Affiliation: Creighton University
Palmer V, Worth A, Scott R, Perry G, Yan M, Li Q, et al
. IL10 restrains autoreactive B cells in transgenic mice expressing inactive RAG1. Cell Immunol. 2018;331:110-120 pubmed publisher
..Furthermore, autoantibody profiling raises a possible link between CD5+ B cell expansion, mitogenic stimulation, and autoantibodies associated with autoimmune complications observed in lupus and lupus-related disorders. ..
Swanson P. The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination. Mol Cell Biol. 2001;21:449-58 pubmed
..The implications of a trans cleavage mode observed in these complexes on the organization of the V(D)J synaptic complex are discussed. ..
Swanson P, Kumar S, Raval P. Early steps of V(D)J rearrangement: insights from biochemical studies of RAG-RSS complexes. Adv Exp Med Biol. 2009;650:1-15 pubmed
..In this chapter we will review the molecular mechanisms of RAG synaptic complex assembly and 12/23-regulated RSS cleavage, focusing on recent advances that shed new light on these processes. ..
Palmer V, Aziz Seible R, Kassmeier M, Rothermund M, Perry G, Swanson P. VprBP Is Required for Efficient Editing and Selection of IgÎº+ B Cells, but Is Dispensable for IgÎ»+ and Marginal Zone B Cell Maturation and Selection. J Immunol. 2015;195:1524-37 pubmed publisher
Schabla N, Perry G, Palmer V, Swanson P. VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation. J Immunol. 2018;201:930-939 pubmed publisher
Palmer V, Nganga V, Rothermund M, Perry G, Swanson P. Cd1d regulates B cell development but not B cell accumulation and IL10 production in mice with pathologic CD5(+) B cell expansion. BMC Immunol. 2015;16:66 pubmed publisher
Swanson P, Volkmer D, Wang L. Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration. J Biol Chem. 2004;279:4034-44 pubmed
Swanson P. The bounty of RAGs: recombination signal complexes and reaction outcomes. Immunol Rev. 2004;200:90-114 pubmed
..Finally, I discuss alternative DNA transactions mediated by the V(D)J recombinase, the protein-DNA complexes that support them, and factors and forces that control them. ..