Genomes and Genes
J B Dale
- Dynamic epidemiology of group A streptococcal serotypesJames B Dale
Lancet 359:889. 2002
- Southern Society for Clinical Investigation Founders' Medal recipient's addressJames B Dale
University of Tennessee College of Medicine, Memphis, USA
Am J Med Sci 324:61-6. 2002
- Intranasal immunization with multivalent group A streptococcal vaccines protects mice against intranasal challenge infectionsMary A Hall
Department of Veterans Affairs Medical Center, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA
Infect Immun 72:2507-12. 2004..Our results indicate that intranasal delivery of adjuvanted multivalent M protein vaccines induces protective antibody responses and may provide an alternative to parenteral vaccine formulations...
- Progress in group A streptococcal vaccine developmentKaren L Kotloff
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
Pediatr Infect Dis J 23:765-6. 2004
- Current status of group A streptococcal vaccine developmentJames B Dale
University of Tennessee Health Science Center, Memphis 38104, USA
Adv Exp Med Biol 609:53-63. 2008..Successful deployment of safe and effective vaccines to prevent GAS infections and their complications could potentially have a significant impact on the health of millions of people around the world...
- New protective antigen of group A streptococciJ B Dale
Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
J Clin Invest 103:1261-8. 1999..These studies reveal the presence of a new protective antigen of certain strains of group A streptococci that may prove to be an important component of vaccines to prevent streptococcal infections...
- Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypesJames B Dale
Department of Veterans Affairs, The University of Health Science Center, Memphis, TN 38104, USA
Clin Diagn Lab Immunol 12:833-6. 2005....
- Antibodies against a synthetic peptide of SagA neutralize the cytolytic activity of streptolysin S from group A streptococciJames B Dale
Department of Veterans Affairs Medical Center and Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA
Infect Immun 70:2166-70. 2002..Our data also provide convincing evidence that the sagA gene actually encodes the SLS peptide of GAS. The synthetic peptide may prove to be an important component of vaccines designed to prevent GAS infections...
- Spa contributes to the virulence of type 18 group A streptococciD G McLellan
VA Medical Center, University of Tennessee, Memphis, Tennessee 38104, USA
Infect Immun 69:2943-9. 2001..The results show that Spa is a virulence determinant of group A streptococci and that expression of both Spa and M18 is required for optimal virulence of type 18 streptococci...
- Conversion of M serotype 24 of Streptococcus pyogenes to M serotypes 5 and 18: effect on resistance to phagocytosis and adhesion to host cellsH S Courtney
Department of Veterans Affairs Medical Center and Department of Medicine, University of Tennessee, Memphis 38104, USA
Infect Immun 65:2472-4. 1997..The data indicate that the M5 and M18 proteins can confer resistance to phagocytosis, that fibrinogen is required for this resistance, and that these M proteins can mediate adhesion to HEp-2 cells...
- Streptococcal protective antigens (Spa): a new family of type-specific proteins of group A streptococciE A Ahmed
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Eur J Clin Microbiol Infect Dis 29:51-7. 2010..Spa proteins may represent a new family of type-specific surface antigens that function in concert with M proteins to elicit protective immune responses...
- Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopesThomas A Penfound
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States
Vaccine 28:5017-22. 2010....
- Cloning, sequencing, and expression of a fibronectin/fibrinogen-binding protein from group A streptococciH S Courtney
Veterans Affairs Medical Center, Memphis, Tennessee 38104
Infect Immun 62:3937-46. 1994..These data suggest that FBP54 may be a surface protein of streptococci that reacts with both Fn and Fgn and therefore may participate in the adhesion of group A streptococci to host cells...
- Serum opacity factor is a major fibronectin-binding protein and a virulence determinant of M type 2 Streptococcus pyogenesH S Courtney
Veterans Affairs Medical Center, Research Service, Memphis, TN 38104, USA
Mol Microbiol 32:89-98. 1999..These data clearly indicate that SOF is a virulence factor, and they provide the first direct evidence that a fibronectin-binding protein contributes to the pathogenesis of group A streptococcal infections in vivo...
- Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenesKathleen H Cox
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
PLoS ONE 4:e5366. 2009..In this study, we have further investigated the effects that mutating dltA has on virulence factor expression in Streptococcus pyogenes...
- Anti-phagocytic mechanisms of Streptococcus pyogenes: binding of fibrinogen to M-related proteinHarry S Courtney
Veterans Affairs Medical Center, University of Tennessee Health Science Center, Memphis, TN 38104, USA
Mol Microbiol 59:936-47. 2006..This may be a common mechanism for evasion of phagocytosis because Mrp is expressed by approximately half of the clinical isolates of S. pyogenes...
- Molecular mechanisms of adhesion, colonization, and invasion of group A streptococciHarry S Courtney
Veterans Affairs Medical Center, Department of Medicine, Memphis, TN, USA
Ann Med 34:77-87. 2002..In this review, we present the different molecular mechanisms of adhesion utilized by group A streptococci and how these interactions lead to colonization and invasion...
- Identification of a gene within a pathogenicity island of enterotoxigenic Escherichia coli H10407 required for maximal secretion of the heat-labile enterotoxinJ M Fleckenstein
Medicine Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
Infect Immun 68:2766-74. 2000..Although previous studies have suggested that E. coli lacks the capacity to secrete LT, our studies show that maximal release of LT from the periplasm of H10407 is dependent on one or more elements encoded on a pathogenicity island...
- Presentation of the Southern Society for Clinical Investigation 2002 Founders' Medal to Dr. James B. DaleAndrew H Kang
Department of Medicine, University of Tennessee College of Medicine, Memphis 39163, USA
Am J Med Sci 324:57-60. 2002
- Serum opacity factor (SOF) of Streptococcus pyogenes evokes antibodies that opsonize homologous and heterologous SOF-positive serotypes of group A streptococciHarry S Courtney
Veterans Affairs Medical Center and Department of Medicine, University of Tennessee, Memphis, Tennessee 38104, USA
Infect Immun 71:5097-103. 2003....
- The NH(2)-terminal region of Streptococcus pyogenes M5 protein confers protection against degradation by proteases and enhances mucosal colonization of miceThomas A Penfound
Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Infect Dis 201:1580-8. 2010..The NH(2)-terminal sequence of the M protein from group A streptococci defines the serotype of the organism and contains epitopes that evoke bactericidal antibodies...
- Mapping the fibrinogen-binding domain of serum opacity factor of group a streptococciHarry S Courtney
Department of Medicine, University of Tennessee, Memphis, TN, USA
Curr Microbiol 44:236-40. 2002..These data suggest that fibrinogen and fibronectin bind to the same domain within SOF. It remains to be determined whether the binding of fibrinogen to SOF contributes to the virulence of group A streptococci...
- Prospects for a group A streptococcal vaccine: rationale, feasibility, and obstacles--report of a National Institute of Allergy and Infectious Diseases workshopAlan L Bisno
University of Miami Miller School of Medicine, Miami, Florida 33125, USA
Clin Infect Dis 41:1150-6. 2005..This report summarizes the deliberations of the workshop...
- Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002Stanford T Shulman
Division of Infectious Diseases, Children s Memorial Hospital, Chicago, IL, USA
Clin Infect Dis 39:325-32. 2004....
- Temporal changes in streptococcal M protein types and the near-disappearance of acute rheumatic fever in the United StatesStanford T Shulman
Division of Infectious Diseases, Children s Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
Clin Infect Dis 42:441-7. 2006..It has been proposed that certain M types of group A streptococci (GAS) include strains that are particularly rheumatogenic and that others are nonrheumatogenic...
- Safety and immunogenicity of a recombinant multivalent group a streptococcal vaccine in healthy adults: phase 1 trialKaren L Kotloff
Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
JAMA 292:709-15. 2004..Group A streptococcal infections and their sequelae represent a global health problem. Recent advances have allowed previous obstacles associated with group A streptococcal vaccine development to be overcome...
- Immunogenicity of a 26-valent group A streptococcal vaccineMary C Hu
ID Biomedical Corporation, Bothell, Washington, USA
Infect Immun 70:2171-7. 2002..Our results indicate that type-specific, protective M protein epitopes can be incorporated into complex, multivalent vaccines designed to elicit broadly protective opsonic antibodies in the absence of tissue-cross-reactive antibodies...
- Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteersShelly A McNeil
Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
Clin Infect Dis 41:1114-22. 2005..New molecular techniques have allowed the previous obstacles to be largely overcome...
- The importance of the group a streptococcus capsule in the pathogenesis of human infections: a historical perspectiveGene H Stollerman
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
Clin Infect Dis 46:1038-45. 2008..We believe that it is time to refocus newer clinical studies and techniques on achieving early recognition of potentially dangerous, heavily encapsulated strains of GAS for which spread may be prevented...