Research Topics
Species | Robert Roy ReckerSummaryAffiliation: Creighton University Country: USA Publications
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Publications
Alendronate with and without cholecalciferol for osteoporosis: results of a 15-week randomized controlled trialRobert Recker
Creighton University, Osteoporosis Research Center, Omaha, NE, USA
Curr Med Res Opin 22:1745-55. 2006..This study assessed the efficacy, safety, and tolerability of a once-weekly tablet containing alendronate 70 mg and cholecalciferol 70 microg (2800 IU) (ALN + D) versus alendronate 70 mg alone (ALN)...
Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear familiesLan Juan Zhao
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Hum Genet 124:171-7. 2008..The results suggest that the TNFR2 gene polymorphisms contribute to the variation of obesity phenotypes...- Early postmenopausal bone loss and what to do about itRobert R Recker
Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
Ann N Y Acad Sci 1240:E26-30. 2011..This presentation examines the data on these questions and focuses on the perimenopausal pattern of rapid bone loss and the implications for identifying and managing the later-life risk of fracture... 
Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosisVolodymyr Dvornyk
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N, 30th St, Suite 6730, Omaha, NE 68131, USA
BMC Genet 5:4. 2004..However, their utility for such studies of diseases with ethnic-dependent background has never been evaluated...- Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patientsRobert Recker
Creighton Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 19:1628-33. 2004..Ac.f nearly doubled 1 year after menopause, tripled 13 years after menopause, and remained elevated in women with osteoporosis... - Trabecular bone microarchitecture after alendronate treatment of osteoporotic womenR Recker
Osteoporosis Research Center, Creighton University, Omaha, NE 68131 2137, USA
Curr Med Res Opin 21:185-94. 2005..To compare the microarchitecture of iliac crest trabecular bone from women treated for two to three years with alendronate versus that of women treated with placebo... - Insufficiently dosed intravenous ibandronate injections are associated with suboptimal antifracture efficacy in postmenopausal osteoporosisR Recker
Osteoporosis Research Center, Creighton University, Omaha, NE 68178, USA
Bone 34:890-9. 2004..The results of a recent phase II/III study (Intermittent Regimen Intravenous Ibandronate Study: the IRIS study) provide support for this hypothesis... - Risedronate for prevention and treatment of osteoporosis in postmenopausal womenRobert R Recker
Creighton University Medical Center, Osteoporosis Research Center, 601 North 30th Street, Suite 5766, Omaha, NE 68131, USA
Expert Opin Pharmacother 6:465-77. 2005..We await reports of experience with risedronate in 'real-world' cases of greater complexity (i.e., in patients with co-morbidities and medications that would have excluded them from published clinical trials)... - Summary--Novel therapies for osteoporosisR R Recker
Creighton University School of Medicine, Omaha, NE, USA
J Musculoskelet Neuronal Interact 5:358-9. 2005 - Histomorphometric evaluation of daily and intermittent oral ibandronate in women with postmenopausal osteoporosis: results from the BONE studyR R Recker
Creighton University School of Medicine, Creighton University, Omaha, Nebraska, USA
Osteoporos Int 15:231-7. 2004..Long-term treatment with oral ibandronate, even when administered with an extended between-dose interval of >2 months, produces normal-quality, newly formed bone in women with PMO... - Comparative effects of raloxifene and alendronate on fracture outcomes in postmenopausal women with low bone massRobert R Recker
Creighton University, Osteoporosis Research Center, 601 North 30th Street, Suite 5766, Omaha, NE 68131, USA
Bone 40:843-51. 2007..Safety profiles were as expected from clinical trial and post-marketing reports. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT00035971... - Genetic research in osteoporosis: Where are we? Where should we go next?R R Recker
Creighton University School of Medicine, Omaha, NE 68131, USA
J Musculoskelet Neuronal Interact 4:86-90. 2004.... - Oral ibandronate preserves trabecular microarchitecture: micro-computed tomography findings from the oral iBandronate Osteoporosis vertebral fracture trial in North America and Europe studyRobert R Recker
Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, Nebraska 68131, USA
J Clin Densitom 12:71-6. 2009..Taken together with previous results from BONE, these findings indicate that ibandronate treatment preserves bone strength by maintaining good quality trabecular microarchitecture in women with postmenopausal osteoporosis... 
Issues in modern bone histomorphometryR R Recker
Osteoporosis Research Center, Creighton University, 601 N 30th St Omaha, NE 68131, USA
Bone 49:955-64. 2011..The conference attendees discussed these problems and their resolutions, and the proceedings reported here summarize their discussions and recommendations...- Skeletal fragility and bone qualityR R Recker
Creighton University Osteoporosis Research Center, Omaha, NE 68131-2137, USA
J Musculoskelet Neuronal Interact 7:54-5. 2007 - Role of genetics in osteoporosisRobert R Recker
Osteoporis Research Center, Creighton University, Omaha, NE 68131, USA
Endocrine 17:55-66. 2002..We focus on linkage studies in humans and quantitative trait loci mapping in mice to supplement the already extensive reviews of association studies made by many investigators for candidate genes... - The effect of antiresorptives on bone qualityRobert R Recker
Osteoporosis Research Center, Creighton University, 601 N 30th Street 5766, Omaha, NE 68131, USA
Clin Orthop Relat Res 469:2207-14. 2011..However, it is now clear increases in bone density account for little of the antifracture effect of these treatments... - Effects of intravenous zoledronic acid once yearly on bone remodeling and bone structureRobert R Recker
School of Medicine, Creighton University, Omaha, Nebraska 68131, USA
J Bone Miner Res 23:6-16. 2008..Zoledronic acid reduced bone turnover by 63% and preserved bone structure and volume, with evidence of ongoing bone remodeling in 99% of biopsies obtained... - Comparative effects of teriparatide and strontium ranelate on bone biopsies and biochemical markers of bone turnover in postmenopausal women with osteoporosisRobert R Recker
Osteoporosis Research Center, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
J Bone Miner Res 24:1358-68. 2009.... - Effects of intermittent intravenous ibandronate injections on bone quality and micro-architecture in women with postmenopausal osteoporosis: the DIVA studyRobert R Recker
Creighton University School of Medicine, Creighton University, Omaha, Nebraska, USA
Bone 46:660-5. 2010..Histomorphometric analysis of transiliac bone biopsies demonstrated normal micro-structure of newly formed bone with normal mineralization and reduced remodeling after oral or IV ibandronate... - Is a gene important for bone resorption a candidate for obesity? An association and linkage study on the RANK (receptor activator of nuclear factor-kappaB) gene in a large Caucasian sampleLan Juan Zhao
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
Hum Genet 120:561-70. 2006..021 for lean mass, 0.016 for BMI, and 0.006 for PFM. The haplotype data analyses provide further association evidence. In conclusion, for the first time, our results suggest that RANK is a novel candidate for determination of obesity... - Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in CaucasiansYuan Yuan Zhang
Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
J Bone Miner Metab 24:36-41. 2006..05). Our findings suggest that the PTHR1 gene may be important for PBMD, height variation, or both, although the significance is dampened by correction for multiple testing... - Association between COL1A1 gene polymorphisms and bone size in CaucasiansJi Rong Long
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Eur J Hum Genet 12:383-8. 2004..011 and 0.010, respectively. In conclusion, the COL1A1 gene may have some effects on bone size variation at the wrist, but not at the spine or hip in our Caucasian nuclear families... - Molecular studies of identification of genes for osteoporosis: the 2002 updateYao-Zhong Liu
Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, Nebraska 68131, USA
J Endocrinol 177:147-96. 2003..The format adopted by this review should be ideal for accommodating future new advances and studies in a fairly young field that is still developing rapidly... - Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian familiesYong Jun Liu
Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska, USA
Physiol Genomics 22:197-203. 2005..003). In haplotype analyses, we also observed evidence of linkage (P = 0.002) and association (P = 0.035) with BMI. In summary, our results suggest that UCP3 gene polymorphisms may contribute to BMI variation in this Caucasian population... - Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear familiesYong Jun Liu
Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
Physiol Genomics 17:101-6. 2004..Our results suggest that the LEPR gene polymorphisms contribute to variation in obesity phenotypes... - Relationship of obesity with osteoporosisLan Juan Zhao
Department of Orthopedic Surgery, School of Medicine, University of Missouri Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA
J Clin Endocrinol Metab 92:1640-6. 2007..Previous analyses, however, did not control for the mechanical loading effects of total body weight on bone mass and may have generated a confounded or even biased relationship between obesity and osteoporosis... - Quantitative trait loci mappingDong Hai Xiong
Osteoporosis Research Center, Creighton University, Omaha, NE, USA
Methods Mol Biol 455:203-35. 2008..The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems... - Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interactionDong Hai Xiong
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 21:1678-95. 2006..Our efforts led to the prioritization of those osteoporosis genes and the detection of gene-gene interactions... - Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whitesDong Hai Xiong
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
J Bone Miner Res 22:385-93. 2007..These data support the concept that LRP5 variation can contribute to minor and major variation in bone structure... - Genome scan for QTLs underlying bone size variation at 10 refined skeletal sites: genetic heterogeneity and the significance of phenotype refinementQing-Yang Huang
Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
Physiol Genomics 17:326-31. 2004..93) to bone size in one skeletal site. Our results indicated that the low power of QTLs mapping for composite phenotypic measurements may result from genetic heterogeneity of complex traits... - Race and sex differences and contribution of height: a study on bone size in healthy Caucasians and ChineseYuan-yuan Zhang
Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
Am J Hum Biol 17:568-75. 2005..We conclude that height is a major predictor for BS, and its contributions vary across sex, race, and skeletal site... - Association tests of interleukin-6 (IL-6) and type II tumor necrosis factor receptor (TNFR2) genes with bone mineral density in Caucasians using a re-sampling approachPeng Xiao
Osteoporosis Research Center, Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68131, USA
Hum Genet 117:340-8. 2005..Our results have significant implications for association studies and interpretation of non-reproducible association findings... - Molecular and genetic mechanisms of obesity: implications for future managementYong-Jun Liu
Osteoporosis Research Center, Creighton University, 601 N. 30th St, Suite 6787, Omaha, NE 68131, USA
Curr Mol Med 3:325-40. 2003..Finally, the implications of the recent advances in the understanding of molecular genetic mechanisms of body weight regulation on prevention and therapeutic intervention of obesity will be discussed... - A follow-up linkage study for bone size variation in an extended sampleFu-Hua Xu
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Bone 35:777-84. 2004..78 (P = 0.002). The genomic region 17q22 includes COL1A1, a strong candidate gene that is significantly associated with osteoporotic fracture risk. Our data suggest that this region is promising for further exploratory studies... - A follow-up linkage study for quantitative trait loci contributing to obesity-related phenotypesYong Jun Liu
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131, USA
J Clin Endocrinol Metab 89:875-82. 2004..24 in two-point analysis and an MLS of 0.92 in multipoint analysis in all 79 pedigrees. Our data support that 1p36, 2q14, and 6q27 are promising regions that may harbor QTLs for obesity phenotypes... - Differences in bone mineral density, bone mineral content, and bone areal size in fracturing and non-fracturing women, and their interrelationships at the spine and hipHong-Wen Deng
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
J Bone Miner Metab 20:358-66. 2002..At the hip, 98.0% of BMD variation is due to BMC and 1.1% due to bone areal size. The current study may be important in understanding the relationship among BMD, BMC, and bone size as risk determinants of osteoporotic fractures... - Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosisDong-Hai Xiong
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 21:424-37. 2006.... - Paternal uniparental isodisomy of the entire chromosome 3 revealed in a person with no apparent phenotypic disordersPeng Xiao
Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, Nebraska, USA
Hum Mutat 27:133-7. 2006..The finding of this paternal UPD case of the entire chromosome 3 with no apparent phenotypic disorders suggests that there are no paternal imprinted genes causing rare genetic disorders on chromosome 3... - Transmission disequilibrium test with discordant sib pairs when parents are availableHong Wen Deng
Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
Hum Genet 110:451-61. 2002..Importantly, the TDT(DS) not only may be more powerful, it also has the advantage of being able to test for segregation distortion that may yield false linkage/association in the TDT(D)... - Genetic dissection of human stature in a large sample of multiplex pedigreesYao-Zhong Liu
Osteoporosis Research Center, Creighton University, 601 N. 30th St. Suite 6787, Omaha, NE 68131, USA
Ann Hum Genet 68:472-88. 2004..To date, our study has achieved the largest sample size in the field of genetic linkage studies of human height. Together with the findings of other studies, the current study has further delineated the genetic basis of human stature... - Bone microstructure in osteoporosis: transilial biopsy and histomorphometryM Janet Barger-Lux
Osteoporosis Research Center, Creighton University School of Medicine, 601 North 30th Street, Omaha, NE 68131, USA
Top Magn Reson Imaging 13:297-305. 2002.... - Genome-wide association scans identified CTNNBL1 as a novel gene for obesityYong Jun Liu
School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
Hum Mol Genet 17:1803-13. 2008..Our study also provided supportive evidence for previously identified associations between obesity and INSIG2 and PFKP, but not FTO... - A whole-genome linkage scan suggests several genomic regions potentially containing QTLs underlying the variation of statureHong Wen Deng
Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
Am J Med Genet 113:29-39. 2002..Based on our findings, further confirmation and fine-mapping studies are to be pursued on expanded samples and/or with denser markers for eventual identification of major functional genes involved in human height variation... - Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trialJoan M Lappe
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
Am J Clin Nutr 85:1586-91. 2007..Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking... - Fine mapping of susceptibility genes by Lewontin's linkage disequilibrium measure with application to Alzheimer's diseaseGordon Gong
Creighton University Osteoporosis Research Center, 601 North 30th Street, Suite 6730, Omaha, NE 68131, USA
Chin Med J (Engl) 115:1233-40. 2002..To formulate an equation for fine mapping of disease loci under complex conditions and determine the marker-disease distance in a specific case using this equation... - A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait Loci for osteoporosisHong Wen Deng
Osteoporosis Research Center, Department of Biomedical Sciences, Creighton University, 601 North 30th Street, Omaha, Nebraska 68131, USA
J Clin Endocrinol Metab 87:5151-9. 2002.... - Several genomic regions potentially containing QTLs for bone size variation were identified in a whole-genome linkage scanHong Wen Deng
Osteoporosis Research Center and Department of Biomedical Research, Creighton University, Omaha, Nebraska 68131, USA
Am J Med Genet A 119:121-31. 2003..The two studies may form a basis for further exploration with larger samples and/or denser markers for confirmation and fine mapping studies to eventually identify major functional genes and the associated etiology for osteoporosis... - A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian familiesLan Juan Zhao
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
Hum Genet 121:145-8. 2007..31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11... - Determination of bone size of hip, spine, and wrist in human pedigrees by genetic and lifestyle factorsHong Wen Deng
Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
J Clin Densitom 5:45-56. 2002..48 (0.09), 0.64 (0.08), and 0.60 (0.09) for bone size at the hip, spine, and wrist... - Relevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human diseasesHong Wen Deng
Osteoporosis Research Center, Creighton University, 601 N 30th St Suite 6787, Omaha, NE 68131, USA
Genet Epidemiol 22:12-25. 2002..This study may have significant implications for the common practice of gene search for complex diseases through underlying risk factors (usually quantitative traits)... - Vitamin D(3) is more potent than vitamin D(2) in humansRobert P Heaney
Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
J Clin Endocrinol Metab 96:E447-52. 2011..Current unitage for the calciferols suggests that equimolar quantities of vitamins D(2) (D2) and D(3) (D3) are biologically equivalent. Published studies yield mixed results... - Phosphate and carbonate salts of calcium support robust bone building in osteoporosisRobert P Heaney
Osteoporosis Research Center, Creighton University, Omaha, NE, USA
Am J Clin Nutr 92:101-5. 2010..The relative effectiveness of various calcium salts for this purpose is uncertain. Many older women with osteoporosis have phosphorus intakes of <70% of the Recommended Dietary Allowance... - Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effectsPeng Xiao
Department of Biomedical Sciences and Osteoporosis Research Center, School of Medicine, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 21:1536-44. 2006..The results of this study provide a foundation for the future fine mapping and gene identification in our population... - The elusive concept of bone qualityRobert R Recker
Creighton University School of Medicine, 601 North 30th Street, Suite 5766, Omaha, NE 68131, USA
Curr Osteoporos Rep 2:97-100. 2004..New technologies for studying bone microstructure and matrix composition, merging with sophisticated biomechanical assessments, are advancing our ideas regarding bone "damageability" and its effects over time... - A genomewide linkage scan for quantitative-trait loci for obesity phenotypesHong Wen Deng
Osteoporosis Research Center, and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
Am J Hum Genet 70:1138-51. 2002.... - Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral densityHong Wen Deng
Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
J Bone Miner Res 17:678-86. 2002..This is the first study in the broad field of bone genetics that tests candidate genes as QTLs for BMD by testing simultaneously for association alone, for linkage alone, and for association and linkage (via the TDT)... - Searching for obesity genes: progress and prospectsYong Jun Liu
Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska 68131, USA
Drugs Today (Barc) 41:345-62. 2005..In this article, we discuss the current status and future perspectives for the genetic dissection of obesity, with a focus on the most striking or representative findings... - In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosisPeng Xiao
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
J Bone Miner Res 23:644-54. 2008..However, the in vivo significance of B cells in human bone metabolism and osteoporosis is still largely unknown, particularly at the systematic gene expression level... - Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populationsQing-Yang Huang
Osteoporosis Research Center, Creighton University, 601 N. 30th St, Suite 6787, Omaha, NE 68131, USA
J Hum Genet 48:430-7. 2003..069) with spine BMD and for association with hip BMD in the sample of multigenerational pedigrees. Our results suggest that genetic variation in or near the IL6 locus may be involved in the etiology of obesity and osteoporosis... - Genetic linkage of human height is confirmed to 9q22 and Xq24Yao Zhong Liu
Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
Hum Genet 119:295-304. 2006.... - Genome-wide association study for femoral neck bone geometryLan Juan Zhao
Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, USA
J Bone Miner Res 25:320-9. 2010..Significant association between a nearby common SNP, rs10514713 of the RTP3 gene, and hip fracture (P = 1.0 x 10(-3)) was found. Our observations suggest that RTP3 may be a novel candidate gene for femoral neck bone geometry... - Mutation patterns at dinucleotide microsatellite loci in humansQing-Yang Huang
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
Am J Hum Genet 70:625-34. 2002..There was no correlation between mutation rate and recombination rate. Our data indicate that mutational dynamics at microsatellite loci are more complicated than the generalized stepwise mutation models... - Molecular genetic studies of gene identification for osteoporosis: a 2004 updateYong-Jun Liu
Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska 68131, USA
J Bone Miner Res 21:1511-35. 2006..The format adopted by this review should be ideal for accommodating future new advances and studies... - The genetics of osteoporosisJi-Rong Long
Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA
Drugs Today (Barc) 41:205-18. 2005.... - Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear familiesLan-Juan Zhao
Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE 68131, USA
Bone 35:395-402. 2004..015). However, after correction for multiple testing, these associations did not reach statistical significance. Denser markers may be necessary to better define the relationship between the ER-alpha gene and BMD variation in our sample... - Effect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of womenRobert R Recker
Creighton University School of Medicine, Omaha, Neb, USA
Mayo Clin Proc 80:856-61. 2005..However, even with weekly dosing, adherence remained inadequate in more than one half of patients. These findings indicate that ways to improve medication adherence in the treatment or prevention of osteoporosis are still needed... - Safety of bisphosphonates in the treatment of osteoporosisRobert R Recker
School of Medicine, Creighton University, Omaha, Nebraska, USA
Am J Med 122:S22-32. 2009..e., postdose) reactions, chronic musculoskeletal pain, renal safety, and cardiovascular safety (specifically, atrial fibrillation)... - Current trends in osteoporosisRobert R Recker
Section of Endocrinology, Osteoporosis Research Center, Creighton University, Omaha, Neb, USA
Manag Care 14:3-8; discussion 21-3. 2005 - A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytesYao-Zhong Liu
Osteoporosis Research Center, Creighton University Medical Center, Creighton University, Omaha, NE 68131, USA
J Biol Chem 280:29011-6. 2005..The results may contribute to identification of new genes and their functions for osteoporosis and suggest genetic markers to discern individuals at higher risk to osteoporosis with an aim for preventive intervention and treatment... - Interpretation of genetic linkage findingsYongjun Liu
J Bone Miner Res 18:2077-8; author reply 2079-80. 2003 - Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean massJian Zhao
Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
Genet Res (Camb) 90:259-68. 2008..Our results suggest that QTLs on chromosomes 20p12, 3p26-25 and Xp22 may jointly influence TBFM and TBLM. Further fine mapping and gene identification studies for these pleiotropic effects are needed... - Evidence for a major gene underlying bone size variation in the ChinesePeng-Yuan Liu
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China
Am J Hum Biol 16:68-77. 2004.... - Predictive factors for age at menopause in Caucasian femalesVolodymyr Dvornyk
Department of Biological Sciences, Kent State University, Kent, OH 44242-0001, USA
Maturitas 54:19-26. 2006..Given the important role of the ER-alpha in estrogen signaling, which directly influences the menopausal process, further studies are required to better define the relationship between this gene and age at menopause... - Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis: 2-year results from the DIVA studyJohn A Eisman
Garvan Institute of Medical Research, St Vincent s Campus and University of New South Wales, Sydney, Australia
J Rheumatol 35:488-97. 2008..We report the effects on lumbar spine and proximal femur bone mineral density (BMD) and bone resorption markers over 2 years... - Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone massVolodymyr Dvornyk
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
Chin Med J (Engl) 118:1235-44. 2005.... - Combination and sequential therapy for osteoporosisRobert P Heaney
N Engl J Med 353:624-5. 2005 - Monthly oral ibandronate therapy in postmenopausal osteoporosis: 1-year results from the MOBILE studyPaul D Miller
Colorado Center for Bone Research, Lakewood, Colorado, USA
J Bone Miner Res 20:1315-22. 2005..5 mg; 3-year vertebral fracture risk reduction: 52%) oral ibandronate regimens were compared in 1609 women with postmenopausal osteoporosis. At least equivalent efficacy and similar safety and tolerability were shown after 1 year... - A new concept for bisphosphonate therapy: a rationale for the development of monthly oral dosing of ibandronateJean Yves Reginster
Unite d Exploration du Metabolisme de l Os et du Cartilage, CHU Centre Ville, Liege, Belgium
Osteoporos Int 17:159-66. 2006..Greater convenience and tolerability may enhance the therapy adherence and, hence, improve long-term therapeutic outcomes in PMO... - Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11: leptin and UCP2/UCP3 are not QTLs for obesity in US CaucasiansJing Jing Guo
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
Biochem Biophys Res Commun 332:602-8. 2005..Our results suggest that the LEP and UCP2/UCP3 genes are unlikely to have a substantial effect on variation in obesity phenotypes in this particular US Caucasian population... - A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass traitRandall D Little
Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
Am J Hum Genet 70:11-9. 2002..Our findings suggest that the HBM mutation confers a unique osteogenic activity in bone remodeling, and this understanding may facilitate the development of novel therapies for the treatment of osteoporosis... - Ibandronate produces significant, similar antifracture efficacy in North American and European women: new clinical findings from BONECharles H Chesnut
Osteoporosis Research Group, University of Washington, Seattle, WA, USA
Curr Med Res Opin 21:391-401. 2005..As osteoporosis medications must be effective across different populations, an additional objective of BONE was to investigate and report the effect of oral ibandronate in North American and European women, as described here... - Genomewide linkage scan for quantitative trait loci underlying variation in age at menarcheYan Guo
Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China
J Clin Endocrinol Metab 91:1009-14. 2006.... - CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populationsQing Yang Huang
College of Life Sciences, Central China Normal University, Hubei, China
J Bone Miner Metab 24:132-7. 2006..Through testing for association and for linkage, our data do not support the TNFR2 gene as a QTL underlying hip or spine BMD variation in our Caucasian populations... - Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association studyYan Fang Guo
Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, PR China
J Med Genet 43:798-803. 2006..The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes... - Genetic and environmental correlations between bone geometric parameters and body compositionsXiao Sun
Laboratory of Molecular and Statistical Genetics, Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P. R. China
Calcif Tissue Int 79:43-9. 2006..The results may help understand the intertwined relationships between bone metabolisms, mechanical loading and body compositions... - Epistatic interactions between genomic regions containing the COL1A1 gene and genes regulating osteoclast differentiation may influence femoral neck bone mineral densityTie Lin Yang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, P R China
Ann Hum Genet 71:152-9. 2007..Our results suggested that the IL6 and TNFRSF1B genes may regulate FN BMD variation through interactions with the COL1A1 gene, which should be substantiated by other, or population-based, association studies... - Bivariate whole genome linkage analysis for femoral neck geometric parameters and total body lean massFei Yan Deng
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
J Bone Miner Res 22:808-16. 2007..A genome-wide bivariate analysis was conducted for femoral neck GPs and TBLM in a large white sample. We found QTLs shared by GPs and TBLM in the total sample and the sex-specific samples. QTLs with potential pleiotropy were also disclosed... - Intravenous ibandronate injections in postmenopausal women with osteoporosis: one-year results from the dosing intravenous administration studyPierre D Delmas
Université Claude Bernard Lyon 1 and INSERM Research Unit 403, Lyon, France
Arthritis Rheum 54:1838-46. 2006..The aim of this study was to identify the optimal intravenous dosing regimen for ibandronate in postmenopausal women with osteoporosis... - Assessment of genetic linkage and parent-of-origin effects on obesityYan-Fang Guo
Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiantong University, Xi'an 710049, People's Republic of China
J Clin Endocrinol Metab 91:4001-5. 2006.... - A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosisZi Hui Tang
Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
J Clin Endocrinol Metab 92:2751-7. 2007..BFM and BMD, as the respective measure for obesity and osteoporosis, are phenotypically and genetically correlated. However, specific genomic regions accounting for their genetic correlation are unknown... - Linkage exclusion mapping with bone size in 79 Caucasian pedigreesXiang-Ding Chen
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, China
J Bone Miner Metab 24:337-43. 2006.... - Chromosome 2q32 may harbor a QTL affecting BMD variation at different skeletal sitesLiang Wang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi, China
J Bone Miner Res 22:1672-8. 2007..BMDs at different skeletal sites share some common genetic determinants. Using PCA and bivariate linkage analysis, we identified a QTL on chromosome 2q32 with significant pleiotropic effects on BMDs at different skeletal sites... - Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trialPierre D Delmas
University of Claude Bernard of Lyon, Hopital Edouard Herriot, Service de Rhumatologie et de Pathologie Osseuse, Lyon 69437, France
J Clin Endocrinol Metab 87:3609-17. 2002..The decreased vertebral fracture risk in yr 4 alone was not different from that observed in the first 3 yr... - Bivariate whole genome linkage analyses for total body lean mass and BMDXiang Li Wang
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
J Bone Miner Res 23:447-52. 2008..We found some QTLs shared by TBLM and BMD in the entire sample and the sex-specific subgroups, and QTLs with potential pleiotropy were disclosed... - The MTHFR gene polymorphism is associated with lean body mass but not fat body massXiaogang Liu
The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an Shaanxi, 710049, People s Republic of China
Hum Genet 123:189-96. 2008..In summary, the MTHFR gene polymorphism is associated with LBM, suggesting that MTHFR may play an important role in LBM variation. In addition, the MTHFR gene polymorphism is not associated with FBM or obesity in this sample... - Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear familiesTie Lin Yang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
Hum Genet 120:119-25. 2006..We thus concluded that CYP19 could be one of the genetic factors influencing adult height in Caucasians. Further studies are required to identify the causal functional variants responsible for Caucasian height within the CYP19 gene... - Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian femalesJian Zhao
The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
Hum Reprod 22:1789-94. 2007..Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females...
Research Grants
- A Study of Reduced Bone Quality as a Cause of FracturesRobert Recker; Fiscal Year: 2009....
- A Study of Reduced Bone Quality as a Cause of FracturesRobert Roy Recker; Fiscal Year: 2010....
- A Study of Reduced Bone Quality as a Cause of FracturesRobert Recker; Fiscal Year: 2009..This study will also provide important biomarkers or genes for future basic research on the mechanisms that cause defects in bone quality. ..
- A Study of Reduced Bone Quality as a Cause of FracturesRobert Roy Recker; Fiscal Year: 2010....