J M Lappe

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. pmc In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis
    Peng Xiao
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 23:644-54. 2008
  2. pmc Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study
    Joan Lappe
    Osteoporosis Research Center, Creighton University Medical Center, 601 North 30th Street, Suite 4820, Omaha, NE 68131, USA E mail
    Eur J Nutr 52:203-215. 2013
  3. pmc The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial
    Jiapeng Zhou
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, USA
    Nutr Metab (Lond) 7:62. 2010
  4. ncbi request reprint Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
    Joan M Lappe
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 85:1586-91. 2007
  5. ncbi request reprint Vitamin D status in a rural postmenopausal female population
    Joan M Lappe
    Creighton University Medical Center, Osteoporosis Research Center, 601 North 30 Street Suite 4820, Omaha, NE 68131, USA
    J Am Coll Nutr 25:395-402. 2006
  6. ncbi request reprint A prospective study of quantitative ultrasound in children and adolescents
    J M Lappe
    Osteoporosis Research Center, Department of Medicine, Creighton University, 601 North 30th St 4820, Omaha, NE 68131, USA
    J Clin Densitom 3:167-75. 2000
  7. ncbi request reprint Quantitative ultrasound: use in screening for susceptibility to stress fractures in female army recruits
    Joan Lappe
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 20:571-8. 2005
  8. ncbi request reprint Girls on a high-calcium diet gain weight at the same rate as girls on a normal diet: a pilot study
    Joan M Lappe
    Osteoporosis Research Center, Creighton University, 601 N 30th Street, Omaha, NE 68131, USA
    J Am Diet Assoc 104:1361-7. 2004
  9. ncbi request reprint Hormones, weight change and menopause
    K M Davies
    Creighton University, Osteoporosis Research Center, 601 North 30th Street, Omaha, NE 68131, USA
    Int J Obes Relat Metab Disord 25:874-9. 2001
  10. ncbi request reprint The impact of lifestyle factors on stress fractures in female Army recruits
    J M Lappe
    Osteoporosis Research Center, Department of Medicine, Creighton University, 601 North 30th Street #4820, Omaha, NE 68131, USA
    Osteoporos Int 12:35-42. 2001

Collaborators

Detail Information

Publications22

  1. pmc In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis
    Peng Xiao
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 23:644-54. 2008
    ..However, the in vivo significance of B cells in human bone metabolism and osteoporosis is still largely unknown, particularly at the systematic gene expression level...
  2. pmc Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study
    Joan Lappe
    Osteoporosis Research Center, Creighton University Medical Center, 601 North 30th Street, Suite 4820, Omaha, NE 68131, USA E mail
    Eur J Nutr 52:203-215. 2013
    ..This study examined the effects of synthetic genistein in combination with other potential bone-protective dietary molecules on bone mineral density (BMD) in early postmenopausal women...
  3. pmc The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial
    Jiapeng Zhou
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE, USA
    Nutr Metab (Lond) 7:62. 2010
    ..It is undetermined whether calcium supplementation has an effect on obesity or body composition in postmenopausal women. The purpose of the study is to detect the effect of calcium supplementation on indices of obesity and body composition...
  4. ncbi request reprint Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
    Joan M Lappe
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 85:1586-91. 2007
    ..Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking...
  5. ncbi request reprint Vitamin D status in a rural postmenopausal female population
    Joan M Lappe
    Creighton University Medical Center, Osteoporosis Research Center, 601 North 30 Street Suite 4820, Omaha, NE 68131, USA
    J Am Coll Nutr 25:395-402. 2006
    ..Inadequate vitamin D nutritional status is increasingly recognized as common in North American and European populations, but the extent of the shortfall and the parameters of the distribution for populations of interest remain uncertain...
  6. ncbi request reprint A prospective study of quantitative ultrasound in children and adolescents
    J M Lappe
    Osteoporosis Research Center, Department of Medicine, Creighton University, 601 North 30th St 4820, Omaha, NE 68131, USA
    J Clin Densitom 3:167-75. 2000
    ..Our findings that QUS values change during childhood and adolescence in a manner similar to DXA values, the "gold standard," provide support for the validity of using QUS to assess bone health in children and adolescents...
  7. ncbi request reprint Quantitative ultrasound: use in screening for susceptibility to stress fractures in female army recruits
    Joan Lappe
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 20:571-8. 2005
    ..QUS predicted stress fracture in female recruits as well as it predicts hip fracture in elderly women. Recruits with low QUS values and a history of smoking and not exercising had an extremely high risk of stress fracture...
  8. ncbi request reprint Girls on a high-calcium diet gain weight at the same rate as girls on a normal diet: a pilot study
    Joan M Lappe
    Osteoporosis Research Center, Creighton University, 601 N 30th Street, Omaha, NE 68131, USA
    J Am Diet Assoc 104:1361-7. 2004
    ..To determine whether pubertal girls assigned to calcium-rich diets or their usual calcium intakes differ significantly in weight gain...
  9. ncbi request reprint Hormones, weight change and menopause
    K M Davies
    Creighton University, Osteoporosis Research Center, 601 North 30th Street, Omaha, NE 68131, USA
    Int J Obes Relat Metab Disord 25:874-9. 2001
    ..CONCLUSIONS: The long-term, total body weight trajectory at mid-life is not influenced appreciably by either cessation of ovarian function or by hormone replacement...
  10. ncbi request reprint The impact of lifestyle factors on stress fractures in female Army recruits
    J M Lappe
    Osteoporosis Research Center, Department of Medicine, Creighton University, 601 North 30th Street #4820, Omaha, NE 68131, USA
    Osteoporos Int 12:35-42. 2001
    ....
  11. ncbi request reprint Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients
    Robert Recker
    Creighton Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 19:1628-33. 2004
    ..Ac.f nearly doubled 1 year after menopause, tripled 13 years after menopause, and remained elevated in women with osteoporosis...
  12. ncbi request reprint Transmenopausal changes in the trabecular bone structure
    M P Akhter
    Osteoporosis Research Center, Creighton University, Suite 4820, 610 N, 30th Street, Omaha, NE 68131, USA
    Bone 41:111-6. 2007
    ..The study was designed to capture true longitudinal transmenopausal changes in three-dimensional (3-D) trabecular bone architecture. Currently, minimal data exist regarding these features...
  13. ncbi request reprint Pathophysiology of osteoporosis and fracture
    J M Lappe
    Creighton University Schools of Nursing and Medicine, Omaha, Nebraska 68131, USA
    Nurs Clin North Am 36:393-400, vii. 2001
    ..An understanding of the material presented here will provide a foundation to assess the bone health of individuals, to promote bone health, and to prevent fracture in patients of all ages...
  14. ncbi request reprint Designer estrogen vs. hormone replacement therapy: the menopausal woman's dilemma
    J M Lappe
    Creighton University Schools of Nursing and Medicine, Omaha, Nebraska, USA
    Orthop Nurs 20:66-72; quiz 72-4. 2001
    ..The purpose of this article is to present a synthesis of information comparing HRT and SERMs so that the reader can help his/her clients make informed choices about replacement therapy...
  15. pmc Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy
    A Cohen
    Department of Medicine, PH8 864, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Osteoporos Int 21:263-73. 2010
    ..Correlations were weak to moderate between parameters measured on biopsies and scans...
  16. doi request reprint Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits
    Joan Lappe
    Creighton University Osteoporosis Research Center, Omaha, Nebraska, USA
    J Bone Miner Res 23:741-9. 2008
    ..The goal of this randomized double-blind, placebo-controlled study was to determine whether a calcium and vitamin D intervention could reduce the incidence of SFx in female recruits during basic training...
  17. pmc Calcium supplementation: Results may not be generalisable
    Joan M Lappe
    BMJ 336:403; author reply 404. 2008
  18. ncbi request reprint Why blame milk?
    Joan M Lappe
    Arch Pediatr Adolesc Med 159:1187-8; author reply 1188. 2005
  19. ncbi request reprint The bone mineral density in childhood study: bone mineral content and density according to age, sex, and race
    Heidi J Kalkwarf
    Division of General and Community Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Clin Endocrinol Metab 92:2087-99. 2007
    ..Low bone mass may increase risk of fracture. Several chronic medical conditions, medications, and lifestyle factors affect bone mineral accrual. Appropriate reference values are essential for identification of children with bone deficits...
  20. ncbi request reprint Accuracy of pubertal Tanner staging self-reporting
    Jean Claude Desmangles
    Department of Pediatrics, Division of Endocrinology Diabetes, Creighton University, Omaha, NE 68131, USA
    J Pediatr Endocrinol Metab 19:213-21. 2006
    ..Previous studies examining the reliability of self-reported Tanner stages have given conflicting results. We report on the reliability of self-reported Tanner stages in lean healthy children...
  21. ncbi request reprint A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes
    Yao Zhong Liu
    Osteoporosis Research Center, Creighton University Medical Center, Creighton University, Omaha, NE 68131, USA
    J Biol Chem 280:29011-6. 2005
    ..The results may contribute to identification of new genes and their functions for osteoporosis and suggest genetic markers to discern individuals at higher risk to osteoporosis with an aim for preventive intervention and treatment...
  22. ncbi request reprint Effects of calcium supplementation on serum lipid levels in postmenopausal women
    Robert P Heaney
    Am J Med 114:620-1; author reply 621. 2003

Research Grants26

  1. Calcium Foods and Bone Health of Adolescent Girls
    Joan Lappe; Fiscal Year: 2006
    ..Negative findings would provide support for further research into other methods of concomitant methods of maximizing skeletal development. ..
  2. EXERCISE AND CALCIUM EFFECT ON PUBERTAL BONE GAIN
    Joan Lappe; Fiscal Year: 2006
    ..If these findings hold, they would provide strong support for the essential role of calcium in addition to exercise in maximizing bone mass in growing females. ..
  3. Calcium Foods and Bone Health of Adolescent Girls
    Joan Lappe; Fiscal Year: 2007
    ..Lack of a calcium effect would provide support for further research into other methods or concomitant methods of maximizing skeletal development. ..
  4. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2009
    ..Positive findings will provide support for health policy changes to promote optimal vitamin D levels in the population. ..
  5. Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent Weight
    Joan Lappe; Fiscal Year: 2009
    ..Such a dairy intervention would be congruent with currently recommended calcium and dairy intake. ..
  6. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2010
    ..It specifically addresses Strategic Objective 2, to "accelerate progress in cancer prevention." Positive findings from our proposed nutritional intervention study will result in an inexpensive, safe method of preventing cancer. ..
  7. Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent Weight
    Joan Lappe; Fiscal Year: 2010
    ..Such a dairy intervention would be congruent with currently recommended calcium and dairy intake. ..
  8. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2009
    ..The genetic factors identified from this revision are important for understanding the mechanisms accounting for population variation in prevalent vitamin D status, and for individualizing dosing with vitamin D supplementation. ..
  9. EXERCISE AND CALCIUM EFFECT ON PUBERTAL BONE GAIN
    Joan Lappe; Fiscal Year: 2001
    ..I.'s work is to test interventions designed to bring about conscious increases in calcium intake and physical activity in children to improve their bone health and develop lifelong bone healthy behaviors. ..
  10. Calcium Foods and Bone Health of Adolescent Girls
    Joan Lappe; Fiscal Year: 2003
    ..Negative findings would provide support for further research into other methods of concomitant methods of maximizing skeletal development. ..
  11. CALCIUM AND VITAMIN D MALNUTRITION IN ELDERLY WOMEN
    Joan Lappe; Fiscal Year: 2003
    ..This is a valid method to determine compliance, far superior to the traditional pill counts, and thus a substantial aid to measure the anti-fracture efficacy of calcium alone or calcium plus vitamin D interventions. ..
  12. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2011
    ..It specifically addresses Strategic Objective 2, to "accelerate progress in cancer prevention." Positive findings from our proposed nutritional intervention study will result in an inexpensive, safe method of preventing cancer. ..