteristics of biofilm on tunneled cuffed hemodialysis catheters in the presence and absence of clinical infection
    Venkataraman Ramanathan
    Renal Section, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Kidney Dis 60:976-82. 2012
    ..We studied biofilm formation on catheters from patients with and without bacteremia to identify the location of bacterial growth and measure biofilm thickness...
  32. doi request reprint Infections of cardiac implantable electronic devices: a retrospective multicenter observational study
    George M Viola
    Division of Infectious Diseases, Department of Medicine, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 91:123-30. 2012
    ....
  33. ncbi request reprint Impact of StatLock securing device on symptomatic catheter-related urinary tract infection: a prospective, randomized, multicenter clinical trial
    Rabih O Darouiche
    Michael E DeBakey Veterans Affairs Medical Center, Houston, TX, USA
    Am J Infect Control 34:555-60. 2006
    ..The objective of this study was to assess the impact of using the StatLock securing device on symptomatic catheter-related urinary tract infection (UTI)...
  34. pmc Colicins prevent colonization of urinary catheters
    Barbara W Trautner
    Department of Medicine, Infectious Diseases Section, Baylor College of Medicine, Houston, TX, USA
    J Antimicrob Chemother 56:413-5. 2005
    ..We investigated in vitro whether a colicin-expressing strain of Escherichia coli could prevent urinary catheter colonization by a colicin-susceptible, uropathgenic strain of E. coli...
  35. doi request reprint Comparison of bacterial adherence to titanium versus polyurethane for cardiac implantable electronic devices
    George M Viola
    Division of Medicine, Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Am J Cardiol 111:1764-6. 2013
    ..Animal studies are warranted to explore the relevance of these laboratory findings...
  36. pmc In vitro potency and in vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization
    Mohammad D Mansouri
    Baylor College of Medicine, Houston, Texas, USA
    Antimicrob Agents Chemother 56:2201-4. 2012
    ..001). Furthermore, device-associated infection was significantly lower in MBX1631-coated catheters than in uncoated ones (P < 0.005)...
  37. pmc Mechanical integrity of hemodialysis catheters after exposure to a novel catheter lock solution
    Saima Aslam
    Section of Infectious Diseases and Center for Prostheses Infection, Baylor College of Medicine and The Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    Infect Control Hosp Epidemiol 31:1124-9. 2010
    ..To examine the mechanical integrity of hemodialysis catheters after exposure to the combination of N-acetylcysteine, tigecycline, and heparin, compared with that of catheters exposed to heparin alone...
  38. doi request reprint Risk factors for subsequent diagnosis of prosthetic joint infection
    Saima Aslam
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Infect Control Hosp Epidemiol 31:298-301. 2010
    ..25 [95% confidence interval {CI}, 1.3-3.8]), nonsurgical trauma to the prosthetic joint (OR, 21.5 [95% CI, 2.6-175.2]), and surgical site infection (OR, 5.25 [95% CI, 1.7-16.7])...
  39. doi request reprint Multicenter randomized controlled trial of bacterial interference for prevention of urinary tract infection in patients with neurogenic bladder
    Rabih O Darouiche
    Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Urology 78:341-6. 2011
    ..To compare the effectiveness of bacterial interference versus placebo in preventing urinary tract infection (UTI)...
  40. pmc Comparative efficacies of telavancin and vancomycin in preventing device-associated colonization and infection by Staphylococcus aureus in rabbits
    Rabih O Darouiche
    Infectious Disease Section and Center for Prostheses Infection, Baylor College of Medicine, 1333 Moursund Avenue, Suite A221, Houston, TX 77030, USA
    Antimicrob Agents Chemother 53:2626-8. 2009
    ....
  41. ncbi request reprint Catheter-related vancomycin-resistant Enterococcus faecium bacteremia: clinical and molecular epidemiology
    Issam I Raad
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 26:658-61. 2005
    ..To study the clinical and molecular epidemiology of vancomycin-resistant Enterococcus faecium organisms causing catheter-related bacteremia in patients with cancer...
  42. doi request reprint Prevention and management of hemodialysis catheter infections
    Venkat Ramanathan
    Renal Section, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd, 111 J, Houston, TX 77030, USA
    Expert Rev Anti Infect Ther 10:1447-55. 2012
    ..However, catheter guidewire exchange is an acceptable alternate strategy in some patients. The most important goal should be to increase the rate of incident arteriovenous fistula use in the HD population...
  43. doi request reprint New strategies to prevent catheter-associated urinary tract infections
    Danish M Siddiq
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, BCM 286, Room N 1319, 1 Baylor Plaza, Houston, TX 77030 3498, USA
    Nat Rev Urol 9:305-14. 2012
    ..More recently, innovative use of iontophoresis, vibroacoustic stimulation, bacterial interference and bacteriophage cocktails has been reported...
  44. ncbi request reprint Efficacy of antimicrobial-impregnated silicone sections from penile implants in preventing device colonization in an animal model
    Rabih O Darouiche
    Center for Prostheses Infection and Infectious Disease Section, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Urology 59:303-7. 2002
    ..Infection constitutes a very serious complication of penile implants...
  45. pmc Incubation alone is adequate as a culturing technique for cardiac rhythm management devices
    George M Viola
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    J Clin Microbiol 47:4168-70. 2009
    ..Incubation alone yielded bacterial colony counts similar to those of other culturing combinations and is the least labor-intensive...
  46. ncbi request reprint Prevention of infections associated with vascular catheters
    R O Darouiche
    Center for Prostheses Infection and Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Int J Artif Organs 31:810-9. 2008
    ..This explains the need to assess the potential clinical protection afforded by anti-infective technologies. In addition to improving patient care, a clinically protective anti-infective approach can also bring tremendous cost savings...
  47. ncbi request reprint Infection-resistant alloplasts
    R O Darouiche
    Department of Physical Medicine and Rehabilitation, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Endourol 14:33-7. 2000
    ..There is a pressing need to explore the clinical efficacy of antimicrobial surfaces suitable for use in devices intended for long-term use...
  48. doi request reprint Sepsis syndrome, bloodstream infections, and device-related infections
    Mayar Al Mohajer
    Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Med Clin North Am 96:1203-23. 2012
    ..This review represents an update on the diagnosis and management of sepsis, catheter-related blood stream infections and some clinically important device-related infections...
  49. ncbi request reprint Antimicrobial approaches for preventing infections associated with surgical implants
    Rabih O Darouiche
    Center for Prostheses Infection and Infectious Diseases Section, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Infect Dis 36:1284-9. 2003
    ..This review article concludes with a perspective on assessing and preventing such serious infections...
  50. pmc Antimicrobial activity of prosthetic heart valve sewing cuffs coated with minocycline and rifampin
    Rabih O Darouiche
    Center for Prostheses Infection, Baylor College of Medicine and Veterans Affairs Medical Center, St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 46:543-5. 2002
    ..An in vitro elution study of these coated sewing cuffs demonstrated residual zones of inhibition against Staphylococcus epidermidis for at least 4 weeks...
  51. doi request reprint Clinical significance of Staphylococcus aureus bacteriuria at a tertiary care hospital
    Mayar Al Mohajer
    Section of Infectious Diseases, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    Scand J Infect Dis 45:688-95. 2013
    ..Staphylococcus aureus bacteriuria has been associated with invasive S. aureus disease. The current project describes the clinical significance of S. aureus bacteriuria...
  52. ncbi request reprint Vancomycin-induced elevation of liver enzyme levels
    Richard M Cadle
    Pharmacy Service and Section of Infectious Diseases, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Ann Pharmacother 40:1186-9. 2006
    ..To report a case of oral vancomycin-induced elevation of liver enzyme levels...
  53. pmc Antifungal activity of amphotericin B, fluconazole, and voriconazole in an in vitro model of Candida catheter-related bloodstream infection
    Russell E Lewis
    University of Houston College of Pharmacy, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 46:3499-505. 2002
    ..Lack of in vitro antifungal activity against biofilm-encased organisms appeared to be the primary reason for mycological failure of antifungal regimens in the model...
  54. pmc Candida infections of medical devices
    Erna M Kojic
    Medical Service, Infectious Disease Section, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Microbiol Rev 17:255-67. 2004
    ..The medical and economic impact of these infections is enormous...
  55. pmc Inactivated influenza vaccination for people with spinal cord injury
    Barbara W Trautner
    Department of Medicine Infectious Disease Section, Veterans Affairs Medical Center nd Baylor College of Medicine, Houston, TX 77030, USA
    Arch Phys Med Rehabil 85:1886-9. 2004
    ..To examine the antibody responses of people with spinal cord injury (SCI) to the commercially available trivalent influenza vaccine...
  56. ncbi request reprint Spinal epidural abscess
    Rabih O Darouiche
    Infectious Disease Section, the Michael E DeBakey Veterans Affairs Medical Center, and the Center for Prostheses Infection, Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 355:2012-20. 2006
  57. ncbi request reprint Skin antisepsis kits containing alcohol and chlorhexidine gluconate or tincture of iodine are associated with low rates of blood culture contamination
    Barbara W Trautner
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 23:397-401. 2002
    ..We assessed blood culture contamination rates associated with the use of skin antisepsis kits containing either 2% alcoholic chlorhexidine gluconate or 2% alcoholic tincture of iodine...
  58. ncbi request reprint Dalbavancin compared with vancomycin for prevention of Staphylococcus aureus colonization of devices in vivo
    R O Darouiche
    Infectious Disease Section and Center for Prostheses Infection, Veterans Affairs Medical Center and Baylor College of Medicine, 1333 Moursund Avenue, Suite A221, Houston, TX 77030, USA
    J Infect 50:206-9. 2005
    ..The objective of this animal study was to examine the ability of dalbavancin and vancomycin to prevent Staphylococcus aureus colonization of devices...
  59. doi request reprint Prevention and treatment of urinary catheter-associated infections
    Mayar Al Mohajer
    Section of Infectious Diseases, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA
    Curr Infect Dis Rep 15:116-23. 2013
    ..Catheter removal or exchange is also useful in management. This review summarizes and analyzes the results of published studies of CA-UTIs and assesses the role of prevention approaches and management strategies...
  60. doi request reprint Bioprosthetic mitral valve endocarditis after percutaneous device closure of severe paravalvular leak
    Alexandra Tuluca
    Division of Cardiothoracic Surgery, The Michael E DeBakey Department of Surgery, Houston, TX 77030, USA
    Ann Thorac Surg 95:1787-9. 2013
    ..This report underscores the risk of device infection that may be increased if there is turbulence related to residual paravalvular leaks...
  61. doi request reprint Infectious complications associated with percutaneous nephrostomy catheters: do we know enough?
    Danish M Siddiq
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Int J Artif Organs 35:898-907. 2012
    ..In this review article, we discuss various aspects of pathogenesis and treatment of the different subtypes of PCNC-associated infections...
  62. pmc Prosthetic joint infections
    Saima Aslam
    Division of Infectious Diseases, Department of Medicine, University of California, San Diego, 200 W Arbor Drive, NARF 307, MC 8415, San Diego, CA, 92103, USA
    Curr Infect Dis Rep 14:551-7. 2012
    ....
  63. ncbi request reprint Staphylococcus aureus Bacteriuria: Source, Clinical Relevance, and Management
    Mayar Al Mohajer
    Section of Infectious Diseases, Michael E DeBakey VA Medical Center and Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA
    Curr Infect Dis Rep 14:601-6. 2012
    ..This review summarizes and analyzes the results of previous reports of S. aureus bacteriuria and assesses the clinical relevance and management of this increasingly recognized entity...
  64. ncbi request reprint Prevention of urinary tract infection in patients with spinal cord injury
    Barbara W Trautner
    Department of Medicine, Infectious Diseases Section, Center for Prostheses Infection, Baylor College of Medicine, Houston, Texas 77030, USA
    J Spinal Cord Med 25:277-83. 2002
    ..Altered voiding dynamics, use of urinary drainage catheters, and frequent exposure to antibiotic agents predispose individuals with SCI to recurrent episodes of UTI, often with resistant organisms...
  65. ncbi request reprint Cardiovascular implantable device infections
    George M Viola
    Department of Medicine, Division of Infectious Diseases, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1460, Houston, TX, 77030, USA
    Curr Infect Dis Rep 13:333-42. 2011
    ....
  66. ncbi request reprint Prevention and treatment of aortic graft infection
    Firas F Mussa
    The Michael E DeBakey VA Medical Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    Expert Rev Anti Infect Ther 5:305-15. 2007
    ..This article will review the pathobiology of aortic graft infection, as well as methods to prevent a prosthetic graft infection. Furthermore, various surgical treatment modalities of aortic graft infection will be discussed...
  67. pmc Skin response to delayed hypersensitivity testing in persons with unilateral stroke-related paresis: implications for people with spinal cord injury
    Barbara W Trautner
    Department of Medicine, Section of Infectious Diseases, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Spinal Cord Med 30:362-5. 2007
    ..This would eliminate the the risk of discomfort and soreness at the injection site...
  68. doi request reprint Candida in the ICU
    Rabih O Darouiche
    Michael E DeBakey Veterans Affairs Medical Center, Infectious Disease Section Room 4B 370, Houston, TX 77030, USA
    Clin Chest Med 30:287-93, vi-vii. 2009
    ....
  69. ncbi request reprint Antifungal activity of antimicrobial-impregnated devices
    R O Darouiche
    Section of Infectious Diseases, Veterans Affairs Medical Center and Center for Prostheses Infection, Baylor College of Medicine, Houston, TX 77030, USA
    Clin Microbiol Infect 12:397-9. 2006
    ..albicans or C. krusei. Impregnated devices also had significantly lower colony counts of C. albicans (58 vs. 1361 CFU; p 0.008) and C. krusei (19 vs. 764 CFU; p 0.008)...
  70. ncbi request reprint Antimicrobial coating of devices for prevention of infection: principles and protection
    R O Darouiche
    Center for Prostheses Infection and Infectious Disease Section, Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Int J Artif Organs 30:820-7. 2007
    ....
  71. ncbi request reprint In vitro antimicrobial activity of N-acetylcysteine against bacteria colonising central venous catheters
    Mohammad D Mansouri
    Int J Antimicrob Agents 29:474-6. 2007

Research Grants4

  1. Prevention of UTI in persons with spinal cord injury
    Rabih Darouiche; Fiscal Year: 2007
    ..The PIs propose a prospective, randomized, double-blind placebo-controlled multicenter trial to evaluate the clinical efficacy of this innovative therapeutic protocol. ..