DAVID ZZ HE

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. pmc Changes in plasma membrane structure and electromotile properties in prestin deficient outer hair cells
    David Z Z He
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA
    Cytoskeleton (Hoboken) 67:43-55. 2010
  2. ncbi request reprint Prestin and the dynamic stiffness of cochlear outer hair cells
    David Z Z He
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, Nebraska 68175, USA
    J Neurosci 23:9089-96. 2003
  3. ncbi request reprint Mouse outer hair cells lacking the alpha9 ACh receptor are motile
    David Z Z He
    Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68175, USA
    Brain Res Dev Brain Res 148:19-25. 2004
  4. ncbi request reprint Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea
    David Z Z He
    Hair Cell Biophysics Laboratory, Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68175, USA
    Nature 429:766-70. 2004
  5. ncbi request reprint Motility-associated hair-bundle motion in mammalian outer hair cells
    Shuping Jia
    Hair Cell Biophysics Laboratory, Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68175, USA
    Nat Neurosci 8:1028-34. 2005
  6. pmc Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia
    Shuping Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Neurosci 29:15277-85. 2009
  7. pmc Prestin forms oligomer with four mechanically independent subunits
    Xiang Wang
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Brain Res 1333:28-35. 2010
  8. pmc Chick hair cells do not exhibit voltage-dependent somatic motility
    David Z Z He
    Hair Cell Biophysics Laboratory, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    J Physiol 546:511-20. 2003
  9. ncbi request reprint Streptomycin and gentamicin have no immediate effect on outer hair cell electromotility
    Xiang Wang
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Hear Res 234:52-8. 2007
  10. ncbi request reprint Mechanoelectric transduction of adult inner hair cells
    Shuping Jia
    Hair Cell Biophysics Laboratory, Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Neurosci 27:1006-14. 2007

Detail Information

Publications15

  1. pmc Changes in plasma membrane structure and electromotile properties in prestin deficient outer hair cells
    David Z Z He
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, USA
    Cytoskeleton (Hoboken) 67:43-55. 2010
    ....
  2. ncbi request reprint Prestin and the dynamic stiffness of cochlear outer hair cells
    David Z Z He
    Department of Biomedical Sciences, Creighton University Medical School, Omaha, Nebraska 68175, USA
    J Neurosci 23:9089-96. 2003
    ..The result suggests that the stiffness of the motor protein is a major contributor to the global axial stiffness of OHCs. ACh was found to affect both the motor protein and other lateral wall stiffness components...
  3. ncbi request reprint Mouse outer hair cells lacking the alpha9 ACh receptor are motile
    David Z Z He
    Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68175, USA
    Brain Res Dev Brain Res 148:19-25. 2004
    ..Results indicate that cochlear sensitivity, based on CAP thresholds, is similar for homozygous mutant and wild-type mice. Electromotility is also present in OHCs, independent of whether the alpha9 subunit is present or absent...
  4. ncbi request reprint Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea
    David Z Z He
    Hair Cell Biophysics Laboratory, Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68175, USA
    Nature 429:766-70. 2004
    ..Here we show that asymmetrical transducer currents and receptor potentials are significantly larger than previously thought, they possess a highly restricted dynamic range and strongly depend on cochlear location...
  5. ncbi request reprint Motility-associated hair-bundle motion in mammalian outer hair cells
    Shuping Jia
    Hair Cell Biophysics Laboratory, Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68175, USA
    Nat Neurosci 8:1028-34. 2005
    ..These findings suggest that the bundle movement originated in somatic motility and that somatic motility has a central role in cochlear amplification in mammals...
  6. pmc Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia
    Shuping Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Neurosci 29:15277-85. 2009
    ..Our study suggests that the dynamic nature of the hair cell's transduction apparatus is retained despite the fact that regeneration of the hair bundle is lost in mammalian cochlear hair cells...
  7. pmc Prestin forms oligomer with four mechanically independent subunits
    Xiang Wang
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Brain Res 1333:28-35. 2010
    ....
  8. pmc Chick hair cells do not exhibit voltage-dependent somatic motility
    David Z Z He
    Hair Cell Biophysics Laboratory, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    J Physiol 546:511-20. 2003
    ..The lack of somatic motility suggests that in avian hair cells the active process resides elsewhere, most likely in the hair cell stereocilia...
  9. ncbi request reprint Streptomycin and gentamicin have no immediate effect on outer hair cell electromotility
    Xiang Wang
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Hear Res 234:52-8. 2007
    ..Theses results suggest that, although streptomycin and gentamicin can block mechanotransduction channels as well as ACh receptors in hair cells, they have no direct affect on OHC somatic motility...
  10. ncbi request reprint Mechanoelectric transduction of adult inner hair cells
    Shuping Jia
    Hair Cell Biophysics Laboratory, Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Neurosci 27:1006-14. 2007
    ..There is a phase lead of IHC transducer currents relative to sinusoidal BM displacement, reflecting viscoelastic coupling of their cilia and their adaptation process...
  11. ncbi request reprint Thyroid hormone is not necessary for the development of outer hair cell electromotility
    David Z Z He
    Hair Cell Biophysics Laboratory, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    Hear Res 175:183-9. 2003
    ..This suggests that the defective auditory function seen in TH-deficient animals is most likely due to morphological and physiological changes in the cochlea, rather than the motor function of the OHCs...
  12. pmc Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification
    Xudong Wu
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Brain Res 1210:20-8. 2008
    ..e., nonlinear capacitance and electromotility) and normal cochlear sensitivity and frequency selectivity. We conclude that Glut5 is not required for OHC motility or cochlear amplification...
  13. pmc Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification
    Peter Dallos
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Neuron 58:333-9. 2008
    ..These animals have knockout-like behavior, demonstrating that prestin-based electromotility is required for cochlear amplification...
  14. ncbi request reprint Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier
    M Charles Liberman
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Nature 419:300-4. 2002
    ....
  15. ncbi request reprint Identification of differentially expressed cDNA clones from gerbil cochlear outer hair cells
    Jing Zheng
    Auditory Physiology Laboratory Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60802, USA
    Audiol Neurootol 7:277-88. 2002
    ....

Research Grants12

  1. Biophysics and Development of Cochlear Hair Cells
    David He; Fiscal Year: 2009
    ..abstract_text> ..
  2. Biophysics and Development of Cochlear Hair Cells
    David He; Fiscal Year: 2007
    ....
  3. BIOPHYSICS AND DEVELOPMENT OF COCHLEAR OUTER HAIR CELLS
    David He; Fiscal Year: 2005
    ....
  4. MECHANOELECTRICAL TRANSDUCTION IN ADULT OUTER HAIR CELLS
    David He; Fiscal Year: 2004
    ....
  5. Biophysics and Development of Cochlear Hair Cells
    David Z Z He; Fiscal Year: 2011
    ..abstract_text> ..