Affiliation: Creighton University
- The tumor spectrum in the Lynch syndromePatrice Watson
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68131, USA
Fam Cancer 4:245-8. 2005..We predict that the spectrum will expand as additional studies are reported, especially as prospective studies of mutation carriers are completed...
- Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancerP Watson
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
J Med Genet 40:591-6. 2003..In hereditary cancer syndrome families with an identified cancer associated mutation, mutation testing changes the carrier risk status of the tested person and may change the carrier risk status of relatives...
- Cancer risk in mismatch repair gene mutation carriersP Watson
Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
Fam Cancer 1:57-60. 2001..Prevention strategies depend on estimates of age-specific risk. Clearly, multicenter studies to obtain such estimates are needed...
- The risk of extra-colonic, extra-endometrial cancer in the Lynch syndromePatrice Watson
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
Int J Cancer 123:444-9. 2008..Other cancer types studied occur too infrequently to justify strenuous cancer control interventions...
- Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome)Patrice Watson
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Neb, USA
Arch Intern Med 164:2429-31. 2004..Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated...
- Phenotypic heterogeneity of hereditary gynecologic cancers: a report from the Creighton hereditary cancer registryMurray Joseph Casey
Departments of Obstetrics and Gynecology and Preventive Medicine, Creighton University School of Medicine, Omaha, NE, USA
Fam Cancer 12:719-40. 2013..This opens possibilities for new approaches to molecular genetic research into carcinogenic pathways and raises important new considerations regarding counseling, screening, prophylaxis and treatment of mutation carriers...
- Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutationsMurray Joseph Casey
Department of Obstetrics and Gynecology, Creighton University School of Medicine and the Creighton Hereditary Cancer Institute, Creighton University Medical Center, 601 North 30th Street, Suite 4700, Omaha, NE 68131, USA
Gynecol Oncol 97:457-67. 2005....
- Familial myelomaHenry T Lynch
Creighton University School of Medicine, Omaha, USA
N Engl J Med 359:152-7. 2008..The putative progenitor had progeny with two female partners. The progeny had prostate cancer, multiple myeloma, and MGUS...
- The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trialJiapeng Zhou
Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, USA
Nutr Metab (Lond) 7:62. 2010..It is undetermined whether calcium supplementation has an effect on obesity or body composition in postmenopausal women. The purpose of the study is to detect the effect of calcium supplementation on indices of obesity and body composition...
- Hereditary chronic lymphocytic leukemia: an extended family study and literature reviewHenry T Lynch
Department of Preventive Medicine and Public Health at Creighton University School of Medicine, Omaha, NE 68178, USA
Am J Med Genet 115:113-7. 2002..Given the explosive developments in molecular genetics during the past decade, it is certain that families of this type will provide important clues to the etiology, pathogenesis, and ultimate prevention of CLL...
- Phosphate and carbonate salts of calcium support robust bone building in osteoporosisRobert P Heaney
Osteoporosis Research Center, Creighton University, Omaha, NE, USA
Am J Clin Nutr 92:101-5. 2010..The relative effectiveness of various calcium salts for this purpose is uncertain. Many older women with osteoporosis have phosphorus intakes of <70% of the Recommended Dietary Allowance...
- The selection and prevalence of natural and fortified calcium food sources in the diets of adolescent girlsKaren Rafferty
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
J Nutr Educ Behav 43:96-102. 2011..To assess the impact of calcium-fortified food and dairy food on selected nutrient intakes in the diets of adolescent girls...
- Familial B-cell chronic lymphocytic leukemia: analysis of cytogenetic abnormalities, immunophenotypic profiles, and immunoglobulin heavy chain gene usagePatricia Aoun
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
Am J Clin Pathol 127:31-8. 2007..Our findings support previous observations that familial and sporadic B-CLL cases are biologically similar and suggest that familial clusters will be useful for studying pathogenetic events in B-CLL...
- Phenotypic heterogeneity in multiple myeloma familiesHenry T Lynch
Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178, USA
J Clin Oncol 23:685-93. 2005..Observations were used to generate hypotheses about the role of genetic factors, the mode of inheritance of these factors, and the association of other cancers with familial MM...
- Screening adherence in BRCA1/2 families is associated with primary physicians' behaviorSusan T Tinley
Creighton University, Preventive Medicine, Omaha, Nebraska 68178, USA
Am J Med Genet A 125:5-11. 2004..The results of this study highlight the essential role that primary physicians play in supporting their very high-risk patients' adherence...
- Aspirin use is associated with lower prostate cancer risk in male carriers of BRCA mutationsMatthew Cossack
Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, 68131, USA
J Genet Couns 23:187-91. 2014..Protective benefits from regular vigorous exercise and daily coffee use trended towards significance, but neither factor withstood the Bonferroni Correction for multiple comparisons. ..
- Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancerKristen M Drescher
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
Fam Cancer 8:231-9. 2009....
- Prevalence of extra-esophageal cancers in patients with Barrett's esophagus and esophageal adenocarcinomaAnjan Talukdar
Department of Surgery, Creighton University, School of Medicine, Omaha, NE 68131, USA
Trop Gastroenterol 33:185-8. 2012..To compare the prevalence of extra-esophageal cancers in patients diagnosed with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) with SEER database...
- Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR)Elizabeth C Chao
Genetic Epidemiology Research Institute, University of California, Irvine, Irvine, California, USA
Hum Mutat 29:852-60. 2008..MAPP-MMR is an effective bioinformatic tool for missense variant interpretation that accurately distinguishes MLH1/MSH2 deleterious variants from neutral variants...
- Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemiaAparna Raval
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Comprehensive Cancer Center at The Ohio State University, Columbus, OH 43214, USA
Cell 129:879-90. 2007..Thus, reduced expression of DAPK1 can result from germline predisposition, as well as epigenetic or somatic events causing or contributing to the CLL phenotype...
- Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomasAndrew Kaz
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Int J Cancer 120:1922-9. 2007..MLH1 methylation in the Lynch syndrome adenomas suggests gene methylation might have a role in the initiation of these neoplasms...
- Prediction of germline mutations and cancer risk in the Lynch syndromeSining Chen
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
JAMA 296:1479-87. 2006..Current clinical guidelines are effective but limited by applicability and cost...
- Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 geneAnja Wagner
Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
Am J Hum Genet 72:1088-100. 2003..Genealogical, molecular, and haplotype studies showed that this deletion represents a North American founder mutation that could be traced back to the 19th century...
- Surfaced-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) differentiation of serum protein profiles of BRCA-1 and sporadic breast cancerStephen Becker
Department of Surgery, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 610, Norfolk, VA 23507, USA
Ann Surg Oncol 11:907-14. 2004..Our objective was to distinguish women with BRCA-1 mutations who developed breast cancer (BRCA-1 Ca) from those who did not (Carrier), normal volunteers (NL), and women with sporadic breast cancer (SBC), using SELDI-TOF...
- BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genesDonald A Berry
Department of Biostatistics, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
J Clin Oncol 20:2701-12. 2002....
- Accuracy of MSI testing in predicting germline mutations of MSH2 and MLH1: a case study in Bayesian meta-analysis of diagnostic tests without a gold standardSining Chen
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21205, USA
Biostatistics 6:450-64. 2005..We address these challenges in the context of a Bayesian meta-analytic implementation of the Hui-Walter design, tailored to account for various forms of incomplete data. Posterior inference is handled via a Gibbs sampler...
- TGFBR1*6A may contribute to hereditary colorectal cancerYansong Bian
Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 880, Chicago, IL 60611, USA
J Clin Oncol 23:3074-8. 2005..To test this hypothesis, we determined whether TGFBR16A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients...
- History and molecular genetics of Lynch syndrome in family G: a century laterJulie A Douglas
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
JAMA 294:2195-202. 2005..Described today as a Lynch syndrome family, family G was last documented in 1971, prior to the modern era of molecular diagnostics...
- Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smokingRhonda M Brand
Division of Emergency Medicine, Department of Internal Medicine, Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern University, Evanston, IL 60201, USA
World J Gastroenterol 12:4485-91. 2006..To investigate whether a fuzzy logic model could predict colorectal cancer (CRC) risk engendered by smoking in hereditary non-polyposis colorectal cancer (HNPCC) patients...
- Analysis of CHEK2 gene for ovarian cancer susceptibilityBora E Baysal
Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Gynecol Oncol 95:62-9. 2004..A deletion variant in the CHEK2 gene (del1100C) has been implicated as a low-penetrance risk factor for breast cancer. We sought to determine contribution of CHEK2 mutations to the etiology of ovarian cancer (OvCa)...
- SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancersChristine Laronga
Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia and the Virginia Prostate Center, Norfolk, VA, USA
Dis Markers 19:229-38. 2003..These initial results indicate the utility of protein profiling approaches for developing new diagnostic and prognostic assays for breast cancers...
- Gynecologic cancer as a "sentinel cancer" for women with hereditary nonpolyposis colorectal cancer syndromeKaren H Lu
Department of Gynecologic Oncology, Division of Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Obstet Gynecol 105:569-74. 2005..The purpose of this study was to estimate whether women with hereditary nonpolyposis colorectal cancer syndrome who develop 2 primary cancers present with gynecologic or colon cancer as their "sentinel cancer."..