Robert Roy Recker

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. ncbi request reprint Alendronate with and without cholecalciferol for osteoporosis: results of a 15-week randomized controlled trial
    Robert Recker
    Creighton University, Osteoporosis Research Center, Omaha, NE, USA
    Curr Med Res Opin 22:1745-55. 2006
  2. doi request reprint Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families
    Lan Juan Zhao
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Hum Genet 124:171-7. 2008
  3. doi request reprint Early postmenopausal bone loss and what to do about it
    Robert R Recker
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Ann N Y Acad Sci 1240:E26-30. 2011
  4. pmc Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis
    Volodymyr Dvornyk
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N, 30th St, Suite 6730, Omaha, NE 68131, USA
    BMC Genet 5:4. 2004
  5. ncbi request reprint Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients
    Robert Recker
    Creighton Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 19:1628-33. 2004
  6. ncbi request reprint Trabecular bone microarchitecture after alendronate treatment of osteoporotic women
    R Recker
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131 2137, USA
    Curr Med Res Opin 21:185-94. 2005
  7. ncbi request reprint Insufficiently dosed intravenous ibandronate injections are associated with suboptimal antifracture efficacy in postmenopausal osteoporosis
    R Recker
    Osteoporosis Research Center, Creighton University, Omaha, NE 68178, USA
    Bone 34:890-9. 2004
  8. ncbi request reprint Risedronate for prevention and treatment of osteoporosis in postmenopausal women
    Robert R Recker
    Creighton University Medical Center, Osteoporosis Research Center, 601 North 30th Street, Suite 5766, Omaha, NE 68131, USA
    Expert Opin Pharmacother 6:465-77. 2005
  9. ncbi request reprint Summary--Novel therapies for osteoporosis
    R R Recker
    Creighton University School of Medicine, Omaha, NE, USA
    J Musculoskelet Neuronal Interact 5:358-9. 2005
  10. ncbi request reprint Histomorphometric evaluation of daily and intermittent oral ibandronate in women with postmenopausal osteoporosis: results from the BONE study
    R R Recker
    Creighton University School of Medicine, Creighton University, Omaha, Nebraska, USA
    Osteoporos Int 15:231-7. 2004

Research Grants

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Alendronate with and without cholecalciferol for osteoporosis: results of a 15-week randomized controlled trial
    Robert Recker
    Creighton University, Osteoporosis Research Center, Omaha, NE, USA
    Curr Med Res Opin 22:1745-55. 2006
    ..This study assessed the efficacy, safety, and tolerability of a once-weekly tablet containing alendronate 70 mg and cholecalciferol 70 microg (2800 IU) (ALN + D) versus alendronate 70 mg alone (ALN)...
  2. doi request reprint Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families
    Lan Juan Zhao
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Hum Genet 124:171-7. 2008
    ..The results suggest that the TNFR2 gene polymorphisms contribute to the variation of obesity phenotypes...
  3. doi request reprint Early postmenopausal bone loss and what to do about it
    Robert R Recker
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Ann N Y Acad Sci 1240:E26-30. 2011
    ..This presentation examines the data on these questions and focuses on the perimenopausal pattern of rapid bone loss and the implications for identifying and managing the later-life risk of fracture...
  4. pmc Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis
    Volodymyr Dvornyk
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N, 30th St, Suite 6730, Omaha, NE 68131, USA
    BMC Genet 5:4. 2004
    ..However, their utility for such studies of diseases with ethnic-dependent background has never been evaluated...
  5. ncbi request reprint Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients
    Robert Recker
    Creighton Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 19:1628-33. 2004
    ..Ac.f nearly doubled 1 year after menopause, tripled 13 years after menopause, and remained elevated in women with osteoporosis...
  6. ncbi request reprint Trabecular bone microarchitecture after alendronate treatment of osteoporotic women
    R Recker
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131 2137, USA
    Curr Med Res Opin 21:185-94. 2005
    ..To compare the microarchitecture of iliac crest trabecular bone from women treated for two to three years with alendronate versus that of women treated with placebo...
  7. ncbi request reprint Insufficiently dosed intravenous ibandronate injections are associated with suboptimal antifracture efficacy in postmenopausal osteoporosis
    R Recker
    Osteoporosis Research Center, Creighton University, Omaha, NE 68178, USA
    Bone 34:890-9. 2004
    ..The results of a recent phase II/III study (Intermittent Regimen Intravenous Ibandronate Study: the IRIS study) provide support for this hypothesis...
  8. ncbi request reprint Risedronate for prevention and treatment of osteoporosis in postmenopausal women
    Robert R Recker
    Creighton University Medical Center, Osteoporosis Research Center, 601 North 30th Street, Suite 5766, Omaha, NE 68131, USA
    Expert Opin Pharmacother 6:465-77. 2005
    ..We await reports of experience with risedronate in 'real-world' cases of greater complexity (i.e., in patients with co-morbidities and medications that would have excluded them from published clinical trials)...
  9. ncbi request reprint Summary--Novel therapies for osteoporosis
    R R Recker
    Creighton University School of Medicine, Omaha, NE, USA
    J Musculoskelet Neuronal Interact 5:358-9. 2005
  10. ncbi request reprint Histomorphometric evaluation of daily and intermittent oral ibandronate in women with postmenopausal osteoporosis: results from the BONE study
    R R Recker
    Creighton University School of Medicine, Creighton University, Omaha, Nebraska, USA
    Osteoporos Int 15:231-7. 2004
    ..Long-term treatment with oral ibandronate, even when administered with an extended between-dose interval of >2 months, produces normal-quality, newly formed bone in women with PMO...
  11. ncbi request reprint Comparative effects of raloxifene and alendronate on fracture outcomes in postmenopausal women with low bone mass
    Robert R Recker
    Creighton University, Osteoporosis Research Center, 601 North 30th Street, Suite 5766, Omaha, NE 68131, USA
    Bone 40:843-51. 2007
    ..Safety profiles were as expected from clinical trial and post-marketing reports. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT00035971...
  12. ncbi request reprint Genetic research in osteoporosis: Where are we? Where should we go next?
    R R Recker
    Creighton University School of Medicine, Omaha, NE 68131, USA
    J Musculoskelet Neuronal Interact 4:86-90. 2004
    ....
  13. doi request reprint Oral ibandronate preserves trabecular microarchitecture: micro-computed tomography findings from the oral iBandronate Osteoporosis vertebral fracture trial in North America and Europe study
    Robert R Recker
    Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, Nebraska 68131, USA
    J Clin Densitom 12:71-6. 2009
    ..Taken together with previous results from BONE, these findings indicate that ibandronate treatment preserves bone strength by maintaining good quality trabecular microarchitecture in women with postmenopausal osteoporosis...
  14. pmc Issues in modern bone histomorphometry
    R R Recker
    Osteoporosis Research Center, Creighton University, 601 N 30th St Omaha, NE 68131, USA
    Bone 49:955-64. 2011
    ..The conference attendees discussed these problems and their resolutions, and the proceedings reported here summarize their discussions and recommendations...
  15. ncbi request reprint Skeletal fragility and bone quality
    R R Recker
    Creighton University Osteoporosis Research Center, Omaha, NE 68131 2137, USA
    J Musculoskelet Neuronal Interact 7:54-5. 2007
  16. ncbi request reprint Role of genetics in osteoporosis
    Robert R Recker
    Osteoporis Research Center, Creighton University, Omaha, NE 68131, USA
    Endocrine 17:55-66. 2002
    ..We focus on linkage studies in humans and quantitative trait loci mapping in mice to supplement the already extensive reviews of association studies made by many investigators for candidate genes...
  17. pmc The effect of antiresorptives on bone quality
    Robert R Recker
    Osteoporosis Research Center, Creighton University, 601 N 30th Street 5766, Omaha, NE 68131, USA
    Clin Orthop Relat Res 469:2207-14. 2011
    ..However, it is now clear increases in bone density account for little of the antifracture effect of these treatments...
  18. ncbi request reprint Effects of intravenous zoledronic acid once yearly on bone remodeling and bone structure
    Robert R Recker
    School of Medicine, Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 23:6-16. 2008
    ..Zoledronic acid reduced bone turnover by 63% and preserved bone structure and volume, with evidence of ongoing bone remodeling in 99% of biopsies obtained...
  19. doi request reprint Comparative effects of teriparatide and strontium ranelate on bone biopsies and biochemical markers of bone turnover in postmenopausal women with osteoporosis
    Robert R Recker
    Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
    J Bone Miner Res 24:1358-68. 2009
    ....
  20. doi request reprint Effects of intermittent intravenous ibandronate injections on bone quality and micro-architecture in women with postmenopausal osteoporosis: the DIVA study
    Robert R Recker
    Creighton University School of Medicine, Creighton University, Omaha, Nebraska, USA
    Bone 46:660-5. 2010
    ..Histomorphometric analysis of transiliac bone biopsies demonstrated normal micro-structure of newly formed bone with normal mineralization and reduced remodeling after oral or IV ibandronate...
  21. pmc Is a gene important for bone resorption a candidate for obesity? An association and linkage study on the RANK (receptor activator of nuclear factor-kappaB) gene in a large Caucasian sample
    Lan Juan Zhao
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
    Hum Genet 120:561-70. 2006
    ..021 for lean mass, 0.016 for BMI, and 0.006 for PFM. The haplotype data analyses provide further association evidence. In conclusion, for the first time, our results suggest that RANK is a novel candidate for determination of obesity...
  22. ncbi request reprint Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in Caucasians
    Yuan Yuan Zhang
    Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
    J Bone Miner Metab 24:36-41. 2006
    ..05). Our findings suggest that the PTHR1 gene may be important for PBMD, height variation, or both, although the significance is dampened by correction for multiple testing...
  23. ncbi request reprint Association between COL1A1 gene polymorphisms and bone size in Caucasians
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Eur J Hum Genet 12:383-8. 2004
    ..011 and 0.010, respectively. In conclusion, the COL1A1 gene may have some effects on bone size variation at the wrist, but not at the spine or hip in our Caucasian nuclear families...
  24. ncbi request reprint Molecular studies of identification of genes for osteoporosis: the 2002 update
    Yao Zhong Liu
    Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, Nebraska 68131, USA
    J Endocrinol 177:147-96. 2003
    ..The format adopted by this review should be ideal for accommodating future new advances and studies in a fairly young field that is still developing rapidly...
  25. ncbi request reprint Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska, USA
    Physiol Genomics 22:197-203. 2005
    ..003). In haplotype analyses, we also observed evidence of linkage (P = 0.002) and association (P = 0.035) with BMI. In summary, our results suggest that UCP3 gene polymorphisms may contribute to BMI variation in this Caucasian population...
  26. ncbi request reprint Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Physiol Genomics 17:101-6. 2004
    ..Our results suggest that the LEPR gene polymorphisms contribute to variation in obesity phenotypes...
  27. pmc Relationship of obesity with osteoporosis
    Lan Juan Zhao
    Department of Orthopedic Surgery, School of Medicine, University of Missouri Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA
    J Clin Endocrinol Metab 92:1640-6. 2007
    ..Previous analyses, however, did not control for the mechanical loading effects of total body weight on bone mass and may have generated a confounded or even biased relationship between obesity and osteoporosis...
  28. doi request reprint Quantitative trait loci mapping
    Dong Hai Xiong
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    Methods Mol Biol 455:203-35. 2008
    ..The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems...
  29. pmc Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 21:1678-95. 2006
    ..Our efforts led to the prioritization of those osteoporosis genes and the detection of gene-gene interactions...
  30. ncbi request reprint Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
    J Bone Miner Res 22:385-93. 2007
    ..These data support the concept that LRP5 variation can contribute to minor and major variation in bone structure...
  31. ncbi request reprint Genome scan for QTLs underlying bone size variation at 10 refined skeletal sites: genetic heterogeneity and the significance of phenotype refinement
    Qing Yang Huang
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Physiol Genomics 17:326-31. 2004
    ..93) to bone size in one skeletal site. Our results indicated that the low power of QTLs mapping for composite phenotypic measurements may result from genetic heterogeneity of complex traits...
  32. ncbi request reprint Race and sex differences and contribution of height: a study on bone size in healthy Caucasians and Chinese
    Yuan Yuan Zhang
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Am J Hum Biol 17:568-75. 2005
    ..We conclude that height is a major predictor for BS, and its contributions vary across sex, race, and skeletal site...
  33. ncbi request reprint Association tests of interleukin-6 (IL-6) and type II tumor necrosis factor receptor (TNFR2) genes with bone mineral density in Caucasians using a re-sampling approach
    Peng Xiao
    Osteoporosis Research Center, Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68131, USA
    Hum Genet 117:340-8. 2005
    ..Our results have significant implications for association studies and interpretation of non-reproducible association findings...
  34. ncbi request reprint Molecular and genetic mechanisms of obesity: implications for future management
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    Curr Mol Med 3:325-40. 2003
    ..Finally, the implications of the recent advances in the understanding of molecular genetic mechanisms of body weight regulation on prevention and therapeutic intervention of obesity will be discussed...
  35. ncbi request reprint A follow-up linkage study for bone size variation in an extended sample
    Fu Hua Xu
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Bone 35:777-84. 2004
    ..78 (P = 0.002). The genomic region 17q22 includes COL1A1, a strong candidate gene that is significantly associated with osteoporotic fracture risk. Our data suggest that this region is promising for further exploratory studies...
  36. ncbi request reprint A follow-up linkage study for quantitative trait loci contributing to obesity-related phenotypes
    Yong Jun Liu
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:875-82. 2004
    ..24 in two-point analysis and an MLS of 0.92 in multipoint analysis in all 79 pedigrees. Our data support that 1p36, 2q14, and 6q27 are promising regions that may harbor QTLs for obesity phenotypes...
  37. ncbi request reprint Differences in bone mineral density, bone mineral content, and bone areal size in fracturing and non-fracturing women, and their interrelationships at the spine and hip
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    J Bone Miner Metab 20:358-66. 2002
    ..At the hip, 98.0% of BMD variation is due to BMC and 1.1% due to bone areal size. The current study may be important in understanding the relationship among BMD, BMC, and bone size as risk determinants of osteoporotic fractures...
  38. ncbi request reprint Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosis
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 21:424-37. 2006
    ..We found significant linkage of FNCS parameters to 20q12 and Xq25, plus significant epistatic interactions and sex-specific QTLs influencing FNCS geometry variation...
  39. ncbi request reprint Paternal uniparental isodisomy of the entire chromosome 3 revealed in a person with no apparent phenotypic disorders
    Peng Xiao
    Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, Nebraska, USA
    Hum Mutat 27:133-7. 2006
    ..The finding of this paternal UPD case of the entire chromosome 3 with no apparent phenotypic disorders suggests that there are no paternal imprinted genes causing rare genetic disorders on chromosome 3...
  40. ncbi request reprint Transmission disequilibrium test with discordant sib pairs when parents are available
    Hong Wen Deng
    Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    Hum Genet 110:451-61. 2002
    ..Importantly, the TDT(DS) not only may be more powerful, it also has the advantage of being able to test for segregation distortion that may yield false linkage/association in the TDT(D)...
  41. ncbi request reprint Genetic dissection of human stature in a large sample of multiplex pedigrees
    Yao Zhong Liu
    Osteoporosis Research Center, Creighton University, 601 N 30th St Suite 6787, Omaha, NE 68131, USA
    Ann Hum Genet 68:472-88. 2004
    ..To date, our study has achieved the largest sample size in the field of genetic linkage studies of human height. Together with the findings of other studies, the current study has further delineated the genetic basis of human stature...
  42. ncbi request reprint Bone microstructure in osteoporosis: transilial biopsy and histomorphometry
    M Janet Barger-Lux
    Osteoporosis Research Center, Creighton University School of Medicine, 601 North 30th Street, Omaha, NE 68131, USA
    Top Magn Reson Imaging 13:297-305. 2002
    ....
  43. pmc Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
    Yong Jun Liu
    School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Hum Mol Genet 17:1803-13. 2008
    ..Our study also provided supportive evidence for previously identified associations between obesity and INSIG2 and PFKP, but not FTO...
  44. ncbi request reprint A whole-genome linkage scan suggests several genomic regions potentially containing QTLs underlying the variation of stature
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Am J Med Genet 113:29-39. 2002
    ..Based on our findings, further confirmation and fine-mapping studies are to be pursued on expanded samples and/or with denser markers for eventual identification of major functional genes involved in human height variation...
  45. ncbi request reprint Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
    Joan M Lappe
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 85:1586-91. 2007
    ..Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking...
  46. ncbi request reprint Fine mapping of susceptibility genes by Lewontin's linkage disequilibrium measure with application to Alzheimer's disease
    Gordon Gong
    Creighton University Osteoporosis Research Center, 601 North 30th Street, Suite 6730, Omaha, NE 68131, USA
    Chin Med J (Engl) 115:1233-40. 2002
    ..To formulate an equation for fine mapping of disease loci under complex conditions and determine the marker-disease distance in a specific case using this equation...
  47. ncbi request reprint A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait Loci for osteoporosis
    Hong Wen Deng
    Osteoporosis Research Center, Department of Biomedical Sciences, Creighton University, 601 North 30th Street, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 87:5151-9. 2002
    ....
  48. ncbi request reprint Several genomic regions potentially containing QTLs for bone size variation were identified in a whole-genome linkage scan
    Hong Wen Deng
    Osteoporosis Research Center and Department of Biomedical Research, Creighton University, Omaha, Nebraska 68131, USA
    Am J Med Genet A 119:121-31. 2003
    ..The two studies may form a basis for further exploration with larger samples and/or denser markers for confirmation and fine mapping studies to eventually identify major functional genes and the associated etiology for osteoporosis...
  49. ncbi request reprint A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families
    Lan Juan Zhao
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
    Hum Genet 121:145-8. 2007
    ..31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11...
  50. ncbi request reprint Determination of bone size of hip, spine, and wrist in human pedigrees by genetic and lifestyle factors
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    J Clin Densitom 5:45-56. 2002
    ..48 (0.09), 0.64 (0.08), and 0.60 (0.09) for bone size at the hip, spine, and wrist...
  51. ncbi request reprint Relevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human diseases
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, 601 N 30th St Suite 6787, Omaha, NE 68131, USA
    Genet Epidemiol 22:12-25. 2002
    ..This study may have significant implications for the common practice of gene search for complex diseases through underlying risk factors (usually quantitative traits)...
  52. doi request reprint Vitamin D(3) is more potent than vitamin D(2) in humans
    Robert P Heaney
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 96:E447-52. 2011
    ..Current unitage for the calciferols suggests that equimolar quantities of vitamins D(2) (D2) and D(3) (D3) are biologically equivalent. Published studies yield mixed results...
  53. pmc Phosphate and carbonate salts of calcium support robust bone building in osteoporosis
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    Am J Clin Nutr 92:101-5. 2010
    ..The relative effectiveness of various calcium salts for this purpose is uncertain. Many older women with osteoporosis have phosphorus intakes of <70% of the Recommended Dietary Allowance...
  54. ncbi request reprint Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effects
    Peng Xiao
    Department of Biomedical Sciences and Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 21:1536-44. 2006
    ..A genome-wide linkage scan was conducted using a large white sample to identify QTLs for BMD. We found QTLs in the total sample and the gender-specific subgroups, as well as significant epistatic interactions underlying BMD variations...
  55. ncbi request reprint The elusive concept of bone quality
    Robert R Recker
    Creighton University School of Medicine, 601 North 30th Street, Suite 5766, Omaha, NE 68131, USA
    Curr Osteoporos Rep 2:97-100. 2004
    ..New technologies for studying bone microstructure and matrix composition, merging with sophisticated biomechanical assessments, are advancing our ideas regarding bone "damageability" and its effects over time...
  56. pmc A genomewide linkage scan for quantitative-trait loci for obesity phenotypes
    Hong Wen Deng
    Osteoporosis Research Center, and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
    Am J Hum Genet 70:1138-51. 2002
    ....
  57. ncbi request reprint Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 17:678-86. 2002
    ..This is the first study in the broad field of bone genetics that tests candidate genes as QTLs for BMD by testing simultaneously for association alone, for linkage alone, and for association and linkage (via the TDT)...
  58. ncbi request reprint Searching for obesity genes: progress and prospects
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska 68131, USA
    Drugs Today (Barc) 41:345-62. 2005
    ..In this article, we discuss the current status and future perspectives for the genetic dissection of obesity, with a focus on the most striking or representative findings...
  59. pmc In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis
    Peng Xiao
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 23:644-54. 2008
    ..However, the in vivo significance of B cells in human bone metabolism and osteoporosis is still largely unknown, particularly at the systematic gene expression level...
  60. ncbi request reprint Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations
    Qing Yang Huang
    Osteoporosis Research Center, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    J Hum Genet 48:430-7. 2003
    ..069) with spine BMD and for association with hip BMD in the sample of multigenerational pedigrees. Our results suggest that genetic variation in or near the IL6 locus may be involved in the etiology of obesity and osteoporosis...
  61. ncbi request reprint Genetic linkage of human height is confirmed to 9q22 and Xq24
    Yao Zhong Liu
    Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
    Hum Genet 119:295-304. 2006
    ....
  62. pmc Genome-wide association study for femoral neck bone geometry
    Lan Juan Zhao
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, USA
    J Bone Miner Res 25:320-9. 2010
    ..Significant association between a nearby common SNP, rs10514713 of the RTP3 gene, and hip fracture (P = 1.0 x 10(-3)) was found. Our observations suggest that RTP3 may be a novel candidate gene for femoral neck bone geometry...
  63. pmc Mutation patterns at dinucleotide microsatellite loci in humans
    Qing Yang Huang
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
    Am J Hum Genet 70:625-34. 2002
    ..There was no correlation between mutation rate and recombination rate. Our data indicate that mutational dynamics at microsatellite loci are more complicated than the generalized stepwise mutation models...
  64. pmc Molecular genetic studies of gene identification for osteoporosis: a 2004 update
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska 68131, USA
    J Bone Miner Res 21:1511-35. 2006
    ..The format adopted by this review should be ideal for accommodating future new advances and studies...
  65. ncbi request reprint The genetics of osteoporosis
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA
    Drugs Today (Barc) 41:205-18. 2005
    ....
  66. ncbi request reprint Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear families
    Lan Juan Zhao
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE 68131, USA
    Bone 35:395-402. 2004
    ..015). However, after correction for multiple testing, these associations did not reach statistical significance. Denser markers may be necessary to better define the relationship between the ER-alpha gene and BMD variation in our sample...
  67. ncbi request reprint Effect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of women
    Robert R Recker
    Creighton University School of Medicine, Omaha, Neb, USA
    Mayo Clin Proc 80:856-61. 2005
    ..To compare medication adherence with daily vs weekly bisphosphonate dosing for the treatment or prevention of osteoporosis in a broad US retail pharmacy database population...
  68. doi request reprint Safety of bisphosphonates in the treatment of osteoporosis
    Robert R Recker
    School of Medicine, Creighton University, Omaha, Nebraska, USA
    Am J Med 122:S22-32. 2009
    ..e., postdose) reactions, chronic musculoskeletal pain, renal safety, and cardiovascular safety (specifically, atrial fibrillation)...
  69. ncbi request reprint Current trends in osteoporosis
    Robert R Recker
    Section of Endocrinology, Osteoporosis Research Center, Creighton University, Omaha, Neb, USA
    Manag Care 14:3-8; discussion 21-3. 2005
  70. ncbi request reprint A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes
    Yao Zhong Liu
    Osteoporosis Research Center, Creighton University Medical Center, Creighton University, Omaha, NE 68131, USA
    J Biol Chem 280:29011-6. 2005
    ..The results may contribute to identification of new genes and their functions for osteoporosis and suggest genetic markers to discern individuals at higher risk to osteoporosis with an aim for preventive intervention and treatment...
  71. ncbi request reprint Interpretation of genetic linkage findings
    Yongjun Liu
    J Bone Miner Res 18:2077-8; author reply 2079-80. 2003
  72. doi request reprint Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass
    Jian Zhao
    Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
    Genet Res (Camb) 90:259-68. 2008
    ..Our results suggest that QTLs on chromosomes 20p12, 3p26-25 and Xp22 may jointly influence TBFM and TBLM. Further fine mapping and gene identification studies for these pleiotropic effects are needed...
  73. ncbi request reprint Evidence for a major gene underlying bone size variation in the Chinese
    Peng Yuan Liu
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Am J Hum Biol 16:68-77. 2004
    ....
  74. ncbi request reprint Predictive factors for age at menopause in Caucasian females
    Volodymyr Dvornyk
    Department of Biological Sciences, Kent State University, Kent, OH 44242 0001, USA
    Maturitas 54:19-26. 2006
    ..The aim of this study was to determine genetic and environmental factors associated with age at natural and surgical menopause...
  75. ncbi request reprint Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis: 2-year results from the DIVA study
    John A Eisman
    Garvan Institute of Medical Research, St Vincent s Campus and University of New South Wales, Sydney, Australia
    J Rheumatol 35:488-97. 2008
    ..We report the effects on lumbar spine and proximal femur bone mineral density (BMD) and bone resorption markers over 2 years...
  76. ncbi request reprint Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass
    Volodymyr Dvornyk
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
    Chin Med J (Engl) 118:1235-44. 2005
    ....
  77. ncbi request reprint Combination and sequential therapy for osteoporosis
    Robert P Heaney
    N Engl J Med 353:624-5. 2005
  78. ncbi request reprint Monthly oral ibandronate therapy in postmenopausal osteoporosis: 1-year results from the MOBILE study
    Paul D Miller
    Colorado Center for Bone Research, Lakewood, Colorado, USA
    J Bone Miner Res 20:1315-22. 2005
    ..5 mg; 3-year vertebral fracture risk reduction: 52%) oral ibandronate regimens were compared in 1609 women with postmenopausal osteoporosis. At least equivalent efficacy and similar safety and tolerability were shown after 1 year...
  79. ncbi request reprint A new concept for bisphosphonate therapy: a rationale for the development of monthly oral dosing of ibandronate
    Jean Yves Reginster
    Unite d Exploration du Metabolisme de l Os et du Cartilage, CHU Centre Ville, Liege, Belgium
    Osteoporos Int 17:159-66. 2006
    ..Greater convenience and tolerability may enhance the therapy adherence and, hence, improve long-term therapeutic outcomes in PMO...
  80. ncbi request reprint Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11: leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians
    Jing Jing Guo
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
    Biochem Biophys Res Commun 332:602-8. 2005
    ..Our results suggest that the LEP and UCP2/UCP3 genes are unlikely to have a substantial effect on variation in obesity phenotypes in this particular US Caucasian population...
  81. pmc A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    Randall D Little
    Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
    Am J Hum Genet 70:11-9. 2002
    ..Our findings suggest that the HBM mutation confers a unique osteogenic activity in bone remodeling, and this understanding may facilitate the development of novel therapies for the treatment of osteoporosis...
  82. ncbi request reprint Ibandronate produces significant, similar antifracture efficacy in North American and European women: new clinical findings from BONE
    Charles H Chesnut
    Osteoporosis Research Group, University of Washington, Seattle, WA, USA
    Curr Med Res Opin 21:391-401. 2005
    ..As osteoporosis medications must be effective across different populations, an additional objective of BONE was to investigate and report the effect of oral ibandronate in North American and European women, as described here...
  83. ncbi request reprint Genomewide linkage scan for quantitative trait loci underlying variation in age at menarche
    Yan Guo
    Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
    J Clin Endocrinol Metab 91:1009-14. 2006
    ..Genetic influence has been shown to contribute greatly to AAM, but the specific genetic determinants are largely unknown...
  84. ncbi request reprint CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations
    Qing Yang Huang
    College of Life Sciences, Central China Normal University, Hubei, China
    J Bone Miner Metab 24:132-7. 2006
    ..Through testing for association and for linkage, our data do not support the TNFR2 gene as a QTL underlying hip or spine BMD variation in our Caucasian populations...
  85. pmc Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study
    Yan Fang Guo
    Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, PR China
    J Med Genet 43:798-803. 2006
    ..The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes...
  86. ncbi request reprint Genetic and environmental correlations between bone geometric parameters and body compositions
    Xiao Sun
    Laboratory of Molecular and Statistical Genetics, Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P R China
    Calcif Tissue Int 79:43-9. 2006
    ..The results may help understand the intertwined relationships between bone metabolisms, mechanical loading and body compositions...
  87. ncbi request reprint Epistatic interactions between genomic regions containing the COL1A1 gene and genes regulating osteoclast differentiation may influence femoral neck bone mineral density
    Tie Lin Yang
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, P R China
    Ann Hum Genet 71:152-9. 2007
    ..Our results suggested that the IL6 and TNFRSF1B genes may regulate FN BMD variation through interactions with the COL1A1 gene, which should be substantiated by other, or population-based, association studies...
  88. ncbi request reprint Bivariate whole genome linkage analysis for femoral neck geometric parameters and total body lean mass
    Fei Yan Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Bone Miner Res 22:808-16. 2007
    ..A genome-wide bivariate analysis was conducted for femoral neck GPs and TBLM in a large white sample. We found QTLs shared by GPs and TBLM in the total sample and the sex-specific samples. QTLs with potential pleiotropy were also disclosed...
  89. ncbi request reprint Intravenous ibandronate injections in postmenopausal women with osteoporosis: one-year results from the dosing intravenous administration study
    Pierre D Delmas
    Université Claude Bernard Lyon 1 and INSERM Research Unit 403, Lyon, France
    Arthritis Rheum 54:1838-46. 2006
    ..The aim of this study was to identify the optimal intravenous dosing regimen for ibandronate in postmenopausal women with osteoporosis...
  90. ncbi request reprint Assessment of genetic linkage and parent-of-origin effects on obesity
    Yan Fang Guo
    Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiantong University, Xi an 710049, People s Republic of China
    J Clin Endocrinol Metab 91:4001-5. 2006
    ..Parent-of-origin effect has been reported to be involved in the development of obesity. But the genes with imprinting effects related to obesity are largely unknown...
  91. ncbi request reprint A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis
    Zi Hui Tang
    Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    J Clin Endocrinol Metab 92:2751-7. 2007
    ..BFM and BMD, as the respective measure for obesity and osteoporosis, are phenotypically and genetically correlated. However, specific genomic regions accounting for their genetic correlation are unknown...
  92. ncbi request reprint Linkage exclusion mapping with bone size in 79 Caucasian pedigrees
    Xiang Ding Chen
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, China
    J Bone Miner Metab 24:337-43. 2006
    ....
  93. ncbi request reprint Chromosome 2q32 may harbor a QTL affecting BMD variation at different skeletal sites
    Liang Wang
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi, China
    J Bone Miner Res 22:1672-8. 2007
    ..BMDs at different skeletal sites share some common genetic determinants. Using PCA and bivariate linkage analysis, we identified a QTL on chromosome 2q32 with significant pleiotropic effects on BMDs at different skeletal sites...
  94. ncbi request reprint Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial
    Pierre D Delmas
    University of Claude Bernard of Lyon, Hopital Edouard Herriot, Service de Rhumatologie et de Pathologie Osseuse, Lyon 69437, France
    J Clin Endocrinol Metab 87:3609-17. 2002
    ..The decreased vertebral fracture risk in yr 4 alone was not different from that observed in the first 3 yr...
  95. pmc Bivariate whole genome linkage analyses for total body lean mass and BMD
    Xiang Li Wang
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Bone Miner Res 23:447-52. 2008
    ..We found some QTLs shared by TBLM and BMD in the entire sample and the sex-specific subgroups, and QTLs with potential pleiotropy were disclosed...
  96. doi request reprint The MTHFR gene polymorphism is associated with lean body mass but not fat body mass
    Xiaogang Liu
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an Shaanxi, 710049, People s Republic of China
    Hum Genet 123:189-96. 2008
    ..In summary, the MTHFR gene polymorphism is associated with LBM, suggesting that MTHFR may play an important role in LBM variation. In addition, the MTHFR gene polymorphism is not associated with FBM or obesity in this sample...
  97. pmc Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families
    Tie Lin Yang
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
    Hum Genet 120:119-25. 2006
    ..We thus concluded that CYP19 could be one of the genetic factors influencing adult height in Caucasians. Further studies are required to identify the causal functional variants responsible for Caucasian height within the CYP19 gene...
  98. ncbi request reprint Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females
    Jian Zhao
    The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
    Hum Reprod 22:1789-94. 2007
    ..Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females...

Research Grants4

  1. A Study of Reduced Bone Quality as a Cause of Fractures
    Robert Recker; Fiscal Year: 2009
    ....
  2. A Study of Reduced Bone Quality as a Cause of Fractures
    Robert Roy Recker; Fiscal Year: 2010
    ....
  3. A Study of Reduced Bone Quality as a Cause of Fractures
    Robert Recker; Fiscal Year: 2009
    ..This study will also provide important biomarkers or genes for future basic research on the mechanisms that cause defects in bone quality. ..
  4. A Study of Reduced Bone Quality as a Cause of Fractures
    Robert Roy Recker; Fiscal Year: 2010
    ....