J B Dale

Summary

Country: USA

Publications

  1. ncbi request reprint Dynamic epidemiology of group A streptococcal serotypes
    James B Dale
    Lancet 359:889. 2002
  2. ncbi request reprint Southern Society for Clinical Investigation Founders' Medal recipient's address
    James B Dale
    University of Tennessee College of Medicine, Memphis, USA
    Am J Med Sci 324:61-6. 2002
  3. pmc Intranasal immunization with multivalent group A streptococcal vaccines protects mice against intranasal challenge infections
    Mary A Hall
    Department of Veterans Affairs Medical Center, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA
    Infect Immun 72:2507-12. 2004
  4. ncbi request reprint Progress in group A streptococcal vaccine development
    Karen L Kotloff
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Pediatr Infect Dis J 23:765-6. 2004
  5. doi request reprint Current status of group A streptococcal vaccine development
    James B Dale
    University of Tennessee Health Science Center, Memphis 38104, USA
    Adv Exp Med Biol 609:53-63. 2008
  6. pmc New protective antigen of group A streptococci
    J B Dale
    Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    J Clin Invest 103:1261-8. 1999
  7. pmc Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes
    James B Dale
    Department of Veterans Affairs, The University of Health Science Center, Memphis, TN 38104, USA
    Clin Diagn Lab Immunol 12:833-6. 2005
  8. pmc Antibodies against a synthetic peptide of SagA neutralize the cytolytic activity of streptolysin S from group A streptococci
    James B Dale
    Department of Veterans Affairs Medical Center and Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA
    Infect Immun 70:2166-70. 2002
  9. pmc Spa contributes to the virulence of type 18 group A streptococci
    D G McLellan
    VA Medical Center, University of Tennessee, Memphis, Tennessee 38104, USA
    Infect Immun 69:2943-9. 2001
  10. pmc Conversion of M serotype 24 of Streptococcus pyogenes to M serotypes 5 and 18: effect on resistance to phagocytosis and adhesion to host cells
    H S Courtney
    Department of Veterans Affairs Medical Center and Department of Medicine, University of Tennessee, Memphis 38104, USA
    Infect Immun 65:2472-4. 1997

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Dynamic epidemiology of group A streptococcal serotypes
    James B Dale
    Lancet 359:889. 2002
  2. ncbi request reprint Southern Society for Clinical Investigation Founders' Medal recipient's address
    James B Dale
    University of Tennessee College of Medicine, Memphis, USA
    Am J Med Sci 324:61-6. 2002
  3. pmc Intranasal immunization with multivalent group A streptococcal vaccines protects mice against intranasal challenge infections
    Mary A Hall
    Department of Veterans Affairs Medical Center, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA
    Infect Immun 72:2507-12. 2004
    ..Our results indicate that intranasal delivery of adjuvanted multivalent M protein vaccines induces protective antibody responses and may provide an alternative to parenteral vaccine formulations...
  4. ncbi request reprint Progress in group A streptococcal vaccine development
    Karen L Kotloff
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Pediatr Infect Dis J 23:765-6. 2004
  5. doi request reprint Current status of group A streptococcal vaccine development
    James B Dale
    University of Tennessee Health Science Center, Memphis 38104, USA
    Adv Exp Med Biol 609:53-63. 2008
    ..Successful deployment of safe and effective vaccines to prevent GAS infections and their complications could potentially have a significant impact on the health of millions of people around the world...
  6. pmc New protective antigen of group A streptococci
    J B Dale
    Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    J Clin Invest 103:1261-8. 1999
    ..These studies reveal the presence of a new protective antigen of certain strains of group A streptococci that may prove to be an important component of vaccines to prevent streptococcal infections...
  7. pmc Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes
    James B Dale
    Department of Veterans Affairs, The University of Health Science Center, Memphis, TN 38104, USA
    Clin Diagn Lab Immunol 12:833-6. 2005
    ....
  8. pmc Antibodies against a synthetic peptide of SagA neutralize the cytolytic activity of streptolysin S from group A streptococci
    James B Dale
    Department of Veterans Affairs Medical Center and Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA
    Infect Immun 70:2166-70. 2002
    ..Our data also provide convincing evidence that the sagA gene actually encodes the SLS peptide of GAS. The synthetic peptide may prove to be an important component of vaccines designed to prevent GAS infections...
  9. pmc Spa contributes to the virulence of type 18 group A streptococci
    D G McLellan
    VA Medical Center, University of Tennessee, Memphis, Tennessee 38104, USA
    Infect Immun 69:2943-9. 2001
    ..The results show that Spa is a virulence determinant of group A streptococci and that expression of both Spa and M18 is required for optimal virulence of type 18 streptococci...
  10. pmc Conversion of M serotype 24 of Streptococcus pyogenes to M serotypes 5 and 18: effect on resistance to phagocytosis and adhesion to host cells
    H S Courtney
    Department of Veterans Affairs Medical Center and Department of Medicine, University of Tennessee, Memphis 38104, USA
    Infect Immun 65:2472-4. 1997
    ..The data indicate that the M5 and M18 proteins can confer resistance to phagocytosis, that fibrinogen is required for this resistance, and that these M proteins can mediate adhesion to HEp-2 cells...
  11. doi request reprint Streptococcal protective antigens (Spa): a new family of type-specific proteins of group A streptococci
    E A Ahmed
    Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Eur J Clin Microbiol Infect Dis 29:51-7. 2010
    ..Spa proteins may represent a new family of type-specific surface antigens that function in concert with M proteins to elicit protective immune responses...
  12. pmc Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes
    Thomas A Penfound
    Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, United States
    Vaccine 28:5017-22. 2010
    ....
  13. pmc Cloning, sequencing, and expression of a fibronectin/fibrinogen-binding protein from group A streptococci
    H S Courtney
    Veterans Affairs Medical Center, Memphis, Tennessee 38104
    Infect Immun 62:3937-46. 1994
    ..These data suggest that FBP54 may be a surface protein of streptococci that reacts with both Fn and Fgn and therefore may participate in the adhesion of group A streptococci to host cells...
  14. ncbi request reprint Serum opacity factor is a major fibronectin-binding protein and a virulence determinant of M type 2 Streptococcus pyogenes
    H S Courtney
    Veterans Affairs Medical Center, Research Service, Memphis, TN 38104, USA
    Mol Microbiol 32:89-98. 1999
    ..These data clearly indicate that SOF is a virulence factor, and they provide the first direct evidence that a fibronectin-binding protein contributes to the pathogenesis of group A streptococcal infections in vivo...
  15. pmc Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes
    Kathleen H Cox
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e5366. 2009
    ..In this study, we have further investigated the effects that mutating dltA has on virulence factor expression in Streptococcus pyogenes...
  16. ncbi request reprint Anti-phagocytic mechanisms of Streptococcus pyogenes: binding of fibrinogen to M-related protein
    Harry S Courtney
    Veterans Affairs Medical Center, University of Tennessee Health Science Center, Memphis, TN 38104, USA
    Mol Microbiol 59:936-47. 2006
    ..This may be a common mechanism for evasion of phagocytosis because Mrp is expressed by approximately half of the clinical isolates of S. pyogenes...
  17. ncbi request reprint Molecular mechanisms of adhesion, colonization, and invasion of group A streptococci
    Harry S Courtney
    Veterans Affairs Medical Center, Department of Medicine, Memphis, TN, USA
    Ann Med 34:77-87. 2002
    ..In this review, we present the different molecular mechanisms of adhesion utilized by group A streptococci and how these interactions lead to colonization and invasion...
  18. pmc Identification of a gene within a pathogenicity island of enterotoxigenic Escherichia coli H10407 required for maximal secretion of the heat-labile enterotoxin
    J M Fleckenstein
    Medicine Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Infect Immun 68:2766-74. 2000
    ..Although previous studies have suggested that E. coli lacks the capacity to secrete LT, our studies show that maximal release of LT from the periplasm of H10407 is dependent on one or more elements encoded on a pathogenicity island...
  19. ncbi request reprint Presentation of the Southern Society for Clinical Investigation 2002 Founders' Medal to Dr. James B. Dale
    Andrew H Kang
    Department of Medicine, University of Tennessee College of Medicine, Memphis 39163, USA
    Am J Med Sci 324:57-60. 2002
  20. pmc Serum opacity factor (SOF) of Streptococcus pyogenes evokes antibodies that opsonize homologous and heterologous SOF-positive serotypes of group A streptococci
    Harry S Courtney
    Veterans Affairs Medical Center and Department of Medicine, University of Tennessee, Memphis, Tennessee 38104, USA
    Infect Immun 71:5097-103. 2003
    ....
  21. pmc The NH(2)-terminal region of Streptococcus pyogenes M5 protein confers protection against degradation by proteases and enhances mucosal colonization of mice
    Thomas A Penfound
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Infect Dis 201:1580-8. 2010
    ..The NH(2)-terminal sequence of the M protein from group A streptococci defines the serotype of the organism and contains epitopes that evoke bactericidal antibodies...
  22. ncbi request reprint Mapping the fibrinogen-binding domain of serum opacity factor of group a streptococci
    Harry S Courtney
    Department of Medicine, University of Tennessee, Memphis, TN, USA
    Curr Microbiol 44:236-40. 2002
    ..These data suggest that fibrinogen and fibronectin bind to the same domain within SOF. It remains to be determined whether the binding of fibrinogen to SOF contributes to the virulence of group A streptococci...
  23. ncbi request reprint Prospects for a group A streptococcal vaccine: rationale, feasibility, and obstacles--report of a National Institute of Allergy and Infectious Diseases workshop
    Alan L Bisno
    University of Miami Miller School of Medicine, Miami, Florida 33125, USA
    Clin Infect Dis 41:1150-6. 2005
    ..This report summarizes the deliberations of the workshop...
  24. ncbi request reprint Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002
    Stanford T Shulman
    Division of Infectious Diseases, Children s Memorial Hospital, Chicago, IL, USA
    Clin Infect Dis 39:325-32. 2004
    ....
  25. ncbi request reprint Temporal changes in streptococcal M protein types and the near-disappearance of acute rheumatic fever in the United States
    Stanford T Shulman
    Division of Infectious Diseases, Children s Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Clin Infect Dis 42:441-7. 2006
    ..It has been proposed that certain M types of group A streptococci (GAS) include strains that are particularly rheumatogenic and that others are nonrheumatogenic...
  26. ncbi request reprint Safety and immunogenicity of a recombinant multivalent group a streptococcal vaccine in healthy adults: phase 1 trial
    Karen L Kotloff
    Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    JAMA 292:709-15. 2004
    ..Group A streptococcal infections and their sequelae represent a global health problem. Recent advances have allowed previous obstacles associated with group A streptococcal vaccine development to be overcome...
  27. pmc Immunogenicity of a 26-valent group A streptococcal vaccine
    Mary C Hu
    ID Biomedical Corporation, Bothell, Washington, USA
    Infect Immun 70:2171-7. 2002
    ..Our results indicate that type-specific, protective M protein epitopes can be incorporated into complex, multivalent vaccines designed to elicit broadly protective opsonic antibodies in the absence of tissue-cross-reactive antibodies...
  28. ncbi request reprint Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Infect Dis 41:1114-22. 2005
    ..New molecular techniques have allowed the previous obstacles to be largely overcome...
  29. doi request reprint The importance of the group a streptococcus capsule in the pathogenesis of human infections: a historical perspective
    Gene H Stollerman
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Clin Infect Dis 46:1038-45. 2008
    ..We believe that it is time to refocus newer clinical studies and techniques on achieving early recognition of potentially dangerous, heavily encapsulated strains of GAS for which spread may be prevented...