Patrice Watson

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. ncbi request reprint The tumor spectrum in the Lynch syndrome
    Patrice Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68131, USA
    Fam Cancer 4:245-8. 2005
  2. pmc The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome
    Patrice Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int J Cancer 123:444-9. 2008
  3. ncbi request reprint Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome)
    Patrice Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Neb, USA
    Arch Intern Med 164:2429-31. 2004
  4. pmc Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer
    P Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Med Genet 40:591-6. 2003
  5. ncbi request reprint Cancer risk in mismatch repair gene mutation carriers
    P Watson
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Fam Cancer 1:57-60. 2001
  6. ncbi request reprint Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations
    Murray Joseph Casey
    Department of Obstetrics and Gynecology, Creighton University School of Medicine and the Creighton Hereditary Cancer Institute, Creighton University Medical Center, 601 North 30th Street, Suite 4700, Omaha, NE 68131, USA
    Gynecol Oncol 97:457-67. 2005
  7. pmc Familial myeloma
    Henry T Lynch
    Creighton University School of Medicine, Omaha, USA
    N Engl J Med 359:152-7. 2008
  8. pmc The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial
    Jiapeng Zhou
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, USA
    Nutr Metab (Lond) 7:62. 2010
  9. ncbi request reprint Hereditary chronic lymphocytic leukemia: an extended family study and literature review
    Henry T Lynch
    Department of Preventive Medicine and Public Health at Creighton University School of Medicine, Omaha, NE 68178, USA
    Am J Med Genet 115:113-7. 2002
  10. pmc Phosphate and carbonate salts of calcium support robust bone building in osteoporosis
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    Am J Clin Nutr 92:101-5. 2010

Detail Information

Publications30

  1. ncbi request reprint The tumor spectrum in the Lynch syndrome
    Patrice Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68131, USA
    Fam Cancer 4:245-8. 2005
    ..We predict that the spectrum will expand as additional studies are reported, especially as prospective studies of mutation carriers are completed...
  2. pmc The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome
    Patrice Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int J Cancer 123:444-9. 2008
    ..Other cancer types studied occur too infrequently to justify strenuous cancer control interventions...
  3. ncbi request reprint Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome)
    Patrice Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Neb, USA
    Arch Intern Med 164:2429-31. 2004
    ..Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated...
  4. pmc Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer
    P Watson
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Med Genet 40:591-6. 2003
    ..In hereditary cancer syndrome families with an identified cancer associated mutation, mutation testing changes the carrier risk status of the tested person and may change the carrier risk status of relatives...
  5. ncbi request reprint Cancer risk in mismatch repair gene mutation carriers
    P Watson
    Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Fam Cancer 1:57-60. 2001
    ..Prevention strategies depend on estimates of age-specific risk. Clearly, multicenter studies to obtain such estimates are needed...
  6. ncbi request reprint Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations
    Murray Joseph Casey
    Department of Obstetrics and Gynecology, Creighton University School of Medicine and the Creighton Hereditary Cancer Institute, Creighton University Medical Center, 601 North 30th Street, Suite 4700, Omaha, NE 68131, USA
    Gynecol Oncol 97:457-67. 2005
    ....
  7. pmc Familial myeloma
    Henry T Lynch
    Creighton University School of Medicine, Omaha, USA
    N Engl J Med 359:152-7. 2008
    ..The putative progenitor had progeny with two female partners. The progeny had prostate cancer, multiple myeloma, and MGUS...
  8. pmc The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial
    Jiapeng Zhou
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, USA
    Nutr Metab (Lond) 7:62. 2010
    ..It is undetermined whether calcium supplementation has an effect on obesity or body composition in postmenopausal women. The purpose of the study is to detect the effect of calcium supplementation on indices of obesity and body composition...
  9. ncbi request reprint Hereditary chronic lymphocytic leukemia: an extended family study and literature review
    Henry T Lynch
    Department of Preventive Medicine and Public Health at Creighton University School of Medicine, Omaha, NE 68178, USA
    Am J Med Genet 115:113-7. 2002
    ..Given the explosive developments in molecular genetics during the past decade, it is certain that families of this type will provide important clues to the etiology, pathogenesis, and ultimate prevention of CLL...
  10. pmc Phosphate and carbonate salts of calcium support robust bone building in osteoporosis
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    Am J Clin Nutr 92:101-5. 2010
    ..The relative effectiveness of various calcium salts for this purpose is uncertain. Many older women with osteoporosis have phosphorus intakes of <70% of the Recommended Dietary Allowance...
  11. pmc The selection and prevalence of natural and fortified calcium food sources in the diets of adolescent girls
    Karen Rafferty
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    J Nutr Educ Behav 43:96-102. 2011
    ..To assess the impact of calcium-fortified food and dairy food on selected nutrient intakes in the diets of adolescent girls...
  12. ncbi request reprint Screening adherence in BRCA1/2 families is associated with primary physicians' behavior
    Susan T Tinley
    Creighton University, Preventive Medicine, Omaha, Nebraska 68178, USA
    Am J Med Genet A 125:5-11. 2004
    ..The results of this study highlight the essential role that primary physicians play in supporting their very high-risk patients' adherence...
  13. ncbi request reprint Phenotypic heterogeneity in multiple myeloma families
    Henry T Lynch
    Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178, USA
    J Clin Oncol 23:685-93. 2005
    ..Observations were used to generate hypotheses about the role of genetic factors, the mode of inheritance of these factors, and the association of other cancers with familial MM...
  14. ncbi request reprint Familial B-cell chronic lymphocytic leukemia: analysis of cytogenetic abnormalities, immunophenotypic profiles, and immunoglobulin heavy chain gene usage
    Patricia Aoun
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Am J Clin Pathol 127:31-8. 2007
    ..Our findings support previous observations that familial and sporadic B-CLL cases are biologically similar and suggest that familial clusters will be useful for studying pathogenetic events in B-CLL...
  15. doi request reprint Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer
    Kristen M Drescher
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Fam Cancer 8:231-9. 2009
    ....
  16. ncbi request reprint Prevalence of extra-esophageal cancers in patients with Barrett's esophagus and esophageal adenocarcinoma
    Anjan Talukdar
    Department of Surgery, Creighton University, School of Medicine, Omaha, NE 68131, USA
    Trop Gastroenterol 33:185-8. 2012
    ..To compare the prevalence of extra-esophageal cancers in patients diagnosed with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) with SEER database...
  17. ncbi request reprint History and molecular genetics of Lynch syndrome in family G: a century later
    Julie A Douglas
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    JAMA 294:2195-202. 2005
    ..Described today as a Lynch syndrome family, family G was last documented in 1971, prior to the modern era of molecular diagnostics...
  18. pmc Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene
    Anja Wagner
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hum Genet 72:1088-100. 2003
    ..Genealogical, molecular, and haplotype studies showed that this deletion represents a North American founder mutation that could be traced back to the 19th century...
  19. ncbi request reprint Surfaced-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) differentiation of serum protein profiles of BRCA-1 and sporadic breast cancer
    Stephen Becker
    Department of Surgery, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 610, Norfolk, VA 23507, USA
    Ann Surg Oncol 11:907-14. 2004
    ..Our objective was to distinguish women with BRCA-1 mutations who developed breast cancer (BRCA-1 Ca) from those who did not (Carrier), normal volunteers (NL), and women with sporadic breast cancer (SBC), using SELDI-TOF...
  20. pmc Accuracy of MSI testing in predicting germline mutations of MSH2 and MLH1: a case study in Bayesian meta-analysis of diagnostic tests without a gold standard
    Sining Chen
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21205, USA
    Biostatistics 6:450-64. 2005
    ..We address these challenges in the context of a Bayesian meta-analytic implementation of the Hui-Walter design, tailored to account for various forms of incomplete data. Posterior inference is handled via a Gibbs sampler...
  21. doi request reprint Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR)
    Elizabeth C Chao
    Genetic Epidemiology Research Institute, University of California, Irvine, Irvine, California, USA
    Hum Mutat 29:852-60. 2008
    ..MAPP-MMR is an effective bioinformatic tool for missense variant interpretation that accurately distinguishes MLH1/MSH2 deleterious variants from neutral variants...
  22. ncbi request reprint Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia
    Aparna Raval
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Comprehensive Cancer Center at The Ohio State University, Columbus, OH 43214, USA
    Cell 129:879-90. 2007
    ..Thus, reduced expression of DAPK1 can result from germline predisposition, as well as epigenetic or somatic events causing or contributing to the CLL phenotype...
  23. ncbi request reprint Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas
    Andrew Kaz
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Int J Cancer 120:1922-9. 2007
    ..MLH1 methylation in the Lynch syndrome adenomas suggests gene methylation might have a role in the initiation of these neoplasms...
  24. ncbi request reprint TGFBR1*6A may contribute to hereditary colorectal cancer
    Yansong Bian
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 880, Chicago, IL 60611, USA
    J Clin Oncol 23:3074-8. 2005
    ..To test this hypothesis, we determined whether TGFBR16A contributes to a proportion of mismatch repair (MMR) gene mutation-negative hereditary nonpolyposis colorectal cancer (HNPCC) patients...
  25. pmc Prediction of germline mutations and cancer risk in the Lynch syndrome
    Sining Chen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    JAMA 296:1479-87. 2006
    ..Current clinical guidelines are effective but limited by applicability and cost...
  26. ncbi request reprint Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking
    Rhonda M Brand
    Division of Emergency Medicine, Department of Internal Medicine, Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern University, Evanston, IL 60201, USA
    World J Gastroenterol 12:4485-91. 2006
    ..To investigate whether a fuzzy logic model could predict colorectal cancer (CRC) risk engendered by smoking in hereditary non-polyposis colorectal cancer (HNPCC) patients...
  27. ncbi request reprint BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes
    Donald A Berry
    Department of Biostatistics, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 20:2701-12. 2002
    ....
  28. ncbi request reprint Gynecologic cancer as a "sentinel cancer" for women with hereditary nonpolyposis colorectal cancer syndrome
    Karen H Lu
    Department of Gynecologic Oncology, Division of Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Obstet Gynecol 105:569-74. 2005
    ..The purpose of this study was to estimate whether women with hereditary nonpolyposis colorectal cancer syndrome who develop 2 primary cancers present with gynecologic or colon cancer as their "sentinel cancer."..
  29. ncbi request reprint Analysis of CHEK2 gene for ovarian cancer susceptibility
    Bora E Baysal
    Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Gynecol Oncol 95:62-9. 2004
    ..A deletion variant in the CHEK2 gene (del1100C) has been implicated as a low-penetrance risk factor for breast cancer. We sought to determine contribution of CHEK2 mutations to the etiology of ovarian cancer (OvCa)...
  30. ncbi request reprint SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers
    Christine Laronga
    Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia and the Virginia Prostate Center, Norfolk, VA, USA
    Dis Markers 19:229-38. 2003
    ..These initial results indicate the utility of protein profiling approaches for developing new diagnostic and prognostic assays for breast cancers...