William C Cushman

Summary

Country: USA

Publications

  1. ncbi request reprint Achieving blood pressure goals: why aren't we?
    William C Cushman
    University of Tennessee College of Medicine, Memphis, TN 38104, USA
    J Clin Hypertens (Greenwich) 8:865-72. 2006
  2. ncbi request reprint Regional and racial differences in response to antihypertensive medication use in a randomized controlled trial of men with hypertension in the United States. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents
    W C Cushman
    Department of Veterans Affairs Research and Development Service, Veterans Affairs Medical Center, Memphis, Tenn 38104, USA
    Arch Intern Med 160:825-31. 2000
  3. ncbi request reprint Pulse pressure changes with six classes of antihypertensive agents in a randomized, controlled trial
    W C Cushman
    Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Hypertension 38:953-7. 2001
  4. ncbi request reprint Hypertension control in clinical practice with a new standard in angiotensin II receptor blockade
    William C Cushman
    Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Am J Hypertens 15:99S-100S. 2002
  5. doi request reprint Azilsartan medoxomil plus chlorthalidone reduces blood pressure more effectively than olmesartan plus hydrochlorothiazide in stage 2 systolic hypertension
    William C Cushman
    University of Tennessee College of Medicine, Memphis, TN, USA
    Hypertension 60:310-8. 2012
  6. pmc Mortality and morbidity during and after the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
    William C Cushman
    Memphis Veterans Affairs Medical Center, Memphis, TN, USA
    J Clin Hypertens (Greenwich) 14:20-31. 2012
  7. pmc Blood pressure control by drug group in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    William C Cushman
    From the Veterans Affairs Medical Center, Memphis, TN, USA
    J Clin Hypertens (Greenwich) 10:751-60. 2008
  8. doi request reprint Home and clinic blood pressure responses in elderly individuals with systolic hypertension
    William C Cushman
    University of Tennessee and the VA Medical Center, Memphis, TN 38103, USA
    J Am Soc Hypertens 6:210-8. 2012
  9. ncbi request reprint Are there benefits to specific antihypertensive drug therapy?
    William C Cushman
    University of Tennessee College of Medicine, Memphis, Tennessee 38104, USA
    Am J Hypertens 16:31S-35S. 2003
  10. ncbi request reprint Rationale and design for the blood pressure intervention of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    William C Cushman
    Memphis Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Am J Cardiol 99:44i-55i. 2007

Detail Information

Publications38

  1. ncbi request reprint Achieving blood pressure goals: why aren't we?
    William C Cushman
    University of Tennessee College of Medicine, Memphis, TN 38104, USA
    J Clin Hypertens (Greenwich) 8:865-72. 2006
    ....
  2. ncbi request reprint Regional and racial differences in response to antihypertensive medication use in a randomized controlled trial of men with hypertension in the United States. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents
    W C Cushman
    Department of Veterans Affairs Research and Development Service, Veterans Affairs Medical Center, Memphis, Tenn 38104, USA
    Arch Intern Med 160:825-31. 2000
    ..Stroke incidence and mortality rates are higher in the southeastern region of the United States, which is called the "Stroke Belt." We compared the response to antihypertensive medication use in patients from different US regions...
  3. ncbi request reprint Pulse pressure changes with six classes of antihypertensive agents in a randomized, controlled trial
    W C Cushman
    Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Hypertension 38:953-7. 2001
    ..0 mm Hg) were intermediate. These data show that classes of antihypertensive agents differ in their ability to reduce pulse pressure. Whether these differences affect rates of cardiovascular events remains to be determined...
  4. ncbi request reprint Hypertension control in clinical practice with a new standard in angiotensin II receptor blockade
    William C Cushman
    Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Am J Hypertens 15:99S-100S. 2002
  5. doi request reprint Azilsartan medoxomil plus chlorthalidone reduces blood pressure more effectively than olmesartan plus hydrochlorothiazide in stage 2 systolic hypertension
    William C Cushman
    University of Tennessee College of Medicine, Memphis, TN, USA
    Hypertension 60:310-8. 2012
    ..This large, forced-titration study has demonstrated superior antihypertensive efficacy of azilsartan medoxomil/chlorthalidone fixed-dose combinations compared with the maximum approved dose of olmesartan/hydrochlorothiazide...
  6. pmc Mortality and morbidity during and after the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
    William C Cushman
    Memphis Veterans Affairs Medical Center, Memphis, TN, USA
    J Clin Hypertens (Greenwich) 14:20-31. 2012
    ..These findings suggest that neither calcium channel blockers nor angiotensin-converting enzyme inhibitors are superior to diuretics for the long-term prevention of major cardiovascular complications of hypertension...
  7. pmc Blood pressure control by drug group in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    William C Cushman
    From the Veterans Affairs Medical Center, Memphis, TN, USA
    J Clin Hypertens (Greenwich) 10:751-60. 2008
    ..BP control was achieved in the majority of each randomized group-a greater proportion with chlorthalidone. Over time, providers and patients should expect multidrug therapy to achieve BP <140/90 mm Hg in a majority of patients...
  8. doi request reprint Home and clinic blood pressure responses in elderly individuals with systolic hypertension
    William C Cushman
    University of Tennessee and the VA Medical Center, Memphis, TN 38103, USA
    J Am Soc Hypertens 6:210-8. 2012
    ..Home BP monitoring, if done with proper technique, provides a reliable indicator of BP control in elderly patients and may help guide drug dosing and titration...
  9. ncbi request reprint Are there benefits to specific antihypertensive drug therapy?
    William C Cushman
    University of Tennessee College of Medicine, Memphis, Tennessee 38104, USA
    Am J Hypertens 16:31S-35S. 2003
    ..A primary goal in treating hypertension should be to reach a patient's goal BP, but initial selection of drugs based on hypertension morbidity study results and other compelling indications should be given priority...
  10. ncbi request reprint Rationale and design for the blood pressure intervention of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    William C Cushman
    Memphis Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
    Am J Cardiol 99:44i-55i. 2007
    ..The ACCORD blood pressure trial should provide the first definitive clinical trial data on the possible benefit of treating to a more aggressive systolic blood pressure goal in reducing CVD events in patients with diabetes mellitus...
  11. ncbi request reprint Efficacy and safety of fixed combinations of irbesartan/hydrochlorothiazide in older vs younger patients with hypertension uncontrolled with monotherapy
    William C Cushman
    University of Tennessee College of Medicine and Veterans Affairs Medical Center, Memphis, TN, USA
    Am J Geriatr Cardiol 17:27-36. 2008
    ..Irbesartan/HCTZ combination therapy allowed SBP goal attainment in 73% of patients aged 65 years or older whose hypertension was previously uncontrolled with antihypertensive monotherapy...
  12. ncbi request reprint JNC-7 guidelines: are they still relevant?
    William C Cushman
    University of Tennessee College of Medicine, Preventive Medicine Section 111Q, Veterans Affairs Medical Center, 1030 Jefferson Ave, Memphis, TN 38104, USA
    Curr Hypertens Rep 9:380-6. 2007
    ..Although a new JNC report would be reassuring to practitioners and should include some changes since JNC 7, I consider most of the recommendations to still be relevant today...
  13. ncbi request reprint The effect of a losartan-based treatment regimen on isolated systolic hypertension
    William C Cushman
    Preventive Medicine Section 111Q, Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    J Clin Hypertens (Greenwich) 4:101-7. 2002
    ..The losartan-based regimen exhibited antihypertensive efficacy that was superior to that of placebo, with a similar tolerability profile...
  14. pmc Disparity implications of Medicare eligibility criteria for medication therapy management services
    Junling Wang
    Department of Pharmaceutical Sciences, University of Tennessee College of Pharmacy, 847 Monroe Avenue, Room 205R, Memphis, TN 38163, USA
    Health Serv Res 45:1061-82. 2010
    ..To determine whether there would be racial and ethnic disparities in meeting eligibility criteria for medication therapy management (MTM) services implemented in 2006 for Medicare beneficiaries...
  15. ncbi request reprint The burden of uncontrolled hypertension: morbidity and mortality associated with disease progression
    William C Cushman
    Department of Preventive Medicine, University of Tennessee College of Medicine, Memphis, TN 38104, USA
    J Clin Hypertens (Greenwich) 5:14-22. 2003
    ....
  16. pmc Antihypertensive medication adherence, ambulatory visits, and risk of stroke and death
    James E Bailey
    Division of General Internal Medicine, Department of Medicine, University of Tennessee Health Science Center, 956 Court Avenue, Coleman D222, Memphis, TN 38163, USA
    J Gen Intern Med 25:495-503. 2010
    ....
  17. ncbi request reprint The efficacy and safety of low- and high-dose fixed combinations of irbesartan/hydrochlorothiazide in patients with uncontrolled systolic blood pressure on monotherapy: the INCLUSIVE trial
    Joel M Neutel
    Orange County Research Center, Tustin, CA 92780, USA
    J Clin Hypertens (Greenwich) 7:578-86. 2005
    ..Treatments were well tolerated. This irbesartan/HCTZ treatment regimen achieved SBP goals in more than 75% of patients uncontrolled on monotherapy...
  18. ncbi request reprint Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods
    John B Buse
    Division of Endocrinology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7172, USA
    Am J Cardiol 99:21i-33i. 2007
    ....
  19. ncbi request reprint Hypertension and heart failure. Roundtable discussion
    Marvin Moser
    J Clin Hypertens (Greenwich) 6:326-32. 2004
  20. ncbi request reprint The treatment of hypertension in the elderly
    Marvin Moser
    J Clin Hypertens (Greenwich) 10:58-68. 2008
    ..The authors maintained full control of the discussion and the resulting content of this article...
  21. ncbi request reprint Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    Aram V Chobanian
    Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:1206-52. 2003
    ..Positive experiences, trust in the clinician, and empathy improve patient motivation and satisfaction. This report serves as a guide, and the committee continues to recognize that the responsible physician's judgment remains paramount...
  22. ncbi request reprint Response to six classes of antihypertensive medications by body mass index in a randomized controlled trial
    Barry J Materson
    Cooperative Studies Program of the Department of Veterans Affairs, Office of Research and Development and the Department of Medicine, University of Miami, Miami, FL 33136, USA
    J Clin Hypertens (Greenwich) 5:197-201. 2003
    ..01). Only prazosin patients gained weight: 1.7 lb (end-titration, p<0.0001; 1-year, p=0.02). Obesity does not appear to cause resistance to antihypertensive medications...
  23. ncbi request reprint The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
    ..Empathy builds trust and is a potent motivator. Finally, in presenting these guidelines, the committee recognizes that the responsible physician's judgment remains paramount...
  24. ncbi request reprint What should our blood pressure goal be in patients with diabetes?
    William C Cushman
    J Clin Hypertens (Greenwich) 9:823-6. 2007
  25. ncbi request reprint Blood pressure control in Hispanics in the antihypertensive and lipid-lowering treatment to prevent heart attack trial
    Karen L Margolis
    HealthPartners Research Foundation PO Box 1524, Mailstop 21111R, Minneapolis, MN 55440 1524, USA
    Hypertension 50:854-61. 2007
    ....
  26. ncbi request reprint Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and lisinopril
    Jackson T Wright
    General Clinical Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    JAMA 293:1595-608. 2005
    ..Few cardiovascular outcome data are available for blacks with hypertension treated with angiotensin-converting enzyme (ACE) inhibitors or calcium channel blockers (CCBs)...
  27. ncbi request reprint Prevention of cardiovascular disease in persons with type 2 diabetes mellitus: current knowledge and rationale for the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    David C Goff
    Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Am J Cardiol 99:4i-20i. 2007
    ..The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial will test hypotheses to address these unanswered questions...
  28. ncbi request reprint The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Heart Failure Validation Study: diagnosis and prognosis
    Paula T Einhorn
    National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, Bethesda, MD 20892 7936, USA
    Am Heart J 153:42-53. 2007
    ..However, questions have been raised regarding the validity of the HF diagnosis...
  29. ncbi request reprint Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1
    Marco Pahor
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 105:457-61. 2002
    ..ACE inhibitors and calcium antagonists may modulate fibrinolysis. We conducted a randomized controlled trial to assess the effects of these drugs on plasminogen activator inhibitor-1 (PAI-1) antigen, an inhibitor of fibrinolysis...
  30. pmc Irbesartan/HCTZ fixed combinations in patients of different racial/ethnic groups with uncontrolled systolic blood pressure on monotherapy
    Elizabeth O Ofili
    Clinical Research Center, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Natl Med Assoc 98:618-26. 2006
    ..In conclusion, irbesartan/HCTZ treatment provided SBP/DBP goal attainment in approximately two-thirds of Caucasian, African-American and Hispanic/Latino patients with SBP uncontrolled on antihypertensive monotherapy...
  31. ncbi request reprint Antihypertensive efficacy of Irbesartan/HCTZ in men and women with the metabolic syndrome and type 2 diabetes
    James R Sowers
    University of Missouri Columbia and Harry S Truman VA Medical Center, 65212, USA
    J Clin Hypertens (Greenwich) 8:470-80. 2006
    ..Irbesartan/HCTZ fixed combinations achieved SBP goals in over half of the T2DM patients and nearly three quarters of patients with the metabolic syndrome, with SBP uncontrolled on antihypertensive monotherapy...
  32. ncbi request reprint Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)
    William C Cushman
    J Clin Hypertens (Greenwich) 4:393-404. 2002
    ..Achievable control rates in varied practice settings and geographic regions and factors that predict improved blood pressure control are not well identified...
  33. ncbi request reprint Hypertension in adults across age groups
    Dan R Berlowitz
    JAMA 294:2970-1; author reply 2971-2. 2005
  34. ncbi request reprint Clinical events in high-risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin-converting enzyme inhibitor in the antihypertensive and lipid-lowering treatment to prevent heart attack trial
    Frans H H Leenen
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Hypertension 48:374-84. 2006
    ..Some, but not all, of these differences may be explained by less effective blood pressure control in the lisinopril arm...
  35. doi request reprint Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  36. doi request reprint Thiazide-induced dysglycemia: call for research from a working group from the national heart, lung, and blood institute
    Barry L Carter
    Division of Clinical and Administrative Pharmacy, Rm 527, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 52:30-6. 2008
  37. ncbi request reprint Clinical outcomes in antihypertensive treatment of type 2 diabetes, impaired fasting glucose concentration, and normoglycemia: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    Paul K Whelton
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
    Arch Intern Med 165:1401-9. 2005
    ....
  38. ncbi request reprint Control of blood pressure: does it matter which agent you use?
    Marvin Moser
    J Clin Hypertens (Greenwich) 9:964-73. 2007
    ..The authors maintained full control of the discussion and the resulting content of this article...