Robert Heaney

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. ncbi Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial
    Mary Beth O'Connell
    Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201 2417, USA
    Am J Med 118:778-81. 2005
  2. ncbi The settling problem in calcium-fortified soybean drinks
    Robert P Heaney
    J Am Diet Assoc 106:1753; author reply 1755. 2006
  3. pmc Why randomized controlled trials of calcium and vitamin D sometimes fail
    Joan M Lappe
    Creighton University Osteoporosis Research Center Omaha, NE USA
    Dermatoendocrinol 4:95-100. 2012
  4. pmc Calcium, dairy, and prostate cancer
    R P Heaney
    Br J Cancer 96:1008; author reply 1009. 2007
  5. doi What is vitamin D insufficiency? And does it matter?
    Robert P Heaney
    Creighton University, 601 N 30th Street, Suite 4841, Omaha, NE 68131, USA
    Calcif Tissue Int 92:177-83. 2013
  6. doi The nutrient problem
    Robert P Heaney
    Creighton University Medical Center, 601 N 30th Street, Omaha, NE 68131, USA
    Nutr Rev 70:165-9. 2012
  7. ncbi Calcium fortification systems differ in bioavailability
    Robert P Heaney
    Creighton University Medical Center, 601 N 30th Street, Omaha, NE 68131, USA
    J Am Diet Assoc 105:807-9. 2005
  8. ncbi The case for improving vitamin D status
    Robert P Heaney
    Creighton University Medical Center, 601 North 30th Street Suite 4841, Omaha, NE 68131, USA
    J Steroid Biochem Mol Biol 103:635-41. 2007
  9. ncbi Bone health
    Robert P Heaney
    Creighton University Medical Center, Omaha, NE 68131, USA
    Am J Clin Nutr 85:300S-303S. 2007
  10. ncbi Vitamin D--the iceberg nutrient
    R P Heaney
    Creighton University, Omaha, NE 68131 2137, USA
    J Musculoskelet Neuronal Interact 6:334-5. 2006

Detail Information

Publications97

  1. ncbi Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial
    Mary Beth O'Connell
    Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201 2417, USA
    Am J Med 118:778-81. 2005
  2. ncbi The settling problem in calcium-fortified soybean drinks
    Robert P Heaney
    J Am Diet Assoc 106:1753; author reply 1755. 2006
  3. pmc Why randomized controlled trials of calcium and vitamin D sometimes fail
    Joan M Lappe
    Creighton University Osteoporosis Research Center Omaha, NE USA
    Dermatoendocrinol 4:95-100. 2012
    ..Our purpose is (1) to inform future study design so as to ensure that relevant biological facts are considered and (2) to aid in the interpretation of the abundant, but often inconsistent literature on this topic...
  4. pmc Calcium, dairy, and prostate cancer
    R P Heaney
    Br J Cancer 96:1008; author reply 1009. 2007
  5. doi What is vitamin D insufficiency? And does it matter?
    Robert P Heaney
    Creighton University, 601 N 30th Street, Suite 4841, Omaha, NE 68131, USA
    Calcif Tissue Int 92:177-83. 2013
    ..What is important to note is that, in the case of vitamin D, the preponderance of the evidence indicates that there is real, preventable disease in the range of vitamin D status values now labeled "insufficient."..
  6. doi The nutrient problem
    Robert P Heaney
    Creighton University Medical Center, 601 N 30th Street, Omaha, NE 68131, USA
    Nutr Rev 70:165-9. 2012
    ..Several alternative approaches, each providing an a priori normal, are described and briefly discussed...
  7. ncbi Calcium fortification systems differ in bioavailability
    Robert P Heaney
    Creighton University Medical Center, 601 N 30th Street, Omaha, NE 68131, USA
    J Am Diet Assoc 105:807-9. 2005
    ..Nutritionists and dietetics professionals should encourage manufacturers of fortified products to provide information on bioavailability...
  8. ncbi The case for improving vitamin D status
    Robert P Heaney
    Creighton University Medical Center, 601 North 30th Street Suite 4841, Omaha, NE 68131, USA
    J Steroid Biochem Mol Biol 103:635-41. 2007
    ..Hence a strong case can be made for immediate improvement in vitamin D status of the general population...
  9. ncbi Bone health
    Robert P Heaney
    Creighton University Medical Center, Omaha, NE 68131, USA
    Am J Clin Nutr 85:300S-303S. 2007
    ..Problems with adherence to a regimen of taking supplements daily make an appropriate fortification strategy the preferred option for improving the status of both nutrients...
  10. ncbi Vitamin D--the iceberg nutrient
    R P Heaney
    Creighton University, Omaha, NE 68131 2137, USA
    J Musculoskelet Neuronal Interact 6:334-5. 2006
  11. ncbi Role of dietary sodium in osteoporosis
    Robert P Heaney
    Creighton University, Omaha, Nebraska 68178, USA
    J Am Coll Nutr 25:271S-276S. 2006
    ..Given the relative difficulty of the former, and the ancillary benefits of the latter, it would seem that the optimal strategy to protect the skeleton is to ensure adequate calcium and potassium intakes...
  12. ncbi Barriers to optimizing vitamin D3 intake for the elderly
    Robert P Heaney
    Creighton University, Omaha, NE 68178, USA
    J Nutr 136:1123-5. 2006
    ..The age-related decline in cutaneous input, taken together with the UL, creates a substantial barrier to the deployment of public health strategies to optimize vitamin D status in the elderly...
  13. ncbi Low calcium intake among African Americans: effects on bones and body weight
    Robert P Heaney
    Creighton University, Omaha, Nebraska, USA
    J Nutr 136:1095-8. 2006
    ..Higher calcium intakes not only support the skeleton in African Americans, just as they do in whites, but reduce the disease burden for other chronic diseases as well...
  14. ncbi Functional indices of vitamin D status and ramifications of vitamin D deficiency
    Robert P Heaney
    Creighton University Medical Center, Omaha, NE 68131, USA
    Am J Clin Nutr 80:1706S-9S. 2004
    ..There is great need for standardization and improved reproducibility and sensitivity of measurements of serum 25(OH)D3 concentrations...
  15. ncbi Hospitalization-related bone loss and the protective effect of risedronate
    Robert P Heaney
    Creighton University, 601 N 30th St, Suite 4841, Omaha, NE 68131, USA
    Osteoporos Int 17:212-6. 2006
    ..Intercurrent illness resulting in hospitalization produced a rapid bone loss across the period of illness comparable in magnitude to documented age-related loss. Risedronate in a dose of 5 mg/day effectively abolished this loss...
  16. ncbi The Vitamin D requirement in health and disease
    Robert P Heaney
    Creighton University, 601 N 30th St, Suite 4841 Omaha, NE 68131, USA
    J Steroid Biochem Mol Biol 97:13-9. 2005
    ..Actual toxicity is not seen below serum 25OHD values of 250nmol/L, a value that would be produced only at continuing oral intakes in excess of 10,000IU (250microg)/day...
  17. pmc Advances in therapy for osteoporosis
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Clin Med Res 1:93-9. 2003
    ....
  18. ncbi Serum 25-hydroxyvitamin D and parathyroid hormone exhibit threshold behavior
    R P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    J Endocrinol Invest 28:180-2. 2005
  19. ncbi Newer perspectives on calcium nutrition and bone quality
    Robert P Heaney
    Creighton University Medical Center, 601 N 30th St, Suite 4841, Omaha, NE 68131, USA
    J Am Coll Nutr 24:574S-81S. 2005
    ..High calcium intakes in postmenopausal and older women reduce this homeostatic remodeling to approximately pre-menopausal values and improve bone strength immediately, well prior to any appreciable change in bone mass...
  20. ncbi Vitamin D in health and disease
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    Clin J Am Soc Nephrol 3:1535-41. 2008
    ..Recent data indicate that cholecalciferol (vitamin D(3)) is substantially more potent than ergocalciferol (vitamin D(2)) and that the safe upper intake level for vitamin D(3) is 10,000 IU/d...
  21. ncbi Assessing vitamin D status
    Robert P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    Curr Opin Clin Nutr Metab Care 14:440-4. 2011
    ..To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status...
  22. doi Why the IOM recommendations for vitamin D are deficient
    Robert P Heaney
    Creighton University, Omaha, NE, USA
    J Bone Miner Res 26:455-7. 2011
    ..Moreover, by failing to use a physiological referent, the IOM approach constitutes precisely the wrong model for development of nutritional policy...
  23. doi Vitamin D(3) is more potent than vitamin D(2) in humans
    Robert P Heaney
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 96:E447-52. 2011
    ..Current unitage for the calciferols suggests that equimolar quantities of vitamins D(2) (D2) and D(3) (D3) are biologically equivalent. Published studies yield mixed results...
  24. doi Variability in the measured response of bone to teriparatide
    R P Heaney
    Creighton University Medical Center, 601 N 30th Street, Suite 4841, Omaha, NE 68131, USA
    Osteoporos Int 22:1703-8. 2011
    ..Apparent non-responders nevertheless show good biomarker response, suggesting that apparent BMD non-response is due to measurement imprecision. Calcium intake may be an important determinant of hip response...
  25. pmc Phosphate and carbonate salts of calcium support robust bone building in osteoporosis
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    Am J Clin Nutr 92:101-5. 2010
    ..The relative effectiveness of various calcium salts for this purpose is uncertain. Many older women with osteoporosis have phosphorus intakes of <70% of the Recommended Dietary Allowance...
  26. ncbi Vitamin D3 distribution and status in the body
    Robert P Heaney
    Creighton University, 601 N 30 St, Suite 4841, Omaha, NE 68131, USA
    J Am Coll Nutr 28:252-6. 2009
    ..To estimate the amount, type, and tissue distribution of vitamin D in the adult body under typical inputs...
  27. ncbi Alendronate plus cholecalciferol for the treatment of osteoporosis
    Robert P Heaney
    Creighton University Medical Center, 601 North 30th St, Suite 4841, Omaha, NE 68131, USA
    Womens Health (Lond Engl) 2:23-7. 2006
    ..Its efficacy in reducing fracture risk is expected to be at least as good as that of once-weekly alendronate given for the same indications...
  28. ncbi Dairy and bone health
    Robert P Heaney
    Creighton University, 2500 California St, Omaha, NE 68178, USA
    J Am Coll Nutr 28:82S-90S. 2009
    ..Given modern food sources, it is difficult to devise a diet that is "bone healthy" without including three servings of dairy per day, not just because of dairy calcium, but dairy protein and potassium as well...
  29. doi Preponderance of the evidence: an example from the issue of calcium intake and body composition
    Robert P Heaney
    Creighton University Medical Center, Osteoporosis Research Center, Omaha, Nebraska 68131, USA
    Nutr Rev 67:32-9. 2009
    ..In this review, one way of doing so is proposed and the recently emergent literature concerning calcium intake and body composition is used as an illustration of how such an approach might be used...
  30. ncbi Calcium supplementation and incident kidney stone risk: a systematic review
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    J Am Coll Nutr 27:519-27. 2008
    ..A report of a small increase in kidney stone risk in the calcium treatment arm of the Women's Health Initiative (WHI) led to a reduction in U.S. calcium supplement sales...
  31. doi Vitamin D: criteria for safety and efficacy
    Robert P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    Nutr Rev 66:S178-81. 2008
    ..Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day)...
  32. ncbi Nutrients, endpoints, and the problem of proof
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    J Nutr 138:1591-5. 2008
  33. ncbi Vitamin D and calcium interactions: functional outcomes
    Robert P Heaney
    Creighton University, Omaha, NE, USA
    Am J Clin Nutr 88:541S-544S. 2008
    ..To a considerable extent, both vitamin D status and the benefits associated therewith appear to be dependent on, or at least augmented by, calcium intakes at or above currently recommended levels...
  34. ncbi 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 87:1738-42. 2008
    ..Neither the efficiency of the 25-hydroxylation of vitamin D nor the steady state relation between vitamin D(3) and 25-hydroxyvitamin D [25(OH)D] has been studied in humans...
  35. ncbi Calcium intake and disease prevention
    Robert P Heaney
    Creighton University Medical Center, Omaha, NE 68131, USA
    Arq Bras Endocrinol Metabol 50:685-93. 2006
    ..The best source of calcium is dairy foods, largely because the disorders concerned depend upon multiple nutrients, not just calcium, and dairy provides a broad array of essential nutrients in addition to calcium, and at low cost...
  36. ncbi Improved estimation of the calcium content of total digestive secretions
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:1193-5. 2004
    ..The partition described facilitated derivation of a formula to calculate TIC for any paired values of EFC and AbsFx, i.e. TIC = EFC/[0.223 + 0.777 (1 - AbsFx)]...
  37. ncbi Ethical issues in the design of osteoporosis clinical trials: the state of the question
    Robert P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 18:1117-20. 2003
  38. ncbi Carbonated beverages and urinary calcium excretion
    R P Heaney
    Creighton University Osteoporosis Research Center, Omaha, NE 68131, USA
    Am J Clin Nutr 74:343-7. 2001
    ..Intake of carbonated beverages has been associated with increased fracture risk in observational studies. The usual explanation given is that one or more of the beverage constituents increase urinary calcium...
  39. ncbi Constructive interactions among nutrients and bone-active pharmacologic agents with principal emphasis on calcium, phosphorus, vitamin D and protein
    R P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    J Am Coll Nutr 20:403S-409S; discussion 417S-420S. 2001
    ..Phosphorus intake, less extensively studied, may be more important than currently recognized, particularly in elderly individuals living alone, eating little meat, and receiving anti-osteoporosis treatment agents...
  40. ncbi Quantifying human calcium absorption using pharmacokinetic methods
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    J Nutr 133:1224-6. 2003
    ..For net absorbed calcium (mmol) the relationship was given by 4.358 x AUC(9) +/- 0.820. The empirical regression coefficient was significant and the error of the estimate (0.820 mmol) acceptably small...
  41. ncbi Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D
    Robert P Heaney
    Creighton University, 601 N 30th Street, Suite 4841, Omaha, NE 68131, USA
    J Am Coll Nutr 22:142-6. 2003
    ..Calcium absorption is generally considered to be impaired under conditions of vitamin D deficiency, but the vitamin D status that fully normalizes absorption is not known for humans...
  42. ncbi Normalizing calcium intake: projected population effects for body weight
    Robert P Heaney
    Creighton University, Omaha, NE, USA
    J Nutr 133:268S-270S. 2003
    ....
  43. ncbi Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 77:204-10. 2003
    ..The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin...
  44. ncbi The importance of calcium intake for lifelong skeletal health
    R P Heaney
    Creighton University, 601 N 30th St, Suite 4841, Omaha, Nebraska 68131, USA
    Calcif Tissue Int 70:70-3. 2002
  45. ncbi Effects of caffeine on bone and the calcium economy
    R P Heaney
    Creighton University, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Food Chem Toxicol 40:1263-70. 2002
    ..There is no evidence that caffeine has any harmful effect on bone status or on the calcium economy in individuals who ingest the currently recommended daily allowances of calcium...
  46. ncbi Calcium needs of the elderly to reduce fracture risk
    R P Heaney
    Creighton University, Osteoporosis Research Center, Omaha, Nebraska 68131, USA
    J Am Coll Nutr 20:192S-197S. 2001
    ..Milk, mainly because of constructive interactions among its several key nutrients, is probably the most nutritionally and cost effective way of meeting the calcium requirement in the elderly...
  47. ncbi Estimation of true calcium absorption in men
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    Clin Chem 48:786-8. 2002
  48. ncbi Calcium and weight: clinical studies
    Robert P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    J Am Coll Nutr 21:152S-155S. 2002
    ..5-3.0 kg lower body weight in adults. Taken together these data suggest that increasing calcium intake by the equivalent of two dairy servings per day could reduce the risk of overweight substantially, perhaps by as much as 70 percent...
  49. ncbi Calcium effects on phosphorus absorption: implications for the prevention and co-therapy of osteoporosis
    Robert P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    J Am Coll Nutr 21:239-44. 2002
    ..To evaluate the effect of calcium intake on absorption of dietary phosphorus, with special reference to typical calcium intakes and to those likely to be encountered in prevention and treatment of osteoporosis...
  50. ncbi Risedronate reduces the risk of first vertebral fracture in osteoporotic women
    R P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    Osteoporos Int 13:501-5. 2002
    ..024). Risedronate treatment therefore significantly reduces the risk of first vertebral fracture in postmenopausal women with osteoporosis, with a similar magnitude of effect early and late after the menopause...
  51. ncbi Calcium and vitamin D
    Robert P Heaney
    Department of Medicine, Creighton University Medical Center, Omaha, NE 68131, USA
    Endocrinol Metab Clin North Am 32:181-94, vii-viii. 2003
    ..Prudent nutritional support for osteoporosis prevention and treatment consists of 30 to 40 mmol Ca/d together with sufficient vitamin D to maintain serum 25(OH)D levels above 80 nmol/L (i.e., approximately 25 microg vitamin D/d)...
  52. ncbi Absorbability and cost effectiveness in calcium supplementation
    R P Heaney
    Creighton University, Osteoporosis Research Center, Omaha, Nebraska 68131, USA
    J Am Coll Nutr 20:239-46. 2001
    ..Published cost-benefit analyses assume equal bioavailability for all calcium sources. Some published studies have suggested that there are differences in both the bioavailability and cost of the major calcium supplements...
  53. ncbi Long-latency deficiency disease: insights from calcium and vitamin D
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 78:912-9. 2003
    ....
  54. ncbi Calcium, dairy products and osteoporosis
    R P Heaney
    Creighton University, Omaha, Nebraska 68178, USA
    J Am Coll Nutr 19:83S-99S. 2000
    ....
  55. ncbi Bioavailability of the calcium in fortified soy imitation milk, with some observations on method
    R P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 71:1166-9. 2000
    ..Additionally, the validity of isotopic labeling methods for fortified liquid products had not been established...
  56. ncbi Phosphorus nutrition and the treatment of osteoporosis
    Robert P Heaney
    Creighton University Medical Center, Omaha, Neb 68131, USA
    Mayo Clin Proc 79:91-7. 2004
    ..A calcium phosphate supplement may be preferable to the usual carbonate or citrate salts because its phosphate serves to spare food phosphorus...
  57. ncbi Is the paradigm shifting?
    Robert P Heaney
    Creighton University, 601 N 30th St, Suite 4841, Omaha, NE 68131, USA
    Bone 33:457-65. 2003
    ..Within this context, reduced bone mass, rather than the primary cause of fracture, is seen as a factor that predisposes individuals to the harmful effects of excessive remodeling...
  58. ncbi How does bone support calcium homeostasis?
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    Bone 33:264-8. 2003
  59. ncbi Dietary protein and phosphorus do not affect calcium absorption
    R P Heaney
    Creighton University Osteoporosis Research Center, Omaha, NE 68131, USA
    Am J Clin Nutr 72:758-61. 2000
    ..Several investigators have suggested that the relatively high phosphorus and protein intakes of the diets of industrialized nations reduce calcium absorption and thereby aggravate the problem of calcium deficiency...
  60. ncbi Factors influencing the measurement of bioavailability, taking calcium as a model
    R P Heaney
    Creighton University, Osteoporosis Research Center, Omaha, NE 68131, USA
    J Nutr 131:1344S-8S. 2001
    ..Hence direct measurement of absorbability is essential to assure regulators and the general public that the source delivers what it promises...
  61. doi Bone mineral density discordance and exploration of one of its causes
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    J Clin Densitom 14:428-33. 2011
    ..One consequence is that if BMC-based T-scores are used to classify patients, substantially fewer individuals would have been judged osteoporotic in this cohort (two-thirds fewer for spine and three-fourths fewer for hip)...
  62. ncbi Differences in bone mineral density, bone mineral content, and bone areal size in fracturing and non-fracturing women, and their interrelationships at the spine and hip
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    J Bone Miner Metab 20:358-66. 2002
    ..At the hip, 98.0% of BMD variation is due to BMC and 1.1% due to bone areal size. The current study may be important in understanding the relationship among BMD, BMC, and bone size as risk determinants of osteoporotic fractures...
  63. ncbi Determinants of endogenous calcium entry into the gut
    K Michael Davies
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    Am J Clin Nutr 80:919-23. 2004
    ..In health, such entry is as large as or larger than urinary calcium excretion. Because calcium absorption is inefficient, most of this endogenous intestinal calcium is excreted...
  64. ncbi Pharmacokinetics of a single, large dose of cholecalciferol
    Marium Ilahi
    Creighton University Medical Center, Omaha, NE 68131, USA
    Am J Clin Nutr 87:688-91. 2008
    ..There is much interest in dosing vitamin D intermittently for patient convenience and long-term adherence...
  65. ncbi Decline in muscle mass with age in women: a longitudinal study using an indirect measure
    K Michael Davies
    Creighton University Osteoporosis Research Center, Omaha, NE 68131, USA
    Metabolism 51:935-9. 2002
    ..Our study is the largest longitudinal study reported to date and provides, perhaps, a more secure basis for estimating muscle mass change with age than has been available heretofore...
  66. ncbi Quantitative ultrasound: use in screening for susceptibility to stress fractures in female army recruits
    Joan Lappe
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 20:571-8. 2005
    ..QUS predicted stress fracture in female recruits as well as it predicts hip fracture in elderly women. Recruits with low QUS values and a history of smoking and not exercising had an extremely high risk of stress fracture...
  67. doi Differential effects of paricalcitol and calcitriol on intestinal calcium absorption in hemodialysis patients
    Richard J Lund
    Department of Medicine, Creighton University, 3316 Dodge Street, Omaha, NE 68154, USA
    Am J Nephrol 31:165-70. 2010
    ..This study compared intestinal Ca absorption in hemodialysis patients treated with calcitriol versus paricalcitol (dose ratio 1:3)...
  68. ncbi Potassium intake and the calcium economy
    Karen Rafferty
    Creighton University, Osteoporosis Research Center, Omaha, Nebraska 68131, USA
    J Am Coll Nutr 24:99-106. 2005
    ..Dietary potassium intake (K) lowers urinary calcium (Ca) excretion and, in short-term studies, may improve Ca balance...
  69. doi Do melanoidins induced by topical 9% dihydroxyacetone sunless tanning spray inhibit vitamin d production? A pilot study
    Laura A G Armas
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    Photochem Photobiol 85:1265-6. 2009
    ..We found that DHA-induced melanoidins in skin act as a topical sunscreen attenuating the formation of 25(OH)D...
  70. ncbi Amount and type of protein influences bone health
    Robert P Heaney
    Creighton University, Omaha, NE, USA
    Am J Clin Nutr 87:1567S-1570S. 2008
    ..The issue for public health professionals is whether recommended protein intakes should be increased, given the prevalence of osteoporosis and sarcopenia...
  71. ncbi Vitamin D endocrine physiology
    Robert P Heaney
    Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 22:V25-7. 2007
    ..Vitamin D(3) inputs from all sources required to sustain such a level amount to 3600-4200 IU/d. Daily oral intakes as high as 10,000 IU are safe...
  72. ncbi Nutrient effects on the calcium economy: emphasizing the potassium controversy
    Karen Rafferty
    Creighton University Osteoporosis Research Center, Omaha, NE 68131, USA
    J Nutr 138:166S-171S. 2008
    ..Mean 24-h urinary potassium averaged 92% of dietary intake. According to nationwide food consumption surveys, milk is the number 1 single food source of potassium in all age groups in the United States...
  73. ncbi Calcium supplementation does not augment bone gain in young women consuming diets moderately low in calcium
    M Janet Barger-Lux
    Creighton University, Omaha, Nebraska, USA
    J Nutr 135:2362-6. 2005
    ....
  74. ncbi Absorbability and utility of calcium in mineral waters
    Robert P Heaney
    Creighton University, Omaha, NE, USA
    Am J Clin Nutr 84:371-4. 2006
    ..Calcium intake in North America remains substantially below recommended amounts. Bottled waters high in calcium could help close that gap...
  75. ncbi Effect of yogurt on a urinary marker of bone resorption in postmenopausal women
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    J Am Diet Assoc 102:1672-4. 2002
    ..Moreover, bone resorption responds rapidly and sensitively to improvements in calcium intake that are readily achievable by an older female population...
  76. ncbi Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption
    M Janet Barger-Lux
    Osteoporosis Research Center, Creighton University, 601 North 30th Street, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 87:4952-6. 2002
    ..Despite this input, at the late winter visit, 25(OH)D was less than 50 nmol/liter in 3 subjects and less than 75 nmol/liter in 15 subjects...
  77. ncbi The basis for the post-parathyroidectomy increase in bone mass
    Robert P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 17:N154-7. 2002
    ....
  78. ncbi Vitamin D status in a rural postmenopausal female population
    Joan M Lappe
    Creighton University Medical Center, Osteoporosis Research Center, 601 North 30 Street Suite 4820, Omaha, NE 68131, USA
    J Am Coll Nutr 25:395-402. 2006
    ..Inadequate vitamin D nutritional status is increasingly recognized as common in North American and European populations, but the extent of the shortfall and the parameters of the distribution for populations of interest remain uncertain...
  79. ncbi Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
    Joan M Lappe
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 85:1586-91. 2007
    ..Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking...
  80. ncbi Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color
    Laura A G Armas
    Creighton University Medical Center, Omaha, Nebraska 68131, USA
    J Am Acad Dermatol 57:588-93. 2007
    ..Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized...
  81. ncbi Vitamin D2 is much less effective than vitamin D3 in humans
    Laura A G Armas
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:5387-91. 2004
    ..5:1. Vitamin D(2) potency is less than one third that of vitamin D(3). Physicians resorting to use of vitamin D(2) should be aware of its markedly lower potency and shorter duration of action relative to vitamin D(3)...
  82. ncbi Determination of bone size of hip, spine, and wrist in human pedigrees by genetic and lifestyle factors
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    J Clin Densitom 5:45-56. 2002
    ..48 (0.09), 0.64 (0.08), and 0.60 (0.09) for bone size at the hip, spine, and wrist...
  83. ncbi Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients
    Robert Recker
    Creighton Osteoporosis Research Center, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 19:1628-33. 2004
    ..Ac.f nearly doubled 1 year after menopause, tripled 13 years after menopause, and remained elevated in women with osteoporosis...
  84. ncbi Interpreting studies of nutritional prevention: a perspective using calcium as a model
    Robert P Heaney
    Creighton University, Omaha, Nebraska 68131, USA
    J Womens Health (Larchmt) 14:889-97. 2005
  85. ncbi Calcium absorptive efficiency is positively related to body size
    M Janet Barger-Lux
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 90:5118-20. 2005
    ..Calcium absorption efficiency is a more important determinant of calcium balance than calcium intake itself. The sources of variability in absorptive performance are only partly elucidated...
  86. ncbi Vitamin D supplement doses and serum 25-hydroxyvitamin D in the range associated with cancer prevention
    Cedric F Garland
    University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Anticancer Res 31:607-11. 2011
    ..Few community-based studies allow estimation of the dose-response relationship between oral intake of vitamin D and corresponding serum 25(OH)D in the range above 1,000 IU/d...
  87. ncbi Estimates of optimal vitamin D status
    Bess Dawson-Hughes
    Osteoporos Int 16:713-6. 2005
    ..Based on the available evidence, we believe that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture...
  88. ncbi Measuring calcium absorption
    Robert P Heaney
    Am J Clin Nutr 81:1451; author reply 1451-2. 2005
  89. ncbi Vitamin D depletion and effective calcium absorption
    Robert P Heaney
    J Bone Miner Res 18:1342; author reply 1343. 2003
  90. ncbi Should calcium and vitamin D be added to the current enrichment program for cereal-grain products?
    Harold L Newmark
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Am J Clin Nutr 80:264-70. 2004
    ..We suggest a full scientific review of cereal-grain enrichment with calcium and vitamin D...
  91. ncbi Nutrition, chronic disease, and the problem of proof
    Robert P Heaney
    Am J Clin Nutr 84:471-2. 2006
  92. ncbi Protein and calcium: antagonists or synergists?
    Robert P Heaney
    Am J Clin Nutr 75:609-10. 2002
  93. ncbi Calcium absorption from three salts and CaSO(4)-fortified bread in premenopausal women
    Berdine R Martin
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907 1264, USA
    J Agric Food Chem 50:3874-6. 2002
    ..0675 +/- 0.016). Calcium sulfate is a bioavailable fortificant for white bread that compares favorably with milk and two other salts...
  94. ncbi Mineral balance and mineral requirement
    Robert P Heaney
    Am J Clin Nutr 87:1960-1; author reply 1961. 2008
  95. ncbi Re: "The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor" by Michaƫlsson et al
    Robert P Heaney
    Bone 40:1669; author reply 1670. 2007
  96. ncbi Monitoring the randomized trials of the Women's Health Initiative: the experience of the Data and Safety Monitoring Board
    Janet Wittes
    Statistics Collaborative, Washington DC, USA
    Clin Trials 4:218-34. 2007
    ..This paper describes the dilemmas faced by the DSMB and the considerations it made over the course of its existence. The paper concludes with some recommendations for other DSMBs...
  97. doi Reply: a responsible approach to maintaining adequate serum vitamin D levels
    Laura A G Armas
    J Am Acad Dermatol 58:516; author reply 516-7. 2008

Research Grants9

  1. BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS
    Robert Heaney; Fiscal Year: 1999
    ....
  2. BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS
    Robert Heaney; Fiscal Year: 2000
    ....
  3. BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS
    Robert Heaney; Fiscal Year: 2001
    ....
  4. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2003
    ..abstract_text> ..
  5. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2004
    ..abstract_text> ..
  6. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2005
    ..abstract_text> ..
  7. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2006
    ..abstract_text> ..