Research Topics
Genomes and Genes
| Lan Juan ZhaoSummaryAffiliation: Creighton University Country: USA Publications
| Collaborators
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Detail Information
Publications
Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear familiesYue juan Qin
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Hunan, China
J Bone Miner Res 18:1028-35. 2003..In conclusion, this study suggests that the ER-alpha gene may have minor effects on PBD variation in our Chinese population...
Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear familiesLan Juan Zhao
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Hum Genet 124:171-7. 2008..The results suggest that the TNFR2 gene polymorphisms contribute to the variation of obesity phenotypes...- SNPP: automating large-scale SNP genotype data managementLan-Juan Zhao
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University Changsha, Hunan 410081, China
Bioinformatics 21:266-8. 2005..Furthermore, SNPP may generate files for repeat genotyping and transform them into files that can be executed by a liquid handling system. AVAILABILITY: http://orclinux.creighton.edu/snpp/ CONTACT: .. 
The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trialJiapeng Zhou
Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, USA
Nutr Metab (Lond) 7:62. 2010..It is undetermined whether calcium supplementation has an effect on obesity or body composition in postmenopausal women. The purpose of the study is to detect the effect of calcium supplementation on indices of obesity and body composition...- Estrogen receptor alpha and vitamin D receptor gene polymorphisms and bone mineral density: association study of healthy pre- and postmenopausal Chinese womenYuan Yuan Zhang
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
Biochem Biophys Res Commun 308:777-83. 2003..02), and PX carriers had lower hip BMD than the non-carriers (p=0.04). Our data suggest that the ER-alpha and VDR genes may be associated with the BMD variation in Chinese women... - APOE haplotypes influence bone mineral density in Caucasian males but not femalesJi Rong Long
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Calcif Tissue Int 75:299-304. 2004..008) for the total hip BMD. These data suggested that in our studied Caucasian population, APOE may have effects on BMD variation in males but not females. Further studies with a larger sample size are required to confirm such results... - Patterns of linkage disequilibrium and haplotype distribution in disease candidate genesJi Rong Long
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
BMC Genet 5:11. 2004..The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers... - Association between COL1A1 gene polymorphisms and bone size in CaucasiansJi Rong Long
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Eur J Hum Genet 12:383-8. 2004..011 and 0.010, respectively. In conclusion, the COL1A1 gene may have some effects on bone size variation at the wrist, but not at the spine or hip in our Caucasian nuclear families... - Is a gene important for bone resorption a candidate for obesity? An association and linkage study on the RANK (receptor activator of nuclear factor-kappaB) gene in a large Caucasian sampleLan Juan Zhao
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
Hum Genet 120:561-70. 2006..021 for lean mass, 0.016 for BMI, and 0.006 for PFM. The haplotype data analyses provide further association evidence. In conclusion, for the first time, our results suggest that RANK is a novel candidate for determination of obesity... - Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosisVolodymyr Dvornyk
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N, 30th St, Suite 6730, Omaha, NE 68131, USA
BMC Genet 5:4. 2004..However, their utility for such studies of diseases with ethnic-dependent background has never been evaluated... - Association analysis of estrogen receptor alpha gene polymorphisms with cross-sectional geometry of the femoral neck in Caucasian nuclear familiesDong Hai Xiong
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N 30th St Suite 6787, Omaha, NE 68131, USA
Osteoporos Int 16:2113-22. 2005..Therefore, we concluded that polymorphisms in the ER-alpha gene were nominally associated with femoral neck (FN) geometry variables estimated from DXA. Such genetic effects on hip geometry were not sex specific... - A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian familiesLan Juan Zhao
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
Hum Genet 121:145-8. 2007..31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11... - A follow-up linkage study for quantitative trait loci contributing to obesity-related phenotypesYong Jun Liu
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131, USA
J Clin Endocrinol Metab 89:875-82. 2004..24 in two-point analysis and an MLS of 0.92 in multipoint analysis in all 79 pedigrees. Our data support that 1p36, 2q14, and 6q27 are promising regions that may harbor QTLs for obesity phenotypes... - Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in CaucasiansYuan Yuan Zhang
Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
J Bone Miner Metab 24:36-41. 2006..05). Our findings suggest that the PTHR1 gene may be important for PBMD, height variation, or both, although the significance is dampened by correction for multiple testing... - The (CA)n polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear familiesHong Xu
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People s Republic of China
J Hum Genet 50:301-4. 2005..007). About 3.14% of lumbar spine BMD variation can be explained by the CA16 allele. In summary, our results suggest that the TNFR2 gene may play an important role in determining lumbar spine BMD variation in Chinese women... - Genetic linkage of human height is confirmed to 9q22 and Xq24Yao Zhong Liu
Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
Hum Genet 119:295-304. 2006.... - Genome-wide association study for femoral neck bone geometryLan Juan Zhao
Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, USA
J Bone Miner Res 25:320-9. 2010..Significant association between a nearby common SNP, rs10514713 of the RTP3 gene, and hip fracture (P = 1.0 x 10(-3)) was found. Our observations suggest that RTP3 may be a novel candidate gene for femoral neck bone geometry... - Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interactionDong Hai Xiong
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 21:1678-95. 2006..Our efforts led to the prioritization of those osteoporosis genes and the detection of gene-gene interactions... - Tests of linkage and/or association of TGF-beta1 and COL1A1 genes with bone massJi-Rong Long
Osteoporosis Research Center, Creighton University, 601 N. 30th Street, Suite 6787, Omaha, NE 68131, USA
Osteoporos Int 16:86-92. 2005..021) in male offspring families. Further studies with denser markers and larger sample size are required to eventually define the relationship between these two genes with bone mass at the spine and hip... - A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosisZi Hui Tang
Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
J Clin Endocrinol Metab 92:2751-7. 2007..BFM and BMD, as the respective measure for obesity and osteoporosis, are phenotypically and genetically correlated. However, specific genomic regions accounting for their genetic correlation are unknown... - Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjectsFeng Xiao Bu
Osteoporosis Research Center, Creighton University Medical Center, Creighton University, 601 N 30th St, Suite 6730, Omaha, NE 68131, USA
Hum Genet 128:549-56. 2010..The CYP2R1 gene and the GC gene remain significant in the pooled cohort. The results suggest that the CYP2R1 and GC genes may contribute to the variation of serum 25(OH)D levels in healthy populations... - Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear familiesLan-Juan Zhao
Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE 68131, USA
Bone 35:395-402. 2004..015). However, after correction for multiple testing, these associations did not reach statistical significance. Denser markers may be necessary to better define the relationship between the ER-alpha gene and BMD variation in our sample... - Genetic dissection of human stature in a large sample of multiplex pedigreesYao-Zhong Liu
Osteoporosis Research Center, Creighton University, 601 N. 30th St. Suite 6787, Omaha, NE 68131, USA
Ann Hum Genet 68:472-88. 2004..To date, our study has achieved the largest sample size in the field of genetic linkage studies of human height. Together with the findings of other studies, the current study has further delineated the genetic basis of human stature... - Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosisDong-Hai Xiong
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 21:424-37. 2006.... - Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effectsPeng Xiao
Department of Biomedical Sciences and Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 21:1536-44. 2006..The results of this study provide a foundation for the future fine mapping and gene identification in our population... - Mapping quantitative trait loci for cross-sectional geometry at the femoral neckHui Shen
Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
J Bone Miner Res 20:1973-82. 2005..The identification of the genes responsible for bone geometric variation will improve our knowledge of bone strength and aid in development of diagnostic approaches and interventions for osteoporotic fractures... - Predictive factors for age at menopause in Caucasian femalesVolodymyr Dvornyk
Department of Biological Sciences, Kent State University, Kent, OH 44242-0001, USA
Maturitas 54:19-26. 2006..Given the important role of the ER-alpha in estrogen signaling, which directly influences the menopausal process, further studies are required to better define the relationship between this gene and age at menopause... - The MTHFR gene polymorphism is associated with lean body mass but not fat body massXiaogang Liu
The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an Shaanxi, 710049, People s Republic of China
Hum Genet 123:189-96. 2008..In summary, the MTHFR gene polymorphism is associated with LBM, suggesting that MTHFR may play an important role in LBM variation. In addition, the MTHFR gene polymorphism is not associated with FBM or obesity in this sample... - Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosisLan Juan Zhao
Department of Orthopedic Surgery, School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, USA
J Bone Miner Res 23:17-29. 2008..Based on our current state of knowledge, it is unclear whether fat has beneficial effects on bone. We anticipate that this will be an active and fruitful focus of research in the coming years... - AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear familiesYan Jun Yang
Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China
Eur J Epidemiol 22:527-32. 2007..To investigate the role of alpha2-HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation... - Relationship of obesity with osteoporosisLan Juan Zhao
Department of Orthopedic Surgery, School of Medicine, University of Missouri Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA
J Clin Endocrinol Metab 92:1640-6. 2007..Previous analyses, however, did not control for the mechanical loading effects of total body weight on bone mass and may have generated a confounded or even biased relationship between obesity and osteoporosis... - Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association studyYan Fang Guo
Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, PR China
J Med Genet 43:798-803. 2006..The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes... - Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean massJian Zhao
Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
Genet Res (Camb) 90:259-68. 2008..Our results suggest that QTLs on chromosomes 20p12, 3p26-25 and Xp22 may jointly influence TBFM and TBLM. Further fine mapping and gene identification studies for these pleiotropic effects are needed... - Assessment of genetic linkage and parent-of-origin effects on obesityYan-Fang Guo
Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiantong University, Xi'an 710049, People's Republic of China
J Clin Endocrinol Metab 91:4001-5. 2006....