FADY I MALIK

Summary

Affiliation: Cytokinetics Inc
Country: USA

Publications

  1. pmc Cardiac myosin activation: a potential therapeutic approach for systolic heart failure
    FADY I MALIK
    Preclinical Research and Development, Cytokinetics, Inc, South San Francisco, CA 94080, USA
    Science 331:1439-43. 2011
  2. doi request reprint Cardiac myosin activation part 1: from concept to clinic
    FADY I MALIK
    Preclinical Research and Development, Cytokinetics, Inc, South San Francisco, CA 94080, USA
    J Mol Cell Cardiol 51:454-61. 2011
  3. pmc Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases
    Alan J Russell
    Preclinical Research and Development, San Francisco, California, USA
    Nat Med 18:452-5. 2012
  4. pmc Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model
    Darren T Hwee
    Cytokinetics, Inc, South San Francisco, California, United States of America
    PLoS ONE 9:e96921. 2014
  5. doi request reprint Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study
    John R Teerlink
    Section of Cardiology, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, CA 94121 1545, USA
    Lancet 378:667-75. 2011
  6. doi request reprint Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure
    You Tang Shen
    CV Dynamics, Inc, North Brunswick, NJ, USA
    Circ Heart Fail 3:522-7. 2010
  7. pmc Tirasemtiv amplifies skeletal muscle response to nerve activation in humans
    Richard Hansen
    Research and Early Development, Cytokinetics, Inc, 280 East Grand Avenue, South San Francisco, California, 94080 4808, USA
    Muscle Nerve 50:925-31. 2014
  8. doi request reprint Novel drug mechanisms in development for heart failure
    Soidjon D Khodjaev
    Section of Cardiology, San Francisco Veterans Affairs Medical Center, 111C, 4150 Clement Street, San Francisco, CA, 94121 1545, USA
    Pflugers Arch 466:1219-25. 2014

Collaborators

  • John R Teerlink
  • You Tang Shen
  • St├ęphane Baudry
  • Xin Zhao
  • David Clarke
  • Dennis R Claflin
  • Christophe Depre
  • Alan J Russell
  • David J Morgans
  • Richard Hansen
  • Soidjon D Khodjaev
  • Darren T Hwee
  • Michael M Chen
  • Aaron C Hinken
  • Zhiheng Jia
  • Vipin Vijayakumar
  • Khalil G Saikali
  • Willis Chou
  • Roger M Enoka
  • Andrew A Wolff
  • Adam Kennedy
  • Randall R Stoltz
  • Julie Ryans
  • Jeffrey R Jasper
  • Daniel L Albertus
  • Julia Schaletzky
  • Pu Ping Lu
  • Raja Kawas
  • Marc Garard
  • Guillermo Godinez
  • DAVID MARQUEZ
  • William F Browne
  • Lena Driscoll
  • James J Hartman
  • Alexander R Muci
  • Scott E Collibee
  • Hector Rodriguez
  • Bradley P Morgan
  • Kenneth H Lee

Detail Information

Publications8

  1. pmc Cardiac myosin activation: a potential therapeutic approach for systolic heart failure
    FADY I MALIK
    Preclinical Research and Development, Cytokinetics, Inc, South San Francisco, CA 94080, USA
    Science 331:1439-43. 2011
    ..Cardiac myosin activation may provide a new therapeutic approach for systolic heart failure...
  2. doi request reprint Cardiac myosin activation part 1: from concept to clinic
    FADY I MALIK
    Preclinical Research and Development, Cytokinetics, Inc, South San Francisco, CA 94080, USA
    J Mol Cell Cardiol 51:454-61. 2011
    ..Cardiac myosin activation may provide a new therapeutic approach for systolic heart failure. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure."..
  3. pmc Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases
    Alan J Russell
    Preclinical Research and Development, San Francisco, California, USA
    Nat Med 18:452-5. 2012
    ..Troponin activation may provide a new therapeutic approach to improve physical activity in diseases where neuromuscular function is compromised...
  4. pmc Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model
    Darren T Hwee
    Cytokinetics, Inc, South San Francisco, California, United States of America
    PLoS ONE 9:e96921. 2014
    ..These results support the potential of fast skeletal troponin activators to improve muscle function in neuromuscular diseases...
  5. doi request reprint Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study
    John R Teerlink
    Section of Cardiology, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, CA 94121 1545, USA
    Lancet 378:667-75. 2011
    ..This study tested the hypothesis that omecamtiv mecarbil, a selective cardiac myosin activator, will augment cardiac function in human beings...
  6. doi request reprint Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure
    You Tang Shen
    CV Dynamics, Inc, North Brunswick, NJ, USA
    Circ Heart Fail 3:522-7. 2010
    ..In this investigation, we examined the effects of a novel cardiac myosin activator, omecamtiv mecarbil (formerly CK-1827452) in 2 different models of heart failure...
  7. pmc Tirasemtiv amplifies skeletal muscle response to nerve activation in humans
    Richard Hansen
    Research and Early Development, Cytokinetics, Inc, 280 East Grand Avenue, South San Francisco, California, 94080 4808, USA
    Muscle Nerve 50:925-31. 2014
    ..In this study we tested the hypothesis that tirasemtiv, a selective fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium, could amplify the response of muscle to neuromuscular input in humans...
  8. doi request reprint Novel drug mechanisms in development for heart failure
    Soidjon D Khodjaev
    Section of Cardiology, San Francisco Veterans Affairs Medical Center, 111C, 4150 Clement Street, San Francisco, CA, 94121 1545, USA
    Pflugers Arch 466:1219-25. 2014
    ....