Garrett Soukup

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. ncbi MicroRNAs sound off
    Michael D Weston
    Department of Oral Biology, Creighton University School of Dentistry, California Plaza, Omaha, Nebraska 68178, USA
    Genome Med 1:59. 2009
  2. ncbi Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Dev Biol 328:328-41. 2009
  3. ncbi Little but loud: small RNAs have a resounding affect on ear development
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Brain Res 1277:104-14. 2009
  4. ncbi Core requirements for glmS ribozyme self-cleavage reveal a putative pseudoknot structure
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Nucleic Acids Res 34:968-75. 2006
  5. ncbi Riboswitches exert genetic control through metabolite-induced conformational change
    Juliane K Soukup
    Department of Chemistry, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Curr Opin Struct Biol 14:344-9. 2004
  6. ncbi Regenerating cochlear hair cells: quo vadis stem cell
    Kirk Beisel
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Cell Tissue Res 333:373-9. 2008
  7. ncbi Molecular evolution of the vertebrate mechanosensory cell and ear
    Bernd Fritzsch
    Creighton University, Dept of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Biol 51:663-78. 2007
  8. ncbi MicroRNA gene expression in the mouse inner ear
    Michael D Weston
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska, NE 68178, USA
    Brain Res 1111:95-104. 2006
  9. ncbi Backbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozyme
    Joshua A Jansen
    Department of Chemistry, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Nat Struct Mol Biol 13:517-23. 2006
  10. ncbi Ligand requirements for glmS ribozyme self-cleavage
    Tom J McCarthy
    Department of Chemistry, Creighton University, Omaha, Nebraska, 68178, USA
    Chem Biol 12:1221-6. 2005

Research Grants

  1. Role of microRNAs in mammalian ear development and neurosensory specification
    Garrett A Soukup; Fiscal Year: 2010
  2. COBRE: CREIGHTON UNIVERISTY: P1:ROLE OF MICRORNAS IN DEVELOPMENT OF THE EAR
    Garrett A Soukup; Fiscal Year: 2009

Collaborators

Detail Information

Publications16

  1. ncbi MicroRNAs sound off
    Michael D Weston
    Department of Oral Biology, Creighton University School of Dentistry, California Plaza, Omaha, Nebraska 68178, USA
    Genome Med 1:59. 2009
    ..The challenge begins to determine whether microRNAs will resonate as therapeutic agents or target molecules to preserve or restore hearing...
  2. ncbi Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Dev Biol 328:328-41. 2009
    ..The correlation of differential and delayed depletion of mature miRNAs with the derailment of inner ear development demonstrates that miRNAs are crucial for inner ear neurosensory development and neurosensory-dependent morphogenesis...
  3. ncbi Little but loud: small RNAs have a resounding affect on ear development
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Brain Res 1277:104-14. 2009
    ..Although there is much yet to be explored in this fledgling aspect of ear biology, the breadth of miRNA expression and functional requirement for ear development are already sounding off...
  4. ncbi Core requirements for glmS ribozyme self-cleavage reveal a putative pseudoknot structure
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Nucleic Acids Res 34:968-75. 2006
    ....
  5. ncbi Riboswitches exert genetic control through metabolite-induced conformational change
    Juliane K Soukup
    Department of Chemistry, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Curr Opin Struct Biol 14:344-9. 2004
    ..Riboswitches now represent a widespread mechanism by which cells monitor their metabolic state and facilely alter gene expression in response to changing conditions...
  6. ncbi Regenerating cochlear hair cells: quo vadis stem cell
    Kirk Beisel
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Cell Tissue Res 333:373-9. 2008
    ..In addition, we highlight currently insurmountable obstacles to the successful transformation of stem cells into hair cell precursors and their injection into the cochlear canal to replace lost hair cells...
  7. ncbi Molecular evolution of the vertebrate mechanosensory cell and ear
    Bernd Fritzsch
    Creighton University, Dept of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Biol 51:663-78. 2007
    ..Recent advances in our molecular understanding of ear and brain development provide novel avenues to this neglected aspect of auditory neurosensory evolution...
  8. ncbi MicroRNA gene expression in the mouse inner ear
    Michael D Weston
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska, NE 68178, USA
    Brain Res 1111:95-104. 2006
    ....
  9. ncbi Backbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozyme
    Joshua A Jansen
    Department of Chemistry, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Nat Struct Mol Biol 13:517-23. 2006
    ..These studies demonstrate that the ligand-binding site lies in close proximity to the cleavage site in an emerging model of ribozyme structure that supports a role for ligand within the catalytic core...
  10. ncbi Ligand requirements for glmS ribozyme self-cleavage
    Tom J McCarthy
    Department of Chemistry, Creighton University, Omaha, Nebraska, 68178, USA
    Chem Biol 12:1221-6. 2005
    ..The data demonstrate that ligand is integral to catalysis, consistent with a coenzyme role for GlcN6P and illustrating an expanded capacity for biological RNA catalysis...
  11. ncbi A versatile communication module for controlling RNA folding and catalysis
    Alexis Kertsburg
    Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
    Nucleic Acids Res 30:4599-606. 2002
    ..Aside from enabling effector-controlled RNA function through rational design, the element can be utilized to identify sites in large RNAs that are susceptible to effector regulation...
  12. ncbi Identification of metabolite-riboswitch interactions using nucleotide analog interference mapping and suppression
    Juliane K Soukup
    Department of Chemistry, Creighton University, Omaha, NE 68178, USA
    Methods Mol Biol 540:193-206. 2009
    ..These techniques can be employed to study a wide variety of RNA-small molecule interactions...
  13. ncbi MicroRNA-183 family conservation and ciliated neurosensory organ expression
    Marsha L Pierce
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Evol Dev 10:106-13. 2008
    ..The results suggest that miR-183 family members contribute specifically to neurosensory development or function, and that extant metazoan sensory organs are derived from cells that share genetic programs of common evolutionary origin...
  14. ncbi MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes
    Ai Yu Gong
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178, USA
    J Immunol 182:1325-33. 2009
    ..Thus, miR-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in human cholangiocytes, suggesting a role for miRNA-mediated gene silencing in the regulation of cholangiocyte response to IFN-gamma...
  15. ncbi Aptamers meet allostery
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska, 68178, USA
    Chem Biol 11:1031-2. 2004
    ..Liu and colleagues now report the isolation and in vivo function of a ligand-dependent RNA-based transcription factor that opens wide the door for allosterically controllable aptamers...
  16. ncbi Engineered catalytic RNA and DNA : new biochemical tools for drug discovery and design
    David Steele
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA
    Am J Pharmacogenomics 3:131-44. 2003
    ..The remarkable versatility of nucleic acid catalysis is thus the fountainhead for wide-ranging applications of ribozymes and deoxyribozymes in biomedical and biotechnological research...

Research Grants3

  1. Role of microRNAs in mammalian ear development and neurosensory specification
    Garrett A Soukup; Fiscal Year: 2010
    ..Understanding how these small RNAs influence such processes is expected to impact molecular therapeutic strategies designed to regenerate sensory cells and restoring hearing. ..
  2. COBRE: CREIGHTON UNIVERISTY: P1:ROLE OF MICRORNAS IN DEVELOPMENT OF THE EAR
    Garrett A Soukup; Fiscal Year: 2009
    ..Specific Aim 3. To identify downstream effector genes through which EGFR regulates the development of the PNS. ..