Richard Levenson

Summary

Affiliation: CRI Inc
Country: USA

Publications

  1. ncbi Spectral imaging perspective on cytomics
    Richard M Levenson
    CRI, Woburn, Massachussets 01801, USA
    Cytometry A 69:592-600. 2006
  2. ncbi Multispectral imaging in biology and medicine: slices of life
    Richard M Levenson
    CRI Inc, Woburn, MA, USA
    Cytometry A 69:748-58. 2006
  3. ncbi Putting the "more" back in morphology: spectral imaging and image analysis in the service of pathology
    Richard Levenson
    CRI, Inc, 35B Cabot Rd, Woburn, MA 01801, USA
    Arch Pathol Lab Med 132:748-57. 2008
  4. ncbi Multiplexing with multispectral imaging: from mice to microscopy
    Richard M Levenson
    CRI Inc, Woburn, MA 01801, USA
    ILAR J 49:78-88. 2008
  5. ncbi Distinguished photons: increased contrast with multispectral in vivo fluorescence imaging
    James R Mansfield
    CRI, Inc, Woburn, MA 01801, USA
    Biotechniques 39:S33-7. 2005
  6. ncbi Visualization of microscopy-based spectral imaging data from multi-label tissue sections
    James R Mansfield
    Cambridge Research and Instrumentation, Woburn, Massachusetts, USA
    Curr Protoc Mol Biol . 2008
  7. ncbi Autofluorescence removal, multiplexing, and automated analysis methods for in-vivo fluorescence imaging
    James R Mansfield
    Cambridge Research and Instrumentation, Inc, 35-B Cabot Road, Woburn, Massachusetts 01801, USA
    J Biomed Opt 10:41207. 2005
  8. ncbi In vivo cancer targeting and imaging with semiconductor quantum dots
    Xiaohu Gao
    Department of Biomedical Engineering, and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, 1639 Pierce Drive, Suite 2001, Atlanta, Georgia 30322, USA
    Nat Biotechnol 22:969-76. 2004
  9. ncbi Fine-needle aspiration of follicular adenoma versus parathyroid adenoma: the utility of multispectral imaging in differentiating lesions with subtle cytomorphologic differences
    Ibrahim Mansoor
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Cancer 114:22-6. 2008
  10. ncbi Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution
    Richard J Byers
    Division of Laboratory and Regenerative Medicine, University of Manchester, United Kingdom
    J Mol Diagn 9:20-9. 2007

Research Grants

  1. Real-time PolScope microscope for live-cell imaging
    Richard Levenson; Fiscal Year: 2006
  2. Spectrally resolved tomographic small-animal fluorescence imager
    Richard Levenson; Fiscal Year: 2007
  3. Spectral imaging for automated malignant blast counting
    Richard Levenson; Fiscal Year: 2007
  4. Cellularly resolved molecular pathway assessment in biopsies via spectral imaging
    Richard Levenson; Fiscal Year: 2007

Collaborators

  • Hisataka Kobayashi
  • James R Mansfield
  • Leland W Chung
  • DAVID L contact RIMM
  • Ibrahim Mansoor
  • Kirk Gossage
  • Richard J Byers
  • Wendy A Wells
  • Cesar Angeletti
  • Xiaohu Gao
  • Farhan Zahid
  • Carola Zalles
  • James M Crawford
  • Peter E Barker
  • Eleni Tholouli
  • Calum Macaulay
  • Dolores Di Vizio
  • Stephen P Finn
  • Todd R Golub
  • Massimo Loda
  • Yu Yang
  • Keith L Ligon
  • Kirk Gossard
  • Joshua Rose
  • David Twomey
  • Marco Novelli
  • Elisa Benedettini
  • Andrew H Fischer
  • Vitali Khomitch
  • Neal R Harvey
  • Shuming Nie
  • Yuanyuan Cui

Detail Information

Publications12

  1. ncbi Spectral imaging perspective on cytomics
    Richard M Levenson
    CRI, Woburn, Massachussets 01801, USA
    Cytometry A 69:592-600. 2006
    ..Simple-to-use instrumentation is available that mounts on standard microscopes and can generate spectral image datasets with excellent spatial and spectral resolution; these can be exploited by sophisticated analysis tools...
  2. ncbi Multispectral imaging in biology and medicine: slices of life
    Richard M Levenson
    CRI Inc, Woburn, MA, USA
    Cytometry A 69:748-58. 2006
    ..The sensitivity of fluorescence-based in-vivo imaging, as with fluorescence microscopy, can be limited by the presence of significant autofluorescence, a limitation which can be overcome through the utilization of MSI...
  3. ncbi Putting the "more" back in morphology: spectral imaging and image analysis in the service of pathology
    Richard Levenson
    CRI, Inc, 35B Cabot Rd, Woburn, MA 01801, USA
    Arch Pathol Lab Med 132:748-57. 2008
  4. ncbi Multiplexing with multispectral imaging: from mice to microscopy
    Richard M Levenson
    CRI Inc, Woburn, MA 01801, USA
    ILAR J 49:78-88. 2008
    ..Due to the same advantages in sensitivity, quantitation, and multiplexing, microscopy-based multispectral techniques form an excellent complement to in vivo imaging...
  5. ncbi Distinguished photons: increased contrast with multispectral in vivo fluorescence imaging
    James R Mansfield
    CRI, Inc, Woburn, MA 01801, USA
    Biotechniques 39:S33-7. 2005
    ..Using manual and automated algorithms to generate these spectra, it is possible to detect as many as three fluorescent protein-labeled tumors and two separate autofluorescent signals in a single subject...
  6. ncbi Visualization of microscopy-based spectral imaging data from multi-label tissue sections
    James R Mansfield
    Cambridge Research and Instrumentation, Woburn, Massachusetts, USA
    Curr Protoc Mol Biol . 2008
    ..These commercially available tools can be attached to the standard laboratory light microscope to significantly enhance the power of light microscopy...
  7. ncbi Autofluorescence removal, multiplexing, and automated analysis methods for in-vivo fluorescence imaging
    James R Mansfield
    Cambridge Research and Instrumentation, Inc, 35-B Cabot Road, Woburn, Massachusetts 01801, USA
    J Biomed Opt 10:41207. 2005
    ..While the availability of spectral "libraries" makes multispectral analysis routine for well-characterized samples, new software tools have been developed that greatly simplify the application of MSI to novel specimens...
  8. ncbi In vivo cancer targeting and imaging with semiconductor quantum dots
    Xiaohu Gao
    Department of Biomedical Engineering, and the Winship Cancer Institute, Emory University and Georgia Institute of Technology, 1639 Pierce Drive, Suite 2001, Atlanta, Georgia 30322, USA
    Nat Biotechnol 22:969-76. 2004
    ..These results raise new possibilities for ultrasensitive and multiplexed imaging of molecular targets in vivo...
  9. ncbi Fine-needle aspiration of follicular adenoma versus parathyroid adenoma: the utility of multispectral imaging in differentiating lesions with subtle cytomorphologic differences
    Ibrahim Mansoor
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Cancer 114:22-6. 2008
    ..Herein, the authors used fine-needle aspirations (FNAs) of follicular adenoma (FA) and parathyroid adenoma (PA) as a test case...
  10. ncbi Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution
    Richard J Byers
    Division of Laboratory and Regenerative Medicine, University of Manchester, United Kingdom
    J Mol Diagn 9:20-9. 2007
    ....
  11. ncbi Detection of malignancy in cytology specimens using spectral-spatial analysis
    Cesar Angeletti
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Lab Invest 85:1555-64. 2005
    ....
  12. ncbi Validation of novel optical imaging technologies: the pathologists' view
    Wendy A Wells
    Dartmouth Medical School, Department of Pathology, 1 Rope Ferry Road, Hanover, New Hampshire 03755, USA
    J Biomed Opt 12:051801. 2007
    ....

Research Grants7

  1. Real-time PolScope microscope for live-cell imaging
    Richard Levenson; Fiscal Year: 2006
    ..This includes advances in the user interface and other software functionalities. These technical advances will be deployed in collaborations. ..
  2. Spectrally resolved tomographic small-animal fluorescence imager
    Richard Levenson; Fiscal Year: 2007
    ..In addition, CRI will work on methods to accelerate time consuming tomographic reconstructions. Finally, easy-to-use software for control, display, quantitation and integration into laboratory information systems will be developed. ..
  3. Spectral imaging for automated malignant blast counting
    Richard Levenson; Fiscal Year: 2007
    ..FDA-sanctioned clinical trials will be conducted in the third year, leading to submission of an application for a 510(k) clearance. ..
  4. Cellularly resolved molecular pathway assessment in biopsies via spectral imaging
    Richard Levenson; Fiscal Year: 2007
    ..e., theranostics). ..