John P Alsobrook
Affiliation: CuraGen Corporation
- A factor analysis of tic symptoms in Gilles de la Tourette's syndromeJohn P Alsobrook
Child Study Center, Department of Psychology, Yale University, New Haven, CT, USA
Am J Psychiatry 159:291-6. 2002..However, the great deal of clinical variability across patients may represent an underlying etiologic complexity. Issues of phenotypic heterogeneity are particularly critical to current efforts at mapping genes involved in this syndrome...
- Association between the COMT locus and obsessive-compulsive disorder in females but not malesJohn P Alsobrook
Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Med Genet 114:116-20. 2002..049), but not in male probands. These findings indicate that COMT may be etiologically relevant to OCD in a gender-specific manner opposite to that shown in previous studies...
- Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndromeJames F Leckman
Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Med Genet B Neuropsychiatr Genet 116:60-8. 2003..We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental...