R M Lawn

Summary

Affiliation: CV Therapeutics
Country: USA

Publications

  1. pmc The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
    R M Lawn
    CV Therapeutics Inc, Palo Alto, California 94304, USA
    J Clin Invest 104:R25-31. 1999
  2. ncbi request reprint Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a)
    G Chiesa
    Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 267:24369-74. 1992
  3. ncbi request reprint Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily
    D T Drayna
    DNA 6:199-204. 1987
  4. ncbi request reprint Assignment of the human gene for cholesteryl ester transfer protein to chromosome 16q12-16q21
    A J Lusis
    Department of Medicine, School of Medicine, University of California, Los Angeles 90024
    Genomics 1:232-5. 1987
  5. pmc 5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family
    D P Wade
    Division of Cardiovascular Medicine, Stanford University School of Medicine, CA 94305 5246
    Proc Natl Acad Sci U S A 90:1369-73. 1993
  6. ncbi request reprint Loss of a splice donor site at a 'skipped exon' in a gene homologous to apolipoprotein(a) leads to an mRNA encoding a protein consisting of a single kringle domain
    C D Byrne
    Falk Cardiovascular Research Center, Stanford University School of Medicine, CA 94305 5246, USA
    Arterioscler Thromb Vasc Biol 15:65-70. 1995
  7. pmc Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice
    X J Lou
    Falk Cardiovascular Research Center, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:12591-5. 1998
  8. ncbi request reprint Localization of human ATP-binding cassette transporter 1 (ABC1) in normal and atherosclerotic tissues
    R M Lawn
    Winship Cancer Institute, Division of Hematology/Oncology, Emory University School of Medicine, Atlanta, GA, USA
    Arterioscler Thromb Vasc Biol 21:378-85. 2001
  9. ncbi request reprint Functional analysis of the chimpanzee and human apo(a) promoter sequences: identification of sequence variations responsible for elevated transcriptional activity in chimpanzee
    T Huby
    INSERM, , , , , , , Paris 75651 Cedex 13, France
    J Biol Chem 276:22209-14. 2001

Collaborators

  • D P Wade
  • John Oram
  • T Huby
  • X J Lou
  • J Wickings
  • M J Chapman
  • C Dachet
  • J Thillet
  • C D Byrne
  • F T Horrigan
  • N W Boonmark
  • J L Degen
  • K Schwartz
  • G Chiesa
  • M L Koschinsky
  • D T Drayna
  • A J Lusis
  • S D Maika
  • H H Hobbs
  • R E Hammer
  • I Klisak
  • D Drayna
  • R S Sparkes
  • K L Wion
  • J M Trent
  • T Mohandas
  • J W McLean
  • H A Drabkin
  • S Zollman

Detail Information

Publications9

  1. pmc The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
    R M Lawn
    CV Therapeutics Inc, Palo Alto, California 94304, USA
    J Clin Invest 104:R25-31. 1999
    ..Thus, ABC1 has the properties of a key protein in the cellular lipid removal pathway, as emphasized by the consequences of its defect in patients with Tangier disease...
  2. ncbi request reprint Reconstitution of lipoprotein(a) by infusion of human low density lipoprotein into transgenic mice expressing human apolipoprotein(a)
    G Chiesa
    Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 267:24369-74. 1992
    ..These studies suggest that apo(a) fails to associate with mouse lipoproteins due to structural differences between human and mouse LDL, and that Lp(a) formation can occur in plasma through the association of apo(a) with circulating LDL...
  3. ncbi request reprint Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily
    D T Drayna
    DNA 6:199-204. 1987
    ..Similarity of intron locations in both apo D and RBP suggests that these two genes derived from a common ancestor...
  4. ncbi request reprint Assignment of the human gene for cholesteryl ester transfer protein to chromosome 16q12-16q21
    A J Lusis
    Department of Medicine, School of Medicine, University of California, Los Angeles 90024
    Genomics 1:232-5. 1987
    ....
  5. pmc 5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family
    D P Wade
    Division of Cardiovascular Medicine, Stanford University School of Medicine, CA 94305 5246
    Proc Natl Acad Sci U S A 90:1369-73. 1993
    ..Flanking genomic fragments of the apoliprotein(a) gene from two individuals with vastly different plasma apolipoprotein(a) concentrations have sequence differences that are reflected in differences in the rate of in vitro transcription...
  6. ncbi request reprint Loss of a splice donor site at a 'skipped exon' in a gene homologous to apolipoprotein(a) leads to an mRNA encoding a protein consisting of a single kringle domain
    C D Byrne
    Falk Cardiovascular Research Center, Stanford University School of Medicine, CA 94305 5246, USA
    Arterioscler Thromb Vasc Biol 15:65-70. 1995
    ..This results in "exon skipping" during maturation of the mRNA, causing a coding frame shift and the presence of premature stop codons...
  7. pmc Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice
    X J Lou
    Falk Cardiovascular Research Center, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:12591-5. 1998
    ..Our results suggest that fibrin(ogen) provides one of the major sites to which apo(a) binds to the vessel wall and participates in the generation of atherosclerosis...
  8. ncbi request reprint Localization of human ATP-binding cassette transporter 1 (ABC1) in normal and atherosclerotic tissues
    R M Lawn
    Winship Cancer Institute, Division of Hematology/Oncology, Emory University School of Medicine, Atlanta, GA, USA
    Arterioscler Thromb Vasc Biol 21:378-85. 2001
    ..However, the presence of ABC1 in ductal cells of the kidney medulla and in the small intestine suggest a more general role for this protein in cholesterol transport in other cell types...
  9. ncbi request reprint Functional analysis of the chimpanzee and human apo(a) promoter sequences: identification of sequence variations responsible for elevated transcriptional activity in chimpanzee
    T Huby
    INSERM, , , , , , , Paris 75651 Cedex 13, France
    J Biol Chem 276:22209-14. 2001
    ..High transcriptional activity of the chimpanzee apo(a) gene may therefore represent a key factor in the elevated plasma Lp(a) levels characteristic of this non-human primate...