Bernd Fritzsch

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. pmc Long-distance three-color neuronal tracing in fixed tissue using NeuroVue dyes
    Heather Jensen-Smith
    Creighton University, Dept of Biomedical Sciences, Omaha, Nebraska, USA
    Immunol Invest 36:763-89. 2007
  2. pmc Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation
    Mengqing Xiang
    Center for Advanced Biotechnology and Medicine, Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    BMC Neurosci 4:2. 2003
  3. ncbi request reprint Nerve dependency of developing and mature sensory receptor cells
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    Ann N Y Acad Sci 855:14-27. 1998
  4. ncbi request reprint Otx1 null mutant mice show partial segregation of sensory epithelia comparable to lamprey ears
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178 0405, USA
    Dev Genes Evol 211:388-96. 2001
  5. doi request reprint Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons
    B Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Adv Space Res 32:1495-500. 2003
  6. pmc Molecular evolution of the vertebrate mechanosensory cell and ear
    Bernd Fritzsch
    Creighton University, Dept of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Biol 51:663-78. 2007
  7. ncbi request reprint Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance
    Bernd Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Prog Brain Res 146:265-78. 2004
  8. pmc Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brain
    Bernd Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, United States
    Hear Res 206:52-63. 2005
  9. pmc The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?
    Bernd Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Bioessays 28:1181-93. 2006
  10. ncbi request reprint Development and evolution of inner ear sensory epithelia and their innervation
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Neurobiol 53:143-56. 2002

Research Grants

  1. Replacing an Animal Resource Facility Cage Washer.
    Kristen Drescher; Fiscal Year: 2007

Collaborators

Detail Information

Publications74

  1. pmc Long-distance three-color neuronal tracing in fixed tissue using NeuroVue dyes
    Heather Jensen-Smith
    Creighton University, Dept of Biomedical Sciences, Omaha, Nebraska, USA
    Immunol Invest 36:763-89. 2007
    ..Use of NV Jade in combination with NV Red and NV Maroon substantially improves the efficiency of connectional analysis in complex mutants and transgenic models where limited numbers of specimens are available...
  2. pmc Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation
    Mengqing Xiang
    Center for Advanced Biotechnology and Medicine, Department of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    BMC Neurosci 4:2. 2003
    ..We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins...
  3. ncbi request reprint Nerve dependency of developing and mature sensory receptor cells
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    Ann N Y Acad Sci 855:14-27. 1998
    ....
  4. ncbi request reprint Otx1 null mutant mice show partial segregation of sensory epithelia comparable to lamprey ears
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178 0405, USA
    Dev Genes Evol 211:388-96. 2001
    ..It also affects constriction of the two main foramina in the ear, but not their initial formation. Otx1 is thus causally related to horizontal canal morphogenesis as well as morphogenesis of these foramina...
  5. doi request reprint Molecular developmental neurobiology of formation, guidance and survival of primary vestibular neurons
    B Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Adv Space Res 32:1495-500. 2003
    ..Such data pave the way to put the research on the influence of altered gravity stimulation within a molecular framework...
  6. pmc Molecular evolution of the vertebrate mechanosensory cell and ear
    Bernd Fritzsch
    Creighton University, Dept of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Biol 51:663-78. 2007
    ..Recent advances in our molecular understanding of ear and brain development provide novel avenues to this neglected aspect of auditory neurosensory evolution...
  7. ncbi request reprint Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance
    Bernd Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Prog Brain Res 146:265-78. 2004
    ..Indeed, BDNF may be one of the earliest genes expressed selectively in hair cells and it appears to be regulated somewhat independently of the genes needed for hair cell differentiation...
  8. pmc Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brain
    Bernd Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, United States
    Hear Res 206:52-63. 2005
    ..This conclusion is derived from data that show no recognizable central projection deviation, even if fibers are massively rerouted in the periphery, as in Ntf3(tgBDNF) mice in which vestibular fibers project to the cochlea...
  9. pmc The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?
    Bernd Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Bioessays 28:1181-93. 2006
    ..Use of these stem cells combined with molecular insights into neurosensory cell specification and proliferation regulation of the ear, might allow for neurosensory regeneration of mammalian ears in the near future...
  10. ncbi request reprint Development and evolution of inner ear sensory epithelia and their innervation
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Neurobiol 53:143-56. 2002
    ....
  11. pmc Cells, molecules and morphogenesis: the making of the vertebrate ear
    Bernd Fritzsch
    Creighton University, Department of Biomedical Sciences, 2500 California Plaza, Omaha, NE 68178, USA
    Brain Res 1091:151-71. 2006
    ..The dramatic progress in deciphering the molecular basis of ear morphogenesis offers grounds for optimism for translational research toward intervention in human morphogenetic defects of the ear...
  12. pmc Development of inner ear afferent connections: forming primary neurons and connecting them to the developing sensory epithelia
    Bernd Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Brain Res Bull 60:423-33. 2003
    ..Null mutations of specific neurotrophic factors lose distinct primary neuron populations which undergo rapid embryonic cell death...
  13. pmc The development of the hindbrain afferent projections in the axolotl: evidence for timing as a specific mechanism of afferent fiber sorting
    Bernd Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Zoology (Jena) 108:297-306. 2005
    ..Later forming ganglia of the same type may grow along existing pathways of earlier formed neurons...
  14. ncbi request reprint Evolution and development of the vertebrate ear
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Brain Res Bull 55:711-21. 2001
    ..The ear thus represents a unique mix of highly conserved developmental elements combined with co-opted and newly evolved developmental elements...
  15. pmc Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention
    B Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Dev Dyn 233:570-83. 2005
    ..Few fibers remain to the saccule, utricle, and the base of the cochlea, all areas with few or no Bdnf-beta-galactosidase-positive cells. Thus, retention of fibers is possible with BDNF, even in the absence of differentiated hair cells...
  16. ncbi request reprint Development of the labyrinthine efferent system
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    Ann N Y Acad Sci 781:21-33. 1996
    ..Examination of the possible basis for pathway selection tends to support the idea that efferents use intact afferent fibers as highways for their navigation to distinct sensory epithelia...
  17. ncbi request reprint How does the urodele ear develop?
    B Fritzsch
    Creighton University, Department Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Biol 40:763-71. 1996
    ....
  18. ncbi request reprint A simple and reliable technique to combine oligonucleotide probe in situ hybridization with neuronal tract tracing in vertebrate embryos
    B Fritzsch
    Dept of Biomedical Sciences, Creighton University, Omaha, Nebraska
    Biotech Histochem 71:289-94. 1996
    ..This technique can be applied to the developing embryo to study topology of a variety of cellular markers with reference to neuronal population or fibers identified by their origin or target...
  19. pmc Keeping sensory cells and evolving neurons to connect them to the brain: molecular conservation and novelties in vertebrate ear development
    B Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Brain Behav Evol 64:182-97. 2004
    ..The other is an increased complexity in the morphology of both adult mechanosensory cells and organs by the addition of end-stage and novel features and associated gene networks to detect specific aspects of mechanosensory stimuli...
  20. ncbi request reprint Of mice and genes: evolution of vertebrate brain development
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Brain Behav Evol 52:207-17. 1998
    ..It is suggested that more comparative developmental data are needed to establish firmly the relationship between homeobox genes and rhombomere specification in vertebrates other than a few model species...
  21. ncbi request reprint Making and breaking the innervation of the ear: neurotrophic support during ear development and its clinical implications
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, 2400 California Plaza, NE 68178, USA
    Cell Tissue Res 295:369-82. 1999
    ..The ear is a model system to test the interactions of the two neurotrophins, BDNF and NT-3, with their two high-affinity receptors, trkB and trkC...
  22. pmc Diffusion and imaging properties of three new lipophilic tracers, NeuroVue Maroon, NeuroVue Red and NeuroVue Green and their use for double and triple labeling of neuronal profile
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Brain Res Bull 66:249-58. 2005
    ..Double labeling experiments using NeuroVue Red and eGFP allowed us to demonstrate that every fiber in the neonatal ear is surrounded by developing Schwann cells...
  23. pmc Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear
    Sarah Pauley
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Dev Dyn 235:2470-82. 2006
    ..Much of the Foxg1 phenotype can be explained by the participation of the protein binding domain in the delta/notch/hes signaling pathway. Additional Foxg1 effects may be mediated by the forkhead DNA binding domain...
  24. pmc MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival
    Michael D Weston
    Creighton University School of Dentistry, Omaha, Nebraska, USA
    Dev Dyn 240:808-19. 2011
    ..Results suggest that hair cell miRNAs subdue cochlear gradient gene expression and are required for hair cell maintenance and survival...
  25. pmc Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis
    David H Nichols
    Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
    Cell Tissue Res 334:339-58. 2008
    ..The adult Lmx1a mutant organ of Corti shows a loss of cochlear hair cells, suggesting that the long-term maintenance of hair cells is also disrupted in these mutants...
  26. pmc Lack of neurotrophin 3 causes losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Neurosci 17:6213-25. 1997
    ..Despite these impressive innervation deficiencies, the morphology of the organ of Corti and the development of inner and outer hair cells appeared comparatively normal...
  27. ncbi request reprint The combined effects of trkB and trkC mutations on the innervation of the inner ear
    B Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Neurosci 16:493-505. 1998
    ....
  28. pmc Development and evolution of the vestibular sensory apparatus of the mammalian ear
    Kirk W Beisel
    Creighton University, Omaha, NE and BTNRH, Omaha, NE 68178, USA
    J Vestib Res 15:225-41. 2005
    ..Additional analyses are needed before gene therapy can help regenerate hair cells, restore otoconia, and reconnect sensory epithelia to the brain...
  29. pmc Evolutionary insights into the unique electromotility motor of mammalian outer hair cells
    Oseremen E Okoruwa
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Evol Dev 10:300-15. 2008
    ..We were able to identify that within the highly conserved meEM motif two regions, which are unique to all therian species, appear to be the most derived features in the SLC26A5 peptide...
  30. pmc Developmental expression of Kcnq4 in vestibular neurons and neurosensory epithelia
    Sonia M S Rocha-Sanchez
    Department of Oral Biology, Creighton University School of Dentistry, 2500 California Plaza, Omaha, NE 68178, USA
    Brain Res 1139:117-25. 2007
    ..Analyses of vestibular HCs of Bdnf conditional mutant mice, which are devoid of any innervation, demonstrate that regulation of Kcnq4 expression in vestibular HCs is independent of innervation...
  31. pmc Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
    Garrett A Soukup
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Dev Biol 328:328-41. 2009
    ..The correlation of differential and delayed depletion of mature miRNAs with the derailment of inner ear development demonstrates that miRNAs are crucial for inner ear neurosensory development and neurosensory-dependent morphogenesis...
  32. pmc Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit
    V Matei
    Department of Biomedical Science, Creighton University, Omaha, Nebraska 68178, USA
    Dev Dyn 234:633-50. 2005
    ..Neurog 1 null mice show a truncation of clonal expansion of hair cell precursors through temporally altered terminal mitosis, thereby resulting in smaller sensory epithelia...
  33. ncbi request reprint Development of the ear and of connections between the ear and the brain: is there a role for gravity?
    B Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Adv Space Res 28:595-600. 2001
    ..This phase is proposed to be critical for a proper calibration of the gravistatic information processing in the brain...
  34. ncbi request reprint The developmental segregation of posterior crista and saccular vestibular fibers in mice: a carbocyanine tracer study using confocal microscopy
    Adel Maklad
    Creighton University, School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Brain Res Dev Brain Res 135:1-17. 2002
    ....
  35. ncbi request reprint Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss
    Kirk W Beisel
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Neurosci 25:9285-93. 2005
    ..Progressive hearing loss associated with aging may result from an increasing mutational load expansion toward the apex in inner hair cells and spiral ganglion neurons...
  36. pmc MicroRNA-183 family conservation and ciliated neurosensory organ expression
    Marsha L Pierce
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Evol Dev 10:106-13. 2008
    ..The results suggest that miR-183 family members contribute specifically to neurosensory development or function, and that extant metazoan sensory organs are derived from cells that share genetic programs of common evolutionary origin...
  37. ncbi request reprint Development of midbrain and anterior hindbrain ocular motoneurons in normal and Wnt-1 knockout mice
    B Fritzsch
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Neurobiol 27:457-69. 1995
    ..Thus, the Wnt-1-/- mutation precludes formation or survival of midbrain and anterior hindbrain neurons, including oculomotor and trochlear motoneurons...
  38. ncbi request reprint Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds
    B Fritzsch
    Creighton University, School of Medicine, Dept of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Neurosci 15:563-76. 1997
    ..These data strongly suggest that the initial-development of many fungiform papillae and taste buds is independent of the specific taste innervation. It remains to be shown why others appear to be more dependent on proper innervation...
  39. ncbi request reprint Partial segregation of posterior crista and saccular fibers to the nodulus and uvula of the cerebellum in mice, and its development
    Adel Maklad
    Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Brain Res Dev Brain Res 140:223-36. 2003
    ..Rather, the segregation may reflect more global cerebellar patterning mechanisms involving guidance for the vestibular afferent fibers independent of the future target cells...
  40. pmc Time course of embryonic midbrain and thalamic auditory connection development in mice as revealed by carbocyanine dye tracing
    Bina Gurung
    Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68178, USA
    J Comp Neurol 479:309-27. 2004
    ....
  41. pmc Development of vestibular afferent projections into the hindbrain and their central targets
    Adel Maklad
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Brain Res Bull 60:497-510. 2003
    ..Overall, the functional significance of both overlapping and segregated projections are not yet fully experimentally explored in mammals. Such lack of details of the adult organization compromises future developmental analysis...
  42. ncbi request reprint Innervation of the maxillary vibrissae in mice as revealed by anterograde and retrograde tract tracing
    Adel Maklad
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Cell Tissue Res 315:167-80. 2004
    ..This suggests that the somatotopic maps of vibrissal projections reported at the different levels in the neuraxis are not faithfully reproduced at the level of the ganglion...
  43. pmc Expression and function of FGF10 in mammalian inner ear development
    Sarah Pauley
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Dev Dyn 227:203-15. 2003
    ..Together these data suggest that FGF10 plays a major role in ear morphogenesis. Most of these data are consistent with earlier findings on a null mutation in FGFR2b, one of FGF10's main receptors...
  44. ncbi request reprint Cochlear whole mount in situ hybridization: identification of longitudinal and radial gradients
    Tiffany N Judice
    Center for Hereditary Communication Disorders, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Brain Res Brain Res Protoc 9:65-76. 2002
    ..Not only can these hair cell gradients be shown in adult tissues, but also the developmental up-regulation and down-regulation of genes and their associated spatio-temporal expression patterns can be demonstrated...
  45. pmc Near-infrared laser illumination transforms the fluorescence absorbing X-Gal reaction product BCI into a transparent, yet brightly fluorescent substance
    V A Matei
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Brain Res Bull 70:33-43. 2006
    ..Therefore, care must be taken in developing imaging strategies. Our findings have implications for the use of X-Gal in gene and protein detection and provide a novel substrate for high density digital information storage...
  46. pmc Molecular conservation and novelties in vertebrate ear development
    B Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Curr Top Dev Biol 57:1-44. 2003
  47. pmc Chick hair cells do not exhibit voltage-dependent somatic motility
    David Z Z He
    Hair Cell Biophysics Laboratory, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    J Physiol 546:511-20. 2003
    ..The lack of somatic motility suggests that in avian hair cells the active process resides elsewhere, most likely in the hair cell stereocilia...
  48. doi request reprint Adaptations of the vestibular system to short and long-term exposures to altered gravity
    L L Bruce
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Adv Space Res 32:1533-9. 2003
    ..This system provides a basis for studying how the vestibular environment can modify cerebellar function, allowing animals to adapt to new environments...
  49. ncbi request reprint Intracranial distribution of the sympathetic system in mice: DiI tracing and immunocytochemical labeling
    A Maklad
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Anat Rec 263:99-111. 2001
    ..All of the intracranial trajectories traced from scg were found to be catecholaminergic, and likely sympathetic, using tyrosine hydroxylase (TH) immunocytochemistry...
  50. ncbi request reprint Whole-mount procedures for simultaneous visualization of nerves, neurons, cartilage and bone
    E Rosa-Molinar
    Creighton University School of Medicine, Department of Biomedical Sciences, Criss II, Room 310, 2500 California Plaza, Omaha, NE 68178, USA
    Brain Res Brain Res Protoc 4:115-23. 1999
    ....
  51. doi request reprint Photo- and bio-physical characterization of novel violet and near-infrared lipophilic fluorophores for neuronal tracing
    J Tonniges
    Creighton University, Department of Physics, Omaha, NE 68178, USA
    J Microsc 239:117-34. 2010
    ....
  52. ncbi request reprint Electron microscopic differentiation of directly and transneuronally transported DiI and applications for studies of synaptogenesis
    L L Bruce
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    J Neurosci Methods 73:107-12. 1997
    ..This labelling pattern can be explained by diffusion through continuous membranes. These characteristics make DiI diffusion a powerful technique for identifying and studying early events in neuronal development and synapse formation...
  53. pmc Lizard and frog prestin: evolutionary insight into functional changes
    Jie Tang
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, United States of America
    PLoS ONE 8:e54388. 2013
    ..Thus, lizard and frog prestins appear to be functionally more advanced than that of chicken prestin, although motor capability is not yet acquired...
  54. pmc Regenerating cochlear hair cells: quo vadis stem cell
    Kirk Beisel
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Cell Tissue Res 333:373-9. 2008
    ..In addition, we highlight currently insurmountable obstacles to the successful transformation of stem cells into hair cell precursors and their injection into the cochlear canal to replace lost hair cells...
  55. ncbi request reprint Partial behavioral compensation is revealed in balance tasked mutant mice lacking otoconia
    M D Crapon de Caprona
    Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
    Brain Res Bull 64:289-301. 2004
    ....
  56. ncbi request reprint Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA2
    K W Beisel
    Department of Genetics, Center for Hereditary Communication Disorders, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68178, USA
    Brain Res Mol Brain Res 82:137-49. 2000
    ..Our data suggest that the primary defect leading to initial high frequency loss and subsequent progressive hearing loss for all frequencies may be due to spiral ganglion and/or IHC dysfunction, rather than an OHC aberration...
  57. pmc A disorganized innervation of the inner ear persists in the absence of ErbB2
    Jacqueline K Morris
    Department of Biology and Geology, Baldwin Wallace College, Berea, OH 44017, USA
    Brain Res 1091:186-99. 2006
    ..This suggests that either ErbB2 mediated alterations in sensory neurons or the absence of Schwann cells affects efferent fiber growth to the organ of Corti...
  58. pmc NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea
    Lino Tessarollo
    Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21701, USA
    J Neurosci 24:2575-84. 2004
    ..Our data provide genetic evidence that neurotrophins in the ear exert both survival and axon guidance roles...
  59. ncbi request reprint Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice
    David Hellard
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 275:34-43. 2004
    ....
  60. pmc Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, 1520 23rd Street South, Great Falls, MT 59405, USA
    Development 131:5561-72. 2004
    ..These analyses define a specific role for both genes in early differentiation and survival of the placodally derived cranial sensory neurons...
  61. pmc The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
    Johanna Mantela
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 132:2377-88. 2005
    ..Our findings demonstrate that the pRb pathway is required for hair cell quiescence and that manipulation of the cell cycle machinery disrupts the coordinated development within the inner ear sensory epithelia...
  62. ncbi request reprint Ancestry of photic and mechanic sensation?
    Bernd Fritzsch
    Creighton U, Omaha, NE
    Science 308:1113-4; author reply 1113-4. 2005
  63. pmc The molecular biology of ear development - "Twenty years are nothing"
    Fernando Giraldez
    Departament de Cincies Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomdica de Barcelona PRBB, Barcelona, Spain
    Int J Dev Biol 51:429-38. 2007
    ....
  64. pmc Targeted knockout and lacZ reporter expression of the mouse Tmhs deafness gene and characterization of the hscy-2J mutation
    Chantal M Longo-Guess
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mamm Genome 18:646-56. 2007
    ....
  65. ncbi request reprint Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons
    Myriam Müller
    Center for Molecular Neurobiology, Martinistrasse 85, 20251 Hamburg, Germany
    Development 130:5815-26. 2003
    ..Taken together, our findings demonstrate a requirement for Nkx6.1 in the development of postmitotic motoneurons, and suggest a cell-autonomous function in the control of branchio-motoneuron migration...
  66. ncbi request reprint Comparative analysis of neurotrophin receptors and ligands in vertebrate neurons: tools for evolutionary stability or changes in neural circuits?
    Christopher S von Bartheld
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, 89557, USA
    Brain Behav Evol 68:157-72. 2006
    ....
  67. ncbi request reprint Auditory system development: primary auditory neurons and their targets
    Edwin W Rubel
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle 98195 7923, USA
    Annu Rev Neurosci 25:51-101. 2002
    ..Ganglion cell innervation and synaptic activity are essential for normal development of neurons in the cochlear nucleus...
  68. pmc Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons
    Antonio Postigo
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Genes Dev 16:633-45. 2002
    ..Our findings show that although TrkB and TrkC signals mediating survival are largely similar, TrkB and TrkC signals required for maintenance of target innervation in vivo are regulated by distinct mechanisms...
  69. pmc Orbital spaceflight during pregnancy shapes function of mammalian vestibular system
    April E Ronca
    Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Behav Neurosci 122:224-32. 2008
    ..Taken together, these studies provide evidence that gravity and angular acceleration shape prenatal organization and function within the mammalian vestibular system...
  70. pmc Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment
    Chandrakala Puligilla
    Section on Developmental Neuroscience, NIDCD NIH, Bethesda, Maryland 20892, USA
    Dev Dyn 236:1905-17. 2007
    ....
  71. pmc Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    Chenghua Gu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 5:45-57. 2003
    ..Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system...
  72. ncbi request reprint Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin
    Yong Tian
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee
    Dev Dyn 231:199-203. 2004
    ..This mouse will be useful for hair-cell-specific gene targeting...
  73. pmc Conditional and inducible gene recombineering in the mouse inner ear
    Yong Tian
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Brain Res 1091:243-54. 2006
    ..Examination of integrase expression at different loci will facilitate studies on the expression of exogenous transgenes. These genetic applications for the mouse genome will dramatically advance in vivo gene function studies...
  74. ncbi request reprint Inner hair cell Cre-expressing transgenic mouse
    Mingyuan Li
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genesis 39:173-7. 2004
    ..This Cre mouse line can thus be used for conditional gene targeting in mature inner hair cells of the cochlea. genesis 39:173-177, 2004...

Research Grants1

  1. Replacing an Animal Resource Facility Cage Washer.
    Kristen Drescher; Fiscal Year: 2007
    ....