Renu Virmani

Summary

Affiliation: CVPath Institute
Country: USA

Publications

  1. ncbi request reprint Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage
    Renu Virmani
    CVPath, International Registry of Pathology, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 25:2054-61. 2005
  2. ncbi request reprint Ex vivo and preclinical assessment of an endothelial progenitor cell capturing bioengineered stent
    S K Yazdani
    CVPath Institute, Inc, Gaithersburg, MD, USA
    Minerva Cardioangiol 60:11-21. 2012
  3. pmc Pathologic Etiologies of Late and Very Late Stent Thrombosis following First-Generation Drug-Eluting Stent Placement
    Fumiyuki Otsuka
    Department of Cardiovascular Pathology, CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Thrombosis 2012:608593. 2012
  4. ncbi request reprint Unique demands of the femoral anatomy and pathology and the need for unique interventions
    F Otsuka
    CVPath Institute, Inc, Gaithersburg, MD 20878, USA
    J Cardiovasc Surg (Torino) 54:191-210. 2013
  5. pmc Effects of intima stiffness and plaque morphology on peak cap stress
    Ali C Akyildiz
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Biomed Eng Online 10:25. 2011
  6. ncbi request reprint Pathology of the vulnerable plaque
    Renu Virmani
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 47:C13-8. 2006
  7. doi request reprint Pathological healing response of explanted MitraClip devices
    Elena Ladich
    Medical Director President, CVPath Institute, Inc, 19 Firstfield Rd, Gaithersburg, MD 20878, USA
    Circulation 123:1418-27. 2011
  8. pmc Morphological characteristics of coronary atherosclerosis in diabetes mellitus
    Renu Virmani
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    Can J Cardiol 22:81B-84B. 2006
  9. ncbi request reprint Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents
    Aloke V Finn
    CVPath, International Registry of Pathology, Gaithersburg, MD 20878, USA
    Circulation 112:270-8. 2005
  10. pmc Pathology of second-generation everolimus-eluting stents versus first-generation sirolimus- and Paclitaxel-eluting stents in humans
    Fumiyuki Otsuka
    From CVPath Institute, Inc, Gaithersburg, MD F O, M V, M N, K S, R K, E L, F D K, R V Virginia Tech Carilion School of Medicine, Roanoke, VA J F Partners Health Care Systems, Boston, MA J B N and Emory University School of Medicine, Atlanta, GA A V F
    Circulation 129:211-23. 2014

Detail Information

Publications120 found, 100 shown here

  1. ncbi request reprint Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage
    Renu Virmani
    CVPath, International Registry of Pathology, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 25:2054-61. 2005
    ..This review discusses the potential role of intraplaque vasa vasorum in lesion instability as it relates to plaque rupture...
  2. ncbi request reprint Ex vivo and preclinical assessment of an endothelial progenitor cell capturing bioengineered stent
    S K Yazdani
    CVPath Institute, Inc, Gaithersburg, MD, USA
    Minerva Cardioangiol 60:11-21. 2012
    ..The focus of this review is to demonstrate the efficacy of the Genous stent in preclinical studies, specifically to show the effectiveness of the anti-CD34+ coating in promoting endothelialization and reducing thrombogenicity...
  3. pmc Pathologic Etiologies of Late and Very Late Stent Thrombosis following First-Generation Drug-Eluting Stent Placement
    Fumiyuki Otsuka
    Department of Cardiovascular Pathology, CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Thrombosis 2012:608593. 2012
    ....
  4. ncbi request reprint Unique demands of the femoral anatomy and pathology and the need for unique interventions
    F Otsuka
    CVPath Institute, Inc, Gaithersburg, MD 20878, USA
    J Cardiovasc Surg (Torino) 54:191-210. 2013
    ..The results from registries support the effectiveness of the atherectomy devices; however, prospective randomized controlled trials are needed to confirm their benefit...
  5. pmc Effects of intima stiffness and plaque morphology on peak cap stress
    Ali C Akyildiz
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Biomed Eng Online 10:25. 2011
    ..A parametric study was conducted to assess the effect of intima stiffness and plaque morphology on peak cap stress...
  6. ncbi request reprint Pathology of the vulnerable plaque
    Renu Virmani
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 47:C13-8. 2006
    ..It has only recently been recognized that their identification in living patients might help reduce the incidence of sudden coronary death...
  7. doi request reprint Pathological healing response of explanted MitraClip devices
    Elena Ladich
    Medical Director President, CVPath Institute, Inc, 19 Firstfield Rd, Gaithersburg, MD 20878, USA
    Circulation 123:1418-27. 2011
    ..The healing response after device implantation has not previously been characterized in humans...
  8. pmc Morphological characteristics of coronary atherosclerosis in diabetes mellitus
    Renu Virmani
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    Can J Cardiol 22:81B-84B. 2006
    ..Further studies are needed to better understand the mechanisms that govern greater inflammation and plaque burden in diabetics...
  9. ncbi request reprint Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents
    Aloke V Finn
    CVPath, International Registry of Pathology, Gaithersburg, MD 20878, USA
    Circulation 112:270-8. 2005
    ..Although effective coverage of challenging coronary lesions has warranted the use of overlapping drug-eluting stents, the histopathological response to stent overlap is unknown...
  10. pmc Pathology of second-generation everolimus-eluting stents versus first-generation sirolimus- and Paclitaxel-eluting stents in humans
    Fumiyuki Otsuka
    From CVPath Institute, Inc, Gaithersburg, MD F O, M V, M N, K S, R K, E L, F D K, R V Virginia Tech Carilion School of Medicine, Roanoke, VA J F Partners Health Care Systems, Boston, MA J B N and Emory University School of Medicine, Atlanta, GA A V F
    Circulation 129:211-23. 2014
    ..It remains unclear whether vascular responses to CoCr-EES are different from those to SES and PES because the pathology of CoCr-EES has not been described in humans...
  11. doi request reprint Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study
    Gaku Nakazawa
    CVPath Institute, Inc, 19 Firstfield Rd, Gaithersburg, MD 20878, USA
    Circulation 118:1138-45. 2008
    ..Using autopsy data, we evaluated the pathological responses of the stented segment in patients treated with DES for AMI and compared with patients with stable angina...
  12. ncbi request reprint Extracellular matrix changes in stented human coronary arteries
    Andrew Farb
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 110:940-7. 2004
    ..The composition of the in-stent ECM has not been well characterized in humans...
  13. pmc Pathology of drug-eluting versus bare-metal stents in saphenous vein bypass graft lesions
    Saami K Yazdani
    CVPath Institute Inc, Gaithersburg, Maryland 20878, USA
    JACC Cardiovasc Interv 5:666-74. 2012
    ..The purpose of this study was to assess the pathological responses of atherosclerotic saphenous vein bypass grafts (SVBGs) to drug-eluting stents (DES) versus bare-metal stents (BMS)...
  14. ncbi request reprint Pioglitazone inhibits in-stent restenosis in atherosclerotic rabbits by targeting transforming growth factor-beta and MCP-1
    Michael Joner
    CVPath Institute Inc, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 27:182-9. 2007
    ....
  15. ncbi request reprint Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk
    Michael Joner
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 48:193-202. 2006
    ..This study examined human drug-eluting stents (DES) to determine the long-term effects of these stents on coronary arterial healing and identified mechanisms underlying late stent thrombosis (LST)...
  16. ncbi request reprint Vascular responses to drug eluting stents: importance of delayed healing
    Aloke V Finn
    CVPath Institute, Inc, 19 Firstfield, Road, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 27:1500-10. 2007
    ..Because the time course of complete healing with DES in man is unknown, the optimal duration of antiplatelet treatment remains to be determined...
  17. ncbi request reprint Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Arterioscler Thromb Vasc Biol 24:1266-71. 2004
    ..Coronary atherosclerotic plaque composition of diabetic subjects and localization of receptor for advanced glycation end products (RAGE) and its ligands have not been extensively studied...
  18. ncbi request reprint Elimination of neoangiogenesis for plaque stabilization: is there a role for local drug therapy?
    Frank D Kolodgie
    CVPath Institute, Gaithersburg, Maryland, USA
    J Am Coll Cardiol 49:2093-101. 2007
    ..A multitargeted approach involving selective local antiangiogenic agents should contribute to prevention of plaque progression and its clinical consequences...
  19. ncbi request reprint Drug-eluting stents: are they really safe?
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th Street NW, Washington, DC 20306 6000, USA
    Am Heart Hosp J 2:85-8. 2004
    ....
  20. doi request reprint Ex vivo assessment of vascular response to coronary stents by optical frequency domain imaging
    Masataka Nakano
    CVPath Institute, Gaithersburg, Maryland 20878, USA
    JACC Cardiovasc Imaging 5:71-82. 2012
    ..This study sought to examine the capability of optical frequency domain imaging (OFDI) to characterize various morphological and histological responses to stents implanted in human coronary arteries...
  21. ncbi request reprint Intraplaque hemorrhage and progression of coronary atheroma
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    N Engl J Med 349:2316-25. 2003
    ..Intraplaque hemorrhage is common in advanced coronary atherosclerotic lesions. The relation between hemorrhage and the vulnerability of plaque to disruption may involve the accumulation of free cholesterol from erythrocyte membranes...
  22. ncbi request reprint The accumulation of specific types of proteoglycans in eroded plaques: a role in coronary thrombosis in the absence of rupture
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Curr Opin Lipidol 15:575-82. 2004
    ..This review discusses the putative role of extracellular matrix molecules, in particular proteoglycans/hyaluronan, in the development of acute coronary thrombosis associated with erosion...
  23. doi request reprint Coronary responses and differential mechanisms of late stent thrombosis attributed to first-generation sirolimus- and paclitaxel-eluting stents
    Gaku Nakazawa
    CVPath Institute, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 57:390-8. 2011
    ..The purpose of this study was to assess the mechanism(s) of late stent thrombosis (LST) and vascular healing responses in first-generation polymeric drug-eluting stents (DES)...
  24. pmc Human autopsy study of drug-eluting stents restenosis: histomorphological predictors and neointimal characteristics
    Masataka Nakano
    CVPath Institute, Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Eur Heart J 34:3304-13. 2013
    ..We interrogated our autopsy registry to determine the underlying mechanisms of DES restenosis, and further we investigated the neointimal characteristics of DESs and compared with bare metal stents (BMSs)...
  25. ncbi request reprint The significance of preclinical evaluation of sirolimus-, paclitaxel-, and zotarolimus-eluting stents
    Gaku Nakazawa
    CVPath Institute Inc, Gaithersburg, Maryland 20878, USA
    Am J Cardiol 100:36M-44M. 2007
    ....
  26. ncbi request reprint Drug-eluting stents: caution and concerns for long-term outcome
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Coron Artery Dis 15:313-8. 2004
    ..This incidence promotes a cautionary view and perhaps supports the use of DES only in high-risk patients...
  27. doi request reprint Drug-eluting stent safety: findings from preclinical studies
    Gaku Nakazawa
    CVPath Institute, Inc, 19 Firstfield Road, Gaithersburg, MD 20850, USA
    Expert Rev Cardiovasc Ther 6:1379-91. 2008
    ....
  28. doi request reprint Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathology
    Aloke V Finn
    CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 30:177-81. 2010
    ..Moreover, in most cases measures of plaque area or volume are generally considered better predictors of an inflammatory process consistent with atherosclerotic disease rather than intimal medial thickness...
  29. doi request reprint Incidence and predictors of drug-eluting stent fracture in human coronary artery a pathologic analysis
    Gaku Nakazawa
    CVPath Institute, Inc, Gaithersburg, Maryland, USA
    J Am Coll Cardiol 54:1924-31. 2009
    ..The aim of this study was to perform pathologic assessment on stent fracture...
  30. doi request reprint Evaluation of polymer-based comparator drug-eluting stents using a rabbit model of iliac artery atherosclerosis
    Gaku Nakazawa
    CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Circ Cardiovasc Interv 4:38-46. 2011
    ..Although atherosclerotic models, especially in the rabbit, have existed for a long time, a comparative study of various drug-eluting stent (DES) implantations in atherosclerotic arteries have not been systematically studied...
  31. ncbi request reprint Pathological mechanisms of fatal late coronary stent thrombosis in humans
    Andrew Farb
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 108:1701-6. 2003
    ..Coronary stent deployment is associated with a low incidence of acute thrombosis. However, late stent thrombosis (LST) has likely been underrecognized clinically, and pathological descriptions are lacking...
  32. doi request reprint Anti-CD34 antibodies immobilized on the surface of sirolimus-eluting stents enhance stent endothelialization
    Gaku Nakazawa
    CVPath Institute, Inc, Gaithersburg, Maryland
    JACC Cardiovasc Interv 3:68-75. 2010
    ..In this study, we hypothesized that an antihuman-CD34 antibody immobilized on the surface of commercially available sirolimus-eluting stents (SES) could enhance re-endothelialization compared with SES alone...
  33. ncbi request reprint Lipoprotein-associated phospholipase A2 protein expression in the natural progression of human coronary atherosclerosis
    Frank D Kolodgie
    CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 26:2523-9. 2006
    ....
  34. ncbi request reprint Pathophysiology of atherosclerosis plaque progression
    Kenichi Sakakura
    CVPath Institute, Inc, Gaithersburg, MD 20878, USA
    Heart Lung Circ 22:399-411. 2013
    ..The underlying lesion morphology in plaque erosion consists of PIT or a thick cap fibroatheroma. Calcified nodule is the least frequent cause of thrombosis, which occurs in older individuals with heavily calcified and tortious arteries...
  35. doi request reprint In vitro and in vivo characterisation of biodegradable polymer-based drug-eluting stent
    Saami K Yazdani
    CVPath Institute, Inc, Gaithersburg, MD 20878, USA
    EuroIntervention 7:835-43. 2011
    ..e., biodegradable polymer) coronary drug-eluting stent (DES) (BioMatrix™; Biosensors International, Singapore) to three currently marketed FDA/CE- mark approved non-erodible polymer-coated DES in a porcine model...
  36. pmc The pathology of neoatherosclerosis in human coronary implants bare-metal and drug-eluting stents
    Gaku Nakazawa
    CVPath Institute, Inc, Gaithersburg, Maryland, USA
    J Am Coll Cardiol 57:1314-22. 2011
    ..Human coronary bare-metal stents (BMS) and drug-eluting stents (DES) from autopsy cases with implant duration >30 days were examined for the presence of neointimal atherosclerotic disease...
  37. doi request reprint Atheroma and coronary bifurcations: before and after stenting
    Saami K Yazdani
    CVPath Institute, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    EuroIntervention 6:J24-30. 2010
    ..The occurrence of late stent thrombosis in DES is also shown to be associated with greater presence of uncovered stent struts at the high shear region, which is likely due to local flow mechanics...
  38. ncbi request reprint Causes of early stent thrombosis in patients presenting with acute coronary syndrome: an ex vivo human autopsy study
    Masataka Nakano
    CVPath Institute, Gaithersburg, Maryland
    J Am Coll Cardiol 63:2510-20. 2014
    ..The study interrogated an autopsy registry to investigate the histopathologic features of early stent thrombosis (ST) in patients presenting with acute coronary syndrome (ACS)...
  39. ncbi request reprint Oral everolimus inhibits in-stent neointimal growth
    Andrew Farb
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 106:2379-84. 2002
    ..The present study evaluated whether orally administered everolimus (a macrolide of the same family as sirolimus) inhibits in-stent neointimal growth in rabbit iliac arteries...
  40. pmc Pathology of atherosclerosis and stenting
    Frank D Kolodgie
    CVPath Institute, Incorporated, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Neuroimaging Clin N Am 17:285-301, vii. 2007
    ..The histologic features associated with symptomatic and asymptomatic carotid disease are also addressed, along with the issues surrounding current stent-based therapies for the prevention of major recurrent vascular events...
  41. ncbi request reprint Preclinical evaluation of second-generation everolimus- and zotarolimus-eluting coronary stents
    Saami K Yazdani
    CVPath Institute Inc, Gaithersburg, Maryland 20878, USA
    J Invasive Cardiol 25:383-90. 2013
    ..This study was designed to evaluate the pharmacokinetic and vascular healing of a second-generation everolimus-eluting stent (EES) and slow-release zotarolimus-eluting stent (R-ZES)...
  42. ncbi request reprint Elevated C-reactive protein values and atherosclerosis in sudden coronary death: association with different pathologies
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 105:2019-23. 2002
    ..Elevations in serum C-reactive protein measured by high-sensitivity assay (hs-CRP) have been associated with unstable coronary syndromes. There have been no autopsy studies correlating hs-CRP to fatal coronary artery disease...
  43. ncbi request reprint Superficial pseudoaneurysms: clinicopathologic aspects and involvement of extracellular matrix proteoglycans
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Mod Pathol 17:482-8. 2004
    ..The immunohistochemical studies confirm that versican is upregulated in areas of tensile stress. In addition, the presence of endothelial expression of decorin supports the concept of decorin's involvement in angiogenesis...
  44. doi request reprint Polymer-free immobilization of a cyclic RGD peptide on a nitinol stent promotes integrin-dependent endothelial coverage of strut surfaces
    Michael Joner
    CVPath Institute, Gaithersburg, Maryland 20878, USA
    J Biomed Mater Res B Appl Biomater 100:637-45. 2012
    ..1 ± 21.9 vs. BSA = 49.9 ± 21.8%, p < 0.03). Immobilization of cRGD peptides on strut surfaces represents an innovative strategy to improve endothelialization, which may facilitate vascular healing after stent implantation...
  45. ncbi request reprint Pathobiology of stent thrombosis after drug-eluting stent implantation
    Marc Vorpahl
    CV Path Institute Inc 19 Firstfield Road Gaithersburg, MD, USA
    Curr Pharm Des 16:4064-71. 2010
    ..DES was also associated with premature atherosclerotic changes versus BMS...
  46. ncbi request reprint Histopathologic evaluation of nitinol self-expanding stents in an animal model of advanced atherosclerotic lesions
    Michael Joner
    CVPath Institute, Inc, Gaithersburg, MD 20878, USA
    EuroIntervention 5:737-44. 2010
    ....
  47. pmc Comparison of pathology of chronic total occlusion with and without coronary artery bypass graft
    Kenichi Sakakura
    CVPath Institute, Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Eur Heart J 35:1683-93. 2014
    ..The aim of our study was to investigate chronic total occlusion (CTO) in human coronary arteries to clarify the difference between CTO with prior coronary artery bypass graft (CABG) and those without prior CABG...
  48. doi request reprint Total anomalous origin of the coronary circulation from the right pulmonary artery
    Fabio Tavora
    CVPath Institute, Gaithersburg, MD, USA
    Cardiovasc Pathol 17:246-9. 2008
    ..No other congenital anomalies were identified. Total anomalous origin of the coronary arteries from the pulmonary trunk or artery should be considered in cases of sudden unexpected death in infants...
  49. ncbi request reprint Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious?
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC, USA
    Circulation 109:701-5. 2004
    ..The US Food and Drug Administration recently issued a warning of subacute thrombosis and hypersensitivity reactions to sirolimus-eluting stents (Cypher). The cause and incidence of these events have not been determined...
  50. ncbi request reprint Pathology of the unstable plaque
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Prog Cardiovasc Dis 44:349-56. 2002
    ..The influence of risk factors for coronary artery disease on culprit lesion morphology is also discussed. Finally, the value of coronary calcification, as a predictor of unstable plaques in the clinical setting, is explored...
  51. ncbi request reprint Morphological predictors of restenosis after coronary stenting in humans
    Andrew Farb
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 105:2974-80. 2002
    ..Despite the increased use of coronary stents in humans, there are only limited pathological data on the morphological features of in-stent restenosis...
  52. ncbi request reprint Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Arterioscler Thromb Vasc Biol 22:1642-8. 2002
    ..The importance of the extracellular matrix molecules versican, biglycan, decorin, and hyaluronan in plaque instability has not been recognized...
  53. ncbi request reprint Thrombotic thrombocytopenic purpura causing rapid unexpected death: value of CD61 immunohistochemical staining in diagnosis
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cardiovasc Pathol 14:150-5. 2005
    ..TTP may result in myocardial hemorrhages and rapid death. We compared rapidly fatal TTP with heart involvement and DIC cases to determine if the differential diagnosis of TTP and DIC could be aided by immunohistochemical techniques...
  54. ncbi request reprint Free cholesterol in atherosclerotic plaques: where does it come from?
    Frank D Kolodgie
    CVPath Institute, Gaithersburg, Maryland 20878, USA
    Curr Opin Lipidol 18:500-7. 2007
    ..Therefore, intraplaque hemorrhage may not be a passive event, as once considered as studies continue to support the relationship of intraplaque hemorrhage and necrotic core expansion...
  55. doi request reprint Pathology of calcific aortic stenosis
    Elena Ladich
    CVPath, Institute Inc, Gaithersburg, MD 20878, USA
    Future Cardiol 7:629-42. 2011
    ..Various atherosclerotic risk factors have been linked to aortic stenosis and there are mechanistic similarities between atherosclerosis and CAS. The precise pathologic mechanisms underlying aortic stenosis are poorly understood...
  56. ncbi request reprint Increased serum homocysteine and sudden death resulting from coronary atherosclerosis with fibrous plaques
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Arterioscler Thromb Vasc Biol 22:1936-41. 2002
    ..Modest elevations of total homocysteine have been associated with increased risk for coronary atherosclerosis but correlation between elevated homocysteine and plaque morphology has not been described in humans...
  57. ncbi request reprint Vascular pathology of drug-eluting stents
    Gaku Nakazawa
    CVPath Institute, Inc, Gaithersburg, MD 20878, USA
    Herz 32:274-80. 2007
    ..Since the time course of complete healing with DES is unknown, the optimal duration of antiplatelet treatment remains to be determined...
  58. ncbi request reprint Cardiac inflammatory myofibroblastic tumor: a "benign" neoplasm that may result in syncope, myocardial infarction, and sudden death
    Allen Burke
    CVPath Institute Inc, Gaithersburg, MD 20878, USA
    Am J Surg Pathol 31:1115-22. 2007
    ..These cardiac myofibroblastic tumors are readily distinguished from other endocardial-based cardiac tumors, including papillary fibroelastoma and myxoma, which may present clinically in the same manner...
  59. ncbi request reprint Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825, 16th Street NW, Washington, DC 20306 6000, USA
    J Interv Cardiol 16:267-72. 2003
    ..Targeted therapy for the purpose of stabilizing coronary lesions that are prone to rupture is a major future goal of the interventionist...
  60. doi request reprint The importance of the endothelium in atherothrombosis and coronary stenting
    Fumiyuki Otsuka
    CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Nat Rev Cardiol 9:439-53. 2012
    ....
  61. ncbi request reprint Atherosclerotic plaque morphology and coronary thrombi
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    J Nucl Cardiol 9:95-103. 2002
  62. doi request reprint A review of current devices and a look at new technology: drug-eluting stents
    Gaku Nakazawa
    CVPath Institute, Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Expert Rev Med Devices 6:33-42. 2009
    ..The next-generation DES will probably be safer, with goals of improving endothelialization and more rapid arterial healing compared with first- and second-generation DES...
  63. ncbi request reprint Sustained reduction of in-stent neointimal growth with the use of a novel systemic nanoparticle paclitaxel
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Circulation 106:1195-8. 2002
    ..The present study tested the efficacy of a novel systemic delivery nanoparticle PXL for reducing in-stent restenosis...
  64. doi request reprint Pathological findings at bifurcation lesions: the impact of flow distribution on atherosclerosis and arterial healing after stent implantation
    Gaku Nakazawa
    CVPath Institute, Inc, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 55:1679-87. 2010
    ....
  65. doi request reprint Omnipresent atherosclerotic disease: time to depart from analysis of individual vascular beds
    Fumiyuki Otsuka
    CVPath Institute, Gaithersburg, MD, USA
    Mt Sinai J Med 79:641-53. 2012
    ..Therefore, the concept of palliative treatment must be reserved for only those who have progressed beyond preventive measures...
  66. doi request reprint Vascular, downstream, and pharmacokinetic responses to treatment with a low dose drug-coated balloon in a swine femoral artery model
    Saami K Yazdani
    CVPath Institute, Inc, Gaithersburg, Maryland
    Catheter Cardiovasc Interv 83:132-40. 2014
    ..This study was designed to evaluate the safety of a novel drug-coated balloon (DCB) with 2 µg/mm(2) paclitaxel and a carrier comprised of polysorbate and sorbitol in a swine femoral artery model...
  67. ncbi request reprint Pathophysiology of vascular healing and stent mediated arterial injury
    Gaku Nakazawa
    CVPath Institute, Inc, Gaithersburg, Maryland, USA
    EuroIntervention 4:C7-10. 2008
    ..Both may lead to late stent thrombosis. Other factors that increase risk are penetration of the necrotic core, bifurcation stenting and malapposition...
  68. doi request reprint Histopathologic assessment of myocardial regeneration
    Naima Carter-Monroe
    CVPath Institute, Gaithersburg, MD, USA
    Methods Mol Biol 660:125-48. 2010
    ..Despite widespread optimism in the success of cell-based therapy, inherent difficulties remain in the identification of effective cell populations proposed for cell-based therapy in the human heart...
  69. doi request reprint In vitro and in vivo characterization of novel biodegradable polymers for application as drug-eluting stent coatings
    Nathan A Lockwood
    SurModics, Inc, Eden Prairie, MN, USA
    J Biomater Sci Polym Ed 21:529-52. 2010
    ....
  70. doi request reprint Detection of lipid core coronary plaques in autopsy specimens with a novel catheter-based near-infrared spectroscopy system
    Craig M Gardner
    InfraReDx, Inc, Burlington, Massachusetts 01803, USA
    JACC Cardiovasc Imaging 1:638-48. 2008
    ..This study sought to assess agreement between an intravascular near-infrared spectroscopy (NIRS) system and histology in coronary autopsy specimens...
  71. doi request reprint The complementary role of microCT and histopathology in characterizing the natural history of stented arteries
    Marc Vorpahl
    CVPath Institute, Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Expert Rev Cardiovasc Ther 9:939-48. 2011
    ..This article outlines a protocol for ex vivo, postmortem cardiac examination of stented arterial segments with microcomputed tomography followed by histopathologic analysis and highlights the complementary nature of these modalities...
  72. doi request reprint The bioabsorption process: tissue and cellular mechanisms and outcomes
    Marc Vorpahl
    CVPath, Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    EuroIntervention 5:F28-35. 2009
    ..In short, the future for bio-erodible polymers to treat symptomatic coronary disease is bright with the promise of important and novel therapeutic potential...
  73. ncbi request reprint Pathophysiology of acute myocardial infarction
    Allen P Burke
    CVPath Institute, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Med Clin North Am 91:553-72; ix. 2007
    ....
  74. ncbi request reprint Pathology and vulnerability of atherosclerotic plaque: identification, treatment options, and individual patient differences for prevention of stroke
    Saami K Yazdani
    CVPath Institute, Inc, 19 Firstfield Road, Gaithersburg, MD, 20878, USA
    Curr Treat Options Cardiovasc Med 12:297-314. 2010
    ..Ultimately, however, the identification of important molecular surrogates in early lesion progression may eventually predict late-term risk and likely will provide the ideal strategy for reducing the morbidity and mortality of stroke...
  75. pmc Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions
    Rogier A van Dijk
    CVPath Institute, Gaithersburg, MD, USA
    J Lipid Res 53:2773-90. 2012
    ..These findings provide a rationale for targeting OSE for biotheranostic applications in humans...
  76. doi request reprint Pediatric heart tumors
    Allen Burke
    CVPath Institute, Gaithersburg, MD 20878, USA
    Cardiovasc Pathol 17:193-8. 2008
    ..Other rare tumors, including histiocytoid cardiomyopathy, hemangioma, germ cell tumors, and sarcomas, may occur in children in the heart and are discussed...
  77. doi request reprint Aortitis and ascending aortic aneurysm: description of 52 cases and proposal of a histologic classification
    Allen P Burke
    CVPath Institute, Gaithersburg, MD 20878, USA
    Hum Pathol 39:514-26. 2008
    ..NNA is less often isolated and best classified as giant cell aortitis. Adult NA has histologic features classically associated with Takayasu disease but is limited primarily to the ascending aorta and has no sex predominance...
  78. ncbi request reprint Histopathology of carotid atherosclerotic disease
    Renu Virmani
    International Registry of Pathology, Inc, Gaithersburg, Maryland, USA
    Neurosurgery 59:S219-27; discussion S3-13. 2006
    ....
  79. ncbi request reprint Sudden cardiac death not related to coronary atherosclerosis
    Elena Ladich
    CVPath, International Registry of Pathology, Inc, Gaithersburg, MD 20878, USA
    Toxicol Pathol 34:52-7. 2006
    ..The important role played by genetics in some of these cardiovascular diseases is presented as well as toxic and drug-related etiologies...
  80. doi request reprint Histogram analysis of lipid-core plaques in coronary computed tomographic angiography: ex vivo validation against histology
    Christopher L Schlett
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Invest Radiol 48:646-53. 2013
    ..We sought to determine whether the quantitative histogram analysis improves accuracy of the detection of lipid-core plaque (LCP) in ex vivo hearts by validation against histological analysis...
  81. pmc Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging
    Michelle Olive
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Arterioscler Thromb Vasc Biol 30:2301-9. 2010
    ..We undertook the first histological comparative evaluation between genetically confirmed HGPS and the CVD of aging...
  82. ncbi request reprint Cardiac tumours: an update: Cardiac tumours
    Allen Burke
    CVPath Institute, Gaithersburg, MD 20878, USA
    Heart 94:117-23. 2008
  83. ncbi request reprint In vitro evaluation of vascular endothelial and smooth muscle cell survival and apoptosis in response to hypothermia and freezing
    Kristine N Tatsutani
    CryoVascular Systems, Inc, 160 Knowles Drive, Los Gatos, California 95032, USA
    Cryo Letters 26:55-64. 2005
    ..Endovascular cryotherapy designed to induce apoptosis in arterial smooth muscle cells may limit neointimal formation and thereby improve the durability of conventional angioplasty...
  84. ncbi request reprint From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II
    Morteza Naghavi
    The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
    Circulation 108:1772-8. 2003
    ..We encourage healthcare policy makers to promote translational research for screening and treatment of vulnerable patients...
  85. ncbi request reprint Characterization of intimal changes in coronary artery specimens with MR microscopy
    Breno S Pessanha
    Department of Cardiovascular Pathology and Magnetic Resonance Microscopy Facility, Armed Forces Institute of Pathology, Washington, DC, USA
    Radiology 241:107-15. 2006
    ..To determine if magnetic resonance (MR) microscopy can yield images sufficient for discriminating early progressive atherosclerotic lesions from nonprogressive atherosclerotic lesions in human coronary arteries...
  86. ncbi request reprint Mechanism of late in-stent restenosis after implantation of a paclitaxel derivate-eluting polymer stent system in humans
    Renu Virmani
    Catheterization Laboratories, Ospedale San Raffaele and Emo Centro Cuore Columbus, Milan, Italy
    Circulation 106:2649-51. 2002
    ..This study presents the histological findings of atherectomy specimens from a subset of these patients receiving implants...
  87. ncbi request reprint Traditional risk factors and the incidence of sudden coronary death with and without coronary thrombosis in blacks
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 105:419-24. 2002
    ..Blacks have a high rate of sudden coronary death (SCD). We determined the rate of SCD in men and women 30 to 69 years of age in a 6-year period recorded at a state Medical Examiner's Office...
  88. ncbi request reprint Granulocyte-colony stimulating factor administration after myocardial infarction in a porcine ischemia-reperfusion model: functional and pathological effects of dose timing
    Nirat Beohar
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Catheter Cardiovasc Interv 69:257-66. 2007
    ..The use of growth factors may prevent this. The aim of this study was to assess early and delayed administration of granulocyte colony-stimulating factor (G-CSF) in a porcine model of myocardial infarction (MI) and reperfusion...
  89. ncbi request reprint Actinomycin-eluting stent for coronary revascularization: a randomized feasibility and safety study: the ACTION trial
    Patrick W Serruys
    Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 44:1363-7. 2004
    ..We sought to demonstrate the safety and performance of the actinomycin D-coated Multilink-Tetra stent(Guidant Corp., Santa Clara, California) in the treatment of patients with single de novo native coronary lesions...
  90. ncbi request reprint Diagnosis of thin-cap fibroatheromas by a self-contained intravascular magnetic resonance imaging probe in ex vivo human aortas and in situ coronary arteries
    Jacob Schneiderman
    Department of Vascular Surgery and Gottesdiener Vascular Biology Laboratory, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Am Coll Cardiol 45:1961-9. 2005
    ..We sought to correlate findings obtained from a self-contained magnetic resonance imaging (MRI) probe with plaque morphology of ex vivo human aortas and coronary arteries...
  91. ncbi request reprint A placebo controlled, dose-ranging, safety study of allogenic mesenchymal stem cells injected by endomyocardial delivery after an acute myocardial infarction
    Seyed M Hashemi
    Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Eur Heart J 29:251-9. 2008
    ..Although mesenchymal stem cells (MSCs) show promising signs in reducing myocardial infarct (MI) size, the safety of endomyocardial delivery and the most efficacious dose is unknown...
  92. ncbi request reprint Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization
    Rakesh K Jain
    Harvard Medical School and Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Cardiovasc Med 4:491-502. 2007
    ..The development of this novel approach to prevent plaque progression might add to the armamentarium of preventive measures for acute myocardial infarction, stroke and sudden cardiac death...
  93. ncbi request reprint Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study
    Pavan K Cheruvu
    Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 50:940-9. 2007
    ..Our purpose was to quantify the frequency and distribution of suspected vulnerable lesions, defined as thin-capped fibroatheroma (TCFA) and ruptured plaque, in human coronary artery autopsy specimens...
  94. ncbi request reprint Adult cellular rhabdomyoma of the heart: a report of 3 cases
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
    Hum Pathol 33:1092-7. 2002
    ..Although surgical excision was possible in all patients, long-term follow-up will be required to determine the true biologic behavior of these neoplasms...
  95. ncbi request reprint Vulnerable plaque: the pathology of unstable coronary lesions
    Renu Virmani
    Dept of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th Street, N W, Washington, DC 20306 6000, USA
    J Interv Cardiol 15:439-46. 2002
    ..Newer catheters and other techniques are at various stages of development and will play a significant role in the understanding of plaque progression and the development of symptomatic coronary artery disease...
  96. ncbi request reprint Adventitial microvessel formation after coronary stenting and the effects of SU11218, a tyrosine kinase inhibitor
    Asim N Cheema
    Roy and Ann Foss Cardiovascular Research Program, Terrence Donnelly Heart Center, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 47:1067-75. 2006
    ....
  97. ncbi request reprint Histopathologic alterations after endovascular radiation and antiproliferative stents: similarities and differences
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Herz 27:1-6. 2002
    ..Conversely, stainless steel control stents show complete healing with the neointima consisting of smooth muscle cells in a proteoglycan-collagen matrix and near complete luminal surface endothelialization...
  98. ncbi request reprint Morphological predictors of arterial remodeling in coronary atherosclerosis
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Circulation 105:297-303. 2002
    ..Although arterial remodeling in atherosclerotic arteries affects luminal patency, the role of plaque components has not been systematically studied...
  99. ncbi request reprint Images in cardiovascular medicine. Sirolimus-eluting stent implanted in human coronary artery for 16 months: pathological findings
    Giulio Guagliumi
    Cardiovascular Department, Ospedali Riuniti di Bergamo, Bergamo, Italy
    Circulation 107:1340-1. 2003
  100. ncbi request reprint Phenotypic modulation of intima and media smooth muscle cells in fatal cases of coronary artery lesion
    Hiroyuki Hao
    Department of Pathology and Immunology, University of Geneva CMU, Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 26:326-32. 2006
    ..Characterize the phenotypic features of media and intima coronary artery smooth muscle cells (SMCs) in mildly stenotic plaques, erosions, stable plaques, and in-stent restenosis...
  101. ncbi request reprint Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5
    Satoshi Isobe
    Division of Cardiology, University of California, Irvine School of Medicine, 92697, USA
    J Nucl Med 47:1497-505. 2006
    ..We evaluated the feasibility of annexin A5 imaging in transgenic apoE(-/-) and LDLR(-/-) mice with or without a cholesterol diet...